公开(公告)号：WO2013028809A3

公开(公告)日：2013-05-16

申请号：PCT/US2012051946

申请日：2012-08-22

Applicant: MEDTRONIC INC ,  KELLY THOMAS D ,  LYU SUPING

Inventor： KELLY THOMAS D ,  LYU SUPING

IPC: A61M1/34 ,  A61J1/06 ,  A61M1/10 ,  A61M1/14

CPC classification number: A61M1/1696 ,  A61M1/16 ,  A61M1/3609 ,  A61M2205/15 ,  A61M2205/3313 ,  A61M2205/3317 ,  A61M2205/50 ,  A61M2205/75 ,  A61M2209/082 ,  A61M2230/65 ,  B01D15/00 ,  B01D15/02 ,  B01D2313/44 ,  B01J20/0211 ,  B01J20/0292 ,  B01J20/20 ,  B01J20/24 ,  B01J2220/62

Abstract: Disclosed are systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, a sorbent cartridge with at least two separate flow paths, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.

Abstract translation: 公开了用于执行肾脏替代疗法的系统和方法，其具有或使用透析器，控制部件，具有至少两个分开的流动路径的吸附剂药筒，以及被配置为具有适于穿戴或携带的重量和尺寸的流体储存器 需要治疗的个体。 用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。 透析电路和用于循环血液的体外循环通过透析膜流体连通。 在体外循环和透析回路之间移动的流体通量由控制泵运行的速率改变，从而可以控制超滤速率和对流间隙。 该系统提供对吸附剂盒的入口和出口导电性的监测，以提供量化或监测吸附剂盒去除尿素的设施。

公开(公告)号：WO2013040082A3

公开(公告)日：2013-05-10

申请号：PCT/US2012054930

申请日：2012-09-12

Applicant: MEDTRONIC INC ,  KELLY THOMAS D ,  LYU SUPING

Inventor： KELLY THOMAS D ,  LYU SUPING

IPC: A61M1/14 ,  A61M1/10 ,  A61M1/38

CPC classification number: A61M1/3621 ,  A61M1/1696

Abstract: Sorbent cartridges having a polystyrene sulfonate resin saturated with calcium ions for the performance of kidney replacement therapy are disclosed. Systems and methods having or using a sorbent cartridge, a dialyzer, control components, a cartridge having a polystyrene sulfonate resin, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. A system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to quantify or monitor the removal of urea by the sorbent cartridge.

Abstract translation: 公开了具有用钙离子饱和的聚苯乙烯磺酸盐树脂进行肾脏替代治疗的吸附剂药筒。 公开了具有或使用吸附剂盒，透析器，控制组件，具有聚苯乙烯磺酸盐树脂的盒和配置为适于由需要治疗的个体穿戴或携带的重量和尺寸的流体储存器的系统和方法。 用于进行肾脏替代治疗的系统具有受控的依从性透析回路，其中控制泵控制流体穿过透析膜的双向运动。 该系统提供了对吸附剂筒的入口和出口电导率的监测，以量化或监测吸附剂筒的尿素去除。

公开(公告)号：WO2007143497A3

公开(公告)日：2007-12-13

申请号：PCT/US2007/070074

申请日：2007-05-31

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  ROGER, Rodolfo G. ,  HOGARD, Michael E. ,  KELLY, Thomas D.

Inventor： ROGER, Rodolfo G. ,  HOGARD, Michael E. ,  KELLY, Thomas D.

IPC: A61M1/14 ,  A61M1/16

Abstract: A kidney failure treatment system includes: (i) a dialysate supply; (ii) a weighing device; a control container coupled operably to the weighing device; (iii) a diffusion membrane; (iv) a drain; first and second pumps; (v) a first fluid conduit coupled fluidly to the dialysate supply and the diffusion membrane, the first fluid conduit coupled operably to the first pump; (vi) a second fluid conduit coupled fluidly to the control container and the drain, the second fluid conduit coupled operably to the first pump; and (vii) a third fluid conduit coupled fluidly to the diffusion membrane and the control conduit, the third fluid conduit coupled operably to the second pump.

