公开(公告)号：US12216101B2

公开(公告)日：2025-02-04

申请号：US17620035

申请日：2020-06-16

Applicant: Cytiva Sweden AB

Inventor： Ana Stern

IPC: G01N30/86 ,  B01D15/34

Abstract: The present invention relates to a computer implemented method (600) performed by a chromatography apparatus (400) configured to separate molecules, having varying size, from an eluent, the method comprising obtaining (610) reference data for a chromatography column of the chromatography apparatus, wherein the reference data is indicative of elution characteristics for a set of molecular sizes, obtaining (620) an elution progress measure and a corresponding quantitative measure indicative of a concentration of molecules in an eluate of the chromatograph) apparatus, estimating (630) a size measure indicative of molecular size of the molecules in the eluate, rendering (640) a representation (300) indicative of the quantitative measure and the size measure, controlling (650) a display to display the representation to a user of the chromatography apparatus.

公开(公告)号：US12209235B2

公开(公告)日：2025-01-28

申请号：US16328431

申请日：2017-08-28

Applicant: CYTIVA SWEDEN AB

Inventor： Klaus Gebauer ,  Pierre Le Greves ,  Andrew David Pris ,  Jozsef Vasi ,  Sam Petrocelli ,  Hanno Ehring ,  Esmaeil Heidari ,  Ali Can

IPC: C12M1/21 ,  C12M1/00 ,  C12M1/36

Abstract: A device and method for detecting the level of foam in a reactor vessel monitors the intensity of the light or the movement of the light detected by a camera which monitors at least one light source positioned inside the reactor vessel or viewable through the reactor vessel.

公开(公告)号：US12152698B2

公开(公告)日：2024-11-26

申请号：US18462316

申请日：2023-09-06

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer

IPC: F16K7/04 ,  F16K7/12 ,  F16K31/12 ,  F16K31/122 ,  F16K31/126

Abstract: A valve configured to be in a first state, which is an open state when a flow through the tube should be allowed; a second state during some parts of a process run in the system, said second state is a closed state were a first closing force is provided; and a third state during some parts of a process run in the system, said third state is a closed state were a second closing force is provided which is a higher force than the first closing force.

公开(公告)号：US12110481B2

公开(公告)日：2024-10-08

申请号：US16607516

申请日：2018-04-18

Applicant: Cytiva Sweden AB

Inventor： Victor Jose ,  Andreas Axen ,  Klaus Gebauer ,  Veena B N Rao ,  Patric Fricking ,  Hanish Lakhani

IPC: C12M1/36 ,  C12M1/00 ,  G16H10/40

CPC classification number: C12M41/48 ,  C12M23/26 ,  C12M23/28 ,  G16H10/40

Abstract: A bio-processing system (100) is presented. The bio-processing system (100) includes one or more bio-processing units (110-114), one or more process supporting devices (116, 118), one or more sensors (120-132), and a bio-processing workflow controller (104) wirelessly coupled to at least one of the one or more bio-processing units (110-114), the one or more process supporting devices (116, 118), and the one or more sensors (120-132). The bio-processing workflow controller (104) includes a processor (202) configured to create a reconfigurable bio-processing workflow, and where the reconfigurable bio-processing workflow is representative of an arrangement of one or more of the one or more bio-processing units (110-114), the one or more process supporting devices (116, 118), and the one or more sensors (120-32) to perform at least one bio-processing operation.

公开(公告)号：US12084645B2

公开(公告)日：2024-09-10

申请号：US16301150

申请日：2017-05-11

Applicant: CYTIVA SWEDEN AB

Inventor： Klaus Gebauer ,  Thomas Erik Arctaedius ,  Patrick Jonsson ,  Andreas Marcstrom

IPC: C12M3/00 ,  C12M1/00

CPC classification number: C12M23/40 ,  C12M23/14 ,  C12M23/26 ,  C12M23/28 ,  C12M23/48

Abstract: The invention discloses a hollow profile wall segment (1) for a bioreactor or mixer support vessel (2;2a;2b), comprising a base profile (3) with two parallel wide sides (4,5), two narrow sides (6,7) and at least one heat exchange channel (8) extending in a longitudinal direction of the base profile through an interior space (9) in the base profile, wherein the hollow profile wall segment is adapted to be joined with similar hollow profile wall segments to form a side wall (12) of a bioreactor or mixer support vessel (2) and wherein each narrow side comprises at least one coupling member (10,11;11a;150) capable of securing the hollow profile wall segment side by side with similar hollow profile wall segments.

