公开(公告)号：US20180064682A1

公开(公告)日：2018-03-08

申请号：US15798530

申请日：2017-10-31

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Menachem RUBINSTEIN ,  Efrat DVASH-RIESENFELD

IPC: A61K31/366 ,  A61K31/381 ,  A61K31/41

Abstract: The present invention relates to the alleviation of adverse side effects resulting from statin therapy. The present invention further relates to the use of an inhibitor of leukotriene C4 (LTC4) mediated activity for alleviating at least one side effects of statin therapy.

公开(公告)号：US09901660B2

公开(公告)日：2018-02-27

申请号：US14902574

申请日：2014-07-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Ronit Goldberg ,  Noa Iuster ,  Raya Sorkin

IPC: A61K9/127 ,  A61L27/52 ,  A61L27/34 ,  A61K9/00 ,  C09D133/06 ,  A61L27/44 ,  C08F2/10 ,  C08F2/44

CPC classification number: A61L27/52 ,  A61K9/0019 ,  A61K9/0024 ,  A61L27/34 ,  A61L27/44 ,  A61L2300/626 ,  A61L2400/10 ,  A61L2430/06 ,  A61L2430/10 ,  A61L2430/24 ,  A61L2430/38 ,  C08F2/10 ,  C08F2/44 ,  C09D133/066

Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.

公开(公告)号：US20180045754A1

公开(公告)日：2018-02-15

申请号：US15557104

申请日：2016-03-10

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Eli ZELDOV ,  Lior EMBON ,  Dorri HALBERTAL ,  Yonathan ANAHORY ,  Yuri MYASOEDOV ,  Jo CUPPENS

IPC: G01Q60/58

CPC classification number: G01Q60/58 ,  G01K7/006 ,  G01K2203/00 ,  G01N27/041

Abstract: A device and methods for use thereof in low-temperature thermal scanning microscopy, providing non-contact, non-invasive localized temperature and thermal conductivity measurements in nanometer scale ranges with a temperature resolution in the micro-Kelvin order. A superconductive cap mounted on the tip of an elongated support probe is electrically-connected to superconductive leads for carrying electrical current through the cap. The critical superconducting current of the leads is configured to be greater than the critical current supported by the cap, and the cap's critical current is configured to be a function of its temperature. Thus, the temperature of the cap is measured by measuring its critical superconducting current. In a related embodiment, driving a current greater than the critical current of the cap quenches the cap's superconductivity, and permits the cap to dissipate resistive heat into the sample being scanned. Scanning of the sample in this mode thus images its thermal conductivity patterns.

公开(公告)号：US20180042994A1

公开(公告)日：2018-02-15

申请号：US15525618

申请日：2015-11-17

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Atan GROSS ,  Yehudit ZALTSMAN ,  Liat PINKAS ,  Maria MARYANOVICH ,  Liat BUZAGLO ,  Antonella RUGGIERO ,  Amir BAHAT ,  Andres GOLDMAN ,  Michael MULLOKANDOV

IPC: A61K38/17 ,  C12N5/00

CPC classification number: A61K38/1761 ,  C12N5/0018

Abstract: Uses of agent which downregulate an activity or expression of a component participating in the mitochondrial apoptotic pathway are disclosed.

公开(公告)号：US09856318B2

公开(公告)日：2018-01-02

申请号：US14797894

申请日：2015-07-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD

Inventor： Michal Eisenbach-Schwartz ,  Kuti Baruch ,  Neta Rosenzweig

IPC: C07K16/28 ,  A61K39/395 ,  A61K38/00 ,  A61K31/4155 ,  A61K38/16 ,  A61K38/18 ,  A61K38/20 ,  A61K38/14 ,  A61K45/06 ,  A61K31/404 ,  A61K31/7068 ,  A61K33/36 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/7068 ,  A61K33/36 ,  A61K38/00 ,  A61K38/005 ,  A61K38/02 ,  A61K38/14 ,  A61K38/168 ,  A61K38/18 ,  A61K38/208 ,  A61K39/395 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2121/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/75 ,  C07K2317/76 ,  A61K2300/00

Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session.

公开(公告)号：US09847494B2

公开(公告)日：2017-12-19

申请号：US15037406

申请日：2014-11-19

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Milko E. Van Der Boom ,  Michal Lahav ,  Sreejith Shankar Pooppanal

IPC: H01L51/00 ,  B82Y10/00 ,  C07D401/06 ,  C07D403/06 ,  C07F15/02 ,  G02F1/15 ,  G11C7/00 ,  C09B57/10 ,  G11C13/00 ,  H01L51/05

CPC classification number: H01L51/0083 ,  B82Y10/00 ,  C07D401/06 ,  C07D403/06 ,  C07F15/025 ,  C09B57/10 ,  G02F1/15 ,  G02F2001/1502 ,  G02F2001/1515 ,  G11C7/00 ,  G11C13/0014 ,  H01L51/0595

Abstract: The present invention relates to metal-based tris-bipyridyl complexes, e.g., iron-based tris-bipyridyl complexes, and their use in fabrication of surface confined assemblies for electrochromic applications. Formulae I and II.

