公开(公告)号：US5753476A

公开(公告)日：1998-05-19

申请号：US458544

申请日：1995-06-02

申请人： Thomas R. Jones ,  Ann E. Campbell

发明人： Thomas R. Jones ,  Ann E. Campbell

IPC分类号： C12N15/00 ,  A61K31/70 ,  A61K35/76 ,  A61K38/00 ,  A61K39/245 ,  A61K48/00 ,  A61P31/12 ,  C07K14/045 ,  C12N7/00 ,  C12N7/01 ,  C12N7/04 ,  C12N15/01 ,  C12N15/09 ,  C12N15/34 ,  C12N15/38 ,  C12N15/86 ,  C12N15/861 ,  C12R1/92 ,  C12N15/64 ,  C12N15/10

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  C12N15/86 ,  C12N7/00 ,  A61K2039/5156 ,  A61K2039/5254 ,  A61K38/00 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2710/16121 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16143 ,  C12N2710/16151 ,  C12N2710/16161 ,  C12N2710/16162

摘要： Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down regulation of cell surface expression of MHC class I. The present invention is directed to a mutant with a 9-kb deletion in the S component of the HCMV genome (including open reading frames IRS1-US9 and US11) which failed to down regulate class I heavy chains. By examining the phenotypes of mutants with smaller deletions with this portion of the HCMV genome, a 7-kb region containing at least 9 open reading frames was shown to contain the genes required for reduction in heavy chain expression. Furthermore, it was determined that two subregions (A and B) of the 7-kb region each contained genes which were sufficient to cause heavy chain down regulation. In subregion B, the US11 gene product is involved. It encodes a endoglycosidase H-sensitive glycoprotein which is intracytoplasmic, similar to the adenovirus type 2 E3-19K glycoprotein which inhibits surface expression of class I heavy chains.

摘要翻译： 用人巨细胞病毒（HCMV）感染人成纤维细胞导致I类MHC细胞表面表达的下调。本发明涉及在HCMV基因组的S成分中具有9-kb缺失的突变体（包括开放阅读框 IRS1-US9和US11），其不能下调I类重链。 通过使用该部分HCMV基因组检查具有较小缺失的突变体的表型，显示含有至少9个开放阅读框的7-kb区域含有重链表达降低所需的基因。 此外，确定了7-kb区域的两个亚区（A和B）各自含有足以引起重链下调的基因。 在次区域B中，涉及US11基因产物。 它编码胞质内H敏感的糖蛋白，其是胞质内的，类似于抑制I类重链表面表达的2型E3-19K糖蛋白。

公开(公告)号：US5720957A

公开(公告)日：1998-02-24

申请号：US459586

申请日：1995-06-02

申请人： Thomas R. Jones ,  Ann E. Campbell

发明人： Thomas R. Jones ,  Ann E. Campbell

IPC分类号： C12N15/00 ,  A61K31/70 ,  A61K35/76 ,  A61K38/00 ,  A61K39/245 ,  A61K48/00 ,  A61P31/12 ,  C07K14/045 ,  C12N7/00 ,  C12N7/01 ,  C12N7/04 ,  C12N15/01 ,  C12N15/09 ,  C12N15/34 ,  C12N15/38 ,  C12N15/86 ,  C12N15/861 ,  C12R1/92

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  C12N15/86 ,  C12N7/00 ,  A61K2039/5156 ,  A61K2039/5254 ,  A61K38/00 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2710/16121 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16143 ,  C12N2710/16151 ,  C12N2710/16161 ,  C12N2710/16162

摘要： Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down regulation of cell surface expression of MHC class I. The present invention is directed to a mutant with a 9-kb deletion in the S component of the HCMV genome (including open reading frames IRS1-US9 and US11) which failed to down regulate class I heavy chains. By examining the phenotypes of mutants with smaller deletions with this portion of the HCMV genome, a 7-kb region containing at least 9 open reading frames was shown to contain the genes required for reduction in heavy chain expression. Furthermore, it was determined that two subregions (A and B) of the 7-kb region each contained genes which were sufficient to cause heavy chain down regulation. In subregion B, the US11 gene product is involved. It encodes a endoglycosidase H-sensitive glycoprotein which is intracytoplasmic, similar to the adenovirus type 2 E3-19K glycoprotein which inhibits surface expression of class I heavy chains.

