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    Versatile reagent for detecting murine leukemia viruses
    91.
    发明授权
    Versatile reagent for detecting murine leukemia viruses 失效
    用于检测鼠白血病病毒的通用试剂

    公开(公告)号：US06709811B1

    公开(公告)日：2004-03-23

    申请号：US08046352

    申请日：1993-04-08

    Applicant: Leonard H Evans ,  William J Britt

    Inventor： Leonard H Evans ,  William J Britt

    IPC: C12Q170

    CPC classification number: C07K16/1036 ,  G01N33/56983 ,  G01N2333/15

    Abstract: A method for detecting broad spectrum of murine leukemia viruses belonging to any or all of the ecotropic, xenotropic, polytropic and amphotropic groups, has been described. The method utilizes a monoclonal antibody designated 83A25 which identifies almost all classes or groups of the murine leukemia virus with only a few exceptions.

    Abstract translation: 已经描述了用于检测属于任何或全部的嗜酸性，异位性，多嗜性和独立性基团的广泛的小鼠白血病病毒的方法。 该方法使用指定为83A25的单克隆抗体，其仅识别几乎所有类别或组的小鼠白血病病毒，仅有少数例外。

    Use of immunogenic immunosuppressive and/or angiogenic proteins which have been rendered inactive, process for their preparation and pharmaceutical or vaccinal uses
    92.
    发明申请
    Use of immunogenic immunosuppressive and/or angiogenic proteins which have been rendered inactive, process for their preparation and pharmaceutical or vaccinal uses 失效
    使用已经失活的免疫原性免疫抑制和/或血管生成蛋白，其制备方法和药物或疫苗用途

    公开(公告)号：US20040001852A1

    公开(公告)日：2004-01-01

    申请号：US10465645

    申请日：2003-06-20

    Applicant: NEOVACS 11, RUE PERNETY

    Inventor： Daniel A. Zagury ,  Jean-Francois Zagury

    IPC: A61K039/21 ,  C07K014/16

    CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K16/084 ,  C07K16/1036 ,  C07K16/1072 ,  C07K2319/21 ,  C07K2319/55 ,  C12N2710/20022 ,  C12N2740/14022 ,  C12N2740/16322

    Abstract: The invention concerns the use of a protein derived from cancer cells, virus-infected cells or immune-defence cells or a fragment of said protein, characterized in that said protein is initially an immunosuppressive and/or angiogenic protein with local activity and said properties are inactivated by at least 70%, through a physical and/or chemical treatment, by genetic recombination or by adjuvant conditioning, said treatment preserving its property of being identified by antibodies directed afainst said protein, and preserving sufficient immunogenic properties for generating antibodies neutralizing or blocking said native protein, to obtain a medicine for use as local anti-immnumosuppression and/or anti-angiogenic agent as an anticancer agent. The invention also concerns the resulting immunogenic compounds, their preparation method and their uses.

    Abstract translation: 本发明涉及使用衍生自癌细胞，病毒感染细胞或免疫防御细胞或所述蛋白质片段的蛋白质，其特征在于所述蛋白质最初是具有局部活性的免疫抑制和/或血管生成蛋白质，并且所述性质是 通过物理和/或化学处理，通过遗传重组或辅助调理灭活至少70％，所述处理保持其被定位在所述蛋白质上的抗体鉴定的性质，并保留足够的免疫原性以产生中和或阻断的抗体 所述天然蛋白质，以获得用作局部抗免疫抑制和/或抗血管生成剂作为抗癌剂的药物。 本发明还涉及所得的免疫原性化合物，其制备方法及其用途。

    Serum preparations for inhibiting retroviruses and tumor growth
    93.
    发明申请
    Serum preparations for inhibiting retroviruses and tumor growth 审中-公开
    用于抑制逆转录病毒和肿瘤生长的血清制剂

    公开(公告)号：US20010043928A1

    公开(公告)日：2001-11-22

    申请号：US09790272

    申请日：2001-02-21

    Inventor： Mark E. Howard

    IPC: A61K039/395 ,  A61K035/16 ,  A61K045/00 ,  A61K047/00

    CPC classification number: C07K16/065 ,  A61K38/00 ,  A61K39/39516 ,  C07K16/1036

    Abstract: Serum preparations obtained from sharks are used to prepare compositions, including pharmaceutical compositions, for inhibiting retrovirus replication in susceptible cells. Thus, the serum preparations are useful for inhibiting diseases associated with retroviral infection, such as acquired immunodeficiency syndrome. The serum concentrates are also used to inhibit growth of tumor cells, especially sarcomas and leukemias.

