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111 条记录 (耗时 0.121 秒)

    MHC peptide complexes and uses thereof in infectious diseases
    91.
    发明授权
    MHC peptide complexes and uses thereof in infectious diseases 有权
    MHC肽复合物及其在感染性疾病中的应用

    公开(公告)号：US08268964B2

    公开(公告)日：2012-09-18

    申请号：US12619039

    申请日：2009-11-16

    申请人： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    发明人： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K16/00 ,  A61K38/16

    CPC分类号： C07K14/70539 ,  A61K38/00 ,  A61K47/61 ,  A61K47/6425 ,  A61K49/1896 ,  G01N33/56905 ,  G01N33/56911 ,  G01N33/56972 ,  G01N33/56977 ,  G01N33/574 ,  G01N2333/70539 ,  G01N2800/24 ,  Y02A50/401 ,  Y02A50/55 ,  Y02A50/57 ,  Y02A50/58

    摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.

    摘要翻译： 公开了携带能够结合相关靶细胞上的对受体的配体的新型化合物。 这些化合物具有许多有利的特征，使得它们非常适用于广泛的应用，包括用作检测系统，相关靶细胞的检测以及许多其它方法。 特别地，公开了包含一种或多种MHC分子的新型MHC复合物。 MHC-肽复合物的亲和性和特异性惊人地高。 向靶细胞呈递多个MHC-肽复合物的可能性使得根据本发明的MHC复合物成为非常强大的工具，例如， 在治疗和诊断领域。 本发明一般涉及治疗领域，包括治疗方法和治疗组合物。 本发明还包括MHC复合物和MHC多聚体的样品安装用途。

    Ligational encoding of small molecules
    93.
    发明授权
    Ligational encoding of small molecules 有权
    小分子的编码编码

    公开(公告)号：US07915201B2

    公开(公告)日：2011-03-29

    申请号：US10549619

    申请日：2004-03-22

    申请人： Thomas Franch ,  Soeren Nyboe Jacobsen ,  Torben Ravn Rasmussen ,  Soeren Neve ,  Henrik Pedersen ,  Alex Haahr Gouliaev

    发明人： Thomas Franch ,  Soeren Nyboe Jacobsen ,  Torben Ravn Rasmussen ,  Soeren Neve ,  Henrik Pedersen ,  Alex Haahr Gouliaev

    IPC分类号： C40B50/00 ,  C40B30/00

    CPC分类号： C07H21/04 ,  C12N15/1068 ,  C12P21/02 ,  C40B40/06 ,  C40B50/04

    摘要： The invention relates to a method for synthesising a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, said method comprising the steps of i) providing a) at least one template comprising one or more codons capable of hybridising to an anti-codon, wherein said template is optionally associated with one or more chemical entities, and b) a plurality of building blocks each comprising an anti-codon associated with one or more chemical entities, and ii) hybridising the anti-codon of one or more of the provided building blocks to the template, iii) covalently linking said anti-codons and/or linking the at least one template with the anti-codon of at least one building block, thereby generating an identifier polynucleotide capable of identifying chemical entities having participated in the synthesis of the encoded molecule, iv) separating the template from one or more of the anti-codons hybridised thereto, thereby generating an at least partly single stranded identifier polynucleotide associated with a plurality of chemical entities, v) generating a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, wherein said encoded molecule is generated by reacting at least two of said plurality of chemical entities associated with the identifier polynucleotide, and wherein said at least two chemical entities are provided by separate building blocks.

    摘要翻译： 本发明涉及一种合成双功能复合物的方法，所述双功能复合物包含编码分子和识别已经参与编码分子合成的化学实体的标识多核苷酸，所述方法包括以下步骤：i）提供a）至少一个包含一个 或更多能够与抗密码子杂交的密码子，其中所述模板任选地与一个或多个化学实体相关联，以及b）多个结构单元，每个结构单元包含与一个或多个化学实体相关的抗密码子，以及ii） 将一个或多个所提供的构建块的抗密码子与模板杂交，iii）共价连接所述抗密码子和/或将至少一个模板与至少一个构建块的抗密码子连接，由此产生 能够识别已经参与编码分子的合成的化学实体的标识符多核苷酸，iv）将模板从一个或多个分离出来 更多的与其杂交的抗密码子，从而产生与多个化学实体相关联的至少部分单链标识多核苷酸，v）产生包含编码分子的双功能复合物和识别参与合成的化学实体的标识符多核苷酸 的编码分子，其中所述编码的分子通过使与所述标识多核苷酸相关联的所述多个化学实体中的至少两个反应而产生，并且其中所述至少两个化学实体由单独的构建块提供。

