Methods of making drawn silk fibers
    3.
    发明授权
    Methods of making drawn silk fibers 有权
    制作拉丝丝纤维的方法

    公开(公告)号:US09074302B2

    公开(公告)日:2015-07-07

    申请号:US13498722

    申请日:2010-09-28

    摘要: The present invention relates to compositions and method for drawing egel silk fibroin fibers. The resulting fibers can transmit light and hence can be used as optical fiber. Silk fibroin fiber is produced by a method comprising applying an electric field to a solubilized silk fibroin solution to create a silk fibroin gel; converting the silk fibroin gel to a viscous silk liquid; and drawing a silk fiber from the viscous silk liquid. The silk fiber of the invention can be used in materials such as textile, medical sutures, and tissue materials, as well as conferring optical properties into these materials.

    摘要翻译: 本发明涉及丝绒丝素纤维的组合物和方法。 所得到的纤维可以透射光,因此可以用作光纤。 丝素蛋白纤维通过包括向溶解的丝素蛋白溶液施加电场以产生丝素蛋白凝胶的方法产生; 将丝素蛋白凝胶转化为粘稠的丝液; 并从粘性丝液中抽出丝纤维。 本发明的丝纤维可以用于纺织品,医用缝合线和组织材料等材料,并且可以赋予这些材料光学特性。

    DRAWN SILK EGEL FIBERS AND METHODS OF MAKING SAME
    5.
    发明申请
    DRAWN SILK EGEL FIBERS AND METHODS OF MAKING SAME 有权
    拉丝丝织物及其制造方法

    公开(公告)号:US20120244143A1

    公开(公告)日:2012-09-27

    申请号:US13498722

    申请日:2010-09-28

    摘要: The present invention relates to compositions and method for drawing egel silk fibroin fibers. The resulting fibers can transmit light and hence can be used as optical fiber. Silk fibroin fiber is produced by a method comprising applying an electric field to a solubilized silk fibroin solution to create a silk fibroin gel; converting the silk fibroin gel to a viscous silk liquid; and drawing a silk fiber from the viscous silk liquid. The silk fiber of the invention can be used in materials such as textile, medical sutures, and tissue materials, as well as conferring optical properties into these materials.

    摘要翻译: 本发明涉及丝绒丝素纤维的组合物和方法。 所得到的纤维可以透射光,因此可以用作光纤。 丝素蛋白纤维通过包括向溶解的丝素蛋白溶液施加电场以产生丝素蛋白凝胶的方法产生; 将丝素蛋白凝胶转化为粘稠的丝液; 并从粘性丝液中抽出丝纤维。 本发明的丝纤维可以用于纺织品,医用缝合线和组织材料等材料,并且可以赋予这些材料光学特性。

    pH-induced silk gels and uses thereof
    6.
    发明授权
    pH-induced silk gels and uses thereof 有权
    pH诱导的丝凝胶及其用途

    公开(公告)号:US08501172B2

    公开(公告)日:2013-08-06

    申请号:US12974796

    申请日:2010-12-21

    IPC分类号: A61K39/395

    摘要: This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to β-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for various medical applications. This invention also provides for methods and compositions for preparing adhesive silk pH-gels. For example, the method comprises reducing pH level of a silk fibroin solution to increase the bulk or local proton concentration of the silk fibroin solution, thereby forming adhesive silk gels.

    摘要翻译: 本发明提供了在称为电凝胶的方法中,使用直接施加电压将丝素蛋白溶液快速转化成丝素蛋白凝胶的组合物,方法和装置。 丝素蛋白凝胶可以通过施加反向电压而可逆地转化为液体形式,或者可以通过施加剪切力或其它处理而进一步转化成β-折叠结构。 电致凝胶丝可以用作提取的体积凝胶,喷雾或凝胶流加工成材料或装置,或者可以用作设备的丝凝胶涂层。 活性剂可以嵌入丝绸凝胶中用于各种医疗应用。 本发明还提供了制备粘性丝pH凝胶的方法和组合物。 例如,该方法包括降低丝素蛋白溶液的pH值以增加丝素蛋白溶液的体积或局部质子浓度,由此形成粘性丝凝胶。

    pH INDUCED SILK GELS AND USES THEREOF
    7.
    发明申请
    pH INDUCED SILK GELS AND USES THEREOF 有权
    pH诱导丝光凝胶及其用途

    公开(公告)号:US20110171239A1

    公开(公告)日:2011-07-14

    申请号:US12974796

    申请日:2010-12-21

    摘要: This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to β-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for various medical applications. This invention also provides for methods and compositions for preparing adhesive silk pH-gels. For example, the method comprises reducing pH level of a silk fibroin solution to increase the bulk or local proton concentration of the silk fibroin solution, thereby forming adhesive silk gels.

    摘要翻译: 本发明提供了在称为电凝胶的方法中,使用直接施加电压将丝素蛋白溶液快速转化成丝素蛋白凝胶的组合物,方法和装置。 丝素蛋白凝胶可以通过施加反向电压而可逆地转化回液体形式,或者可以通过施加剪切力或其它处理而进一步转化为“薄片”结构。 电致凝胶丝可以用作提取的体积凝胶,喷雾或凝胶流加工成材料或装置,或者可以用作设备的丝凝胶涂层。 活性剂可以嵌入丝绸凝胶中用于各种医疗应用。 本发明还提供了制备粘性丝pH凝胶的方法和组合物。 例如,该方法包括降低丝素蛋白溶液的pH值以增加丝素蛋白溶液的体积或局部质子浓度,由此形成粘性丝凝胶。