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公开(公告)号:US10053542B2
公开(公告)日:2018-08-21
申请号:US14423496
申请日:2013-07-10
申请人: Merck Patent GmbH
IPC分类号: H01L51/54 , C08G75/06 , H01B1/20 , C08L81/02 , C07D519/00 , C07D495/04 , H01L51/05 , H01L51/42 , C07D495/22 , C08G61/12 , H01L51/00 , C07D409/10 , C07D498/22 , C07D513/22 , C07D517/22
CPC分类号: C08G75/06 , C07D409/10 , C07D495/04 , C07D495/22 , C07D498/22 , C07D513/22 , C07D517/22 , C07D519/00 , C08G61/126 , C08G2261/124 , C08G2261/1336 , C08G2261/1412 , C08G2261/148 , C08G2261/18 , C08G2261/3243 , C08G2261/414 , C08G2261/51 , C08G2261/91 , C08G2261/92 , C08G2261/95 , C08L81/02 , H01B1/20 , H01L51/0036 , H01L51/0043 , H01L51/0512 , H01L51/0558 , H01L51/4253 , Y02E10/549 , Y02P70/521
摘要: The invention relates to novel conjugated polymers containing one or more polycyclic repeating units, to methods for their preparation and educts or intermediates used therein, to polymer blends, mixtures and formulations containing them, to the use of the polymers, polymer blends, mixtures and formulations as organic semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices and organic photodetectors (OPD), and to OE, OPV and OPD devices comprising these polymers, polymer blends, mixtures or formulations.
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公开(公告)号:US20180162859A1
公开(公告)日:2018-06-14
申请号:US15892142
申请日:2018-02-08
申请人: PharmAkea, Inc.
IPC分类号: C07D471/14 , A61K9/51 , A61K31/437 , C07D471/12 , A61K45/06 , A61K31/4375 , A61K31/444 , A61K31/4985 , C07D471/22 , A61K9/10 , C07D498/22 , C07D498/14
CPC分类号: C07D471/14 , A61K9/10 , A61K9/5153 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4985 , A61K45/06 , C07D471/12 , C07D471/22 , C07D498/14 , C07D498/22 , A61K2300/00
摘要: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
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公开(公告)号:US09932356B2
公开(公告)日:2018-04-03
申请号:US15115758
申请日:2015-02-10
IPC分类号: C07D513/22 , C07D498/22 , C07D471/22
CPC分类号: C07D513/22 , C07D471/22 , C07D498/22
摘要: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号:US20180065987A1
公开(公告)日:2018-03-08
申请号:US15487371
申请日:2017-04-13
发明人: Giuseppe Claudio VISCOMI , Manuela CAMPANA , Dario BRAGA , Donatella CONFORTINI , Vincenzo CANNATA , Paolo RIGHI , Goffredo ROSINI , Denis SEVERINI
IPC分类号: C07D498/22
CPC分类号: C07D498/22 , C07B2200/13 , C07D491/22
摘要: Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin cc and rifaximin β, and a poorly crystalline form named rifaximin γ, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.
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公开(公告)号:US09902740B2
公开(公告)日:2018-02-27
申请号:US15606512
申请日:2017-05-26
发明人: Yong Zhang , Robert M. Borzilleri , Andrew J. Tebben , Erik M. Stang , Andrew F. Donnell , Gretchen M. Schroeder , Heidi L. Perez , Donna D. Wei
IPC分类号: C07D519/00 , C07D498/22 , A61K47/48 , C07K16/30 , A61K31/5513 , A61K31/5517
CPC分类号: C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48384 , A61K47/48569 , A61K47/48592 , A61K47/48615 , A61K47/48638 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K47/6889 , C07D519/00 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069
摘要: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
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公开(公告)号:US09873716B2
公开(公告)日:2018-01-23
申请号:US14740680
申请日:2015-06-16
发明人: Caroline Aciro , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Petr Jansa , Kapil Kumar Karki , Andrew J. Keats , Linos Lazarides , Richard L. Mackman , Simon N. Pettit , Karine G. Poullennec , Adam James Schrier , Dustin Siegel , Victoria Alexandra Steadman
IPC分类号: A61K38/21 , C07K5/062 , C07D487/08 , C07D498/08 , C07D498/18 , A61K38/12 , A61K39/29 , A61K45/06 , C07K5/02 , C07D471/18 , C07D498/22 , A61K38/55 , A61K31/403 , A61K31/497 , A61K31/504 , A61K31/7056 , A61K31/7072 , C07K5/078 , C07K5/065 , A61K38/15 , A61K38/00
CPC分类号: C07K5/06034 , A61K31/403 , A61K31/497 , A61K31/504 , A61K31/7056 , A61K31/7072 , A61K38/00 , A61K38/05 , A61K38/12 , A61K38/15 , A61K38/21 , A61K38/55 , A61K39/29 , A61K45/06 , C07D471/18 , C07D487/08 , C07D498/08 , C07D498/18 , C07D498/22 , C07K5/02 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06139 , C07K5/06191 , C07K19/00 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395 , A61K2300/00
摘要: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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公开(公告)号:US09839641B2
公开(公告)日:2017-12-12
申请号:US15353325
申请日:2016-11-16
IPC分类号: C07D498/22 , A61K31/5383
CPC分类号: A61K31/5383 , C07D498/22
摘要: Compounds of formula (I), pharmaceutically acceptable salts thereof, and uses of the compounds of formula (I) for treating bacterial infections are disclosed.
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公开(公告)号:US09834566B2
公开(公告)日:2017-12-05
申请号:US15119431
申请日:2015-02-13
发明人: John F. Kadow , B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Tao Wang , Zhiwei Yin , Zhongxing Zhang
IPC分类号: C07D498/16 , C07D498/22 , A61K31/519 , A61K45/06
CPC分类号: C07D498/16 , A61K31/519 , A61K45/06 , C07D498/22
摘要: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号:US09782415B2
公开(公告)日:2017-10-10
申请号:US15401913
申请日:2017-01-09
发明人: Shelley Allen , Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Lily Huang , Yutong Jiang , Timothy Kercher , Jeongbeob Seo
IPC分类号: A01N43/90 , A61K31/519 , A61K31/5377
CPC分类号: C07D487/04 , A61K31/519 , A61K31/5377 , C07D453/02 , C07D471/22 , C07D498/22 , C07D519/00
摘要: Compounds of Formula I: and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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公开(公告)号:US20170267693A1
公开(公告)日:2017-09-21
申请号:US15598671
申请日:2017-05-18
IPC分类号: C07D498/14 , C07D471/14 , C07D498/04 , C07D471/22 , C07D498/20 , C07D498/22 , A61K31/4985 , A61K31/5365 , C07D471/04 , A61K45/06
CPC分类号: C07D498/14 , A61K9/0053 , A61K31/4985 , A61K31/519 , A61K31/5365 , A61K31/551 , A61K45/06 , C07D471/04 , C07D471/14 , C07D471/22 , C07D498/04 , C07D498/20 , C07D498/22
摘要: The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. (wherein Z1 is NR4; R1 is hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SO2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; R2 is optionally substituted aryl; R3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and R4 and Z2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.
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