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公开(公告)号：US20190110973A1
公开(公告)日：2019-04-18
申请号：US15580019
申请日：2016-06-08
CPC分类号： A61K8/4973 , A61K8/49 , A61P31/10 , A61Q5/006 , C12P17/162 , C12R1/645
摘要： A novel anti-dandruff agent being a fumagillin derivative according to formula (I), and use of said agent as an anti-dandruff actives in anti-dandruff compositions, particularly shampoos and conditioners. The active is particularly effective against Malassezia yeasts and Malassezia furfur which may cause dandruff. A method of obtaining the fumagillin derivative from culturing of Peyronellaea sp. strain RKDO347 is also described.
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公开(公告)号：US20180355385A1
公开(公告)日：2018-12-13
申请号：US16060182
申请日：2016-12-09
发明人： Kyohei ISOBE , Kenji KAWAMURA , Masateru ITO , Katsushige YAMADA
IPC分类号： C12P7/50
摘要： A method of producing 3-oxoadipic acid from an aliphatic compound easily utilizable by a microorganism, such as a saccharide, by utilization of a metabolic pathway of the microorganism is disclosed. The method of producing 3-oxoadipic acid includes the step of culturing at least one type of microorganism having a capacity to produce 3-oxoadipic acid, selected from the group consisting of, for example, microorganisms belonging to the genus Serratia, microorganisms belonging to the genus Corynebacterium, microorganisms belonging to the genus Hafnia, microorganisms belonging to the genus Bacillus, microorganisms belonging to the genus Escherichia, microorganisms belonging to the genus Pseudomonas, microorganisms belonging to the genus Acinetobacter, microorganisms belonging to the genus Alcaligenes, microorganisms belonging to the genus Shimwellia, microorganisms belonging to the genus Planomicrobium, microorganisms belonging to the genus Nocardioides, microorganisms belonging to the genus Yarrowia, microorganisms belonging to the genus Cupriavidus, microorganisms belonging to the genus Rhodosporidium, microorganisms belonging to the genus Streptomyces, and microorganisms belonging to the genus Microbacterium.
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公开(公告)号：US20180195093A1
公开(公告)日：2018-07-12
申请号：US15849223
申请日：2017-12-20
CPC分类号： C12P7/18 , C07K14/39 , C12N1/16 , C12P7/04 , C12P7/06 , C12P7/16 , C12P7/22 , C12R1/645 , Y02E50/10 , Y02E50/17
摘要： Provided herein are Metschnikowia species that produce useful compounds from xylose when cultured, as well as methods to make and use these Metschnikowia species.
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公开(公告)号：US20180187226A1
公开(公告)日：2018-07-05
申请号：US15911028
申请日：2018-03-02
发明人： Chiao-Ying Huang , Yu-Chen Cheng , Yi-Sheng Lin , Guey-Yuh Liou , Shie-Jea Lin , Jinn-Tsyy Lai
摘要： The present application provides a culture medium for producing β-glucan. The culture medium comprises: a carbon source, lecithin and an ascorbic acid. The present application further provides a method for producing β-glucan, the method comprising culturing Aureobasidium pullulans in the culture medium for fermentation. The Aureobasidium pullulans is advantageous in producing no melanin; as a result, the yield of β-glucan can be increased and the waste can be reduced with the improved culture medium composition and culturing method.
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5.发明申请公开(公告)号：US20180179560A1
公开(公告)日：2018-06-28
申请号：US15845697
申请日：2017-12-18
IPC分类号： C12P7/64 , C12P23/00 , C12P21/00 , C12R1/89 , C12N1/12 , A23L33/135 , A23K50/00 , A23K10/18 , A23K20/147
CPC分类号： C12P7/6427 , A23K10/18 , A23K20/147 , A23K20/158 , A23K50/00 , A23L33/115 , A23L33/135 , A23V2002/00 , C12N1/10 , C12N1/12 , C12N1/14 , C12P7/6409 , C12P7/6472 , C12P21/00 , C12P23/00 , C12R1/645 , C12R1/89
摘要： Provided herein are eukaryotic microorganisms having a simple lipid profile comprising long chain fatty acids (LCFAs). Also provided are compositions and cultures comprising the eukaryotic microorganisms as well as methods of using the eukaryotic microorganisms.
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公开(公告)号：US09950986B2
公开(公告)日：2018-04-24
申请号：US15126182
申请日：2015-03-16
IPC分类号： C07C69/675 , C07C69/21 , C07C69/33 , C12P19/44 , C12P7/62 , C12R1/645 , A01N37/36 , C07C69/003 , A61K31/191
CPC分类号： C07C69/675 , A01N37/36 , A61K31/191 , C07C69/003 , C07C69/21 , C07C69/33 , C12P7/62 , C12P19/44 , C12R1/645
摘要： Novel compounds, called liamocins from Aureobasidium pullulans, having the general structure in Formula 1 are disclosed. where R1 is either COCH3 or H; and R2 is between two to ten O-linked 3,5-dihydroxydecanoate; and R3 can be a polyol (e.g., L- or D-glycerol, L- or D-threitol, L- or D-erythritol, L- or D-arabitol, L- or D-xylitol, L- or D-lyxitol, L- or D-ribitol, L- or D-allitol, L- or D-altritol, L- or D-mannitol, L- or D-iditol, L- or D-gulitol, L- or D-glucitol (also called sorbitol), L- or D-galactitol (also called dulcitol), and L- or D-talitol), 2-amino-D-mannitol, 2N-acetylamino-D-mannitol, L-rhamnitol, or D-fucitol; except when R3 is D-mannitol, R2 is not 2 nor 3 O-linked 3,5-dihydroxydecanoate chains. These liamocins described above in addition to D-mannitol liamocin A1, D-mannitol liamocin A2, D-mannitol liamocin B1, and D-mannitol liamocin B2, alone or in combination with each other, can be used to kill certain bacteria and to treat certain bacterial infections.