摘要翻译： 用人巨细胞病毒（HCMV）感染人成纤维细胞导致I类MHC细胞表面表达的下调。本发明涉及在HCMV基因组的S成分中具有9-kb缺失的突变体（包括开放阅读框 IRS1-US9和US11），其不能下调I类重链。 通过使用该部分HCMV基因组检查具有较小缺失的突变体的表型，显示含有至少9个开放阅读框的7-kb区域含有重链表达降低所需的基因。 此外，确定了7-kb区域的两个亚区（A和B）各自含有足以引起重链下调的基因。 在次区域B中，涉及US11基因产物。 它编码胞质内H敏感的糖蛋白，其是胞质内的，类似于抑制I类重链表面表达的2型E3-19K糖蛋白。

公开(公告)号：US5846806A

公开(公告)日：1998-12-08

申请号：US282696

申请日：1994-07-29

申请人： Thomas R. Jones ,  Ann E. Campbell

发明人： Thomas R. Jones ,  Ann E. Campbell

IPC分类号： C12N15/00 ,  A61K31/70 ,  A61K35/76 ,  A61K38/00 ,  A61K39/245 ,  A61K48/00 ,  A61P31/12 ,  C07K14/045 ,  C12N7/00 ,  C12N7/01 ,  C12N7/04 ,  C12N15/01 ,  C12N15/09 ,  C12N15/34 ,  C12N15/38 ,  C12N15/86 ,  C12N15/861 ,  C12R1/92

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  C12N15/86 ,  C12N7/00 ,  A61K2039/5156 ,  A61K2039/5254 ,  A61K38/00 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2710/16121 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16143 ,  C12N2710/16151 ,  C12N2710/16161 ,  C12N2710/16162

摘要： Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down regulation of cell surface expression of MHC class I. The present invention is directed to a mutant with a 9-kb deletion in the S component of the HCMV genome (including open reading frames IRS1-US9 and US11) which failed to down regulate class I heavy chains. By examining the phenotypes of mutants with smaller deletions with this portion of the HCMV genome, a 7-kb region containing at least 9 open reading frames was shown to contain the genes required for reduction in heavy chain expression. Furthermore, it was determined that two subregions (A and B) of the 7-kb region each contained genes which were sufficient to cause heavy chain down regulation. In subregion B, the US11 gene product is involved. It encodes a endoglycosidase H-sensitive glycoprotein which is intracytoplasmic, similar to the adenovirus type 2 E3-19K glycoprotein which inhibits surface expression of class I heavy chains.

摘要翻译： 用人巨细胞病毒（HCMV）感染人成纤维细胞导致I类MHC细胞表面表达的下调。本发明涉及在HCMV基因组的S成分中具有9-kb缺失的突变体（包括开放阅读框 IRS1-US9和US11），其不能下调I类重链。 通过使用该部分HCMV基因组检查具有较小缺失的突变体的表型，显示含有至少9个开放阅读框的7-kb区域含有重链表达降低所需的基因。 此外，确定了7-kb区域的两个亚区（A和B）各自含有足以引起重链下调的基因。 在次区域B中，涉及US11基因产物。 它编码胞质内H敏感的糖蛋白，其是胞质内的，类似于抑制I类重链表面表达的2型E3-19K糖蛋白。

公开(公告)号：US5906935A

公开(公告)日：1999-05-25

申请号：US946598

申请日：1997-10-07

申请人： Thomas R. Jones ,  Ann E. Campbell

发明人： Thomas R. Jones ,  Ann E. Campbell

IPC分类号： C12N15/00 ,  A61K31/70 ,  A61K35/76 ,  A61K38/00 ,  A61K39/245 ,  A61K48/00 ,  A61P31/12 ,  C07K14/045 ,  C12N7/00 ,  C12N7/01 ,  C12N7/04 ,  C12N15/01 ,  C12N15/09 ,  C12N15/34 ,  C12N15/38 ,  C12N15/86 ,  C12N15/861 ,  C12R1/92 ,  C12N5/10 ,  C12N1/00 ,  C12N15/79