    Abstract translation: 使用从鲨鱼获得的血清制剂用于制备用于抑制易感细胞中逆转录病毒复制的组合物，包括药物组合物。 因此，血清制剂可用于抑制与逆转录病毒感染相关的疾病，例如获得性免疫缺陷综合征。 血清浓缩物也用于抑制肿瘤细胞，特别是肉瘤和白血病的生长。

    Monoclonal antibody immunoassay kit for avian reticuloendotheliosis virus
    98.
    发明授权
    Monoclonal antibody immunoassay kit for avian reticuloendotheliosis virus 失效
    用于禽网状内皮组织增生病毒的单克隆抗体免疫测定试剂盒

    公开(公告)号：US5130232A

    公开(公告)日：1992-07-14

    申请号：US536860

    申请日：1990-06-12

    Applicant: Lucy F. Lee ,  Zhizhong Cui ,  Richard L. Witter

    Inventor： Lucy F. Lee ,  Zhizhong Cui ,  Richard L. Witter

    IPC: C07K16/10

    CPC classification number: C07K16/1036 ,  Y10S435/973 ,  Y10S436/811

    Abstract: The combination of monoclonal antibodies 11A25 and 11E32, which recognize two distinct antigenic sites on the 62-kd glycoprotein of reticuloendotheliosis virus (REV) in ELISA, enables an increase in the sensitivity of an ELISA assay for subtype 2 REV over what was heretofore possible. The combination of MAbs is useful for diagnosing REV antigen and antibody in poultry flocks and for detecting new strains and variants of the viral subtype.

    Abstract translation: 在ELISA中识别网状内皮组织增生病毒（REV）的62-kd糖蛋白上的两个不同抗原位点的单克隆抗体11A25和11E32的组合使得能够增加针对亚型2 REV的ELISA测定的灵敏度比迄今为止可能的更高。 MAb的组合可用于诊断家禽群中的REV抗原和抗体，并用于检测病毒亚型的新菌株和变体。

    Antibodies to human leukemia virus-related peptides and a process for production of the antibodies
    99.
    发明授权
    Antibodies to human leukemia virus-related peptides and a process for production of the antibodies 失效
    人类白血病病毒相关肽的抗体和抗体的制备方法

    公开(公告)号：US4804746A

    公开(公告)日：1989-02-14

    申请号：US713659

    申请日：1985-03-19

    Applicant: Mitsuaki Yoshida ,  Haruo Sugano ,  Fumio Shimizu ,  Kenichi Imagawa

    Inventor： Mitsuaki Yoshida ,  Haruo Sugano ,  Fumio Shimizu ,  Kenichi Imagawa

    IPC: C07K14/15 ,  C07K16/10 ,  C07K15/14 ,  A61K39/395

    CPC classification number: C07K14/005 ,  C07K16/1036 ,  C12N2740/14022 ,  Y10S530/806 ,  Y10S930/221

    Abstract: An antibody of a human leukemia virus-related peptide obtained by collecting an antibody produced in a mammal body by administering to the mammal an antigen prepared by reacting a human leukemia virus-related peptide selected from the group consisting of:(a) a peptide represented by formula (1):H-Tyr-Val-Glu-Pro-Thr-Ala-Pro-Gln-Val-Leu-H (1)(b) a peptide represented by formula (2): psR-Ile-Pro-His-Pro-Lys-Asn-Ser-Ile-Gly-Gly-Glu-Val-OH (2)wherein R is the same as defined above;(c) a peptide represented by formula (3):R-Thr-Trp-Thr-Pro-Lys-Asp-Lys-Thr-Lys-Val-Leu-OH (3)wherein R is the same as defined above;(d) a peptide represented by formula (4):H-Val-Val-Gln-Pro-Lys-Lys-Pro-Pro-Pro-Tyr-OH (4)(e) a peptide represented by formula (5):R-Met-Gly-Gln-Ile-Phe-Ser-Arg-Ser-Ala-Ser-Pro-OH (5)wherein R is the same as defined above; and(f) a peptide represented by formula (6):H-Tyr-Pro-Glu-Gly-Thr-Pro-Lys-Asp-Pro-Ile-Leu-Arg-Ser-Leu-OH (6)as a hapten, with a carrier in the presence of a haptencarrier binding agent.

    Abstract translation: 通过对哺乳动物体内产生的抗体进行收集而获得的人类白血病病毒相关肽的抗体，其通过向哺乳动物施用通过使人白血病病毒相关肽反应而制备的抗原，所述人白血病病毒相关肽选自：（a） 式（1）表示的肽：H-Tyr-Val-Glu-Pro-Thr-Ala-Pro-Gln-Val-Leu-H（1）（b）由式（2）表示的肽：ps R-Ile-Pro -His-Pro-Lys-Asn-Ser-Ile-Gly-Gly-Glu-Val-OH（2）其中R与上述定义相同; （c）由式（3）表示的肽：R-Thr-Trp-Thr-Pro-Lys-Asp-Lys-Thr-Lys-Val-Leu-OH（3）其中R与上述定义相同; （d）由式（4）表示的肽：H-Val-Val-Gln-Pro-Lys-Lys-Pro-Pro-Pro-Tyr-OH（4）（e）由式（5）表示的肽： R-Met-Gly-Gln-Ile-Phe-Ser-Arg-Ser-Ala-Ser-Pro-OH（5）其中R与上述定义相同; 和（f）由式（6）表示的肽：作为半抗原的H-Tyr-Pro-Glu-Gly-Thr-Pro-Lys-Asp-Pro-Ile-Leu-Arg-Ser-Leu-OH 在载体中存在半载体结合剂。

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