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    NOVEL PHENYLPYRROLE DERIVATIVE
    1.
    发明申请
    NOVEL PHENYLPYRROLE DERIVATIVE 有权
    新颖的灵性衍生物

    公开(公告)号：US20110003787A1

    公开(公告)日：2011-01-06

    申请号：US12843348

    申请日：2010-07-26

    申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

    发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

    IPC分类号： A61K31/427 ,  C07D417/04 ,  C07D413/14 ,  C07D413/12 ,  A61P3/10 ,  A61K31/501 ,  A61K31/4439 ,  A61K31/428 ,  C07D403/04 ,  A61K31/497 ,  C07D207/34 ,  A61K31/40 ,  C07D413/04 ,  A61K31/422 ,  A61K31/5355 ,  C07D417/14 ,  A61K31/5377

    CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

    摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

    摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

    Phenylpyrrole derivative
    2.
    发明授权
    Phenylpyrrole derivative 有权
    苯基吡咯衍生物

    公开(公告)号：US08017610B2

    公开(公告)日：2011-09-13

    申请号：US12843348

    申请日：2010-07-26

    申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

    发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

    IPC分类号： A61K31/501 ,  A61K31/497 ,  A61K31/443 ,  A61K31/421 ,  C07D403/14 ,  C07D413/14 ,  C07D265/08

    CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

    摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

    摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

    Phenylpyrrole derivative
    3.
    发明授权
    Phenylpyrrole derivative 有权
    苯基吡咯衍生物

    公开(公告)号：US08415359B2

    公开(公告)日：2013-04-09

    申请号：US13198819

    申请日：2011-08-05

    申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

    发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

    IPC分类号： A61K31/497 ,  A61K31/4439 ,  A61K31/443 ,  A61K31/428 ,  A61K31/427 ,  A61K31/421 ,  A61K31/4155 ,  A61K31/4025 ,  A61K31/40 ,  C07D401/14 ,  C07D401/12 ,  C07D413/04 ,  C07D413/14 ,  C07D277/62 ,  C07D277/20 ,  C07D263/08 ,  C07D263/30 ,  C07D403/04 ,  C07D403/14 ,  C07D207/323

    CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

    摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

    摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

    LIGHT EMITTING DIODE
    8.
    发明申请
    LIGHT EMITTING DIODE 有权
    发光二极管

    公开(公告)号：US20090315059A1

    公开(公告)日：2009-12-24

    申请号：US12548112

    申请日：2009-08-26

    申请人： Yusuke FUJITA ,  Masahiro Konishi

    发明人： Yusuke FUJITA ,  Masahiro Konishi

    IPC分类号： H01L33/00

    CPC分类号： H01L33/60 ,  H01L25/0753 ,  H01L33/54 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2924/00014 ,  H01L2924/00

    摘要： A light-emitting diode includes a substrate having a main surface, a light-emitting diode device arranged on the main surface, a translucent sealing resin portion sealing the light-emitting diode device so that the light-emitting diode device is implemented as an independent convex portion projecting from the main surface, and a reflector arranged on the main surface so as to surround an outer perimeter of the sealing resin portion with an inclined surface at a distance from the outer perimeter.

    摘要翻译： 发光二极管包括具有主表面的基板，设置在主表面上的发光二极管器件，密封发光二极管器件的透光性密封树脂部分，使得发光二极管器件被实现为独立的 凸起部分从主表面突出，以及反射器，其布置在主表面上以便围绕密封树脂部分的外周边，并具有与外周距离一定距离的倾斜表面。

    Ceramic heater, glow plug, and ceramic heater manufacturing method
    10.
    发明申请
    Ceramic heater, glow plug, and ceramic heater manufacturing method 有权
    陶瓷加热器，电热塞和陶瓷加热器制造方法

    公开(公告)号：US20060011602A1

    公开(公告)日：2006-01-19

    申请号：US11168534

    申请日：2005-06-29

    申请人： Masahiro Konishi ,  Haruhiko Sato ,  Tetsuya Suzuki ,  Takahiro Matsui

    发明人： Masahiro Konishi ,  Haruhiko Sato ,  Tetsuya Suzuki ,  Takahiro Matsui

    IPC分类号： F23Q7/22

    CPC分类号： F23Q7/00 ,  F23Q7/001 ,  F23Q2007/004 ,  H05B3/141 ,  H05B2203/027

    摘要： A ceramic heater which includes: a cylindrical substrate including an insulator; a resistor provided in one end side of the substrate; a pair of lead parts provided in the substrate, connected to the resistor and extending to an opposite end side of the substrate; and a pair of electrode parts exposed to a surface at an opposite end side of the substrate and connected respectively to the lead parts. Both lead parts are made of the same material as both electrode parts. An axial cross-sectional area of the electrode part is equal to or larger than a cross-sectional area of the lead part in a direction perpendicular to an axis of the ceramic heater.

    摘要翻译： 一种陶瓷加热器，包括：包括绝缘体的圆柱形基板; 设置在所述基板的一端侧的电阻器; 一对引线部分，设置在所述基板中，连接到所述电阻器并延伸到所述基板的相对端侧; 以及一对电极部件，其暴露于基板的相对端侧的表面并分别连接到引线部分。 两个引线部分由与两个电极部分相同的材料制成。 电极部分的轴向截面积等于或大于引线部件在垂直于陶瓷加热器的轴线的方向上的横截面面积。