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  C12N15/86 ,  C12N7/00 ,  A61K2039/5156 ,  A61K2039/5254 ,  A61K38/00 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2710/16121 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16143 ,  C12N2710/16151 ,  C12N2710/16161 ,  C12N2710/16162

摘要： Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down regulation of cell surface expression of MHC class I. The present invention is directed to a mutant with a 9-kb deletion in the S component of the HCMV genome (including open reading frames IRS1-US9 and US11) which failed to down regulate class I heavy chains. By examining the phenotypes of mutants with smaller deletions with this portion of the HCMV genome, a 7-kb region containing at least 9 open reading frames was shown to contain the genes required for reduction in heavy chain expression. Furthermore, it was determined that two subregions (A and B) of the 7-kb region each contained genes which were sufficient to cause heavy chain down regulation. In subregion B, the US11 gene product is involved. It encodes a endoglycosidase H-sensitive glycoprotein which is intracytoplasmic, similar to the adenovirus type 2 E3-19K glycoprotein which inhibits surface expression of class I heavy chains.

摘要翻译： 用人巨细胞病毒（HCMV）感染人成纤维细胞导致I类MHC细胞表面表达的下调。本发明涉及在HCMV基因组的S成分中具有9-kb缺失的突变体（包括开放阅读框 IRS1-US9和US11），其不能下调I类重链。 通过使用该部分HCMV基因组检查具有较小缺失的突变体的表型，显示含有至少9个开放阅读框的7-kb区域含有重链表达降低所需的基因。 此外，确定了7-kb区域的两个亚区（A和B）各自含有足以引起重链下调的基因。 在次区域B中，涉及US11基因产物。 它编码胞质内H敏感的糖蛋白，其是胞质内的，类似于抑制I类重链表面表达的2型E3-19K糖蛋白。

公开(公告)号：US5382370A

公开(公告)日：1995-01-17

申请号：US39046

申请日：1993-04-07

申请人： Thomas R. Jones ,  Reginald L. Phillips ,  Hugh R. Falcon-Steward

发明人： Thomas R. Jones ,  Reginald L. Phillips ,  Hugh R. Falcon-Steward

IPC分类号： B01D33/15 ,  B01D33/27 ,  B03B5/00 ,  B03B5/56 ,  B07B1/00 ,  B07B1/08 ,  B07B13/16 ,  B01D33/06 ,  B01D33/56 ,  B01D33/82

CPC分类号： B07B13/16 ,  B01D33/15 ,  B07B1/00 ,  B07B1/08 ,  Y10S209/906

摘要： A process for continuously separating relatively coarse particles from a suspension of a mixture of particles in a liquid wherein the suspension is caused to pass through a screening medium which is rotating in its own plane so that the coarse particles are retained on the surface of the screening medium; characterized in that atmospheric pressure above the screening medium is caused to be in excess of the pressure below that medium.

摘要翻译： PCT No.PCT / GB91 / 02106 Sec。 371日期：1993年4月7日 102（e）日期1993年4月7日PCT 1991年11月28日PCT PCT。 出版物WO92 / 09743 日期：1992年6月11日。一种用于将液体中的颗粒混合物的悬浮液中的相对粗粒子连续分离的方法，其中使悬浮液通过在其自身平面中旋转的筛分介质，使得粗颗粒为 保留在筛选介质的表面上; 其特征在于使筛选介质上方的大气压力超过该介质以下的压力。

