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公开(公告)号：US20180100160A1
公开(公告)日：2018-04-12
申请号：US15717216
申请日：2017-09-27
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： Daniel Bawdon , Stephen Thomas Cartman , Jonathan Kennedy
Abstract: Nonnaturally occurring host cells altered to increase their ability to transfer genetic molecules into the host cells as compared to an unaltered host cell are provided. Also provided are methods for identifying endogenous loci of a host cell which inhibit transformation efficiency and/or electroporation of genetic molecules into the cell as well as methods for producing nonnaturally occurring host cells with enhanced transformation efficiency and/or the modified ability to allow for genomic integration of an exogenous DNA sequence via electroporation. Methods for producing biochemicals and products produced with the nonnaturally occurring host cells are also provided.
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92.发明授权公开(公告)号：US09920336B2
公开(公告)日：2018-03-20
申请号：US14139142
申请日：2013-12-23
Applicant: INVISTA North America S.á r.l.
Inventor： Paul S. Pearlman , Alex Van Eck Conradie , Changlin Chen , Adriana Leonora Botes
IPC: C12P37/02 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/16 , C12N9/10 , C12N15/00 , C07H21/04 , C12P7/46 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/00
CPC classification number: C12P7/46 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis.
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公开(公告)号：US09896702B2
公开(公告)日：2018-02-20
申请号：US14740554
申请日：2015-06-16
Applicant: INVISTA North America S.á r.l.
Inventor： Alex Van Eck Conradie , Adriana Leonora Botes
IPC: C12P7/62 , C12P13/00 , C12P7/42 , C12N9/18 , C12P7/44 , C12P7/18 , C12P11/00 , C12N9/16 , C12N9/10 , C12N9/02 , C07C69/533 , C12P7/24 , C12P7/40 , C12P17/10
CPC classification number: C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
Abstract: This document describes biochemical pathways for producing 2(E)-heptenedioyl-CoA methyl ester from precursors such as 2-oxo-glutarate, acetyl-CoA, or succinyl-CoA using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase, a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2(E)-heptenedioyl-CoA methyl ester can be enzymatically converted to pimeloyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
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94.发明申请公开(公告)号：US20180023103A1
公开(公告)日：2018-01-25
申请号：US15659505
申请日：2017-07-25
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： Alexander Brett FOSTER , Stephen Thomas CARTMAN , Jonathan KENNEDY , William Joseph SIMMONS
IPC: C12P7/62 , C07C59/147 , C07C47/19 , C07C223/02 , C07C225/06 , C07C47/12 , C07C55/16 , C12P13/00 , C12P7/44 , C12P7/18 , C12N9/88 , C12N9/04 , C12N9/10 , C12N9/16 , C07C229/08
Abstract: This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation. The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.
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95.发明申请公开(公告)号：US20180023102A1
公开(公告)日：2018-01-25
申请号：US15658958
申请日：2017-07-25
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： Alexander Brett FOSTER , Stephen Thomas CARTMAN , Jonathan KENNEDY
CPC classification number: C12P7/44 , C12N15/52 , C12P7/24 , C12P7/62 , C12P13/001 , C12P13/005 , C12Y102/01 , C12Y102/99006 , C12Y206/01 , C12Y206/01018 , C12Y301/02
Abstract: Disclosed are methods for regulating biosynthesis of at least one of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, 7-aminohelptanol and 1,7-heptanediol (C7 building blocks) using a pathway having a pimeloyl-ACP intermediate, the method including the step of downregulating the activity of BioF. Also disclosed are recombinant hosts by fermentation in which the above methods are performed. Further disclosed are recombinant hosts for producing pimeloyl-ACP, the recombinant host including a deletion of a bioF gene.
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Patent Agency Ranking
公开(公告)号：US20180023097A1
公开(公告)日：2018-01-25
申请号：US15493431
申请日：2017-04-21
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： Paul S. Pearlman , Changlin Chen , Adriana Leonora Botes
CPC classification number: C12P5/026 , C12N9/001 , C12N9/0071 , C12N9/88 , C12N15/52 , C12P5/02 , C12P7/16 , C12P7/18 , C12Y103/01035 , C12Y103/08 , C12Y114/11022 , C12Y401/01033 , C12Y402/01 , C12Y402/01127 , C12Y402/03027 , Y02E50/10 , Y02E50/343 , Y02P20/52
Abstract: Disclosed are methods for producing butadiene from one or more of several diverse feedstocks including bioderived feedstocks, renewable feedstocks, petrochemical feedstocks and natural gas.
