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    ANALYTICAL DEVICES HAVING COMPACT LENS TRAIN ARRAYS
    121.
    发明申请
    ANALYTICAL DEVICES HAVING COMPACT LENS TRAIN ARRAYS 有权
    具有紧凑型镜头火腿阵列的分析装置

    公开(公告)号：US20150024968A1

    公开(公告)日：2015-01-22

    申请号：US14289905

    申请日：2014-05-29

    Applicant: Pacific Biosciences of California, Inc.

    Inventor： Aaron Rulison ,  Mark McDonald ,  Paul Lundquist

    IPC: G01N21/75

    CPC classification number: G01N21/6452 ,  C12Q1/6874 ,  G01J3/2803 ,  G01J3/36 ,  G01N21/6428 ,  G01N21/75 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/0633 ,  G02B3/0056 ,  G02B3/0062 ,  G02B5/045 ,  G02B13/006 ,  G02B13/0065 ,  G02B13/0085 ,  G02B27/1013

    Abstract: Apparatus, systems and methods for use in analyzing discrete reactions are provided. The analytical devices of the invention use an array of nanoscale regions (a chip) that has discrete patches of nanoscale regions. The chip mates with a collection device comprising an array of compact lens trains (CLTs) where each of the CLTs corresponds to a single patch of nanoscale regions. Each CLT collects the emitted light from a patch on the chip, collimates the light, performs color separation on the collimated emitted light, and focuses the separated light onto a portion of pixels on the detector below the CLT. Such systems are useful for monitoring many analytical reactions at one time including single molecule sequencing reactions.

    Abstract translation: 提供了用于分析离散反应的装置，系统和方法。 本发明的分析装置使用具有分散的纳米尺度区域的纳米尺度区域（芯片）阵列。 该芯片与包括紧凑型透镜列阵列（CLT）的收集装置配合，其中每个CLT对应于单个纳米尺度区域。 每个CLT收集来自芯片上的贴片的发射光，准直光，在准直发射的光上进行颜色分离，并将分离的光聚焦到CLT下方的检测器上的像素部分上。 这样的系统可用于一次监测许多分析反应，包括单分子测序反应。

    PARTICLE DETECTORS
    122.
    发明申请
    PARTICLE DETECTORS 有权
    颗粒检测器

    公开(公告)号：US20140340892A1

    公开(公告)日：2014-11-20

    申请号：US14451330

    申请日：2014-08-04

    Applicant: Xtralis Technologies Ltd

    Inventor： Ron Knox ,  Karl Boettger ,  Kemal Ajay

    IPC: F21K99/00 ,  G01N21/53

    CPC classification number: G01N21/53 ,  F21K9/00 ,  G01N15/0205 ,  G01N15/10 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/538 ,  G01N2201/061 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0627 ,  G01N2201/0633 ,  G01N2201/0696

    Abstract: A beam detector including a light source, a receiver, and a target, acting in cooperation to detect particles in a monitored area. The target reflects incident light, resulting in reflected light being returned to receiver. The receiver is capable of recording and reporting light intensity at a plurality of points across its field of view. In the preferred form the detector emits a first light beam in a first wavelength band; a second light beam in a second wavelength band; and a third light beam in a third wavelength band, wherein the first and second wavelengths bands are substantially equal and are different to the third wavelength band.

    Abstract translation: 一种包括光源，接收器和目标的光束检测器，其协同作用以检测被监视区域中的微粒。 目标反射入射光，导致反射光返回到接收器。 接收机能够在整个视场的多个点上记录和报告光强度。 在优选形式中，检测器发射第一波长带中的第一光束; 在第二波长带中的第二光束; 以及第三波长带中的第三光束，其中所述第一和第二波长带基本相等并且与所述第三波长带不同。

    Particle detectors
    123.
    发明授权
    Particle detectors 有权
    粒子探测器

    公开(公告)号：US08797531B2

    公开(公告)日：2014-08-05

    申请号：US13318309

    申请日：2010-05-03

    Applicant: Ron Knox ,  Karl Boettger ,  Kemal Ajay

    Inventor： Ron Knox ,  Karl Boettger ,  Kemal Ajay

    IPC: G01N21/00 ,  G01N15/02 ,  G01N15/14 ,  G01N21/53

    CPC classification number: G01N21/53 ,  F21K9/00 ,  G01N15/0205 ,  G01N15/10 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/538 ,  G01N2201/061 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0627 ,  G01N2201/0633 ,  G01N2201/0696

    Abstract: A beam detector (10) including a light source (32), a receiver (34), and a target (36), acting in co-operation to detect particles in a monitored area (38). The target (36), reflects incident light (40), resulting in reflected light (32) being returned to receiver (34). The receiver (34) is a receiver is capable of recording and reporting light intensity at a plurality of points across its field of view. In the preferred form the detector (10) emits a first light beam (3614) in a first wavelength band; a second light beam (3618) in a second wavelength band; and a third light beam (3616) in a third wavelength band, wherein the first and second wavelengths bands are substantially equal and are different to the third wavelength band.

