公开(公告)号：US08747385B2

公开(公告)日：2014-06-10

申请号：US13468956

申请日：2012-05-10

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61M31/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

公开(公告)号：US08821473B2

公开(公告)日：2014-09-02

申请号：US12632612

申请日：2009-12-07

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61M31/00 ,  A61K31/7088 ,  A61K9/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

公开(公告)号：US07641643B2

公开(公告)日：2010-01-05

申请号：US10414767

申请日：2003-04-15

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Nadine Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Nadine Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61M31/00

CPC classification number: A61N1/3625 ,  A61K9/0024 ,  A61K31/00 ,  A61K31/728 ,  A61K31/732 ,  A61K31/734 ,  A61K31/78 ,  A61K31/79 ,  A61K36/886 ,  A61K38/40 ,  A61K41/0042 ,  A61K45/06 ,  A61K47/02 ,  A61K47/34 ,  A61K47/60 ,  A61K47/62 ,  A61K49/0404 ,  A61L24/043 ,  A61L27/20 ,  A61L27/50 ,  A61L27/54 ,  A61L2430/20 ,  A61N1/36521 ,  A61K2300/00

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

公开(公告)号：US20050003011A1

公开(公告)日：2005-01-06

申请号：US10892050

申请日：2004-07-15

Applicant: Srinivasan Sridharan ,  Murthy Simhambhatla

Inventor： Srinivasan Sridharan ,  Murthy Simhambhatla

IPC: A61L27/16 ,  A61L27/50 ,  A61L27/56 ,  A61L29/04 ,  B29C55/00 ,  B29C55/06 ,  B29D7/01 ,  B29C43/22 ,  A61K9/14

CPC classification number: A61L27/56 ,  A61L27/16 ,  A61L27/507 ,  A61L29/041 ,  B29C55/005 ,  B29C55/065 ,  B29D7/01 ,  B29K2023/0683 ,  B29K2105/0061 ,  C08L23/06

Abstract: A method including forming a pseudo-gel of a semi-crystalline polymer material and a solvent. The pseudo-gel is shaped into a first form and stretched. A portion of the solvent is removed to create a second form. The second form is stretched into a microstructure including nodes interconnected by fibrils. A method including forming a first form of a pseudo-gel including an ultra-high molecular weight polyethylene material and a solvent; stretching the first form; removing the solvent to form a second form; stretching the second form into a microstructure including nodes interconnected by fibrils; and annealing the stretched second form. An apparatus including a body portion formed of a dimension suitable for a medical device application and including a polyolefin polymer including a node and a fibril microstructure. An apparatus including a body portion including an ultra-high molecular weight polyolefin material including a node and a fibril microstructure.

Abstract translation: 一种包括形成半结晶聚合物材料和溶剂的假凝胶的方法。 假凝胶成型为第一种形式并拉伸。 除去一部分溶剂以产生第二种形式。 第二种形式被拉伸成包括由原纤维相互连接的节点的微结构。 一种包括形成包含超高分子量聚乙烯材料和溶剂的第一种形式的假凝胶的方法; 拉伸第一种形式; 除去溶剂以形成第二种形式; 将第二形式拉伸成包括通过纤维互连的节点的微结构; 并退火拉伸的第二种形式。 一种装置，包括由适于医疗装置应用的尺寸形成的主体部分，并且包括包含节点和原纤维微结构的聚烯烃聚合物。 一种包括主体部分的装置，其包括包含节点和原纤维微结构的超高分子量聚烯烃材料。

公开(公告)号：US08383158B2

公开(公告)日：2013-02-26

申请号：US10414602

申请日：2003-04-15

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61K9/14

CPC classification number: A61N1/3625 ,  A61K9/0024 ,  A61K31/00 ,  A61K31/728 ,  A61K31/732 ,  A61K31/734 ,  A61K31/78 ,  A61K31/79 ,  A61K36/886 ,  A61K38/40 ,  A61K41/0042 ,  A61K45/06 ,  A61K47/02 ,  A61K47/34 ,  A61K47/60 ,  A61K47/62 ,  A61K49/0404 ,  A61L24/043 ,  A61L27/20 ,  A61L27/50 ,  A61L27/54 ,  A61L2430/20 ,  A61N1/36521 ,  A61K2300/00

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents.

Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些试剂可以包括但不限于前成纤维细胞和血管生成剂。

公开(公告)号：US20100144635A1

公开(公告)日：2010-06-10

申请号：US12632612

申请日：2009-12-07

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61M37/00 ,  A61M25/00 ,  A61K38/22 ,  A61K31/7088 ,  A61K47/34 ,  A61P9/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

公开(公告)号：US09824790B2

公开(公告)日：2017-11-21

申请号：US14240788

申请日：2012-08-16

Applicant: Dongshe Zhang ,  Aziz S. Shaikh ,  Srinivasan Sridharan ,  Himal Khatri ,  Hong Jiang ,  George E. Graddy, Jr.

Inventor： Dongshe Zhang ,  Aziz S. Shaikh ,  Srinivasan Sridharan ,  Himal Khatri ,  Hong Jiang ,  George E. Graddy, Jr.

