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公开(公告)号:US5643957A
公开(公告)日:1997-07-01
申请号:US335148
申请日:1994-10-25
申请人: Andrea Leone-Bay , Duncan R. Paton , Koc-Kan Ho , Frenel DeMorin
发明人: Andrea Leone-Bay , Duncan R. Paton , Koc-Kan Ho , Frenel DeMorin
IPC分类号: A61K9/06 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/16 , A61K31/352 , A61K31/727 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K39/00 , A61K39/395 , A61K47/18 , A61K47/42 , C07C229/42 , C07C233/48 , C07C233/51 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/82 , C07C233/87 , C07C235/26 , C07C235/38 , C07C235/64 , C07C235/78 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/107 , C07K5/06 , A01N37/12 , A61K31/195
CPC分类号: A61K38/25 , A61K31/16 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/27 , A61K47/183 , A61K9/1617 , A61K9/1641 , C07C229/42 , C07C233/48 , C07C233/55 , C07C233/63 , C07C233/82 , C07C233/87 , C07C235/26 , C07C235/38 , C07C235/64 , C07C235/78 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/1077 , C07K5/06043 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译: 提供了可用于递送活性剂的改性氨基酸化合物。 也提供给药和制备方法。
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公开(公告)号:US06663887B2
公开(公告)日:2003-12-16
申请号:US10090012
申请日:2002-02-21
申请人: Andrea Leone-Bay , Duncan R. Paton , Koc-Kan Ho , Frenel DeMorin
发明人: Andrea Leone-Bay , Duncan R. Paton , Koc-Kan Ho , Frenel DeMorin
IPC分类号: A61K648
CPC分类号: A61K31/727 , A61K9/1617 , A61K9/1641 , A61K31/16 , A61K31/352 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , A61K47/183 , C07C229/42 , C07C233/48 , C07C233/55 , C07C233/63 , C07C233/82 , C07C233/87 , C07C235/26 , C07C235/38 , C07C235/64 , C07C235/78 , C07C235/84 , C07C237/22 , C07C279/14 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07K1/1077 , C07K5/06043
摘要: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号:US5955503A
公开(公告)日:1999-09-21
申请号:US795833
申请日:1997-02-06
申请人: Andrea Leone-Bay , Duncan R. Paton , Koc-Kan Ho , Frenel DeMorin
发明人: Andrea Leone-Bay , Duncan R. Paton , Koc-Kan Ho , Frenel DeMorin
IPC分类号: A61K9/06 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/16 , A61K31/352 , A61K31/727 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K39/00 , A61K39/395 , A61K47/18 , A61K47/42 , C07C229/42 , C07C233/48 , C07C233/51 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/82 , C07C233/87 , C07C235/26 , C07C235/38 , C07C235/64 , C07C235/78 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/107 , C07K5/06 , A01N37/12 , A01N37/44
CPC分类号: A61K38/25 , A61K31/16 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/27 , A61K47/183 , A61K9/1617 , A61K9/1641 , C07C229/42 , C07C233/48 , C07C233/55 , C07C233/63 , C07C233/82 , C07C233/87 , C07C235/26 , C07C235/38 , C07C235/64 , C07C235/78 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/1077 , C07K5/06043 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号:US6100298A
公开(公告)日:2000-08-08
申请号:US795837
申请日:1997-02-06
申请人: Andrea Leone-Bay , Duncan R. Paton , Koc-Kan Ho , Frenel DeMorin
发明人: Andrea Leone-Bay , Duncan R. Paton , Koc-Kan Ho , Frenel DeMorin