公开(公告)号：WO2013025844A2

公开(公告)日：2013-02-21

申请号：PCT/US2012/051011

申请日：2012-08-15

Applicant: MEDTRONIC, INC. ,  KELLY, Thomas D. ,  LYU, SuPing ,  PUDIL, Bryant J. ,  MEYER, Thomas E.

Inventor： KELLY, Thomas D. ,  LYU, SuPing ,  PUDIL, Bryant J. ,  MEYER, Thomas E.

IPC: A61M1/16 ,  A61M1/38 ,  A61M1/10 ,  A61M1/34

CPC classification number: A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1696 ,  A61M1/3609 ,  A61M1/3612 ,  A61M2205/15 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2230/207

Abstract: Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.

Abstract translation: 用于进行具有或使用透析器，对照组分，吸附剂盒和流体储存器的肾替代疗法的设备，系统和方法，所述透析器，对照组分，吸附剂盒和流体储存器被构造为适于佩戴或携带的重量和尺寸 由需要治疗的个体进行披露。 该系统具有受控的符合性透析回路，其中控制泵控制流体穿过透析膜的双向移动。 提供第一吸附剂盒用于具有活性炭和氧化锆的便携式处理模块。 该系统还提供了对含有脲酶的吸附剂盒的入口和出口电导率的监测，以提供量化或监测通过可拆卸的尿素去除模块去除尿素的设施。

公开(公告)号：WO2008100671A1

公开(公告)日：2008-08-21

申请号：PCT/US2008/051269

申请日：2008-01-17

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  ROGER, Rodolfo G. ,  CHILDERS, Robert W. ,  KELLY, Thomas D.

Inventor： ROGER, Rodolfo G. ,  CHILDERS, Robert W. ,  KELLY, Thomas D.

IPC: A61M1/36 ,  A61M1/16 ,  A61M1/34

CPC classification number: A61M1/3656 ,  A61M1/14 ,  A61M1/3607 ,  A61M1/3639 ,  A61M1/3653 ,  A61M2205/058 ,  A61M2205/15 ,  A61M2205/3306 ,  A61M2205/3317 ,  A61M2205/3331 ,  A61M2205/3344 ,  A61M2205/3375 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2230/04

Abstract: An access disconnection system includes: an arterial line (14); a venous line (18); a transmitter (62) configured to transmit a sound wave in one of the arterial (14) and venous lines (18) when connected to a patient (12); a receiver (64) configured to receive the sound wave from the other of the arterial (14) and venous lines (18) when connected to the patient (12); and electronic circuitry (66) coupled to at least one of the transmitter and receiver, the circuitry (66) configured to send a disconnection output indicative of a change in the sound waves received by the receiver (64) from the transmitter (62) sufficient to expect that an access disconnection of one of the arterial line (14) and venous lines (18) has occurred.

Abstract translation: 一种接入断开系统，包括：动脉线（14）; 静脉线（18）; 发射器（62），被配置为当连接到患者（12）时在所述动脉（14）和静脉线（18）中的一个中传输声波; 接收器（64），被配置为当连接到患者（12）时从动脉（14）和静脉线（18）中的另一个接收声波; 和电子电路（66），其耦合到所述发射机和接收机中的至少一个，所述电路（66）经配置以向所述发射机（62）发送指示所述接收器（64）接收的声波的变化的断开输出足够 期望出现动脉线（14）和静脉线（18）之一的进入断开。

公开(公告)号：WO2005061026A3

公开(公告)日：2005-12-15

申请号：PCT/US2004040145

申请日：2004-12-01

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  KELLY THOMAS D ,  EL SAYYID WALEED M

Inventor： KELLY THOMAS D ,  EL SAYYID WALEED M

IPC: A61M1/16 ,  A61M1/34 ,  A61M1/36

CPC classification number: A61M1/3462 ,  A61M1/1601 ,  A61M1/1635 ,  A61M1/1672 ,  A61M1/30 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3647 ,  A61M1/3649 ,  A61M2205/3303 ,  A61M2205/3306 ,  A61M2205/50 ,  A61M2205/7518

Abstract: Systems and methods for improving medical fluid delivery systems, such as hemofiltration ("HF") and hemodiafiltration ("HDF") are provided. In first embodiments, systems and methods for selectively performing pre-and postdilution HF and HDF clearance modes is provided. In other embodiments, systems and methods for providing prime bolus and rinseback fluid volumes before, during and/or after HF and HDF therapies are provided. In further embodiments, improved systems and methods for removing ultrafiltrate from the patient are provided. Still further, improved filtration configurations and methods are provided.

