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公开(公告)号：US10213491B2
公开(公告)日：2019-02-26
申请号：US15860966
申请日：2018-01-03
摘要： Neonatal seizure is different from adult seizure, and many antiepileptic drugs that are effective in adults often fail to treat neonatal seizure. Gluconic acid, a natural organic acid enriched in fruits and honey, and the glucose oxidase enzyme, is shown herein to potently inhibit neonatal epilepsy both in vitro and in vivo. Sodium gluconate is shown to inhibit epileptiform burst activity in cell cultures and protect neurons from kainic acid-induced cell death. Sodium gluconate also inhibited epileptiform burst activity in brain slices in a manner that was much more potent in neonatal animals than in older animals. Consistently, in vivo EEG recordings also revealed that sodium gluconate inhibited the epileptic seizure activity in a manner that was much more potent in neonates than in adult animals. Mechanistically, sodium gluconate inhibits voltage-dependent CLC-3 Cl− channels both in neuronal cultures and in hippocampal slices. Together, these data suggest a novel antiepileptic drug gluconate that potently inhibits neonatal seizures through blocking CLC-3 Cl− channels.
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112.发明申请公开(公告)号：US20190054183A1
公开(公告)日：2019-02-21
申请号：US16089824
申请日：2017-04-13
发明人： Jian YANG , Cheng DONG , Zhiwei XIE
IPC分类号： A61K47/69 , A61K47/65 , A61K47/59 , A61K31/437 , A61P35/00
摘要： In one aspect, methods of targeted nanoparticle and cell delivery are described herein. In some embodiments, methods described herein comprise coupling nanoparticles and cells to a carrier cell to form a nanoparticle-cell conjugate or cell-cell conjugate, disposing the nanoparticle-cell or cell-cell conjugate in a biological environment, and delivering the nanoparticles and cells to target cells or tissues located within the biological environment. The nanoparticles comprise a biodegradable photoluminescent polymer, and the nanoparticle-cell conjugate is formed using one or more click chemistry reaction products.
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公开(公告)号：US10202517B2
公开(公告)日：2019-02-12
申请号：US14894914
申请日：2014-07-15
IPC分类号： C09D101/28 , C09D105/00 , C09D105/08 , C08L1/02 , D21H11/18 , D21H17/22 , D21H17/25 , D21H17/68 , D21H19/40 , D21H19/50 , C08K3/26 , C08L89/00
摘要： This document provides polymer compositions (e.g., biopolymer compositions) and coatings. For example, methods and materials related to polymer compositions (e.g., biopolymer compositions) and coatings as well as methods and materials for making and using such compositions (e.g., biopolymer compositions) and coatings are provided.
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公开(公告)号：US20190023742A1
公开(公告)日：2019-01-24
申请号：US16043935
申请日：2018-07-24
发明人： Melik Demirel , Benjamin Allen , Huihun Jung
IPC分类号： C07K14/00 , C07K14/435
摘要： Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming subsequences form crystallites comprising stacks of one or more β-sheets and the amorphous subsequences form a network of hydrogen bonds. The supramolecular polypeptides are capable of exhibiting self-healing behavior.
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公开(公告)号：US10176790B2
公开(公告)日：2019-01-08
申请号：US15873460
申请日：2018-01-17
发明人： Jonathan J. Gangi
IPC分类号： G10G5/00
摘要： A guitar support for supporting a guitar during a performance includes a base, a stand having an upper portion, a lower portion, and a curved middle portion. A lower end of the lower portion is connected to the base. A shaped support element is connected to a top end of the upper portion, the shaped support element having a top surface shaped to support a guitar body.
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公开(公告)号：US20180353498A1
公开(公告)日：2018-12-13
申请号：US16026934
申请日：2018-09-05
发明人： Gong Chen , Zheng Wu , Ziyuan Guo
IPC分类号： A61K31/455 , A61K31/7088 , A61K51/04 , A61K9/00 , A61K31/5517 , A61K51/10 , G01N33/94 , A61K45/06 , A61K31/445 , A61K31/454 , A61K31/551
摘要： This document relates to methods and materials for reducing memory loss. For example, methods and materials for using inhibitors of GAT-3 polypeptide activity to reduce memory loss in mammals suffering from Alzheimer's disease are provided.