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97.发明授权公开(公告)号：US09783833B2
公开(公告)日：2017-10-10
申请号：US13715826
申请日：2012-12-14
Applicant: INVISTA NORTH AMERICA S.A. R.L.
Inventor： Paul S. Pearlman , Changlin Chen , Adriana Leonora Botes
IPC: C12P7/44 , C12P7/40 , C12P7/46 , C12P7/52 , C12P17/10 , C12P13/00 , C12N9/18 , C12N9/20 , C12N1/21 , C12N1/19 , C02F3/00 , C07C51/21 , C07C55/14 , C02F3/34 , C12P1/02 , C12P5/02 , C12P7/42 , C12N1/16 , C12P7/18
CPC classification number: C12P7/44 , C02F3/342 , C07C51/21 , C07C55/14 , C12N1/16 , C12N9/18 , C12P1/02 , C12P5/02 , C12P7/18 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/52 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y301/01001 , C12Y301/01003 , C12Y301/01017 , C12Y301/01025 , C12Y301/01074 , C12Y301/01075 , C12Y301/01076 , Y02P20/52
Abstract: The invention relates to methods for enriching monomer content in a cycloalkane oxidation process mixed organic waste stream. In particular, the methods involve combining a biocatalyst with a mixed organic waste stream from a cycloalkane oxidation process, and enzymatically converting dimeric and/or oligomeric components of said waste stream into monomeric components. The methods may enrich the content of diacids, adipic acid, and/or other α,ω-difunctional C6 alkanes in the mixed organic waste stream. Additionally, the treated mixed organic waste streams may have improved burning efficiency.
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公开(公告)号：US09777302B2
公开(公告)日：2017-10-03
申请号：US14741259
申请日：2015-06-16
Applicant: INVISTA North America S.á r.l.
Inventor： Alex Van Eck Conradie , Adriana Leonora Botes , Ramdane Haddouche
IPC: C07C47/02 , C12P13/00 , C12P7/64 , C12N9/10 , C12N9/02 , C12P7/24 , C07C59/01 , C08G63/06 , C12P7/40 , C12P7/42 , C07C47/12 , C07C59/325 , C07C223/02 , C12P7/44 , C12P7/62
CPC classification number: C12P13/001 , C07C47/02 , C07C47/12 , C07C59/01 , C07C59/325 , C07C223/02 , C08G63/06 , C12N9/0008 , C12N9/0077 , C12N9/1007 , C12N9/1096 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/6409 , C12P7/6436 , C12Y102/99006 , C12Y114/15001 , C12Y114/15003 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082
Abstract: This document describes biochemical pathways for producing 5-hydroxypentanoate methyl ester and pentanoic acid pentyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 5-hydroxypentanoate methyl esters and pentanoic acid pentyl esters can be enzymatically converted to glutaric acid, 5-aminopentanoate, 5-hydroxypentanoate, cadaverine, or 1,5-pentanediol.
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99.发明申请公开(公告)号：US20170254000A1
公开(公告)日：2017-09-07
申请号：US15596735
申请日：2017-05-16
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： Thomas E. Schmitt , Deborah M. Sarzotti
CPC classification number: D02G3/443 , A41D31/08 , D10B2201/20 , D10B2331/021 , Y10T442/2631
Abstract: Disclosed are technical fibers and yarns made with partially aromatic polyamides and a fiber having vapor phase action such as an FR cellulosic fiber. Fabrics made from such fibers and yarns demonstrate superior flame retardancy over traditional flame retardant nylon 6,6 fabrics. Further, the disclosed fibers and yarns, when blended with other flame retardant fibers, do not demonstrate the dangerous “scaffolding effect” common with flame retardant nylon 6,6 blended fabrics.
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公开(公告)号：US09689091B2
公开(公告)日：2017-06-27
申请号：US15097446
申请日：2014-10-14
Applicant: INVISTA TECHNOLOGIES S.à r.l.
Inventor： Tianyi Liao , Fred C. Wynegar , Raymond S. P. Leung , Cheng-Yuan Chuang , Juan Cera
IPC: D04B1/18
CPC classification number: D04B1/18 , D10B2403/0114 , Y02P70/633
Abstract: An article comprising a knit fabric having a surface side and a base side, and including a set of ground yarns and a layer of effect yarns, wherein the ground yarns and effect yarns are knit through intermesh points in a predetermined arrangement wherein the effect yarns are alternately arranged with the ground yarns and wherein the ground yarns comprise at least one elastic fiber and optionally at least one hard fiber, and the effect yarns comprise at least one hard fiber and optionally an elastic fiber.
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