公开(公告)号：WO2012170707A9

公开(公告)日：2012-12-13

申请号：PCT/US2012/041382

申请日：2012-06-07

Applicant: XYLECO INC. ,  MEDOFF, Marshall ,  BAE, Seul-a ,  VALDEZ, Randy ,  MASTERMAN, Thomas Craig

Inventor： MEDOFF, Marshall ,  BAE, Seul-a ,  VALDEZ, Randy ,  MASTERMAN, Thomas Craig

IPC: C12P7/10 ,  C13K1/02 ,  C08H8/00 ,  B01F7/00 ,  C08J3/00

Abstract: Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, which can then be fermented to produce a product such as a biofuel.

公开(公告)号：WO2012154904A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/037208

申请日：2012-05-10

Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  BEUTLER, John A. ,  LEGRICE, Stuart F.J. ,  THOMAS, Craig ,  JIANG, Jian-Kang ,  CHUNG, Suhman ,  WILSON, Jennifer

Inventor： BEUTLER, John A. ,  LEGRICE, Stuart F.J. ,  THOMAS, Craig ,  JIANG, Jian-Kang ,  CHUNG, Suhman ,  WILSON, Jennifer

IPC: A61K31/12 ,  C07D233/60 ,  C07D295/088 ,  C07C49/733 ,  C07C225/18 ,  C07C317/24 ,  C07C323/22

CPC classification number: A61K31/4453 ,  A61K31/122 ,  A61K31/4164 ,  A61K45/06 ,  C07C49/573 ,  C07C49/733 ,  C07C225/14 ,  C07C317/24 ,  C07C323/22 ,  C07C2602/32 ,  C07D233/60 ,  C07D233/64 ,  C07D295/088 ,  C07D295/116

Abstract: Disclosed are compounds that inhibit RNase H activity of retroviruses, for example, a compound of formula (I) wherein R 1 , R 2 , and R 3 are as described herein, as well as pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment or prevention of infection by human immunodeficiency virus (HIV).

Abstract translation: 公开了抑制逆转录病毒的RNase H活性的化合物，例如式（I）的化合物，其中R 1，R 2和R 3如本文所述，以及其药学上可接受的盐，溶剂合物，立体异构体和前药。 包含这些化合物的药物组合物，以及使用方法，以及治疗或预防人类免疫缺陷病毒（HIV）的感染。

公开(公告)号：WO2011127388A2

公开(公告)日：2011-10-13

申请号：PCT/US2011031752

申请日：2011-04-08

Applicant: US HEALTH ,  GERSHENGORN MARVIN ,  NEUMANN SUSANNE ,  HUANG WENWEI ,  THOMAS CRAIG J

Inventor： GERSHENGORN MARVIN ,  NEUMANN SUSANNE ,  HUANG WENWEI ,  THOMAS CRAIG J

IPC: C07D405/06 ,  A61K31/517 ,  A61P35/00 ,  C07D239/91 ,  C07D401/06

CPC classification number: C07D401/06 ,  A61K31/517 ,  C07D239/91 ,  C07D405/06

Abstract: TSHR inverse agonists and neutral antagonists that are useful for treating Graves' orbitopathy, Graves' hyperthyroidism and/or thyroid cancer.

Abstract translation: TSHR反向激动剂和中枢拮抗剂，可用于治疗格雷夫斯眶前病变，格雷夫斯甲状腺功能亢进症和/或甲状腺癌。

公开(公告)号：WO2011100455A1

公开(公告)日：2011-08-18

申请号：PCT/US2011/024382

申请日：2011-02-10

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  FITZGERALD, David J. ,  PASTAN, Ira H. ,  ONDA, Masanori ,  O'SHEA, John ,  THOMAS, Craig ,  JIANG, Jian-kang

Inventor： FITZGERALD, David J. ,  PASTAN, Ira H. ,  ONDA, Masanori ,  O'SHEA, John ,  THOMAS, Craig ,  JIANG, Jian-kang

IPC: A61K38/16 ,  A61K31/506 ,  A61P37/02

CPC classification number: A61K31/506 ,  A61K38/16 ,  A61K45/06 ,  Y02A50/471 ,  A61K2300/00

Abstract: The present invention provides methods and compositions for reducing, inhibiting or preventing the development and/or production of neutralizing antibodies against therapeutic foreign proteins by co-administering the therapeutic foreign protein with a Janus kinase 3 (JAK3) inhibitor.

