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158 条记录 (耗时 0.068 秒)

    Silk-Based Drug Delivery System
    121.
    发明申请
    Silk-Based Drug Delivery System 有权
    丝绸药物输送系统

    公开(公告)号：US20080085272A1

    公开(公告)日：2008-04-10

    申请号：US11628930

    申请日：2005-06-13

    申请人： David L. Kaplan ,  Meinel Lorenz

    发明人： David L. Kaplan ,  Meinel Lorenz

    IPC分类号： A61K38/02 ,  A61K31/70 ,  A61K39/395 ,  A61K47/00

    CPC分类号： A61K47/42 ,  A61K9/0002 ,  A61K9/7007 ,  A61K38/17 ,  A61K47/46

    摘要： The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crytallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer.

    摘要翻译： 本发明提供了新颖的持续释放的基于丝的递送系统。 本发明还提供了生产这种制剂的方法。 通常，将丝素蛋白溶液与治疗剂组合以形成丝素蛋白制品。 然后对该文章进行处理，以改变其构象。 构象的变化增加其胆固醇或液体结晶度，从而控制治疗剂从制剂中的释放。 这可以作为单一材料载体或以逐层方式实现，以在每个层中加载不同的治疗剂或不同浓度的这些试剂。

    Fabrication of nanoscale materials using self-assembling proteins
    123.
    发明授权
    Fabrication of nanoscale materials using self-assembling proteins 失效
    使用自组装蛋白制备纳米级材料

    公开(公告)号：US5712366A

    公开(公告)日：1998-01-27

    申请号：US452592

    申请日：1995-05-25

    申请人： Kevin P. McGrath ,  David L. Kaplan

    发明人： Kevin P. McGrath ,  David L. Kaplan

    IPC分类号： C07K14/00 ,  A61K38/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00

    CPC分类号： B82Y30/00 ,  B82Y5/00 ,  C07K14/001

    摘要： A method of fabricating nanoscale structural materials via the spontaneous organization of self-assembling proteins and the self-assembling proteins themselves. In a preferred embodiment of the invention, the self-assembling proteins included at least one occurrence of the following recognition sequence: ##STR1## wherein Xaa is a charged residue selected from the group consisting of Glu, Lys, Arg and Asp, and the method comprises admixing proteins which include species of the aforementioned recognition sequence which are prone to dimerization, whereby the admixed proteins are caused to spontaneously organize into nanoscale structural materials via their respective recognition sequences.

    摘要翻译： 通过自组装蛋白质和自组装蛋白质自发组织制备纳米级结构材料的方法。 在本发明的优选实施方案中，自组装蛋白包括以下识别序列的至少一个出现：其中Xaa是选自Glu，Lys，Arg的带电残基 和Asp，并且所述方法包括将包括易于二聚化的上述识别序列的物质的蛋白质混合，由此使混合的蛋白质通过其各自的识别序列自发组织成纳米级结构材料。

    Method to achieve solubilization of spider silk proteins
    124.
    发明授权
    Method to achieve solubilization of spider silk proteins 失效
    实现蜘蛛丝蛋白溶解的方法

    公开(公告)号：US5245012A

    公开(公告)日：1993-09-14

    申请号：US953323

    申请日：1992-09-29

    申请人： Stephen J. Lombari ,  David L. Kaplan

    发明人： Stephen J. Lombari ,  David L. Kaplan

    IPC分类号： C07K14/435

    CPC分类号： C07K14/43518

    摘要： A recombinant spider silk protein can be obtained in a commercially useful form by cloning and the expression in a host cell of a polynucleotide encoding an endogenous spider silk protein or variant thereof. The sequencing of a spider silk protein is made possible by a method for solubilizing a spider silk protein.

    摘要翻译： 通过克隆和在宿主细胞中表达编码内源性蜘蛛丝蛋白的多核苷酸或其变体，可以以商业上有用的形式获得重组蜘蛛丝蛋白。 蜘蛛丝蛋白质的测序可以通过一种溶解蜘蛛丝蛋白的方法来实现。

    Non-invasive optical characterization of biomaterial mineralization
    126.
    发明授权
    Non-invasive optical characterization of biomaterial mineralization 有权

    公开(公告)号：US09952148B2

    公开(公告)日：2018-04-24

    申请号：US12867383

    申请日：2009-02-19

    申请人： Irene Georgakoudi ,  Sharad Gupta ,  Martin Hunter ,  David L. Kaplan

    发明人： Irene Georgakoudi ,  Sharad Gupta ,  Martin Hunter ,  David L. Kaplan

    IPC分类号： G01N21/47 ,  G01N21/21

    CPC分类号： G01N21/47 ,  G01N21/21 ,  G01N2021/4792

    摘要： In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing radiation scattered from the material in response to the illumination. For example, in some embodiments, a material can be illuminated with polarized radiation at a plurality of wavelengths and the elastically scattered radiation corresponding to two or more of those wavelengths can be collected at two polarizations: one parallel and the other perpendicular to the illumination polarization. A differential intensity of the scattered radiation at the two polarizations can be analyzed as a function of wavelength to obtain information regarding the morphology of mineral deposits in the sample. Further, the total scattered radiation can be analyzed to derive information regarding the level of mineralization.