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公开(公告)号：US20180337508A1
公开(公告)日：2018-11-22
申请号：US15980839
申请日：2018-05-16
发明人： Zhiwen Liu , Victor Bucklew , Perry Edwards , Chenji Zhang
CPC分类号： H01S3/0071 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0237 , G01J3/0245 , G01J3/10 , G01J3/42 , G01J3/44 , G01J2003/1282 , G02B27/10 , G02F1/39 , H01S3/005 , H01S3/0057 , H01S3/0092 , H01S2301/08 , H04B10/524 , H04J14/02
摘要： A divided pulse nonlinear optical source may be generated by combining nonlinear wave generation techniques with pulse division that can divide a parent pulse into N divided pulses, each divided pulse separate temporally. The N divided pulses can be passed into a nonlinear optical medium to generate an output. The output can include at least one output pulse for each divided pulse. The center wavelengths of each output pulse can be tuned so that each may have a center wavelength that is the same as, or differs from, each other output pulse. In some embodiments, the output pulses may be combined to generate the output. The output can be power scalable and wavelength tunable.
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公开(公告)号：US20180330791A1
公开(公告)日：2018-11-15
申请号：US15976315
申请日：2018-05-10
发明人： Xueqing Li , Sumitha George , John Sampson , Sumeet Gupta , Suman Datta , Vijaykrishnan Narayanan , Kaisheng Ma
CPC分类号： G11C14/0072 , G11C11/1675 , G11C11/1693 , G11C11/223 , G11C11/2275 , G11C11/2293 , G11C13/0002 , G11C13/0007 , G11C13/0061 , G11C13/0069 , G11C14/0054 , G11C14/0081 , G11C14/009 , H01L29/78391
摘要： Embodiments include nonvolatile a memory (NVM) device that can be configured for logic switching and/or digital computing. For example, embodiments of the NVM device can be configured as any one or combination of a memory cell, a D flip flop (DFF), a Backup and Restore circuit (B&R circuit), and/or a latch for a DFF. Any of the NVM devices can have a Fe field effect transistors (FeFET) configured to exploit the IDS−VG hysteresis of the steep switch at low voltage for logic memory synergy. The FeFET-based devices can be configured to include a wide hysteresis, a steep hysteresis edge, and high ratio between the two IDS states at VG=0.
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公开(公告)号：US10106647B2
公开(公告)日：2018-10-23
申请号：US14916140
申请日：2014-09-04
发明人： Jian Yang , Jinshan Guo
IPC分类号： C08G63/52 , C08G63/12 , A61L27/34 , C08G18/68 , C08G18/73 , C08G18/46 , A61L27/46 , C08G63/685 , A61L27/56
摘要： In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises the reaction product of (i) citric acid, a citrate, or an ester of citric acid with (ii) a polyol, and (iii) a monomer comprising one or more alkyne moieties and/or azide moieties. The reaction product, in some instances, comprises a polymer. Further, in some cases, a composition described herein comprises a plurality of polymers. In some embodiments, the polymers are selected to be reactive with one another through a click chemistry reaction scheme to form a polymer network. In another aspect, medical implants and medical devices are described herein, the implants and devices comprising a polymer or polymer network described herein.
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公开(公告)号：US20180299468A1
公开(公告)日：2018-10-18
申请号：US15766889
申请日：2016-10-10
发明人： Shannon L. Kelleher
IPC分类号： G01N33/68 , C12Q1/6883
摘要： The present invention provides for the first time the identification of breastmilk exosomal biomarkers useful in diagnosing lactation insufficiency. The present invention therefore provides methods, kits and systems for diagnosing lactation insufficiency, by examining relevant proteins and RNA in exosomes isolated from a patient's breastmilk.
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