公开(公告)号：US09649279B2

公开(公告)日：2017-05-16

申请号：US14572346

申请日：2014-12-16

Applicant: Massachusetts Institute of Technology ,  Tokitae LLC

Inventor： Ana Jaklenec ,  Xian Xu ,  Lowell L. Wood, Jr. ,  Philip A. Eckhoff ,  William Gates ,  Boris Nikolic ,  Robert S. Langer

IPC: A23L1/304 ,  A23L1/00 ,  A61K47/00 ,  A61K9/50 ,  A61K31/519 ,  A61K47/26 ,  A61K47/36 ,  A61K31/295 ,  A61K33/30 ,  A61K31/07 ,  A61K31/714 ,  A61K31/375 ,  A61K31/593 ,  A61K33/18 ,  A23P10/30 ,  A23L27/00 ,  A23L33/10 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16

CPC classification number: A61K9/5026 ,  A23L27/72 ,  A23L27/74 ,  A23L33/10 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/4866 ,  A61K9/501 ,  A61K9/5073 ,  A61K31/07 ,  A61K31/23 ,  A61K31/295 ,  A61K31/375 ,  A61K31/519 ,  A61K31/593 ,  A61K31/714 ,  A61K33/18 ,  A61K33/26 ,  A61K33/30 ,  A61K45/06 ,  A61K47/26 ,  A61K47/36

Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.

公开(公告)号：US20170112776A1

公开(公告)日：2017-04-27

申请号：US15349681

申请日：2016-11-11

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Sangyong Jon ,  Omid C. Farokhzad ,  Robert S. Langer ,  Jianjun Cheng

IPC: A61K9/51 ,  A61K38/28

CPC classification number: A61K9/5138 ,  A61K9/0043 ,  A61K9/0065 ,  A61K9/5036 ,  A61K9/5153 ,  A61K9/5192 ,  A61K38/28

Abstract: A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer may include covalently linked poly(ethylene glycol) chains, and the mucoadhesive coating may be selected to facilitate transfer of the particle through the intestinal mucosa. A molecular weight and cross-link density of the polymer may be selected such that the polymer core will decompose in a predetermined time interval. The fraction of the dose of the drug entering the system at circulation during the predetermined time interval may be between about 0.25% and about 25%. The composition may be formulated as a plurality of nanoparticles or microparticles that are combined with a pharmaceutically acceptable carrier to produce an edible or inhalable drug product.

公开(公告)号：US09512073B2

公开(公告)日：2016-12-06

申请号：US13662002

申请日：2012-10-26

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC: A61K31/535 ,  C07C229/00 ,  C07C323/58 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88

CPC classification number: A61K31/7105 ,  A61K31/711 ,  A61K47/22 ,  A61K2121/00 ,  C07C229/12 ,  C07C229/22 ,  C07C229/24 ,  C07C229/26 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C07C271/22 ,  C07C279/14 ,  C07C323/58 ,  C07D207/16 ,  C07D209/20 ,  C07D209/24 ,  C07D233/64 ,  C07D241/08 ,  C07D265/32 ,  C07D403/06 ,  C07D413/06 ,  C07D487/04 ,  C07D487/06 ,  C12N15/87 ,  C12N15/88 ,  C12Q1/025 ,  G01N33/15

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US09440008B2

公开(公告)日：2016-09-13

申请号：US14694466

申请日：2015-04-23

Applicant: Children's Medical Center Corporation ,  Massachusetts Institute of Technology

Inventor： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC: A61F13/00 ,  A61L31/06 ,  A61K9/00 ,  A61F2/02 ,  A61L31/14 ,  A61L27/26 ,  A61L27/58 ,  A61L31/16 ,  A61F2/44 ,  A61L31/00 ,  A61L31/04

CPC classification number: A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

公开(公告)号：US09301926B2

公开(公告)日：2016-04-05

申请号：US14250025

申请日：2014-04-10

Applicant: Massachusetts Institute of Technology ,  The General Hospital Corporation

Inventor： Laura Indolfi ,  Elazer R. Edelman ,  Robert S. Langer ,  Jeffrey W. Clark ,  David T. Ting ,  Cristina Rosa Annamaria Ferrone ,  Matteo Ligorio

IPC: A61K9/70 ,  A61K31/337 ,  A61L31/10 ,  A61K47/34 ,  A61K9/00 ,  A61L31/16 ,  A61F2/04 ,  A61F2/915

CPC classification number: A61L31/10 ,  A61F2/915 ,  A61F2002/041 ,  A61F2230/0021 ,  A61K9/0024 ,  A61K9/0034 ,  A61K9/7007 ,  A61K31/337 ,  A61K47/34 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2420/06 ,  C08L67/04

Abstract: Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 μm to about 1000 μm, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.