公开(公告)号：US4937209A

公开(公告)日：1990-06-26

申请号：US248437

申请日：1988-09-23

申请人： Thomas R. Jones ,  Caryl Gould ,  Alan J. Brown ,  Roger James

发明人： Thomas R. Jones ,  Caryl Gould ,  Alan J. Brown ,  Roger James

IPC分类号： B01J20/16 ,  C04B38/00 ,  C12N11/14 ,  D21H17/68

CPC分类号： C04B38/0051 ,  B01J20/16 ,  C04B38/009 ,  C12N11/14 ,  D21H17/68

摘要： There is provided a porous cellular material comprising a plurality of cavities each defined by a substantially spherical wall formed of a rigid intermeshing matrix of ceramic needles said wall being pierced by at least one aperture to provide access to the cavity, and the or each aperture having a diameter such that the ratio of the diameter of the aperture to the diameter of the cavity into which the aperture opens is in the range of from 0.1:1 to 1:1.

摘要翻译： 提供了多孔多孔材料，其包括多个空腔，每个空腔由基本上为球形的壁形成，该壁由陶瓷针的刚性啮合基体形成，所述壁被至少一个孔刺穿以提供对腔的通路，并且所述或每个孔具有 使得孔的直径与孔的开口直径的比率在0.1:1至1:1的范围内的直径。

公开(公告)号：US4929580A

公开(公告)日：1990-05-29

申请号：US368068

申请日：1989-06-15

申请人： Thomas R. Jones

发明人： Thomas R. Jones

IPC分类号： C09C1/42 ,  D21H19/40 ,  D21H19/62 ,  C04B33/00

CPC分类号： C09C1/42 ,  D21H19/40 ,  D21H19/62 ,  C01P2004/32 ,  C01P2004/51 ,  C01P2004/61 ,  C01P2006/22 ,  C01P2006/80

摘要： There is disclosed a process for treating a clay mineral thereby to change its rheological properties when in aqueous suspension such that the fluidity of the aqueous suspension at a given temperature and percentage by weight of completely deflocculated clay mineral solids in the suspension is increased, which process comprises the steps of mixing with the clay mineral in a plastic state a minor proportion by weight of a water-soluble organic compound having a plurality of basic groups and a number average molecular weight not greater than 1000, and subsequently or simultaneously subjecting the mixture to mechanical working under conditions such that from 25 to 1000 KJ of energy per Kg of dry clay mineral are dissipated in the mixture.

摘要翻译： 公开了一种处理粘土矿物的方法，从而在水性悬浮液中改变其流变性能，使得悬浮液中给定温度下的水悬浮液的流动性和完全絮凝的粘土矿物固体的重量百分比增加，该方法 包括以少量重量的具有多个碱性基团和数均分子量不大于1000的水溶性有机化合物与塑料状态的粘土矿物混合的步骤，随后或同时使该混合物 在每公斤干粘土矿物25至1000KJ的能量在混合物中消散的条件下进行机械加工。

公开(公告)号：US4520168A

公开(公告)日：1985-05-28

申请号：US593743

申请日：1984-03-27

申请人： James H. Kawakami ,  Benito See ,  Thomas R. Jones ,  Louis M. Maresca

发明人： James H. Kawakami ,  Benito See ,  Thomas R. Jones ,  Louis M. Maresca

IPC分类号： C08G63/193 ,  C08G63/78 ,  C08G63/83 ,  C08G63/90 ,  C08L67/03 ,  C08G63/18

CPC分类号： C08G63/90 ,  C08G63/193 ,  C08G63/78 ,  C08G63/83 ,  C08L67/03

摘要： Color improved polyarylates having a reduced viscosity of from about 0.1 to greater than 1.0 dl/gm produced by a process comprising the following steps:(a) reacting an acid anhydride derived from an acid containing from 2 to 8 carbon atoms with at least one dihydric phenol to form the corresponding diester; and(b) reacting said diester with at least one aromatic dicarboxylic acid at a temperature sufficient to form the polyarylate, wherein the improvement comprises carrying out said process in the presence of a particular solid adsorbent.

