公开(公告)号：US20250049835A1

公开(公告)日：2025-02-13

申请号：US18926385

申请日：2024-10-25

Applicant: Yeda Research and Development Co. Ltd. ,  Dana-Farber Cancer Institute, Inc.

Inventor： Rotem SOREK ,  Gil AMITAI ,  Azita LEAVITT ,  Erez YIRMIYA ,  Philip J. KRANZUSCH ,  Allen LU ,  Samuel J. HOBBS

IPC: A61K31/7076 ,  A61K39/39 ,  A61K39/395

Abstract: Methods of treating a disease or disorder associated with a down or up-regulation of an immune response of a subject are disclosed. The methods comprising administering to the subject a therapeutically effective amount of any one or more of the molecule 1′-2′ glycosyl cyclic adenosine diphosphate ribose (1′-2′ gcADPR), 1′-3′ gcADPR or Tad1 protein.

公开(公告)号：US20230072222A1

公开(公告)日：2023-03-09

申请号：US17583378

申请日：2022-01-25

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD

Inventor： Helena SHOMAR MONGES ,  Rotem SOREK ,  Lianet NODA GARCIA ,  Arthur MACHLENKIN ,  David SPERANDIO

IPC: C07H19/20 ,  C07H19/10 ,  A61P31/14

Abstract: Disclosed herein are 3, 4-didehydro- and 3′-deoxy-3, 4-didehydro-compounds and pharmaceutical compositions thereof. Methods of use of these pharmaceutical compositions include those for treating diseases including virus-induced diseases, cancer, autoimmune diseases, immune disorders, and bacterial-associated diseases or infections, or combinations thereof. Examples of viral-induced diseases include viral infections by RNA or DNA viruses, for example SAR-CoV-2, EBV, BKV, JCV and HCMV.

公开(公告)号：US20140178353A1

公开(公告)日：2014-06-26

申请号：US14140793

申请日：2013-12-26

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Rotem SOREK ,  Hila Sberro ,  Azita Leavitt

IPC: C12N9/22 ,  A61K38/46 ,  A61K38/45 ,  C12N9/12

CPC classification number: A61K38/45 ,  A61K38/00 ,  C07K14/8107 ,  C12N9/1241 ,  C12N9/22 ,  C12Y207/07

Abstract: An isolated polypeptide is disclosed comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2773-5544 and 11089-11094, wherein the polypeptide has antimicrobial activity. Uses thereof for treating microbial infections are also disclosed.

Abstract translation: 公开了分离的多肽，其包含选自SEQ ID NO：2773-5544和11089-11094的氨基酸序列，其中所述多肽具有抗微生物活性。 还公开了其用于治疗微生物感染的用途。

公开(公告)号：US20250032566A1

公开(公告)日：2025-01-30

申请号：US18713665

申请日：2022-12-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem SOREK ,  Erez YIRMIYA ,  Azita LEAVITT ,  Gil AMITAI ,  Jeremy Elliot GARB

IPC: A61K35/76 ,  C12N7/00

Abstract: Genetically modified phages are provided. Accordingly, there is provided a genetically modified phage comprising a polynucleotide encoding an anti-defense system polypeptide. Also provided are methods of producing and using same.

公开(公告)号：US20220175807A1

公开(公告)日：2022-06-09

申请号：US17442198

申请日：2020-03-29

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Rotem SOREK ,  Auda BERNHEIM ,  Adl Jenny MILLMAN DAYAN

IPC: A61K31/708 ,  A61K31/7068 ,  C07K14/195 ,  A61K31/7072 ,  A61P31/12

Abstract: Disclosed herein are prokaryotic homologs of viperin (pVips), and nucleotide and nucleoside analogs produced from pVips. These nucleotide and nucleoside analogs stop nucleotide chain synthesis and provide host cells with resistance to viral infections by targeting actively replicating viral genome. Further, these nucleotide and nucleoside analogs decrease DNA replication in malignant cells. Further disclosed are methods of identifying pVips, and nucleotide and nucleoside analogs produced thereof.

公开(公告)号：US20180237774A1

公开(公告)日：2018-08-23

申请号：US15750193

申请日：2016-08-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem SOREK ,  Daniel DAR

IPC: C12N15/113 ,  C12N15/115 ,  C12N15/67 ,  C07H21/02 ,  C12Q1/04 ,  G01N33/58

CPC classification number: C12N15/113 ,  C07H21/02 ,  C12N15/115 ,  C12N15/67 ,  C12Q1/04 ,  G01N33/582

Abstract: A method of determining a transcription termination site in bacterial DNA is disclosed. Uses of sequences comprising transcription termination sites are also disclosed.