IPC分类号: A61K9/06 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/16 , A61K31/352 , A61K31/727 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K39/00 , A61K39/395 , A61K47/18 , A61K47/42 , C07C229/42 , C07C233/48 , C07C233/51 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/82 , C07C233/87 , C07C235/26 , C07C235/38 , C07C235/64 , C07C235/78 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/107 , C07K5/06 , A01N37/12 , A01N37/44 , A61K31/195
CPC分类号: A61K38/25 , A61K31/16 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/27 , A61K47/183 , A61K9/1617 , A61K9/1641 , C07C229/42 , C07C233/48 , C07C233/55 , C07C233/63 , C07C233/82 , C07C233/87 , C07C235/26 , C07C235/38 , C07C235/64 , C07C235/78 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/1077 , C07K5/06043 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号:US06972300B2
公开(公告)日:2005-12-06
申请号:US10623142
申请日:2003-07-18
IPC分类号: C07D295/20 , A61K9/00 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/197 , A61K31/198 , A61K31/40 , A61K31/44 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C53/126 , C07C53/134 , C07C229/08 , C07C229/10 , C07C229/42 , C07C231/12 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/62 , C07C235/64 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C239/06 , C07C239/08 , C07C259/06 , C07C271/22 , C07C303/22 , C07C303/40 , C07C309/59 , C07C311/19 , C07D207/34 , C07D207/416 , C07D213/75 , C07D213/81 , C07D295/215 , C07D317/68 , C07D333/38 , A61K31/195 , C07C229/00
CPC分类号: C07D333/38 , A61K9/0019 , A61K9/0043 , A61K9/0056 , A61K9/1617 , A61K9/4858 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/541 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68
摘要: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
摘要翻译: 提供了可用于递送活性剂的改性氨基酸化合物。 活性剂可以是肽,例如rhGH。 提供口服,皮下,舌下和鼻内给药的给药方法,提供修饰的氨基酸化合物的制备方法。
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公开(公告)号:US06358504B1
公开(公告)日:2002-03-19
申请号:US08796336
申请日:1997-02-07
申请人: Andrea Leone-Bay , Eric Wang , Donald J. Sarubbi , Harry Leipold , Koc-Kan Ho , David Gschneidner
发明人: Andrea Leone-Bay , Eric Wang , Donald J. Sarubbi , Harry Leipold , Koc-Kan Ho , David Gschneidner
IPC分类号: A61K3800
CPC分类号: C07D209/48 , A61K9/1617 , A61K31/195 , A61K31/445 , A61K31/4965 , A61K31/727 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K45/06 , C07C229/42 , C07C233/51 , C07C233/54 , C07C233/69 , C07C233/81 , C07C233/83 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30 , A61K2300/00
摘要: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译: 提供了可用于递送活性剂的载体化合物及其组合物。 也提供给药和制备方法。
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7.Method for preparing .omega.-aminoalkanoic acid derivatives from cycloalkanones 失效
标题翻译: 从环烷酮制备ω-氨基链烷酸衍生物的方法公开(公告)号:US6084112A
公开(公告)日:2000-07-04
申请号:US894490
申请日:1997-12-15
申请人: Koc-Kan Ho , Andrea Leone-Bay
发明人: Koc-Kan Ho , Andrea Leone-Bay
IPC分类号: C07C227/22 , C07C269/04 , C07C271/22 , C07K5/02 , C07C227/00
CPC分类号: C07C269/04 , C07C227/22 , C07K5/021
摘要: A convenient synthetic route to .omega.-aminoalkanoic acids, N-Boc protected .omega.-aminoalkanoic acids and Boc-amino acid coupled .omega.-aminoalkanoic acids is disclosed. The method provides high purity compounds that generally do not require further purification.
