公开(公告)号：US11826724B2

公开(公告)日：2023-11-28

申请号：US17372985

申请日：2021-07-12

Applicant: CytoSorbents Corporation

Inventor： Tamaz Guliashvili ,  Thomas Golobish ,  Maryann Gruda ,  Pamela O'Sullivan ,  Andrew Scheirer ,  Vincent Capponi ,  Phillip Chan ,  Wei-Tai Young

IPC: A61K38/00 ,  B01J20/26 ,  B01D15/34 ,  B01J20/28 ,  B01J20/32 ,  A61K9/00 ,  A61K31/745 ,  A61M1/36 ,  B01D15/12

CPC classification number: B01J20/261 ,  A61K9/0031 ,  A61K9/0053 ,  A61K31/745 ,  A61M1/3679 ,  B01D15/34 ,  B01J20/262 ,  B01J20/267 ,  B01J20/2808 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/327 ,  B01J20/3208 ,  B01J20/3231 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3289 ,  B01D15/125

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

公开(公告)号：US20200276381A1

公开(公告)日：2020-09-03

申请号：US16645965

申请日：2018-09-13

Applicant: CYTOSORBENTS CORPORATION

Inventor： Dominik GUTZLER ,  Wei-Tai YOUNG

IPC: A61M1/36 ,  A61M39/28 ,  A61M39/24 ,  A61M1/16

Abstract: Connector assemblies and methods of replacing components in an extra-corporeal circuit (ECC) system are disclosed. A connector assembly for use in an ECC system includes a tubular body having an inner surface defining a lumen extending through the tubular body with the lumen extending along a longitudinal axis, a first connection interface in fluid communication with the lumen, second connection interface in fluid communication with the lumen, and a plurality of closure mechanisms, each closure mechanism being configured to occlude the lumen.

公开(公告)号：US20200246532A1

公开(公告)日：2020-08-06

申请号：US16851305

申请日：2020-04-17

Applicant: CytoSorbents Corporation

Inventor： Thomas D. Golobish ,  Vincent J. Capponi ,  David R. Clay

IPC: A61M1/36 ,  A61M1/34 ,  B01J20/32 ,  B01J20/26 ,  A01N1/02 ,  B01J20/28 ,  A61M1/02

Abstract: The invention concerns methods of removing undesirable molecules from the blood or physiologic fluid; said method comprising contacting said blood or physiologic fluid with a sorbent, said sorbent comprising a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of ligands attached to the surface of said cross-linked polymeric material, comprising (i) zwitterionic moieties, (ii) oligo(ethylene glycol) moieties or (iii) mixtures thereof; said contacting comprising said sorbent sorbing a plurality of said undesirable molecules when said sorbent is administered within a patient's body.

公开(公告)号：US09931357B2

公开(公告)日：2018-04-03

申请号：US15515328

申请日：2015-10-02

Applicant: CYTOSORBENTS CORPORATION

Inventor： Humayra Begum Ali ,  Thomas D. Golobish ,  Vincent J. Capponi ,  Phillip P. Chan ,  Wei-Tai Young ,  Andrew Robert Scheirer

IPC: A61M31/00 ,  A61K31/74 ,  A61K31/765 ,  A61K9/00

CPC classification number: A61K31/765 ,  A61K9/0053 ,  A61K31/75 ,  A61K31/79 ,  A61P1/00 ,  A61P1/04 ,  A61P1/06

Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).

公开(公告)号：US20250009951A1

公开(公告)日：2025-01-09

申请号：US18713370

申请日：2022-11-29

Applicant: CYTOSORBENTS CORPORATION

Inventor： Phillip P. CHAN ,  Karl-Gustav RUGGEBERG ,  Ritu TRIPATHI ,  Ophir ORTIZ ,  Richard R. MCKAY

IPC: A61M1/36 ,  B01J20/26 ,  B01J20/28

Abstract: Methods of treating cancer in a subject by administering a therapeutically effective amount of a porous biocompatible sorbent are disclosed. The porous biocompatible sorbents comprise a range of pore diameters between about 50 Å to about 40,000 Å and a pore volume between about 0.5 cc/g to about 5.0 cc/g dry polymer.

公开(公告)号：US20230310493A1

公开(公告)日：2023-10-05

申请号：US18320417

申请日：2023-05-19

Applicant: CYTOSORBENTS CORPORATION

Inventor： Andreas Viktor SIMM ,  Jorg SCHEIER ,  Christian STEINER ,  Vincent CAPPONI ,  Phillip P. CHAN

IPC: A61K31/79 ,  A61K31/717 ,  A61K31/78

CPC classification number: A61K31/79 ,  A61K31/717 ,  A61K31/78

Abstract: The invention concerns removing advanced glycation end products from a bodily fluid by contacting the bodily fluid with a sorbent.

公开(公告)号：US11723916B2

公开(公告)日：2023-08-15

申请号：US17341912

申请日：2021-06-08

Applicant: CytoSorbents Corporation

Inventor： Thomas Golobish ,  Maryann Gruda ,  Tamaz Guliashvili ,  Pamela O'Sullivan ,  Andrew Scheirer ,  Vi Dan ,  Wei-Tai Young ,  Vincent Capponi ,  Phillip Chan

IPC: A61K31/795 ,  A61M5/165 ,  B01J20/26 ,  B01J39/20 ,  B01J20/28 ,  A61K47/20 ,  A61K47/26 ,  A61M1/36 ,  A61M5/14

CPC classification number: A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M5/165 ,  B01J20/264 ,  B01J20/267 ,  B01J20/28069 ,  B01J39/20 ,  A61M1/3679 ,  A61M5/14

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

公开(公告)号：US11602585B2

公开(公告)日：2023-03-14

申请号：US15497640

申请日：2017-04-26

Applicant: CytoSorbents Corporation

Inventor： Phillip P. Chan ,  Vincent J. Capponi ,  Thomas D. Golobish ,  Humayra Begum Ali

IPC: A61M1/36 ,  A61K9/16 ,  B01J20/28 ,  A61K31/765 ,  B01J20/26 ,  C08F299/00 ,  C08J9/26

Abstract: Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.

公开(公告)号：US11202855B2

公开(公告)日：2021-12-21

申请号：US16497982

申请日：2018-03-22

Applicant: CYTOSORBENTS CORPORATION

Inventor： Wei-Tai Young ,  Tamaz Guliashvili ,  Andrew Scheirer ,  Josh Vichare ,  Timothy Kovacs ,  Maryann Gruda ,  Thomas Golobish ,  Vincent Capponi ,  Phillip Chan

IPC: A61M1/34 ,  A61M1/36

Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

公开(公告)号：US10967001B2

公开(公告)日：2021-04-06

申请号：US16018603

申请日：2018-06-26

Applicant: CytoSorbents Corporation

Inventor： Phillip P. Chan ,  Wei-Tai Young ,  Vincent J. Capponi ,  Thomas D. Golobish ,  Humayra Begum Ali

IPC: A61K31/745 ,  A61K31/74 ,  A61K31/75 ,  A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  C08F212/36 ,  C08J9/26 ,  A61K47/58

Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.