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105 条记录 (耗时 0.059 秒)

    Enzymatic synthesis of optically pure beta-hydroxy carboxylic acids and their derivatives
    92.
    发明申请
    Enzymatic synthesis of optically pure beta-hydroxy carboxylic acids and their derivatives 审中-公开
    光学纯的β-羟基羧酸及其衍生物的酶合成

    公开(公告)号：US20100267100A1

    公开(公告)日：2010-10-21

    申请号：US11689243

    申请日：2007-03-21

    申请人： Ling Hua ,  Dunming Zhu ,  Chandrani Mukherjee ,  Edward R. Biehl

    发明人： Ling Hua ,  Dunming Zhu ,  Chandrani Mukherjee ,  Edward R. Biehl

    IPC分类号： C12P7/40

    CPC分类号： C12P7/42 ,  C12P13/002 ,  C12P13/004 ,  C12P13/02 ,  C12P17/12

    摘要： The present disclosure is related to systems, compositions, and methods for producing a β-hydroxy carboxylic acid and/or a β-hydroxy carboxylic amide in enantiomeric excess (e.g., enantiomerically pure). In some specific example embodiments, a method may include contacting a substrate and/or intermediate with a cyanide, a ketoreductase, a nitrilase, and/or a nitrile hydratase. Systems, compositions, and methods, in some embodiments, may produce a β-hydroxy carboxylic acid and/or a β-hydroxy carboxylic amide in enantiomeric excess under convenient conditions (e.g., pH 5-9 and temperatures under 50° C.).

    摘要翻译： 本公开涉及用于制备对映异构体过量（例如，对映异构体纯的）中的β-羟基羧酸和/或β-羟基羧酰胺的体系，组合物和方法。 在一些具体示例性实施方案中，方法可以包括使底物和/或中间体与氰化物，酮还原酶，腈水解酶和/或腈水合酶接触。 在一些实施方案中，系统，组合物和方法可以在方便的条件（例如，pH 5-9和低于50℃的温度下）产生对映体过量的β-羟基羧酸和/或β-羟基羧酸酰胺 ）。

    Process for production of optically active 3-hydroxypentanenitrile
    98.
    发明授权
    Process for production of optically active 3-hydroxypentanenitrile 失效
    光学活性3-羟基戊腈的制备方法

    公开(公告)号：US07148055B2

    公开(公告)日：2006-12-12

    申请号：US10491115

    申请日：2002-10-03

    申请人： Shigeru Kawano ,  Yoshihiko Yasohara

    发明人： Shigeru Kawano ,  Yoshihiko Yasohara

    IPC分类号： C12P41/00

    CPC分类号： C07C253/30 ,  C12P13/002 ,  C12P13/004 ,  C07C255/17

    摘要： The present invention provides a method for preparing optically active 3-hydroxypentanenitrile with high yield. Optically active 3-hydroxypentanenitrile is prepared by stereoselectively reducing 3-ketopentanenitrile by action of an enzyme, which asymmetrically reduces 3-ketopentanenitrile to optically active 3-hydroxypentanenitrile. Also, alkali metal salt of 3-ketopentanenitrile, which is a stable compound without problems regarding storage, can be efficiently obtained.

    摘要翻译： 本发明提供了一种以高产率制备光学活性3-羟基戊腈的方法。 通过酶的作用立体选择性还原3-酮戊腈制备光学活性3-羟基戊腈，其将3-酮戊腈不对称地还原成光学活性3-羟基戊腈。 此外，可以有效地获得作为没有储存问题的稳定化合物的3-酮戊腈的碱金属盐。

    Optically active fluorinated vasoconstrictors, methods for making them, and anesthetic formulations comprising them
    100.
    发明授权
    Optically active fluorinated vasoconstrictors, methods for making them, and anesthetic formulations comprising them 失效
    光学活性氟化血管​​收缩剂，其制备方法和包含它们的麻醉剂制剂

    公开(公告)号：US06900203B2

    公开(公告)日：2005-05-31

    申请号：US10190856

    申请日：2002-07-08

    申请人： Hamilton J. Lenox ,  Elena Terentieva ,  Mikhail Y. Gololobov

    发明人： Hamilton J. Lenox ,  Elena Terentieva ,  Mikhail Y. Gololobov

    IPC分类号： A61K31/137 ,  A61K31/167 ,  C07C215/60 ,  C07C217/70 ,  C07C233/18 ,  C07C255/37 ,  C12P13/00 ,  A61K31/535 ,  A61K31/135 ,  A61K31/16 ,  A61K31/24 ,  A61K31/445

    CPC分类号： C12P13/004 ,  A61K31/137 ,  A61K31/167 ,  C07B2200/07 ,  C07C215/60 ,  C07C217/70 ,  C07C233/18 ,  C07C255/37 ,  A61K2300/00

    摘要： (R)-6F-phenylephrine, essentially free of (S)-6F-phenylephrine, and an anesthetic formulation comprising (R)-6F-epinephrin or (R)-6F-phenylephrine and having improved stability compared to formulations containing their non-fluorinated analog, are disclosed. Further disclosed is a method of providing vasoconstriction in a mammal by administering the anesthetic formulation. The anesthetic composition can include an anesthetic, an (R)-chiral compound having the structure: wherein R1, R2, and R4 are independently selected from —H or —F, at least one of R1, R2, and R4 is —F, and R3 is selected from —OH, —H or —F, or a pharmaceutically acceptable salt or ester thereof, said vasoconstrictor being essentially free of the (S)-chiral form. Also, a method of chiral addition of cyanide to a ring-fluorinated phenaldehyde, employing an almond hydroxynitrile lyase enzyme, provided in the form of a reversibly soluble polymer conjugate ((R)-Finezyme™-H series biocatalysts) is disclosed. Several such biocatalysts are disclosed.

    摘要翻译： （R）-6F-去氧肾上腺素，以及包含（R）-6F-肾上腺素或（R）-6F-去氧肾上腺素）的麻醉剂制剂，并且与含有它们的非 - 氟化类似物。 进一步公开的是通过施用麻醉剂制剂在哺乳动物中提供血管收缩的方法。 麻醉剂组合物可以包括麻醉剂，具有以下结构的（R） - 手性化合物：其中R 1，R 2和R 4， 独立地选自-H或-F，R 1，R 2和R 4中的至少一个是-F，R 选自-OH，-H或-F，或其药学上可接受的盐或酯，所述血管收缩剂基本上不含（S） - 手性形式。 此外，公开了以可逆可溶性聚合物缀合物（（R）-Finezyme TM -H系列生物催化剂）的形式提供的使用杏仁羟基腈裂解酶的氰化氰手性加入到环氟化苯醛中的方法。 公开了几种这样的生物催化剂。