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公开(公告)号：US08465772B2
公开(公告)日：2013-06-18
申请号：US13472324
申请日：2012-05-15
Applicant: Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
Inventor： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
CPC classification number: A61K47/42 , A61K9/0024 , A61K47/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/48 , A61L27/52 , Y10S530/812 , Y10S530/815 , C08L89/00 , C08L71/02
Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.
Abstract translation: 本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。 还公开了包括适合递送组合物的递送装置的试剂盒。 在一些实施方案中，组合物可以包括至少三种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。 在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。
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公开(公告)号：US08192760B2
公开(公告)日：2012-06-05
申请号：US11566643
申请日：2006-12-04
Applicant: Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
Inventor： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
CPC classification number: A61K47/42 , A61K9/0024 , A61K47/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/48 , A61L27/52 , Y10S530/812 , Y10S530/815 , C08L89/00 , C08L71/02
Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.
Abstract translation: 本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。 还公开了包括适合递送组合物的递送装置的试剂盒。 在一些实施方案中，组合物可以包括至少三种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。 在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。
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93.发明申请Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers 审中-公开用生物可吸收载体处理病变部位的方法，组成和装置公开(公告)号：US20110027188A1
公开(公告)日：2011-02-03
申请号：US12901402
申请日：2010-10-08
Applicant: Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian N. Ludwig
Inventor： Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian N. Ludwig
CPC classification number: A61K9/143 , A61K9/0019 , A61K9/1611 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00 , C08L67/04
Abstract: An implantable medical device is disclosed having a plurality of smaller particles contained in a plurality of larger particles and configured to be released from the larger particles when the device is implanted in a patient. The smaller particles and the larger particles are made of bioabsorbable metal, glass or ceramic. A substance can be associated with the smaller particles. The larger particles can be embedded within at least a portion of the device.
Abstract translation: 公开了一种植入式医疗装置，其具有包含在多个较大颗粒中的多个较小颗粒，并且构造成当将该装置植入患者时从较大颗粒释放。 较小的颗粒和较大的颗粒由生物可吸收的金属，玻璃或陶瓷制成。 物质可以与较小的颗粒相关联。 较大的颗粒可以嵌入装置的至少一部分内。
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公开(公告)号：US20090238854A1
公开(公告)日：2009-09-24
申请号：US12475296
申请日：2009-05-29
Applicant: STEPHEN DIRK PACETTI , Yiwen Tang , Syed Hossainy
Inventor： STEPHEN DIRK PACETTI , Yiwen Tang , Syed Hossainy
CPC classification number: A61K47/34 , A61K31/436 , A61L27/34 , A61L27/502 , A61L31/10 , A61L31/141 , C08K5/1575 , C08L67/04 , C09D167/00
Abstract: A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
Abstract translation: 提供了可用于形成具有生物相容性聚合物的涂料组合物的生物相容性增塑剂。 涂料组合物还可以包括生物有益的聚合物和/或生物活性剂。 涂料组合物可以在可植入装置上形成涂层。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞 ，输尿管阻塞，肿瘤阻塞或其组合。
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公开(公告)号：US20080131509A1
公开(公告)日：2008-06-05
申请号：US11566643
申请日：2006-12-04
Applicant: Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
Inventor： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
CPC classification number: A61K47/42 , A61K9/0024 , A61K47/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/48 , A61L27/52 , Y10S530/812 , Y10S530/815 , C08L89/00 , C08L71/02
Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.
Abstract translation: 本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。 还公开了包括适合递送组合物的递送装置的试剂盒。 在一些实施方案中，组合物可以包括至少三种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。 在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。
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Patent Agency Ranking
公开(公告)号：US20080114293A1
公开(公告)日：2008-05-15
申请号：US12013286
申请日：2008-01-11
Applicant: Charles Claude , Paul Kawula , Syed Hossainy , Kimchi Tran
Inventor： Charles Claude , Paul Kawula , Syed Hossainy , Kimchi Tran
IPC: A61M37/00
CPC classification number: A61K9/0024 , A61K9/06
Abstract: A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.
Abstract translation: 一种方法，包括在哺乳动物宿主内的处理部位引入处理剂; 并在处理部位引入可生物浸渍的凝胶材料。 一种包括第一环形构件的装置，所述第一环形构件具有围绕所述第一环形构件的长度设置的第一腔和在所述第一环形构件的近端处的第一入口，以及联接到所述第一环形构件的第二环形构件，所述第二环形构件具有第二内腔 设置在所述第二环形构件的大约一定长度处和在所述第二环形构件的近端处的第二入口，其中所述第一环形构件和所述第二环形构件被定位成允许通过每个环形构件引入的处理剂在 治疗部位。
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公开(公告)号：US07335314B2
公开(公告)日：2008-02-26
申请号：US10912025
申请日：2004-08-04
Applicant: Steven Z. Wu , Sameer Harish , Deborra Sanders-Millare , Judy A. Guruwaiya , Daryush Mirzaee , Syed Hossainy , Charlene Chen
Inventor： Steven Z. Wu , Sameer Harish , Deborra Sanders-Millare , Judy A. Guruwaiya , Daryush Mirzaee , Syed Hossainy , Charlene Chen
CPC classification number: A61F2/0077 , A61F2/848 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2230/0013 , A61F2250/0067 , A61F2250/0068 , Y10S623/901
Abstract: An implantable medical device, such as a stent or graft, having asperities on a designated region of its outer surface is disclosed. The asperities can serve to improve retention of one or more layers of a coating on the device and to increase the amount of coating that can be carried by the device. The asperities can be formed by using a stream of pressurized grit to roughen the surface. The asperities can also be formed by removing material from the outer surface, for example, by chemical etching with or without a patterned mask. Alternatively, the asperities can be formed by adding material to the outer surface, for example, by welding powder particles to the outer surface or sputtering.
