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    Opto-acoustic recanilization delivery system
    1.
    发明授权
    Opto-acoustic recanilization delivery system 失效
    光声补偿输送系统

    公开(公告)号：US06368318B1

    公开(公告)日：2002-04-09

    申请号：US09012379

    申请日：1998-01-23

    申请人： Steven R. Visuri ,  Luiz B. Da Silva ,  Peter M. Celliers ,  Richard A. London ,  William Benett ,  Kathryn Broughton ,  Victor Esch

    发明人： Steven R. Visuri ,  Luiz B. Da Silva ,  Peter M. Celliers ,  Richard A. London ,  William Benett ,  Kathryn Broughton ,  Victor Esch

    IPC分类号： A61B1818

    CPC分类号： A61B18/26 ,  A61B18/245 ,  A61B2017/22061 ,  A61B2018/00029 ,  A61B2018/2211

    摘要： Fiber delivered laser pulses emulsify thrombus by mechanical stresses that include a combination of pressure, tension and shear stress. Laser radiation is delivered to the locality of a thrombus and the radiation is absorbed by blood, blood dot, or other present materials. The combination of a leading pressure wave and subsequent vapor bubble cause efficient, emulsification of thrombus. Operating the laser in a low average power mode alleviates potential thermal complications. The laser is operated in a high repetition rate mode to take advantage of ultrasound frequency effects of thrombus dissolution as well as to decrease the total procedure time. Specific parameter ranges for operation are described. The device includes optical fibers surrounding a lumen intended for flow of a cooling agent. The fibers may be arranged concentrically around the lumen to deliver radiation and heat over as large an area as possible. An alternative design approach incorporates the optical fibers into the wall of the guiding catheter and utilizes the catheter lumen as the cooling channel. An eccentric tip enables rotation of the device to address all parts of the vasculature. The eccentricity can be provided via a variety of means: spring dip, balloon, protrusion, etc.

    摘要翻译： 纤维传递的激光脉冲通过机械应力乳化血栓，包括压力，张力和剪切应力的组合。 激光辐射被输送到血栓的位置，并且辐射被血液，血液点或其他现有材料吸收。 导致压力波和随后的蒸汽气泡的组合导致血栓的有效的乳化。 以较低的平均功率模式操作激光可以减轻潜在的并发症。 激光以高重复率模式运行，以利用血栓溶解的超声频率效应以及减少总的手术时间。 描述操作的具体参数范围。 该装置包括围绕用于冷却剂流动的内腔的光纤。 纤维可以围绕内腔同心地布置，以在尽可能大的面积上传送辐射和热量。 另一种设计方法将光纤结合到引导导管的壁中并利用导管内腔作为冷却通道。 偏心的尖端能够使装置旋转以解决脉管系统的所有部分。 偏心度可以通过各种方式提供：弹簧浸渍，气球，突起等

    System for diffusing light from an optical fiber or light guide
    2.
    发明申请
    System for diffusing light from an optical fiber or light guide 有权
    用于漫射光纤或光导的光的系统

    公开(公告)号：US20080019657A1

    公开(公告)日：2008-01-24

    申请号：US11489138

    申请日：2006-07-18

    申请人： Duncan Maitland ,  Ward Small ,  Thomas Wilson ,  William Benett

    发明人： Duncan Maitland ,  Ward Small ,  Thomas Wilson ,  William Benett

    IPC分类号： G02B6/00 ,  G02B6/26 ,  G02B6/42

    CPC分类号： G02B6/262 ,  G02B6/0008

    摘要： A system for diffusing light from an optical fiber wherein the optical fiber is coupled to a light source, comprising forming a polymer element adapted to be connected to the optical fiber and incorporating a scattering element with the polymer element wherein the scattering element diffuses the light from the polymer element. The apparatus of the present invention comprises a polymer element operatively connected to the optical fiber and a scattering element operatively connected with the shape polymer element that diffuses the light from the polymer element.

    摘要翻译： 一种用于从光纤漫射光的系统，其中所述光纤耦合到光源，包括形成适于连接到所述光纤的聚合物元件并且与所述聚合物元件结合散射元件，其中所述散射元件将来自 聚合物元素。 本发明的装置包括可操作地连接到光纤的聚合物元件和与聚合物元件的光扩散的形状聚合物元件可操作地连接的散射元件。

    Opto-acoustic transducer for medical applications
    9.
    发明授权
    Opto-acoustic transducer for medical applications 失效
    用于医疗应用的光学传感器

    公开(公告)号：US06379325B1

    公开(公告)日：2002-04-30

    申请号：US09350494

    申请日：1999-07-09

    申请人： William Benett ,  Peter Celliers ,  Luiz Da Silva ,  Michael Glinsky ,  Richard London ,  Duncan Maitland ,  Dennis Matthews ,  Peter Krulevich ,  Abraham Lee

    发明人： William Benett ,  Peter Celliers ,  Luiz Da Silva ,  Michael Glinsky ,  Richard London ,  Duncan Maitland ,  Dennis Matthews ,  Peter Krulevich ,  Abraham Lee

    IPC分类号： A61B1720

    CPC分类号： A61B18/26 ,  A61B17/2202 ,  A61B2017/00106 ,  A61B2017/22084 ,  A61B2090/378

    摘要： This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.

    摘要翻译： 本发明是用于在生物介质中产生声振动的光学激活换能器。 传感器位于可以位于导管内的光纤的端部。 用于操作换能器的能量由通过光纤传输到换能器的激光光学地提供。 脉冲激光被吸收在换能器的工作流体中，以产生热压力并随之导致换能器头部的绝热膨胀，使其对环境介质起作用。 传感器通过热冷却过程返回到其原始状态。 传感器在环境介质中的运动将声能耦合到介质中。 通过以高重复率脉冲激光（其可以从CW变化到100kHz），可以在介质中局部地建立超声辐射场。 这种生产超声波振动的方法可以在体内用于治疗人类中风相关病症，特别是用于溶解血栓。 导管还可以掺入抗血栓溶解药物治疗作为辅助治疗，并且其可以与用于成像和反馈控制的超声波检测设备结合操作。