公开(公告)号：US20190264213A1

公开(公告)日：2019-08-29

申请号：US16346124

申请日：2017-11-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem SOREK ,  Gil AMITAI ,  Erez ZOHAR

IPC: C12N15/63 ,  C12N15/75

Abstract: Methods of expressing an expression product of interest are provided. Accordingly there is provided a method comprising introducing into a cell a polynucleotide comprising an AimR responsive element operatively linked to a nucleic acid sequence encoding the expression product of interest, and contacting said cell with an AimP peptide comprising an amino acid sequence of XXXXGG/A, wherein said AimP peptide is capable of binding said AimR polypeptide and dissociating said AimR polypeptide from said AimR responsive element. Also provided are articles of manufacture, isolated peptides, polynucleotides and nucleic acid constructs.

公开(公告)号：US20160287677A1

公开(公告)日：2016-10-06

申请号：US15131102

申请日：2016-04-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem SOREK ,  Hila SBERRO ,  Azita LEAVITT

IPC: A61K38/45

CPC classification number: A61K38/45 ,  A61K38/00 ,  C07K14/8107 ,  C12N9/1241 ,  C12N9/22 ,  C12Y207/07

Abstract: An isolated polypeptide is disclosed comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2773-5544 and 11089-11094, wherein the polypeptide has antimicrobial activity. Uses thereof for treating microbial infections are also disclosed.

Abstract translation: 公开了分离的多肽，其包含选自SEQ ID NO：2773-5544和11089-11094的氨基酸序列，其中所述多肽具有抗微生物活性。 还公开了其用于治疗微生物感染的用途。

公开(公告)号：US20160281053A1

公开(公告)日：2016-09-29

申请号：US15030876

申请日：2014-10-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Rotem SOREK ,  Hila SBERRO ,  Tamara GOLDFARB

IPC: C12N1/20 ,  C07K14/195 ,  C12N9/10 ,  C12N9/48 ,  A23C9/123 ,  C12N9/12 ,  C12N9/02 ,  C07K14/245 ,  C07K14/32 ,  C12N15/52 ,  C12N9/16 ,  C12N9/14

CPC classification number: C12N1/20 ,  A23C9/1234 ,  A23C2220/202 ,  C07K14/195 ,  C07K14/245 ,  C07K14/32 ,  C12N9/0051 ,  C12N9/1007 ,  C12N9/12 ,  C12N9/14 ,  C12N9/16 ,  C12N9/48 ,  C12N15/52 ,  C12Y108/04008 ,  C12Y201/01072 ,  C12Y207/11001 ,  C12Y301/03001 ,  C12Y304/00 ,  C12Y306/04012 ,  C12Y306/04013

Abstract: Isolated polynucleotides encoding a BREX system are provided. Accordingly there is provided an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ and at least one of pglX, pglXI, brxP, brxHI, brxHII, brxL, brxD, brxA, brxB, brxF, and brxE, with the proviso that said BREX system does not comprise pglW, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same; Also provided is an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ, pglX, pglW and at least one of brxD and brxHI, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same. Also provided are compositions and methods for conferring phage resistance to bacteria or for conferring bacterial susceptibility to phages.

Abstract translation: 提供编码BREX系统的分离的多核苷酸。 因此，提供了编码BREX系统的分离的多核苷酸，其包含编码包含brxC / pglY，pglZ和pglX，pglXI，brxP，brxHI，brxHII，brxL，brxD，brxA，brxB，brxD，brxA，brxB，brxF中的至少一种的BREX系统的核酸序列 和brxE，条件是所述BREX系统不包含pglW，并且其中所述BREX系统赋予对重组表达的细菌的噬菌体抗性; 还提供了编码BREX系统的分离的多核苷酸，其包含编码包含brxC / pglY，pglZ，pglX，pglW和至少一种brxD和brxHI的BREX系统的核酸序列，并且其中所述BREX系统将重组的噬菌体抗性赋予细菌 表达相同。 还提供了赋予细菌噬菌体抗性或赋予细菌对噬菌体易感性的组合物和方法。