Abstract translation: 本发明提供了用Janus激酶3（JAK3）抑制剂共同施用治疗性外源蛋白来减少，抑制或预防用于治疗性外源蛋白的中和抗体的发生和/或产生的方法和组合物。

公开(公告)号：WO2011041655A1

公开(公告)日：2011-04-07

申请号：PCT/US2010/051090

申请日：2010-10-01

Applicant: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  THOMAS, Craig, J. ,  MOTT, Bryan, T. ,  TANEGA, Cordelle ,  SHEN, Min ,  AULD, Douglas, S. ,  ROSENTHAL, Andrew, S. ,  MALONEY, David, J.

Inventor： THOMAS, Craig, J. ,  MOTT, Bryan, T. ,  TANEGA, Cordelle ,  SHEN, Min ,  AULD, Douglas, S. ,  ROSENTHAL, Andrew, S. ,  MALONEY, David, J.

IPC: C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D419/12 ,  C07D419/14 ,  A61K31/517

CPC classification number: C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: Disclosed herein are novel quinazolin-4-amine derivatives that are inhibitors of Clk1, Clk2, Clk3, Clk4, or Dyrk1A. Also disclosed are quinazolin-4-amine derivatives as potent and selective inhibitors of Clk1, Clk4, and Dyrk1A. These agents provide useful tools for the study of Clk1, Clk4 and Dyrk1A and their respective roles in pre-mRNA splicing. Methods of treating Clk1, Clk2, Clk4, or Dyrk1A kinase mediated disorders with certain quinazolin-4-amine derivatives are also disclosed.

Abstract translation: 本文公开的是作为Clk1，Clk2，Clk3，Clk4或Dyrk1A的抑制剂的新的喹唑啉-4-胺衍生物。 还公开了喹唑啉-4-胺衍生物作为Clk1，Clk4和Dyrk1A的有效和选择性抑制剂。 这些试剂为研究Clk1，Clk4和Dyrk1A及其各自在mRNA前剪接中的作用提供了有用的工具。 还公开了用某些喹唑啉-4-胺衍生物治疗Clk1，Clk2，Clk4或Dyrk1A激酶介导的病症的方法。

公开(公告)号：WO2010042867A3

公开(公告)日：2010-04-15

申请号：PCT/US2009/060237

申请日：2009-10-09

Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  THOMAS, Craig J. ,  AULD, Douglas S. ,  INGLESE, James ,  SKOUMBOURDIS, Amanda P. ,  JIANG, Jian-Kang ,  BOXER, Matthew

Inventor： THOMAS, Craig J. ,  AULD, Douglas S. ,  INGLESE, James ,  SKOUMBOURDIS, Amanda P. ,  JIANG, Jian-Kang ,  BOXER, Matthew

IPC: C07D209/08 ,  C07D211/54 ,  C07D215/36 ,  C07D265/36 ,  C07D277/64 ,  C07D295/26 ,  C07D311/70 ,  C07D317/62 ,  C07D319/18 ,  C07D321/10 ,  C07D401/12 ,  C07D403/12 ,  C07D495/14 ,  A61K31/18 ,  A61P35/00

Abstract: Disclosed are pyruvate kinase M2 activators, which are bis sulfonamide piperazinyl and piperidinyl compounds of Formula (I), 2,4-disubstituted 4 H - thieno[3,2- c ]pyrrole-2-(substituted benzyl)pyridazin-3(2 H )-ones of Formula (II) and 6-(3,4-dimethylphenylaminosulfonyl)-3,4-dihydro-1 H -quinolin-2-one of formula (III), wherein L, R 1 , R 2 , R 11 to R 16 , R 21 and R 22 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia.

