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91.发明授权公开(公告)号：US10603316B2
公开(公告)日：2020-03-31
申请号：US16114815
申请日：2018-08-28
发明人： Zhigang Xiong , Roger P. Simon
IPC分类号： A61K31/4965 , A61K31/55 , C07K14/435 , A61K9/00 , A61K31/155 , A61K31/40
摘要： A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.
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公开(公告)号：US10040831B2
公开(公告)日：2018-08-07
申请号：US15383454
申请日：2016-12-19
IPC分类号： A61K38/16 , A61K47/64 , C07K14/00 , C07K19/00 , C07K14/005 , A61K47/48 , A61K45/06 , C12N7/00
CPC分类号： C07K14/005 , A61K38/162 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/641 , C07K2319/035 , C07K2319/70 , C12N7/00 , C12N2740/16022 , C12N2740/16322
摘要： A multipartite peptide that inhibits release of exosomes in a cell, comprising an N-terminal end and a C-terminal end and comprising at least one secretion modifying region (SMR) peptide from HIV-1 Nef and at least one Clusterin (Clu)-binding peptide (Clu-BP). Pharmaceutical compositions comprising these peptides alone or in synergistic combinations with other active agents in methods for treating cancers and/or infectious diseases are further provided herein.
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公开(公告)号：US09777042B2
公开(公告)日：2017-10-03
申请号：US13327244
申请日：2011-12-15
申请人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/005 , C07K14/16 , G01N33/543 , A61K9/127 , A61K38/16 , A61K39/39 , A61K45/06 , G01N33/566 , C12P21/02 , C12N15/00 , A61K39/00 , A61K38/00
CPC分类号： C07K14/005 , A61K9/127 , A61K38/00 , A61K38/162 , A61K39/39 , A61K45/06 , A61K2039/55555 , C07K14/163 , C07K2319/055 , C07K2319/50 , C07K2319/60 , C12N15/00 , C12N2740/16322 , C12P21/02 , G01N33/543 , G01N33/566
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US09629838B2
公开(公告)日：2017-04-25
申请号：US13972558
申请日：2013-08-21
发明人： Zhigang Xiong , Roger P. Simon
IPC分类号： A61K31/4965 , C07K14/435 , A61K9/00 , A61K31/155 , A61K31/40 , A61K31/55
CPC分类号： A61K31/4965 , A61K9/00 , A61K9/0019 , A61K9/0085 , A61K31/155 , A61K31/40 , A61K31/55 , C07K14/43518
摘要： This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US09556224B2
公开(公告)日：2017-01-31
申请号：US14156119
申请日：2014-01-15
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , C07K7/06 , C12N7/00 , C12N2740/16032 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
摘要翻译： 本申请公开了一种使用抗微生物组合物治疗微生物感染的方法，其包含含有至少一种VGFPV基序的抗微生物肽。
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96.发明授权Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue and as regulators of neuronal stem cell migration 有权神经保护素用于预防和治疗急性突击对血管和神经元组织的损伤以及作为神经元干细胞迁移的调节剂公开(公告)号：US08785369B2
公开(公告)日：2014-07-22
申请号：US12359773
申请日：2009-01-26
申请人： Byron D. Ford
发明人： Byron D. Ford
CPC分类号： A61K38/17 , Y10S977/915
摘要： Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when administered into the cerebral spinal fluid, can ameliorate damage to neuronal tissue caused by stroke or inflammation. Additionally, neuregulin has been found to be useful for enhancement of stem cell migration from the ventricle to the site of injury to the brain.
摘要翻译： 已发现神经调节蛋白是一种已知的神经蛋白，用于改善或预防由机械或化学物质侵袭血管引起的损伤，并且当施用于脑脊髓液时，可以改善由中风或炎症引起的神经元组织的损伤。 另外，已经发现神经调节蛋白可用于增强从脑室到脑损伤部位的干细胞迁移。
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公开(公告)号：US20140155319A1
公开(公告)日：2014-06-05
申请号：US14156119
申请日：2014-01-15
IPC分类号： C07K7/06
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , C07K7/06 , C12N7/00 , C12N2740/16032 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
摘要翻译： 本申请公开了一种使用抗微生物组合物治疗微生物感染的方法，其包含含有至少一种VGFPV基序的抗微生物肽。
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98.发明申请公开(公告)号：US20140134606A1
公开(公告)日：2014-05-15
申请号：US14159612
申请日：2014-01-21
发明人： Gale W. NEWMAN , Sam Anyanwu
IPC分类号： C12Q1/70
CPC分类号： G01N33/56988 , C12Q1/70 , C12Q1/703 , C12Q1/706 , C12Q1/707 , G01N1/40 , G01N33/493 , G01N33/56983 , G01N33/576 , G01N33/6893 , G01N2333/02 , G01N2333/10 , G01N2333/161 , G01N2333/162 , G01N2333/163 , G01N2333/186 , G01N2800/347 , G01N2800/52 , G01N2800/56
摘要： A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. Also disclosed are a method for monitoring the course of a hepatitis virus infection or a hepatitis disease condition in a subject and a method for monitoring effectiveness of treatment to a subject with an anti-hepatitis virus agent based on hepatitis virus-associated biomarkers present on exosomes in bodily fluid samples from the subject, as well as a kit for diagnosing hepatitis virus infection and/or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers on exosomes in bodily fluid samples from the subject.
摘要翻译： 公开了一种用于诊断受试者中基于肝炎病毒相关生物标志物的肝炎病毒感染或肝炎病症的方法，所述肝炎病毒相关生物标志物存在于来自受试者的体液样品中的外来体上。 还公开了一种用于监测受试者中肝炎病毒感染或肝炎疾病状况的过程的方法以及基于存在于外来体上的肝炎病毒相关生物标志物来监测具有抗肝炎病毒剂的受试者治疗有效性的方法 来自受试者的体液样本，以及用于诊断受试者中基于肝炎病毒相关生物标志物的肝炎病毒感染和/或肝炎疾病状况的试剂盒，其来自受试者的体液样品中的外来体。
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99.发明申请公开(公告)号：US20130330337A1
公开(公告)日：2013-12-12
申请号：US13962362
申请日：2013-08-08
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/521 , C07K2319/30 , Y02A50/401
摘要： This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be used for treating chemokine receptor-mediated disorders and modulating inflammation, inflammatory cell motility, cancer cell motility, or cancer cell survival.
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公开(公告)号：US08568784B2
公开(公告)日：2013-10-29
申请号：US12943588
申请日：2010-11-10
申请人： James W. Lillard , Rajesh Singh , Shailesh Singh
发明人： James W. Lillard , Rajesh Singh , Shailesh Singh
IPC分类号： A61K9/14
CPC分类号： A61K31/337 , A61K9/146 , A61K9/1641 , A61K9/1652 , A61K9/5031 , A61K9/5146 , A61K9/5161 , A61K33/24 , A61K38/00 , A61K47/593 , A61K47/62 , A61K47/6939
摘要： Milled nanoparticles comprising a biologically active agent, at least one biopolymer and a coating containing at least one coating which is a polymer or ligand are produced using milling and coating techniques which have not previously been used for these applications.
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