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公开(公告)号：US09872502B2
公开(公告)日：2018-01-23
申请号：US14127786
申请日：2012-06-01
IPC分类号： A01N63/00 , A01N65/00 , A01H15/00 , A01N63/04 , C07K14/37 , C12N9/02 , C12P17/18 , C12R1/645 , A01N43/90 , A01N65/44
CPC分类号： A01N65/00 , A01H15/00 , A01N43/90 , A01N63/04 , A01N65/44 , C07K14/37 , C12N9/0008 , C12P17/182 , C12R1/645 , C12Y102/01009
摘要： The present invention relates to fungi of Acremonium spp, wherein said fungi are purified or isolated from plants of the Brachiaria-Urochloa complex and wherein, when said fungi are inoculated into a plant, said plant has improved resistance to diseases and/or pests relative to an uninocualated control plant. The present invention also relates to plants inoculated with such fungi, products produced by the fungi and related genes, proteins and methods.
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公开(公告)号：US20170356017A1
公开(公告)日：2017-12-14
申请号：US15506960
申请日：2015-10-06
发明人： Futoshi Hara , Ayako Kashima , Shuichiro Kimura
CPC分类号： C12P7/56 , C12N9/0006 , C12N9/88 , C12N15/52 , C12R1/645 , C12Y101/01027 , C12Y401/01001
摘要： Provided is a transformant which can produce lactic acid with a high productivity without requiring neutralization with an alkali and is excellent in both of lactic acid production capability and growth ability and its production process, and a method for producing lactic acid by using the transformant.A transformant containing from 3 to 5 copies of a lactate dehydrogenase gene derived from human and introduced into a Schizosaccharomyces pombe host, wherein a gene that is a part of a group of genes encoding pyruvate decarboxylase of the Schizosaccharomyces pombe host is deleted or inactivated. A transformant characterized by providing a cell concentration of at least 4.0 g (on a dry cell weight basis)/L of a culture broth prepared by inoculating cells, at an initial cell concentration of 0.04 g (on a dry cell weight basis)/L, into a 500 mL Sakaguchi flask containing 100 mL of a liquid culture broth which includes 1% of yeast extract, 2% of peptone and 6% of glucose, and then cultivating 20 hours at a temperature of 32° C. under shaking conditions of 110 rpm and 7 cm stroke, and providing a lactic acid concentration of at least 80 g/L of a fermentation liquor prepared by inoculating cells obtained by cultivating 20 hours under the above-described conditions, at an initial cell concentration of 36 g (on a dry cell weight basis)/L, into a 11.1% glucose aqueous solution, and then fermenting 3 hours at a temperature of 32° C. under shaking conditions of 110 rpm and 7 cm stroke. A method for producing lactic acid by using these transformants.
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公开(公告)号：US20170312247A1
公开(公告)日：2017-11-02
申请号：US15508369
申请日：2015-09-02
申请人： GRAPE KING BIO LTD.
发明人： Pei-Shan Liu , Chien-Chih Chen , Chin-Chu Chen , Li-Ya Lee , Wan-Ping Chen , Ting-Wei Lin , Jui-Hsia Hsu , Wei-Ching Chu
IPC分类号： A61K31/343 , C12P17/18 , A61K9/14 , A61K36/07
CPC分类号： A01G18/00 , A61K9/14 , A61K31/343 , A61K36/07 , A61K2236/11 , A61K2236/33 , A61K2236/331 , A61K2236/53 , C07D493/06 , C12P17/181 , C12R1/645
摘要： The present invention is related to an active substance of Hericium erinaceus having a pain-relieving effect, and a pharmaceutical composition including the active substance. The active substance is prepared using the following steps: (a) inoculating a mycelium of H. erinaceus on an agar plate and incubating at 15-32° C. for 8-16 days; (b) inoculating the incubated H. erinaceus mycelia from step (a) into a medium in a flask and incubating at 20-30° C. and pH 4.5-6.5 for 3-5 days; (c) inoculating the incubated H. erinaceus mycelia from step (b) into a medium in a fermentation tank and incubating at 24-32° C. and pH 4.5-5.5 for 8-16 days to obtain a fermented medium of the H. erinaceus mycelia; and (d) desiccating the fermented medium of the H. erinaceus mycelia from step (c) to obtain the powder of the H. erinaceus mycelia, which is further purified and isolated to obtain a novel compound of H. erinaceus.
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公开(公告)号：US09758758B2
公开(公告)日：2017-09-12
申请号：US15021425
申请日：2014-09-11
发明人： John Sutton , Todd Gordon Mason
摘要： Described is an isolated strain of the fungus Colonostachys rosea termed BVT Cr-7 useful as a biological control agent for the treatment of plants. The isolated strain, formulations comprising said strain and/or spores derived from said strain may be applied to plants or plant materials in order to improve plant yield, to improve plant growth, or for the treatment or prevention of diseases or pathogens in the plant.
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