公开(公告)号：WO2009134816A1

公开(公告)日：2009-11-05

申请号：PCT/US2009/042000

申请日：2009-04-28

Applicant: XYLECO, INC. ,  MEDOFF, Marshall ,  MASTERMAN, Thomas, Craig

Inventor： MEDOFF, Marshall ,  MASTERMAN, Thomas, Craig

IPC: C12P7/06 ,  C12N1/20 ,  C07H3/00

CPC classification number: C12P7/10 ,  C07H3/02 ,  C07H3/04 ,  C12N1/20 ,  C12N1/38 ,  C12P5/02 ,  C12P7/04 ,  C12P7/06 ,  C12P7/16 ,  C12P7/18 ,  C12P7/20 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/52 ,  C12P7/54 ,  C12P7/56 ,  C12P7/58 ,  C12P7/6409 ,  C12P19/02 ,  C12P2201/00 ,  C12P2203/00 ,  Y02E50/16 ,  Y02E50/17 ,  Y02E50/343

Abstract: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.

Abstract translation: 加工生物质（例如，植物生物量，动物生物质和城市废物生物质）以产生有用的产物，例如燃料。 例如，系统可以使用原料如纤维素和/或木质纤维素材料来生产乙醇和/或丁醇，例如通过发酵。

公开(公告)号：WO2006014231A3

公开(公告)日：2006-10-19

申请号：PCT/US2005021857

申请日：2005-06-20

Applicant: AVERY DENNISON CORP ,  KIAN KOUROCHE ,  EDWARDS DAVID N ,  MUNN JASON ,  MEHRABI REZA ,  FORSTER IAN J ,  WEAKLEY THOMAS CRAIG

Inventor： KIAN KOUROCHE ,  EDWARDS DAVID N ,  MUNN JASON ,  MEHRABI REZA ,  FORSTER IAN J ,  WEAKLEY THOMAS CRAIG

IPC: H01L21/00 ,  H01L21/30 ,  H01L21/44 ,  H01L21/46 ,  H01L21/48 ,  H01L21/50 ,  H01L21/60 ,  H01L21/603

CPC classification number: H01L24/75 ,  H01L24/81 ,  H01L2224/16 ,  H01L2224/75315 ,  H01L2224/81801 ,  H01L2924/01019 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/07802 ,  H01L2924/10253 ,  H01L2924/14 ,  H01L2924/19041 ,  H01L2924/19042 ,  H01L2924/19043 ,  H01L2924/30105 ,  H01L2924/3011 ,  H01L2924/00

Abstract: A method of thermocompressive bonding of one or more electrical devices using individual heating elements and a resilient member to force the individual heating elements into compressive engagement with the electrical devices is provided. The individual heating elements may be Curie-point heating elements or conventional resistive heating elements. A method of thermocompressive bonding of one or more electrical devices using a transparent flexible platen and thermal radiation is also provided. In one embodiment, the thermal radiation is near infra-red thermal radiation and the transparent flexible platen is composed of silicone rubber. The bonding material may be an adhesive or a thermoplastic bonding material. A method of capacitively coupling a semiconductor chip to an electrical component with a pressure sensitive adhesive is also provided. The method includes compressing the chip by forcing a flexible platen of a bonding device into compressive engagement with the semiconductor chip.

Abstract translation: 提供了一种使用各个加热元件和一个弹性部件热压接合一个或多个电气装置以迫使各个加热元件与电气装置压缩接合的方法。 各个加热元件可以是居里点加热元件或常规电阻加热元件。 还提供了使用透明柔性压板和热辐射的一个或多个电气装置的热压接合方法。 在一个实施例中，热辐射接近红外热辐射，透明柔性压板由硅橡胶组成。 接合材料可以是粘合剂或热塑性粘合材料。 还提供了利用压敏粘合剂将半导体芯片电容耦合到电气部件的方法。 该方法包括通过迫使粘合装置的柔性压板与半导体芯片压缩接合来压缩芯片。

公开(公告)号：WO2006014231A2

公开(公告)日：2006-02-09

申请号：PCT/US2005/021857

申请日：2005-06-20

Applicant: AVERY DENNISON CORPORATION ,  KIAN, Kouroche ,  EDWARDS, David, N. ,  MUNN, Jason ,  MEHRABI, Reza ,  FORSTER, Ian, J. ,  WEAKLEY, Thomas, Craig