IPC: H01L31/00 ,  H01B1/22 ,  C07F9/11 ,  C03C8/16 ,  C03C8/18 ,  C03C8/22 ,  H01L31/0224 ,  H01L21/22 ,  C03C8/10 ,  C03C8/08

CPC classification number: H01B1/22 ,  C03C8/08 ,  C03C8/10 ,  C03C8/16 ,  C03C8/18 ,  C03C8/22 ,  C07F9/11 ,  H01L21/2225 ,  H01L31/022425 ,  H01L31/022441 ,  Y02E10/50

Abstract: Paste compositions, methods of making a paste composition, photovoltaic cells, and methods of making a photovoltaic cell contact are disclosed. The paste composition can include a conductive metal component such as aluminum, phosphate glass, phosphorus compounds such as alky! phosphate, and a vehicle. The contact can be formed on a passivation layer on a silicon wafer by applying the paste on the passivation layer and firing the paste. During firing, the metal component can fire through the passivation layer, thereby electrically contacting the silicon substrate.

公开(公告)号：US09272497B2

公开(公告)日：2016-03-01

申请号：US13808422

申请日：2011-07-22

Applicant: Chandrashekhar S. Khadilkar ,  Robert P. Blonski ,  Srinivasan Sridharan ,  Jackie D. Davis ,  John J. Maloney ,  James D. Walker ,  Andrew M. Rohn, Jr.

Inventor： Chandrashekhar S. Khadilkar ,  Robert P. Blonski ,  Srinivasan Sridharan ,  Jackie D. Davis ,  John J. Maloney ,  James D. Walker ,  Andrew M. Rohn, Jr.

IPC: B32B37/12 ,  B05D3/00 ,  C09D5/34 ,  C09D7/12 ,  H01L31/048 ,  C08K7/14 ,  H01L51/52

CPC classification number: B32B37/12 ,  B05D3/007 ,  C08K7/14 ,  C09D5/34 ,  C09D7/70 ,  H01L31/048 ,  H01L31/0481 ,  H01L31/0488 ,  H01L51/5246 ,  Y02E10/50 ,  Y10T428/1314

Abstract: A glass-flake loaded organic sealant system is useful for sealing active layers such as those in electronic devices and solar cells.

Abstract translation: 玻璃片装载的有机密封剂系统可用于密封诸如电子设备和太阳能电池中的活性层的活性层。

公开(公告)号：US09156735B2

公开(公告)日：2015-10-13

申请号：US13642553

申请日：2011-04-27

Applicant: John J. Maloney ,  Robert P. Blonski ,  Chandrashekhar S. Khadilkar ,  Srinivasan Sridharan

Inventor： John J. Maloney ,  Robert P. Blonski ,  Chandrashekhar S. Khadilkar ,  Srinivasan Sridharan

IPC: H01L31/048 ,  C03C27/04 ,  H01L21/02 ,  H01L21/50 ,  H01L23/10 ,  C03C3/066 ,  C03C3/12 ,  C03C3/14 ,  C03C8/04 ,  C03C8/14 ,  H01L51/52

CPC classification number: C03C27/044 ,  C03C3/066 ,  C03C3/122 ,  C03C3/14 ,  C03C8/04 ,  C03C8/14 ,  H01L21/02345 ,  H01L21/50 ,  H01L23/10 ,  H01L31/0481 ,  H01L31/0488 ,  H01L51/5246 ,  H01L2924/0002 ,  H01L2924/09701 ,  H01L2924/12044 ,  Y02E10/50 ,  H01L2924/00

Abstract: Durable hermetic seals between two inorganic substrates are produced using a high-intensity electromagnetic energy source, such as laser, to heat and seal enamel layers with controlled absorption of high-intensity energy source. Durable hermetic seals incorporating electrical feedthroughs are also produced.

Abstract translation: 使用高强度电磁能源（例如激光）产生两个无机基底之间的耐久气密密封，以加热和密封具有受控吸收的高强度能量源的搪瓷层。 还生产结合电馈通的耐用气密密封件。

公开(公告)号：US09023010B2

公开(公告)日：2015-05-05

申请号：US11923068

申请日：2007-10-24

Applicant: Jessica G. Chiu ,  Gregory Waimong Chan ,  Gabriel Asongwe ,  Robert C. Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Joan Bei ,  William E. Webler ,  Stephen G. Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark J. Bly ,  Thomas R. Hatten

Inventor： Jessica G. Chiu ,  Gregory Waimong Chan ,  Gabriel Asongwe ,  Robert C. Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Joan Bei ,  William E. Webler ,  Stephen G. Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark J. Bly ,  Thomas R. Hatten

IPC: A61M31/00 ,  A61M25/10

CPC classification number: A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

Abstract: Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

Abstract translation: 实施例包括具有输送导管的输液阻塞系统，适于接收输送导管的引导导管，以及具有适于容纳在引导导管内的闭塞装置的导丝。 导管套件的引导导管可以在引导导管的远端处设置有闭塞装置。 输送导管可以具有附件腔，同轴或共线腔，支撑心轴或其远端处的闭塞装置。 此外，根据一些实施例，闭塞装置可以是具有内衬和不同材料外层的单一材料或复合球囊，高顺应性低压气球或限制颗粒通过但不限制的过滤装置 限制流体，如血液。 可以使用具有大体积和低体积注射器的充气装置来使气囊膨胀。