摘要翻译： 通过包括以下步骤的方法生产的具有约0.1至大于1.0dl / gm的比浓粘度的颜色改进的多芳基化合物：（a）使来自含有2至8个碳原子的酸的酸酐与至少一种二羟基 苯酚形成相应的二酯; 和（b）使所述二酯与至少一种芳族二羧酸在足以形成多芳基化合物的温度下反应，其中所述改进包括在特定固体吸附剂存在下进行所述方法。

公开(公告)号：US4422721A

公开(公告)日：1983-12-27

申请号：US406302

申请日：1982-08-09

申请人： Robert E. Hahn ,  Thomas R. Jones ,  Peter H. Berning

发明人： Robert E. Hahn ,  Thomas R. Jones ,  Peter H. Berning

IPC分类号： G02B1/11 ,  G02B1/10

CPC分类号： G02B1/116

摘要： Optical article having a substrate with first and second surfaces and with a conductive antireflection coating disposed on the first surface. The conductive antireflection coating is comprised of at least one layer of a low index material carried by said first surface and a thin transparent conducting layer of a material having a high index of refraction carried by the layer of material having a low index of refraction. The conducting layer provides an exposed surface to which the direct electrical contact can be made. The conducting layer has an optical thickness ranging from 1.0 to 30.0 nanometers. The layer of material having a low index of refraction has its design thickness reduced to compensate for the thickness of the conducting layer whereby the conducting layer does not seriously degrade the optical performance of the coating over that which could be obtained without the use of the conducting layer.

摘要翻译： 具有具有第一表面和第二表面的基底和设置在第一表面上的导电抗反射涂层的光学制品。 导电抗反射涂层由至少一层由所述第一表面承载的低折射率材料层和由具有低折射率的材料层承载的具有高折射率的材料的薄透明导电层组成。 导电层提供暴露的表面，直接电接触可以被制成。 导电层的光学厚度范围为1.0至30.0纳米。 具有低折射率的材料层具有减小的设计厚度以补偿导电层的厚度，由此导电层不会严重劣化涂层的光学性能，而不需要使用导电层 层。

公开(公告)号：US06483688B1

公开(公告)日：2002-11-19

申请号：US09614621

申请日：2000-07-12

申请人： Thomas R. Jones

发明人： Thomas R. Jones

IPC分类号： H01H4700

CPC分类号： F16K31/0627 ,  F16K11/044 ,  F16K11/048 ,  F16K31/0634 ,  H01F7/124 ,  H01F7/1872

摘要： A circuit for controlling a valve assembly in applications where electrical isolation of the two control signal supply lines is required to prevent damage of control circuits caused by a reverse polarity feedback signal or other transient signal. The circuit includes a solenoid having a coil. The coil has a first end and a second end. The circuit also includes a first switching circuit electrically connected to the first and second ends of the coil to allow current to pass therethrough in a first direction to move a permanent magnet against a pushpin a first axial direction. The circuit further includes a second switching circuit electrically connected to the first and second ends of the coil to allow a current to pass therethrough in a second direction to move the permanent magnet away from the pushpin in a second axial direction. Further, when either switching circuit is allowing current to flow through the coil, it electrically isolates one negative control source from the other. The use of a pair of switching circuits electrically connected to the coil results in a relatively low voltage drop across the circuit.

摘要翻译： 在需要两个控制信号电源线的电隔离以防止由反极性反馈信号或其它瞬态信号引起的控制电路损坏的应用中，用于控制阀组件的电路。 该电路包括具有线圈的螺线管。 线圈具有第一端和第二端。 电路还包括电连接到线圈的第一和第二端的第一开关电路，以允许电流沿第一方向通过，以使第一轴向方向上的永久磁体移动到图钉上。 电路还包括电连接到线圈的第一和第二端的第二开关电路，以允许电流沿第二方向通过，以使永磁体在第二轴向方向上从图钉移开。 此外，当任一开关电路允许电流流过线圈时，它将一个负控制源与另一个负控制源电隔离。 电连接到线圈的一对开关电路的使用导致跨越电路的相对低的压降。