Inventor： KIAN, Kouroche ,  EDWARDS, David, N. ,  MUNN, Jason ,  MEHRABI, Reza ,  FORSTER, Ian, J. ,  WEAKLEY, Thomas, Craig

IPC: H01L21/00

CPC classification number: H01L24/75 ,  H01L24/81 ,  H01L2224/16 ,  H01L2224/75315 ,  H01L2224/81801 ,  H01L2924/01019 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/07802 ,  H01L2924/10253 ,  H01L2924/14 ,  H01L2924/19041 ,  H01L2924/19042 ,  H01L2924/19043 ,  H01L2924/30105 ,  H01L2924/3011 ,  H01L2924/00

Abstract: A method of thermocompressive bonding of one or more electrical devices using individual heating elements and a resilient member to force the individual heating elements into compressive engagement with the electrical devices is provided. The individual heating elements may be Curie-point heating elements or conventional resistive heating elements. A method of thermocompressive bonding of one or more electrical devices using a transparent flexible platen and thermal radiation is also provided. In one embodiment, the thermal radiation is near infra-red thermal radiation and the transparent flexible platen is composed of silicone rubber. The bonding material may be an adhesive or a thermoplastic bonding material. A method of capacitively coupling a semiconductor chip to an electrical component with a pressure sensitive adhesive is also provided. The method includes compressing the chip by forcing a flexible platen of a bonding device into compressive engagement with the semiconductor chip.

Abstract translation: 提供了一种使用单独的加热元件和弹性构件来热压结合一个或多个电气装置以迫使各个加热元件与电气装置压缩接合的方法。 各个加热元件可以是居里点加热元件或传统的电阻加热元件。 还提供了使用透明柔性台板和热辐射热压粘结一个或多个电气装置的方法。 在一个实施例中，热辐射接近红外热辐射并且透明柔性台板由硅橡胶构成。 结合材料可以是粘合剂或热塑性结合材料。 还提供了利用压敏粘合剂将半导体芯片电容耦合到电气部件的方法。 该方法包括通过迫使键合装置的柔性平台与半导体芯片压缩接合来压缩芯片。

公开(公告)号：WO2004072892A2

公开(公告)日：2004-08-26

申请号：PCT/US2004/004227

申请日：2004-02-13

Applicant: AVERY DENNISON CORPORATION ,  FORSTER, Ian, J. ,  WEAKLEY, Thomas, Craig ,  KINGSTON, Benjamin

Inventor： FORSTER, Ian, J. ,  WEAKLEY, Thomas, Craig ,  KINGSTON, Benjamin

IPC: G06K

CPC classification number: G06K7/10465 ,  G06F19/00 ,  G06K7/0008 ,  G06K7/0095 ,  Y10T29/49004

Abstract: An RFID device tester includes coupling elements for capacitively coupling a reader to an RFID device to be tested. The reader may power the RFID device by sending an outgoing signal, such as an outgoing AC power signal, which may be rectified and/or reflected by the RFID device, if the RFID device is operating properly. The outgoing signal may have a frequency that is different from the resonant frequency of an antenna of the RFID device. A reader in the RFID device tester detects the reflected and/or transmitted signal to confirm proper operation of the RFID device. The RFID device tester may be used as part of a roll-to-roll process, to individually test RFID devices on a roll of material. By utilizing short-range capacitive coupling, difficulties caused by simultaneous activation of multiple RFID devices may be reduced or avoided.

Abstract translation: RFID设备测试器包括用于将读取器电容耦合到待测试的RFID设备的耦合元件。 如果RFID设备正常运行，则读取器可以通过发送诸如输出AC电力信号的输出信号来为RFID装置供电，RFID输出装置可以由RFID装置整流和/或反射。 输出信号可以具有与RFID设备的天线的谐振频率不同的频率。 RFID设备测试器中的读取器检测反射和/或发射的信号以确认RFID设备的正常操作。 RFID设备测试器可以用作卷对卷过程的一部分，以单独测试一卷材料上的RFID设备。 通过利用短距离电容耦合，可以减少或避免由同时激活多个RFID装置引起的困难。