公开(公告)号：US20170306049A1

公开(公告)日：2017-10-26

申请号：US15508112

申请日：2015-09-08

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Yosef YARDEN ,  Nadège GABORIT ,  Moshit LINDZEN

IPC: C07K16/32 ,  G01N33/574 ,  C07K16/30 ,  A61K39/00

Abstract: An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain specifically binding human HER-3 with a KD value of 10 nM or lower, wherein the polypeptide inhibits neuregulin (NRG) binding to the human HERS and NRG-induced cancer cell migration and proliferation.

公开(公告)号：US20170298361A1

公开(公告)日：2017-10-19

申请号：US15516405

申请日：2015-10-01

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef SHAUL ,  Rom David KESHET ,  Nina REUVEN

IPC: C12N15/113 ,  A61K31/506 ,  A61K31/553

CPC classification number: C12N15/1137 ,  A61K31/506 ,  A61K31/553 ,  C12N2310/14 ,  C12N2310/531

Abstract: Use of agents that down-regulates an amount and/or activity of Abelson murine leukemia viral oncogene homolog 1 (c-Abl) or checkpoint kinase 1 (Chk1) in the production of a medicament for treating obesity are disclosed.

公开(公告)号：US20170294572A1

公开(公告)日：2017-10-12

申请号：US15128609

申请日：2015-03-25

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF HEBREW UNIVERSITY OF JERUSALEM LTD.

Inventor： Ron NAAMAN ,  Nirit KANTOR-URIEL ,  Shinto P. MATHEW ,  Yossef PALTIEL ,  Oren BEN-DOR ,  Shira YOCHELIS ,  Nir PEER

IPC: H01L43/04 ,  G11C13/04 ,  G11C11/18 ,  H01L43/06 ,  G11C11/16

CPC classification number: H01L43/04 ,  G01R33/07 ,  G01R33/091 ,  G11C11/16 ,  G11C11/161 ,  G11C11/18 ,  G11C13/0014 ,  G11C13/04 ,  G11C13/043 ,  H01L43/065 ,  H03K19/18

Abstract: An electronic device is presented, the device comprises: a spin accumulating structure; a spin selective filter electrically connected at a first end thereof to a first surface of said spin accumulating layer structure; a charge carrier source attached to said spin selective filter at a second end of the spin selective filter; wherein the spin selective filter is configured to allow passage of the charge carriers having a predetermined spin orientation from the charge carrier source to the spin accumulating structure, thereby causing a variation of spin distribution of the charge carriers within the spin accumulating structure. The device comprises further at least first and second pairs of electrical contacts which are connected to the spin accumulating structure and define first and second electrical paths through said spin accumulating structure, said first and second electrical paths intersecting within said spin accumulating structure. The device including a circuit configured to apply an electrical current between the first pair of electrical contacts and to detect the variation of spin-distribution of charge carriers within the spin accumulating structure by determining electrical voltage between the second pair of electrical contacts in response to the applied electrical current.

公开(公告)号：US09738685B2

公开(公告)日：2017-08-22

申请号：US15017049

申请日：2016-02-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Milstein ,  Chidambaram Gunanathan ,  Yehoshua Ben-David ,  Ekambaram Balaraman ,  Boopathy Gnanaprakasam ,  Jing Zhang

IPC: C07K5/12 ,  C07C209/50 ,  C07C213/00 ,  C07C231/00 ,  C07C231/02 ,  C07D307/52 ,  C08L79/02 ,  C07C67/03 ,  C07C45/00 ,  C07C51/235 ,  C07C67/28 ,  C07D241/12 ,  C07D295/185 ,  C07D487/14 ,  C07C29/136 ,  C07C67/39 ,  C07K1/02 ,  C07K1/10

CPC classification number: C07K5/12 ,  C07C29/136 ,  C07C45/002 ,  C07C51/235 ,  C07C67/03 ,  C07C67/28 ,  C07C67/39 ,  C07C209/50 ,  C07C213/00 ,  C07C231/00 ,  C07C231/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D241/12 ,  C07D295/185 ,  C07D307/52 ,  C07D487/14 ,  C07K1/02 ,  C07K1/10 ,  C08L79/02 ,  Y02P20/52 ,  C07C233/05 ,  C07C235/06 ,  C07C235/10 ,  C07C233/36 ,  C07C211/27 ,  C07C215/28 ,  C08L1/00 ,  C07C69/14 ,  C07C69/24 ,  C07C31/04 ,  C07C31/08 ,  C07C31/10 ,  C07C31/12

Abstract: A process for preparing amides by reacting a primary amine and a primary alcohol in the presence of a Ruthenium complex to generate the amide and molecular hydrogen. Primary amines are directly acylated by equimolar amounts of alcohols to produce amides and molecular hydrogen (the only byproduct) in high yields and high turnover numbers. Also disclosed are processes for hydrogenation of amides to alcohols and amines; hydrogenation of organic carbonates to alcohols; hydrogenation of carbamates or urea derivatives to alcohols and amines; amidation of esters; acylation of alcohols using esters; coupling of alcohols with water and a base to form carboxylic acids; dehydrogenation of beta-amino alcohols to form pyrazines and cyclic dipeptides; and dehydrogenation of secondary alcohols to ketones. These reactions are catalyzed by a Ruthenium complex which is based on a dearomatized PNN-type ligand of formula A1 or precursors thereof of formulae A2 or A3.