    MHC Peptide Complexes and Uses Thereof in Infectious Diseases
    94.
    发明申请
    MHC Peptide Complexes and Uses Thereof in Infectious Diseases 有权
    MHC肽复合物及其在传染病中的应用

    公开(公告)号：US20100226854A1

    公开(公告)日：2010-09-09

    申请号：US12619039

    申请日：2009-11-16

    申请人： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    发明人： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    IPC分类号： A61K39/00 ,  C07K14/74 ,  A61P31/12 ,  C12N9/96 ,  C07K16/00 ,  C12N5/07 ,  A61K51/08 ,  A61K39/395 ,  C12Q1/02 ,  C12N5/0783

    CPC分类号： C07K14/70539 ,  A61K38/00 ,  A61K47/61 ,  A61K47/6425 ,  A61K49/1896 ,  G01N33/56905 ,  G01N33/56911 ,  G01N33/56972 ,  G01N33/56977 ,  G01N33/574 ,  G01N2333/70539 ,  G01N2800/24 ,  Y02A50/401 ,  Y02A50/55 ,  Y02A50/57 ,  Y02A50/58

    摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.

    摘要翻译： 公开了携带能够结合相关靶细胞上的对受体的配体的新型化合物。 这些化合物具有许多有利的特征，使得它们非常适用于广泛的应用，包括用作检测系统，相关靶细胞的检测以及许多其它方法。 特别地，公开了包含一种或多种MHC分子的新型MHC复合物。 MHC-肽复合物的亲和性和特异性惊人地高。 向靶细胞呈递多个MHC-肽复合物的可能性使得根据本发明的MHC复合物成为非常强大的工具，例如， 在治疗和诊断领域。 本发明一般涉及治疗领域，包括治疗方法和治疗组合物。 本发明还包括MHC复合物和MHC多聚体的样品安装用途。

    PROTEIN
    95.
    发明申请
    PROTEIN 有权
    蛋白

    公开(公告)号：US20100086640A1

    公开(公告)日：2010-04-08

    申请号：US12552572

    申请日：2009-09-02

    申请人： Janne Brunstedt ,  Jørn Dalgaard Mikkelsen ,  Henrik Pedersen ,  Jørn Borch Søe

    发明人： Janne Brunstedt ,  Jørn Dalgaard Mikkelsen ,  Henrik Pedersen ,  Jørn Borch Søe

    IPC分类号： A21D13/06 ,  A21D8/04

    CPC分类号： A21D8/042 ,  A23C19/0328 ,  A23D7/02 ,  A23K20/189 ,  A23K50/75 ,  A23L7/107 ,  A23L7/109 ,  A23L7/111 ,  A23L27/60 ,  A23L29/06 ,  C11B3/003 ,  C12N9/18 ,  C12P7/62 ,  C12P19/44 ,  C12Y301/01

    摘要： A fungal wild-type lipolytic enzyme having a higher ratio of activity on polar lipids compared with triglycerides, wherein the enzyme preferably has a phospholipid:triglyceride activity ratio of at least 4. Preferably, the lipolytic enzyme according to the present invention has a glycolipid:triglyceride hydrolyzing activity ratio of at least 1.5. In one embodiment, the fungal lipolytic enzyme according to the present invention comprises an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID No. 2 or SEQ ID No. 4 or SEQ ID No. 6 or an amino acid sequence which has at least 90% identity thereto. The present invention further encompasses a nucleic acid encoding a fungal lipolytic enzyme, which nucleic acid is selected from the group consisting of: (a) a nucleic acid comprising a nucleotide shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7; (b) a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7 by the degeneration of the genetic code; and (c) nucleic acid comprising a nucleotide sequence which has at least 90% identity with the nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7.

    摘要翻译： 与甘油三酯相比，极性脂质活性比例更高的真菌野生型脂肪分解酶，其中所述酶优选具有至少为4的磷脂：甘油三酯活性比。优选地，根据本发明的脂肪分解酶具有糖脂： 甘油三酯水解活性比至少为1.5。 在一个实施方案中，根据本发明的真菌脂肪分解酶包含如SEQ ID NO：1或SEQ ID No.2或SEQ ID No.4或SEQ ID No.6所示的氨基酸序列或氨基酸序列， 与其具有至少90％的同一性。 本发明还包括编码真菌脂肪分解酶的核酸，该核酸选自：（a）包含SEQ ID No.3，SEQ ID No.5或SEQ ID No.5所示核苷酸的核酸 第7号 （b）通过遗传密码的退化与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7的核苷酸序列有关的核酸; 和（c）核酸，其包含与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7所示的核苷酸序列具有至少90％同一性的核苷酸序列。