Abstract translation: 公开了一种在其外表面的指定区域上具有凹凸的可植入医疗装置，例如支架或移植物。 粗糙度可用于改善设备上一层或多层涂层的保留性并增加该装置可承载的涂层量。 可以通过使用加压砂粒流粗糙表面来形成凹凸。 也可以通过从外表面去除材料来形成凹凸，例如通过具有或不具有图案化掩模的化学蚀刻来形成。 或者，可以通过向外表面添加材料，例如通过将粉末颗粒焊接到外表面或溅射来形成凹凸。
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公开(公告)号：US20080038310A1
公开(公告)日：2008-02-14
申请号：US11803031
申请日：2007-05-10
Applicant: Syed Hossainy , Yiwen Tang , Lothar Kleiner
Inventor： Syed Hossainy , Yiwen Tang , Lothar Kleiner
IPC: A61F2/06 , A61F2/04 , A61K31/337 , A61K31/4353 , A61K31/445 , A61K31/496 , A61K31/56 , A61K38/43 , A61K47/42 , A61P13/02 , A61P9/00 , A61P9/10
CPC classification number: A61L31/10 , A61K38/08 , A61K38/39 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2420/02 , B05D3/007 , C07K14/001 , C08H1/00 , Y10T428/3154 , Y10T428/31909
Abstract: A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided.
Abstract translation: 提供了包含弹性蛋白五肽嵌段的共聚物以及制备和使用该共聚物的方法。
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99.发明申请Implantable devices comprising biologically absorbable polymers having constant rate of degradation and methods for fabricating the same 审中-公开可植入装置包括具有恒定降解速率的生物可吸收聚合物及其制造方法公开(公告)号：US20080004400A1
公开(公告)日：2008-01-03
申请号：US11820314
申请日：2007-06-18
Applicant: Syed Hossainy , Stephen Pacetti , David Gale
Inventor： Syed Hossainy , Stephen Pacetti , David Gale
IPC: C08L53/00
CPC classification number: A61L31/16 , A61L31/06 , A61L31/10 , A61L31/14 , A61L2300/606 , C08G63/06 , C08G63/08 , C08G64/0208 , C08G64/0241 , C09D167/04 , C09D169/00 , C08L67/04
Abstract: Polymers that can form the substrate of an implantable medical device and form coatings for implantable medical devices and methods for their fabrication are disclosed, the coatings comprising polymers that are hydrolyzed at a substantially constant rate or that have been prepared so that they degrade at a rate closer to constant.
Abstract translation: 公开了可以形成可植入医疗装置的基底并形成用于可植入医疗装置的涂层的聚合物及其制造方法，所述涂层包含以基本上恒定的速率水解或已被制备以使其以一定速率降解的聚合物 更接近常数。
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公开(公告)号：US20070275175A1
公开(公告)日：2007-11-29
申请号：US11800951
申请日：2007-05-07
Applicant: Syed Hossainy
Inventor： Syed Hossainy
IPC: B05D1/02
CPC classification number: B05B13/0235 , A61F2/82 , A61F2/91 , B05B7/04 , B05B13/0207 , B05B13/0228 , B05D1/002 , B05D1/02 , B05D3/0413 , B05D3/0426 , B05D2401/10
Abstract: An apparatus for coating stents and a method of using the same is provided. The apparatus includes a first stent support and a second stent support for supporting stents. The first and second stent supports are positioned with respect to one another in an adjacent serial configuration such that one end of the first stent support extends from an end of the adjacent second stent support. A motor can be coupled to the first stent support to rotate the first stent support such that the rotation of the first stent support rotates the second stent support. The apparatus further includes an applicator for applying a coating composition to the stents.
Abstract translation: 提供一种用于涂覆支架的装置及其使用方法。 该装置包括第一支架支架和用于支撑支架的第二支架支架。 第一和第二支架支撑件在相邻的串联配置中相对于彼此定位，使得第一支架支架的一端从相邻的第二支架支架的端部延伸。 马达可以联接到第一支架支架以旋转第一支架支架，使得第一支架支架的旋转使第二支架支架旋转。 该装置还包括用于将涂层组合物施加到支架的施加器。
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