摘要翻译: PCT No.PCT / US96 / 14805 Sec。 371日期:1997年12月16日 102(e)日期1997年12月16日PCT提交1996年9月10日PCT公布。 公开号WO97 / 10197 日期1997年3月20日公开了一种方便的ω-氨基链烷酸合成路线,N-Boc保护的ω-氨基链烷酸和Boc-氨基酸偶联的ω-氨基链烷酸。 该方法提供通常不需要进一步纯化的高纯度化合物。
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公开(公告)号:US5650386A
公开(公告)日:1997-07-22
申请号:US414654
申请日:1995-03-31
IPC分类号: C07D295/20 , A61K9/00 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/197 , A61K31/198 , A61K31/40 , A61K31/44 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C53/126 , C07C53/134 , C07C229/08 , C07C229/10 , C07C229/42 , C07C231/12 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/62 , C07C235/64 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C239/06 , C07C239/08 , C07C259/06 , C07C271/22 , C07C303/22 , C07C303/40 , C07C309/59 , C07C311/19 , C07D207/34 , C07D207/416 , C07D213/75 , C07D213/81 , C07D295/215 , C07D317/68 , C07D333/38 , A61K38/17 , A61K31/725 , C07C229/14
CPC分类号: C07D213/81 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/4803 , A61K9/0019 , A61K9/1617 , A61K9/4858 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07D207/34 , C07D295/215 , C07D317/68 , C07D333/38 , A61K9/0043 , A61K9/0056 , C07C2101/14 , C07C2101/18 , C07C2103/74
摘要: Modified amino acid compounds useful for the delivery of active agents are provided. The amino acids, non-alpha-amino acids, have been modified by acylation on the amino group particularly with phenyl or cyclohexyl groups. These groups have a variety of substituents including but not limited to hydroxy, methyl, fluoro, chloro, and the like. The compounds of the invention can be combined with numerous active agents including but not limited to heparin, peptides, and parathyroid hormone, and can then be used for effective administration of the active agent. Administration can be, for example, oral or parenteral.
摘要翻译: 提供了可用于递送活性剂的改性氨基酸化合物。 氨基酸,非α-氨基酸已经通过氨基上的酰化,特别是用苯基或环己基进行改性。 这些基团具有多种取代基,包括但不限于羟基,甲基,氟,氯等。 本发明的化合物可以与许多活性剂组合,包括但不限于肝素,肽和甲状旁腺激素,然后可用于有效施用活性剂。 给药可以是例如口服或肠胃外。
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公开(公告)号:US07125910B2
公开(公告)日:2006-10-24
申请号:US10373582
申请日:2003-02-24
申请人: Andrea Leone-Bay , Eric Wang , Donald J. Sarubbi , Harry Leipold , David Gschneidner , Koc-Kan Ho
发明人: Andrea Leone-Bay , Eric Wang , Donald J. Sarubbi , Harry Leipold , David Gschneidner , Koc-Kan Ho
IPC分类号: A61K31/192 , C07C229/34
CPC分类号: C07D209/48 , A61K9/1617 , A61K31/195 , A61K31/445 , A61K31/4965 , A61K31/727 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K45/06 , C07C229/42 , C07C233/51 , C07C233/54 , C07C233/69 , C07C233/81 , C07C233/83 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30 , A61K2300/00
摘要: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号:US20050272815A1
公开(公告)日:2005-12-08
申请号:US11172562
申请日:2005-06-29
申请人: Andrea Leone-Bay , Koc-Kan Ho , Donald Sarubbi , Sam Milstein
发明人: Andrea Leone-Bay , Koc-Kan Ho , Donald Sarubbi , Sam Milstein
IPC分类号: C07D295/20 , A61K9/00 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/197 , A61K31/198 , A61K31/40 , A61K31/44 , A61K38/00 , A61K38/04 , A61K38/095 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C53/126 , C07C53/134 , C07C229/08 , C07C229/10 , C07C229/42 , C07C231/12 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/62 , C07C235/64 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C239/06 , C07C239/08 , C07C259/06 , C07C271/22 , C07C303/22 , C07C303/40 , C07C309/59 , C07C311/19 , C07D207/34 , C07D207/416 , C07D213/75 , C07D213/81 , C07D295/215 , C07D317/68 , C07D333/38
CPC分类号: C07D333/38 , A61K9/0019 , A61K9/0043 , A61K9/0056 , A61K9/1617 , A61K9/4858 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/541 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68
摘要: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modified amino acid compounds are also provided.
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