Abstract translation: 提供了用于改善医疗流体递送系统的系统和方法，例如血液滤过（“HF”）和血液透析滤过（“HDF”）。 在第一实施例中，提供用于选择性地执行前后稀释HF和HDF清除模式的系统和方法。 在其它实施方案中，提供在HF和HDF治疗之前，期间和/或之后提供初次推注和冲洗液体体积的系统和方法。 在另外的实施例中，提供了用于从患者去除超滤液的改进的系统和方法。 此外，提供了改进的过滤构造和方法。

公开(公告)号：WO2005044339A2

公开(公告)日：2005-05-19

申请号：PCT/US2004/037053

申请日：2004-11-05

Applicant: BAXTER HEALTHCARE CORPORATION ,  BAXTER HEALTHCARE S.A. ,  KELLY, Thomas, D. ,  CHILDERS, Robert, W. ,  BUSBY, Don ,  ROGER, Rodolfo ,  EL SAYYID, Waleed, Mutasem ,  DIN, Shahid, Q.

Inventor： KELLY, Thomas, D. ,  CHILDERS, Robert, W. ,  BUSBY, Don ,  ROGER, Rodolfo ,  EL SAYYID, Waleed, Mutasem ,  DIN, Shahid, Q.

IPC: A61M1/16

CPC classification number: A61M1/3621 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1037 ,  A61M1/1039 ,  A61M1/1062 ,  A61M1/1081 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1607 ,  A61M1/1613 ,  A61M1/1621 ,  A61M1/1629 ,  A61M1/1633 ,  A61M1/1635 ,  A61M1/1656 ,  A61M1/166 ,  A61M1/1668 ,  A61M1/167 ,  A61M1/1672 ,  A61M1/1696 ,  A61M1/267 ,  A61M1/288 ,  A61M1/341 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3427 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3444 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3486 ,  A61M1/3624 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3647 ,  A61M1/3649 ,  A61M1/365 ,  A61M1/3652 ,  A61M1/3656 ,  A61M2202/0413 ,  A61M2205/12 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/276 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3327 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/75

Abstract: A system, method and apparatus for performing a renal replacement therapy is provided. In one embodiment, two small high flux dialyzers are connected in series. A restriction is placed between the two dialyzers in the dialysate flow path. The restriction is variable and adjustable in one preferred embodiment. The restriction builds a positive pressure in the venous dialyzer, causing a high degree of intentional backfiltration. That backfiltration causes a significant flow of dialysate through the high flux venous membrane directly into the patient's blood. That backfiltered solution is subsequently ultrafiltered from the patient from the arterial dialyzer. The diffusion of dialysate into the venous filter and removal of dialysate from the arterial dialyzer causes a convective transport of toxins from the patient. Additionally, the dialysate that does not diffuse directly into the patient but instead flows across the membranes of both dialyzers provides a diffusive clearance of waste products.

Abstract translation: 提供了一种用于进行肾脏替代疗法的系统，方法和装置。 在一个实施例中，两个小型高通量透析器串联连接。 在透析液流动路径中的两个透析器之间设置限制。 在一个优选实施例中，限制是可变的和可调节的。 限制在静脉透析器中产生正压，导致高度有意的反渗透。 该回流导致透析液通过高通量静脉膜直接流入患者血液中。 随后从动脉透析器将患者的过滤后的溶液进行超滤。 透析液扩散到静脉过滤器中，从动脉透析器中除去透析液会导致患者的毒素对流运输。 另外，透析液不直接扩散到患者体内，而是穿过两个透析器的膜，从而提供废物的扩散清除。

公开(公告)号：WO2013019994A3

公开(公告)日：2013-04-25

申请号：PCT/US2012049398

申请日：2012-08-02

Applicant: MEDTRONIC INC ,  KELLY THOMAS D ,  LYU SUPING ,  PUDIL BRYANT J ,  MEYER THOMAS E

Inventor： KELLY THOMAS D ,  LYU SUPING ,  PUDIL BRYANT J ,  MEYER THOMAS E

IPC: A61M1/34 ,  A61M1/16 ,  A61M1/38

CPC classification number: A61M1/3482 ,  A61M1/1696 ,  A61M2202/0021 ,  A61M2202/0413

Abstract: Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.

