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公开(公告)号：US20240384347A1
公开(公告)日：2024-11-21
申请号：US18694166
申请日：2022-09-23
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Miranda ORR
IPC: C12Q1/6883 , A61B6/03 , A61B6/50 , C07K16/40
Abstract: Provided herein according to some embodiments is a method of detecting senescent cells and/or neurofibrillary tangles in a subject, comprising: assaying for the expression of CDKN2D in the brain of the subject; and comparing the amount of CDKN2D expression to a control, whereby increased CDKN2D expression relative to the control is indicative of the presence of neurofibrillary tangles in the subject. Methods of treating and monitoring a subject so identified are also provided.
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公开(公告)号：US20240285694A1
公开(公告)日：2024-08-29
申请号：US18645616
申请日：2024-04-25
Applicant: Wake Forest University Health Sciences
Inventor： Ji Hyun KIM , Anthony ATALA , James J. YOO
CPC classification number: A61K35/34 , A61K38/1825 , A61L27/3625 , A61L2430/40
Abstract: Methods and compositions are disclosed for repair of shoulder injuries by employing disaggregated muscle fiber fragments to regenerate functional shoulder muscle tissue. In some embodiments, the fragments retain functional satellite cells but exhibit cell wall rupture and have an average size of less than 150 μm. The methods include the preparation and implantation of compositions by extracting muscle tissue from a donor site, disaggregating muscle fibers from the extracted tissue, and fragmenting disaggregated muscle fibers into fiber fragments that exhibit cell wall rupture and preferably have an average size of less than 150 microns, more preferable less than about 100 microns, while retaining functional satellite cells. Upon injection, e.g., into the supraspinatus or other rotator cuff muscles, the muscle fiber fragment compositions are capable of reconstituting or reconstructing elongated muscle fibers from the fragments and orienting in alignment with native shoulder muscle fibers.
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公开(公告)号：US12036326B2
公开(公告)日：2024-07-16
申请号：US16355073
申请日：2019-03-15
Applicant: Wake Forest University Health Sciences
Inventor： Emmanuel C. Opara , Adam R. Hall
IPC: C12N5/00 , A61K9/50 , B01L3/00 , C12N5/0775 , C12N11/04
CPC classification number: A61K9/5036 , B01L3/502761 , C12N5/0012 , C12N5/0663 , C12N11/04
Abstract: The present disclosure describes a method of encapsulating cells in a crosslinked alginate microbead using a microfluidic encapsulation device.
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公开(公告)号：US12031026B2
公开(公告)日：2024-07-09
申请号：US16263222
申请日：2019-01-31
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Carlos Kengla
IPC: A61L27/12 , A61L27/38 , A61L27/46 , A61L27/50 , A61L27/56 , A61L27/58 , B29C64/118 , B29C64/205 , B33Y10/00 , B33Y70/10 , C08K3/32 , C08L67/04 , B29K67/00 , B29K509/02
CPC classification number: C08L67/04 , A61L27/3847 , A61L27/46 , A61L27/56 , A61L27/58 , B29C64/118 , B29C64/205 , B33Y10/00 , B33Y70/10 , C08K3/32 , A61L2430/02 , B29K2067/04 , B29K2509/02 , C08K2003/325 , C08K3/32 , C08L67/04
Abstract: Provided herein are improved compositions and methods of making and using the same, the composition comprising a polymer and a ceramic present at a ratio of from 3:1 to 1:3 of polymer:ceramic by weight, wherein the composition comprises or is a composite of the polymer and the ceramic having improved printability and/or having an improved elastic modulus and/or improved stress at failure (e.g., as compared to a blend of the polymer and the ceramic). Improved medical implants incorporating the same are also provided.
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公开(公告)号：US20240200023A1
公开(公告)日：2024-06-20
申请号：US18544936
申请日：2023-12-19
Applicant: Wake Forest University Health Sciences
CPC classification number: C12N5/0068 , C12N5/0622 , C12N5/067 , C12N5/0693 , G01N33/502 , C12N2503/02 , C12N2503/04 , C12N2513/00 , C12N2533/54 , C12N2533/80 , C12N2533/90 , C12N2537/10 , C12Y302/01035 , C12Y304/24007 , G01N2800/52
Abstract: An extrudable hydrogel composition useful for making a three-dimensional organ construct is described herein. Methods of using the same and products so made are also described. Also described herein is a multicellular organoid including at least two tumor cells or cell lines that are of the same tissue type, but are distinct from one another (e.g., distinct in morphology, growth rate, and/or at least one mutation); and at least one type of non-cancerous (i.e., normal or differentiated) tissue cells, wherein the at least one type of non-cancerous tissue cells are of the same tissue type as the at least two tumor cells or cell lines. In some embodiments, the at least two tumor cells or cell lines and/or the non-cancerous tissue cells are labeled with and/or comprise a detectable compound, optionally so that each of the different cells can be distinguished from each other (e.g., optically and/or electrically distinguished).