    Abstract translation: 一种包括光源（32），接收器（34）和目标（36）的光束检测器（10），用于协调以检测被监视区域（38）中的颗粒。 目标（36）反射入射光（40），导致反射光（32）返回到接收器（34）。 接收器（34）是能够在其视场上的多个点处记录和报告光强度的接收器。 在优选形式中，检测器（10）发射第一波长带中的第一光束（3614） 在第二波长带中的第二光束（3618）; 以及第三波长带中的第三光束（3616），其中所述第一和第二波长带基本相等并且与所述第三波长带不同。

    HANDHELD LIBS SPECTROMETER
    124.
    发明申请
    HANDHELD LIBS SPECTROMETER 有权
    手持式射线光谱仪

    公开(公告)号：US20140204377A1

    公开(公告)日：2014-07-24

    申请号：US14179670

    申请日：2014-02-13

    Applicant: SciAps, Inc.

    Inventor： David R. Day ,  Konstantin Derman ,  John Francis Egan ,  Paul Edward Soucy

    IPC: G01J3/443

    CPC classification number: G01J3/0272 ,  G01J3/0208 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/443 ,  G01J2003/2879 ,  G01N21/718 ,  G01N2201/0221 ,  G01N2201/06113 ,  G01N2201/0633

    Abstract: A handheld LIBS spectrometer includes an optics stage movably mounted to a housing and including a laser focusing lens and a detection lens. One or more motors advance and retract the optics stage, move the optics stage left and right, and/or move the optics stage up and down. A laser source in the housing is oriented to direct a laser beam to the laser focusing lens. A spectrometer subsystem in the housing is configured to receive electromagnetic radiation from the detection lens and to provide an output. A controller subsystem is responsive to the output of the spectrometer subsystem and is configured to control the laser source and motors. In this way, auto-calibration, auto-clean, and auto-focus, and/or moving spot functionality is possible.

    Abstract translation: 手持式LIBS光谱仪包括可移动地安装到壳体并包括激光聚焦透镜和检测透镜的光学台。 一个或多个电机推进和缩回光学平台，左右移动光学台，和/或上下移动光学平台。 壳体中的激光源被定向成将激光束引导到激光聚焦透镜。 外壳中的光谱仪子系统被配置为从检测透镜接收电磁辐射并提供输出。 控制器子系统响应于光谱仪子系统的输出，并被配置为控制激光源和电动机。 这样就可以进行自动校准，自动清理和自动对焦，和/或移动点功能。

    Optical device components
    128.
    发明授权
    Optical device components 有权
    光器件组件

    公开(公告)号：US07961305B2

    公开(公告)日：2011-06-14

    申请号：US12256028

    申请日：2008-10-22

    Applicant: Zhi Xu ,  Robert D. Rosenthal

    Inventor： Zhi Xu ,  Robert D. Rosenthal

    IPC: G01N33/48

    CPC classification number: G01N21/474 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/1455 ,  G01N2201/0633

    Abstract: Embodiments of the invention relate to an internal reflection light funnel, including an internal reflection cone having a first diameter at an entrance end and a second diameter at an exit end, the first diameter being greater than the second diameter; and a light source embedded within the cone. The funnel has a half angle of less than about 25 degrees.

    Abstract translation: 本发明的实施例涉及一种内反射光漏斗，其包括在入射端具有第一直径且在出射端具有第二直径的内反射锥体，第一直径大于第二直径; 以及嵌入锥体内的光源。 漏斗的半角小于约25度。

    Combination reader
    130.
    发明申请
    Combination reader 失效
    组合阅读器

    公开(公告)号：US20050269530A1

    公开(公告)日：2005-12-08

    申请号：US11188243

    申请日：2005-07-22

    Applicant: Mark Oldham ,  Howard King ,  Douwe Haga ,  Tracy Ferea

    Inventor： Mark Oldham ,  Howard King ,  Douwe Haga ,  Tracy Ferea

    IPC: G01N21/64 ,  G01V8/00

    CPC classification number: G01N21/76 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0633 ,  G01N2201/0634

    Abstract: An apparatus for imaging an array of a plurality of features associated with a sample tile. The apparatus can comprise a stage that supports the sample tile in an illumination region, and an illumination source having a plurality of LEDs adapted to emit light. At least a portion of the light can illuminate the illumination region. Additionally, the apparatus can comprise an image collecting device adapted to selectively collect images of either a first signal when the illumination source is illuminating the illumination region, or a second signal absent illumination of the illumination region. The first signal can have wavelengths effectively different from the wavelengths of the portion of the light emitted by the LEDs that illuminates the illumination region.

    Abstract translation: 一种用于对与样本瓦片相关联的多个特征的阵列进行成像的装置。 该装置可以包括在照明区域中支撑样品瓦片的平台和具有适于发光的多个LED的照明源。 光的至少一部分可以照亮照明区域。 另外，该装置可以包括图像采集装置，适于当照明源照射照明区域时选择性地收集第一信号的图像，或者不存在照明区域的照明的第二信号。 第一信号可以具有与照亮照明区域的LED发射的光的部分的波长有效地不同的波长。

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