Abstract translation: 公开了用于执行肾脏替代疗法的系统和方法，其具有或使用透析器，控制组件，吸附剂盒和流体储存器，其被配置为适于被需要治疗的个体穿戴或携带的重量和尺寸。 用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。 透析电路和用于循环血液的体外循环通过透析膜流体连通。 在体外循环和透析回路之间移动的流体通量由控制泵运行的速率改变，从而可以控制超滤速率和对流间隙。 该系统提供对吸附剂盒的入口和出口导电性的监测，以提供量化或监测吸附剂盒去除尿素的设施。

公开(公告)号：WO2009064540A2

公开(公告)日：2009-05-22

申请号：PCT/US2008/077668

申请日：2008-09-25

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  KELLY, Thomas D. ,  MINKUS, Marc S. ,  BERNARDO, Angelito A. ,  BURNS, William P. ,  CHILDERS, Robert W. ,  MALIEKKAL, Shincy J. ,  MULLER, Matthew R. ,  ROHDE, Justin B. ,  HOGARD, Michael E.

Inventor： KELLY, Thomas D. ,  MINKUS, Marc S. ,  BERNARDO, Angelito A. ,  BURNS, William P. ,  CHILDERS, Robert W. ,  MALIEKKAL, Shincy J. ,  MULLER, Matthew R. ,  ROHDE, Justin B. ,  HOGARD, Michael E.

IPC: A61M1/36

CPC classification number: A61M1/3643 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/282 ,  A61M1/288 ,  A61M1/3624 ,  A61M1/3627 ,  A61M1/3644 ,  A61M1/3649 ,  A61M2202/02 ,  A61M2202/0413 ,  A61M2205/10 ,  A61M2205/3382 ,  A61M2205/3386 ,  A61M2205/75 ,  Y10T137/0402

公开(公告)号：WO2009055639A2

公开(公告)日：2009-04-30

申请号：PCT/US2008/081058

申请日：2008-10-24

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  CHILDERS, Robert W. ,  KELLY, Thomas D. ,  ROGER, Rodolfo

Inventor： CHILDERS, Robert W. ,  KELLY, Thomas D. ,  ROGER, Rodolfo

IPC: A61M1/16 ,  A61M1/28

CPC classification number: A61M1/16 ,  A61M1/14 ,  A61M1/1601 ,  A61M1/1605 ,  A61M1/1621 ,  A61M1/1649 ,  A61M1/166 ,  A61M1/168 ,  A61M1/1686 ,  A61M1/1688 ,  A61M1/28 ,  A61M1/281 ,  A61M1/3465 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3649 ,  A61M1/3652 ,  A61M2205/128 ,  A61M2205/3313 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2205/3379 ,  A61M2205/6036 ,  B01D61/243 ,  B01D61/30 ,  Y10T29/49826 ,  Y10T137/0396 ,  Y10T137/87893

Abstract: A dialysis machine includes a dialysis instrument having a pump actuator and first and second valve actuators, and a disposable cassette operable with the dialysis instrument, the disposable cassette including a pump portion operable with the pump actuator, first and second valve chambers operable with the first and second valve actuators, the first and second valve chambers communicating fluidly with each other, at least the first valve chamber communicating fluidly with a compliance chamber, the compliance chamber negating a first backpressure due to a pneumatic closing pressure used to close the first valve chamber to help to ensure the pneumatic pressure applied to the first valve chamber will close the first valve chamber against a second backpressure from an existing closure of the second valve chamber.

Abstract translation: 透析机包括具有泵致动器和第一和第二阀致动器的透析仪器，以及可与透析仪器一起操作的一次性盒，该一次性盒包括可与泵致动器一起操作的泵部分，第一和第二阀室可与第一 以及第二阀致动器，所述第一阀室和所述第二阀室彼此流体连通，至少所述第一阀室与顺应室流体连通，所述顺应室由于用于关闭所述第一阀室的气动闭合压力而使第一背压无效 以帮助确保施加到第一阀室的气动压力将相对于来自第二阀室的现有闭合件的第二背压而关闭第一阀室。