公开(公告)号：US12072344B2

公开(公告)日：2024-08-27

申请号：US18131043

申请日：2023-04-05

Applicant: Cytiva Sweden AB

Inventor： Johan Blomberg ,  Mats Lundkvist

IPC: G01N35/10 ,  B01D15/10 ,  B01D29/60 ,  G01N30/24 ,  G01N30/38 ,  G01N30/88 ,  B01D15/08 ,  B01D17/12 ,  G01N30/02 ,  G01N35/00

CPC classification number: G01N35/1097 ,  B01D15/10 ,  B01D29/60 ,  G01N30/24 ,  G01N30/38 ,  G01N30/88 ,  B01D15/08 ,  B01D17/12 ,  B01D2201/54 ,  G01N2030/027 ,  G01N2030/8804 ,  G01N2030/8881 ,  G01N2035/00326 ,  Y10T137/6416 ,  Y10T137/6525 ,  Y10T137/6851 ,  Y10T137/85986 ,  Y10T137/87885

Abstract: Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.

公开(公告)号：US11981887B2

公开(公告)日：2024-05-14

申请号：US18174322

申请日：2023-02-24

Applicant: Cytiva Sweden AB

Inventor： Andreas Andersson ,  Lars Johan Carlsson ,  Christian Elnegard ,  Henrik K. Eriksson ,  Thomas Falkman ,  Patric Fricking ,  Linnea Troeng ,  Claes Peterson

IPC: C12M1/00 ,  B01F31/23 ,  B01F35/513 ,  C12M3/06

CPC classification number: C12M27/16 ,  B01F31/23 ,  B01F35/513 ,  C12M23/14 ,  C12M23/50

Abstract: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).

公开(公告)号：US20240150697A1

公开(公告)日：2024-05-09

申请号：US18550075

申请日：2022-04-25

Applicant: CYTIVA SWEDEN AB

Inventor： Klaus Gebauer ,  Tim Francois ,  Andreas Lundin ,  Bjorn Markus Olovsson ,  Kerstin Erickson ,  Tomas Dalmo

IPC: C12M1/00 ,  C12M1/36 ,  C12M3/00

CPC classification number: C12M23/40 ,  C12M23/28 ,  C12M23/44 ,  C12M29/04 ,  C12M29/06 ,  C12M41/48

Abstract: The present invention relates to a reconfigurable bioprocessing system (80) operable to perform a predetermined set of bioprocessing operations therein. The reconfigurable bioprocessing system (80) comprises a base unit (60) comprising a plurality of valve actuators (102). At least one of the plurality of valve actuators (102) is operable to releasably engage with at least part of a pinch valve cassette (103, 203) to control fluid flow through the pinch valve cassette (103, 203). At least part of the pinch valve cassette (103, 203) is removably attachable to the base unit (60) and the pinch valve cassette (103, 203) is provided adjacent to said plurality of valve actuators (102). The reconfigurable bioprocessing system (80) also includes a control system operable to selectively actuate respective of said plurality of valve actuators (102) to provide a valve configuration within the pinch valve cassette (103, 203) to enable the base unit (60) and the pinch valve cassette (103, 203) together to perform one of the predetermined set of bioprocessing operations. A flow kit (107) for use in reconfigurable bioprocessing systems (80) and various methods (1000) for reconfiguring bioprocessing systems (80) (e.g. automatically) are also disclosed.

公开(公告)号：US11969669B2

公开(公告)日：2024-04-30

申请号：US17690975

申请日：2022-03-09

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer

IPC: G01N30/56 ,  B01D15/20 ,  B01D15/22 ,  C07K1/14 ,  C07K1/18 ,  C07K1/20 ,  C07K1/22 ,  G01N30/60

CPC classification number: B01D15/206 ,  B01D15/22 ,  C07K1/14 ,  C07K1/18 ,  C07K1/20 ,  C07K1/22 ,  G01N30/56 ,  G01N30/6017 ,  G01N30/6069 ,  G01N2030/562 ,  G01N30/6082 ,  G01N30/6086

Abstract: The invention relates to containers or bags for chromatographic media and methods of packing chromatography columns using such containers. The bags may be used for storing and/or transporting chromatographic media and can be inserted directly into the chamber of a chromatography column in readiness for use.

公开(公告)号：US20240027337A1

公开(公告)日：2024-01-25

申请号：US18481117

申请日：2023-10-04

Applicant: Cytiva Sweden AB

Inventor： Mikael Anders Hornqvist

IPC: G01N21/33 ,  G01N21/05 ,  G01N30/74 ,  G01N21/85

CPC classification number: G01N21/33 ,  G01N21/05 ,  G01N30/74 ,  G01N21/8507 ,  G01N2021/3125

Abstract: Disclosed is a method for measuring the absorbance of light of a substance in a solution in a measuring cell, said method comprising the steps of: transmitting a first light beam from a light source towards a beam splitter; dividing the first light beam into a signal light ray and a reference light ray by the beam splitter; modulating the signal light ray; modulating the reference light ray; providing the measuring cell such that the signal light ray passes through the measuring cell; detecting a signal in a detector, which signal is the combined signal intensity of the signal light ray and the reference light ray detected by the detector; performing synchronous detection of the detected signal in order to reconstruct the intensities of the signal light ray and the reference light ray from the combined signal detected by the detector, said synchronous detection being based on the modulation performed to the signal light ray and the reference light ray. Disclosed also is a measuring device for carrying out said method