Abstract translation: 提供了用于治疗胰腺，胆汁系统，胆囊，肝脏，小肠或结肠肿瘤的药物洗脱装置和方法。 方法包括部署具有膜的药物洗脱装置，该膜包括可降解聚合物和化学治疗药物的混合物，其中所述膜具有约2μm至约1000μm的厚度，进入组织部位并释放治疗有效量的 来自膜的化学治疗药物以治疗肿瘤，其中通过在组织部位的聚合物的体内降解来控制来自膜的治疗有效量的药物的释放。

公开(公告)号：US09101695B2

公开(公告)日：2015-08-11

申请号：US14496742

申请日：2014-09-25

Applicant: Children's Medical Center Corporation ,  Massachusetts Institute of Technology

Inventor： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC: A61L31/06 ,  A61K9/00 ,  A61F2/02 ,  A61L31/14 ,  A61L27/26 ,  A61L27/58 ,  A61L31/16

CPC classification number: A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

Abstract translation: 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物“填充”绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。

公开(公告)号：US09101666B2

公开(公告)日：2015-08-11

申请号：US14029552

申请日：2013-09-17

Applicant: Massachusetts Institute of Technology

Inventor： Robert S. Langer ,  David M. Lynn ,  David A. Putnam ,  Mansoor M. Amiji ,  Daniel Griffith Anderson

IPC: A61K47/34 ,  A61K47/48 ,  A61K9/51 ,  C08G73/02 ,  C08G73/06 ,  C12N15/88 ,  B82Y5/00

CPC classification number: A61K47/34 ,  A61K9/5146 ,  A61K31/711 ,  A61K31/713 ,  A61K47/59 ,  A61K47/593 ,  A61K47/6929 ,  B82Y5/00 ,  C08G63/685 ,  C08G73/02 ,  C08G73/0273 ,  C08G73/06 ,  C08G73/0611 ,  C08G73/0616 ,  C12N15/88

Abstract: Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

Abstract translation: 描述了从双（仲胺）或伯胺向双（丙烯酸酯）共轭加成制备的聚（＆（bgr。 - 氨基酯））。 还提供了从市售的原料制备这些聚合物的方法。 这些含叔胺的聚合物优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。 鉴于这些聚合物的聚（胺）性质，它们特别适用于递送多核苷酸。 已经制备了含有聚合物/多核苷酸复合物的纳米颗粒。 本发明的聚合物也可以用于包封待递送的其它试剂。 考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

公开(公告)号：US20150144259A1

公开(公告)日：2015-05-28

申请号：US14405917

申请日：2013-06-06

Applicant: The Brigham and Women s Hospital, Inc. ,  Massachusetts Institute of Technology

Inventor： Bryan Laulicht ,  Jeffrey M. Karp ,  Robert S. Langer

IPC: A61F13/02 ,  B32B38/10 ,  B32B37/26 ,  C09J7/02 ,  B29C65/50

CPC classification number: A61F13/024 ,  A61F13/0246 ,  A61F13/025 ,  A61F13/0253 ,  A61F13/0256 ,  A61F13/0259 ,  A61F13/0269 ,  A61F2013/00412 ,  A61F2013/00676 ,  A61F2013/00685 ,  A61F2013/00702 ,  A61F2013/0071 ,  A61F2013/00748 ,  A61F2013/008 ,  A61F2013/00804 ,  A61F2013/00838 ,  A61F2013/15569 ,  B29C65/5021 ,  B32B37/26 ,  B32B38/10 ,  B32B2037/268 ,  C09J7/255 ,  C09J2205/302 ,  C09J2467/006 ,  Y10T428/24851 ,  Y10T428/2839

Abstract: Methods and compositions for securing to and removing adhesive tapes from substrates, e.g., delicate substrates such as skin, are described. The methods include providing an adhesive tape comprising an adhesive layer and a support layer in contact with the adhesive layer. A first adhesion level between the adhesive layer and the support layer is, or can be controlled to be, less than a second adhesion level between the adhesive layer and the substrate. The methods further include applying the adhesive tape to the substrate by contacting the adhesive layer to the substrate while the support layer remains in contact with the adhesive layer; and removing the support layer from the substrate by separating the support layer from the adhesive layer.

Abstract translation: 描述了用于固定和从胶片上去除粘合带的方法和组合物，例如，诸如皮肤等精细基材。 所述方法包括提供包含粘合剂层和与粘合剂层接触的支撑层的胶带。 粘合剂层和支撑层之间的第一粘合水平是或可以被控制为小于粘合剂层和基材之间的第二粘合水平。 所述方法还包括通过在粘合剂层与粘合剂层保持接触的同时使粘合​​剂层与基材接触而将粘合带施加到基材上; 以及通过从粘合剂层分离支撑层而从支撑层移除支撑层。

公开(公告)号：US20150104515A1

公开(公告)日：2015-04-16

申请号：US14277977

申请日：2014-05-15

Applicant: Massachusetts Institute of Technology

Inventor： David A. Edwards ,  Robert S. Langer ,  Rita Vanbever ,  Jeffrey D. Mintzes ,  Jue Wang ,  Donghao Chen

IPC: A61K9/00 ,  A61K47/24 ,  A61K31/137 ,  A61K47/18 ,  A61K31/566 ,  A61K38/28 ,  A61K47/12

CPC classification number: A61K9/0073 ,  A61K9/0075 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1658 ,  A61K9/1694 ,  A61K31/135 ,  A61K31/137 ,  A61K31/566 ,  A61K38/28 ,  A61K38/38 ,  A61K47/12 ,  A61K47/183 ,  A61K47/24 ,  A61K47/6927

Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

公开(公告)号：US20140234938A1

公开(公告)日：2014-08-21

申请号：US13771565

申请日：2013-02-20

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Robert S. Langer ,  Daniel S. Kohane ,  Aoune Barhoumi

IPC: A61N5/06 ,  C12N13/00

CPC classification number: A61N5/062

Abstract: Systems and methods for the activation of species and/or the delivery of species to a target environment using harmonic generation materials are generally described.

Abstract translation: 通常描述使用谐波发生材料激活物种和/或物种传递到目标环境的系统和方法。