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Patent Agency Ranking
公开(公告)号：US20240192194A1
公开(公告)日：2024-06-13
申请号：US18444941
申请日：2024-02-19
Applicant: Wake Forest University Health Sciences
Inventor： Aleksander Skardal , Konstantinos Votanopoulos
IPC: G01N33/50 , C12M1/12 , C12M1/26 , C12M1/34 , C12M1/42 , C12M3/06 , C12N5/00 , C12N5/071 , C12N5/09
CPC classification number: G01N33/5011 , C12M23/16 , C12M25/16 , C12M33/14 , C12M35/08 , C12M41/46 , C12N5/0012 , C12N5/0679 , C12N5/0693 , C12N2503/02 , C12N2503/04 , C12N2513/00 , C12N2533/30 , C12N2533/80 , G01N2500/10
Abstract: Described herein are devices useful for evaluating tumor cells in vitro, comprising: (a) a device having a chamber, and a channel in fluid communication with the chamber; (b) a live tumor cell construct in the chamber; (c) a growth media in the chamber and the channel; (d) a pump operatively associated with the chamber and channel and configured for circulating the media from the chamber through the channel and back to the chamber; (e) a microporous membrane in the channel and positioned so that the media flows therethrough. Methods of using such devices are also described.
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公开(公告)号：US12006592B2
公开(公告)日：2024-06-11
申请号：US17316342
申请日：2021-05-10
Applicant: Wake Forest University Health Sciences
Inventor： Sang Jin Lee , James J. Yoo , Young Min Ju , Anthony Atala
IPC: D01D5/00 , A61K31/728 , A61K31/729 , A61K31/737 , A61K35/44 , A61K38/18 , A61K38/36 , A61K38/39 , A61L27/24 , C07D315/00 , C07K16/18 , C07K16/28 , C07K16/46 , D01F1/10 , D01F6/92 , D01F4/00 , D01F6/62
CPC classification number: D01D5/003 , A61K31/728 , A61K31/729 , A61K31/737 , A61K35/44 , A61K38/1858 , A61K38/363 , A61K38/39 , A61L27/24 , C07D315/00 , C07K16/18 , C07K16/289 , C07K16/46 , D01D5/0076 , D01F1/10 , D01F6/92 , C07K16/2896 , D01F4/00 , D01F6/625
Abstract: The invention is directed to products and methods for preparing self-seeding vascular constructs generated as a bi-layered electrospun matrices, conjugated with EPC-specific antibodies and anti-thrombogenic agents on the inner surfaces of their lumens.
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公开(公告)号：US20240180557A1
公开(公告)日：2024-06-06
申请号：US18287491
申请日：2021-04-23
Applicant: Wake Forest University Health Sciences
Inventor： James A. Smith , James E. Johnson
CPC classification number: A61B17/12013 , A61B2017/00823 , A61B2017/12018
Abstract: Disclosed are methods and devices for minimally-invasive appendectomies. The methods may comprise inserting an inverter apparatus into an interior cavity of the appendix of a subject and inverting the appendix, closing the base portion of the inverted appendix with the one or more closure devices, separating the inverted appendix from the cecum with a separation apparatus positioned at the base portion of the inverted appendix adjacent to the one or more closure devices, and removing the separated appendix from the subject through the colon.
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公开(公告)号：US20240115304A1
公开(公告)日：2024-04-11
申请号：US18534992
申请日：2023-12-11
Applicant: Wake Forest University Health Sciences
Inventor： Philip J. Brown , Andrea Morgan Rich , Aaron Ross Van Gorkom
CPC classification number: A61B17/8875 , A61B17/1626 , A61B2560/0462 , A61B2560/0475
Abstract: Disclosed herein are surgical tool systems and methods of using such to install a fixator in a biological tissue. The systems are capable of accurately measuring torque and rotational velocity and providing real time feedback to a user during surgery.
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公开(公告)号：US11871975B2
公开(公告)日：2024-01-16
申请号：US16339400
申请日：2017-10-05
Applicant: Wake Forest University Health Sciences
Inventor： Philip J. Brown , Andrea Morgan Rich , Aaron Ross Van Gorkom
CPC classification number: A61B17/8875 , A61B17/1626 , A61B2560/0462 , A61B2560/0475
Abstract: Disclosed herein are surgical tool systems and methods of using such to install a fixator in a biological tissue. The systems are capable of accurately measuring torque and rotational velocity and providing real time feedback to a user during surgery.
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