PLASMONIC NANOPARTICLE-DOPED SILK MATERIALS

    公开(公告)号:US20130310908A1

    公开(公告)日:2013-11-21

    申请号:US13819419

    申请日:2011-09-03

    IPC分类号: A61N5/06 H01L35/30

    摘要: Provided herein are silk fibroin-based photothermal elements and uses thereof. The silk fibroin-based photothermal elements comprise a plurality of plasmonic nanoparticle distributed in a silk fibroin matrix, and can generate heat when the plasmonic nanoparticles are exposed to electromagnetic radiation. The silk fibroin-based photothermal elements can be adapted to be conformable and biodegradable, and can further be integrated with various electronic components, such as a thermo-electric device for conversion of heat into electricity. The invention is useful for various in vivo applications, such as photothermal therapy, controlled drug-delivery devices or wireless powering of implanted micro-devices.

    摘要翻译: 本文提供的是丝素蛋白基光热元件及其用途。 基于丝素蛋白的光热元件包括分布在丝素蛋白基质中的多个等离子体激元纳米颗粒,当等离子体激元纳米粒子暴露于电磁辐射时可产生热量。 丝素蛋白的光热元件可以适应和可生物降解,并且可以进一步与各种电子部件集成,例如用于将热量转换成电的热电装置。 本发明可用于各种体内应用,例如光热治疗,受控药物递送装置或植入的微器件的无线供电。

    ALL-PROTEIN IMPLANTABLE, RESORBABLE REFLECTORS
    8.
    发明申请
    ALL-PROTEIN IMPLANTABLE, RESORBABLE REFLECTORS 有权
    全蛋白可植入,可折叠的反射器

    公开(公告)号:US20120188640A1

    公开(公告)日:2012-07-26

    申请号:US13386388

    申请日:2010-07-20

    摘要: The invention provides for compositions and process for fabricating an optical reflector constructed from biocompatible and bioresorbable silk fibroin proteins. For example, the silk retroreflectors may be built based on millimeter size microprism arrays to rotate the image plane of imaged cortical layers, thus enhancing the amount of photons that are detectable in the reflected direction when inserted in a sample to be analyzed, and ultimately increasing in contrast ratio in multiphoton microscopy. Such device can be used as a label-free, biocompatible, bioresorbable, implantable device for various applications ranging from medical imaging/diagnostics, drug/therapeutic delivery, to food chain safety and environmental monitoring.

    摘要翻译: 本发明提供了用于制造由生物相容性和生物可再吸收的丝素蛋白构成的光反射体的组合物和方法。 例如,丝绸后向反射器可以基于毫米尺寸的微棱镜阵列构建,以旋转成像的皮质层的图像平面,从而增加当插入待分析的样品中时在反射方向上可检测的光子的量,并且最终增加 在多光子显微镜中的对比度。 这种装置可用作用于各种应用的无标签,生物相容性,生物可再吸收的可植入装置,从医学成像/诊断,药物/治疗递送,食品链安全和环境监测。