    Fungal lipolytic enzymes, nucleic acids encoding, and uses thereof
    97.
    发明授权
    Fungal lipolytic enzymes, nucleic acids encoding, and uses thereof 有权
    真菌脂肪分解酶，编码的核酸及其用途

    公开(公告)号：US07622290B2

    公开(公告)日：2009-11-24

    申请号：US11519734

    申请日：2006-09-12

    申请人： Janne Brunstedt ,  Jørn Dalgaard Mikkelsen ,  Henrik Pedersen ,  Jørn Borch Søe

    发明人： Janne Brunstedt ,  Jørn Dalgaard Mikkelsen ,  Henrik Pedersen ,  Jørn Borch Søe

    IPC分类号： C12P1/00 ,  C12N9/00 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

    CPC分类号： A21D8/042 ,  A23C19/0328 ,  A23D7/02 ,  A23K20/189 ,  A23K50/75 ,  A23L7/107 ,  A23L7/109 ,  A23L7/111 ,  A23L27/60 ,  A23L29/06 ,  C11B3/003 ,  C12N9/18 ,  C12P7/62 ,  C12P19/44 ,  C12Y301/01

    摘要： A fungal wild-type lipolytic enzyme having a higher ratio of activity on polar lipids compared with triglycerides, wherein the enzyme preferably has a phospholipid:triglyceride activity ratio of at least 4. Preferably, the lipolytic enzyme according to the present invention has a glycolipid:triglyceride hydrolyzing activity ratio of at least 1.5. In one embodiment, the fungal lipolytic enzyme according to the present invention comprises an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID No. 2 or SEQ ID No. 4 or SEQ ID No. 6 or an amino acid sequence which has at least 90% identity thereto. The present invention further encompasses a nucleic acid encoding a fungal lipolytic enzyme, which nucleic acid is selected from the group consisting of: (a) a nucleic acid comprising a nucleotide shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7; (b) a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7 by the degeneration of the genetic code; and (c) nucleic acid comprising a nucleotide sequence which has at least 90% identity with the nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7.

    摘要翻译： 与甘油三酯相比，极性脂质活性比例更高的真菌野生型脂肪分解酶，其中所述酶优选具有至少为4的磷脂：甘油三酯活性比。优选地，根据本发明的脂肪分解酶具有糖脂： 甘油三酯水解活性比至少为1.5。 在一个实施方案中，根据本发明的真菌脂肪分解酶包含如SEQ ID NO：1或SEQ ID No.2或SEQ ID No.4或SEQ ID No.6所示的氨基酸序列或氨基酸序列， 与其具有至少90％的同一性。 本发明还包括编码真菌脂肪分解酶的核酸，该核酸选自：（a）包含SEQ ID No.3，SEQ ID No.5或SEQ ID No.5所示核苷酸的核酸 第7号 （b）通过遗传密码的退化与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7的核苷酸序列有关的核酸; 和（c）核酸，其包含与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7所示的核苷酸序列具有至少90％同一性的核苷酸序列。

    Functional cover for use with a wireless terminal
    100.
    发明授权
    Functional cover for use with a wireless terminal 有权
    与无线终端一起使用的功能封面

    公开(公告)号：US07421269B2

    公开(公告)日：2008-09-02

    申请号：US10085010

    申请日：2002-03-01

    申请人： Pekka Kostiainen ,  Kenn Berend Pedersen ,  Henrik Pedersen

    发明人： Pekka Kostiainen ,  Kenn Berend Pedersen ,  Henrik Pedersen

    IPC分类号： H04M3/00

    CPC分类号： H04M1/72575

    摘要： A wireless communication terminal has a user exchangeable cover part. The wireless communication terminal and user exchangeable cover part are electrically interconnected by means of an electrical connector. The user exchangeable cover part comprises identification means. The user exchangeable cover part has electrical circuitry for supporting a user interface of the wireless terminal. The wireless terminal identifies the user exchangeable cover part by detecting the identification means. The wireless terminal operates the electrical circuitry of the user exchangeable cover part in dependence of the identification of user exchangeable cover part.

    摘要翻译： 无线通信终端具有用户可更换盖部分。 无线通信终端和用户可更换盖部分通过电连接器电互连。 用户可更换盖部分包括识别装置。 用户可更换盖部分具有用于支持无线终端的用户接口的电路。 无线终端通过检测识别装置识别用户可交换盖部分。 无线终端根据用户可更换盖部分的识别操作用户可更换盖部分的电路。