公开(公告)号：US20180125875A1

公开(公告)日：2018-05-10

申请号：US15126777

申请日：2015-03-17

Applicant: Hiroshi Ide ,  STC.UNM

Inventor： Yoshihiro Matsumoto ,  Alan Edward Tomkinson ,  Hiroshi Ide

IPC: A61K31/7072 ,  A61K31/513 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61K31/7072 ,  A61K31/337 ,  A61K31/4184 ,  A61K31/44 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/513 ,  A61K31/519 ,  A61K31/55 ,  A61K31/555 ,  A61K31/675 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K33/24 ,  A61K38/14 ,  A61K45/06 ,  A61K2300/00 ,  A61P35/00

Abstract: In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant cancer) by administering to the subject a therapeutically effective amount of (a) 5-formyl-2′-deoxyuridine (fdU or foUdR) or a 5-formyl-2′-deoxyuridine derivative, optionally in combination with 5-hydroxy-2′-deoxyuridine (hUdR); and (b) at least one composition selected from the group consisting of either 5-fluorouracil (5-FU), a 5-FU prodrug (e.g. 5-fluoro-2′-deoxyuridine (FdU)) or 5-FU metabolite. In a preferred embodiment, a subject who suffers from colorectal cancer (CRC) or metastatic colorectal cancer (mCRC) is treated with a therapeutically-effective amount of fdU and either 5-FU or the 5-FU prodrug 5-fluoro-2′-deoxyuridine (FdU). Related pharmaceutical compositions are also provided.

公开(公告)号：US09966728B2

公开(公告)日：2018-05-08

申请号：US15410406

申请日：2017-01-19

Applicant: STC.UNM

Inventor： Ravinder K. Jain

IPC: H01S3/30 ,  H01S3/102 ,  H01S3/105 ,  H01S3/094 ,  G02B6/02 ,  H01S3/10

CPC classification number: H01S3/302 ,  G02B6/02138 ,  G02B6/02142 ,  H01S3/0675 ,  H01S3/08086 ,  H01S3/094042 ,  H01S3/094046 ,  H01S3/094096 ,  H01S3/09415 ,  H01S3/1003 ,  H01S3/1028 ,  H01S3/1053

Abstract: Improved Raman Fiber Laser (RFL) generators may include a mid-infrared fiber, e.g., a fiber comprising a tellurite glass, a chalcogenide glass, a fluoride glass, or similar material. A phase-shifted fiber Bragg grating may be inscribed in the fiber. A pump laser generator may be coupled with the fiber in order to supply a pump laser to the fiber. When stimulated by the pump laser, the RFL generator may emit an output laser having a mid-infrared wavelength. A tuner may be used to tune the output laser.

公开(公告)号：US09958252B1

公开(公告)日：2018-05-01

申请号：US15642911

申请日：2017-07-06

Applicant: STC.UNM

Inventor： Jean-Claude Diels ,  Ladan Arissian

IPC: G01B9/02 ,  H01S3/106 ,  H01S3/108 ,  G02F1/39 ,  H01S3/067 ,  H01S3/086

CPC classification number: G01B9/02049 ,  G01B9/02015 ,  G02F1/39 ,  H01S3/0014 ,  H01S3/06712 ,  H01S3/082 ,  H01S3/086 ,  H01S3/106 ,  H01S3/1062 ,  H01S3/1083 ,  H01S3/1118

Abstract: Apparatus, systems, and methods of operating a fiber laser having polarization-preserving fibers can be applied as a sensor to detect a physical quantity. In various embodiments, polarization-preserving fibers can provide a laser cavity having an interferometer disposed in the laser cavity. In various embodiments, a fiber optical parametric oscillator can include an interferometer disposed in the cavity of the optical parametric oscillator. Additional apparatus, systems, and methods are disclosed.

公开(公告)号：US20180110831A1

公开(公告)日：2018-04-26

申请号：US15557000

申请日：2016-03-09

Applicant: STC.UNM

Inventor： C. Jeffrey Brinker ,  Eric C. Carnes ,  Carlee Erin Ashley ,  Jacob Ongundi Agola ,  Kimberly Butler ,  Christophe Theron

IPC: A61K38/17 ,  A61K47/64 ,  A61K47/69 ,  A61K9/51 ,  C07K14/705

CPC classification number: A61K38/1774 ,  A61K9/127 ,  A61K9/5115 ,  A61K9/5123 ,  A61K47/6425 ,  A61K47/6911 ,  B82Y5/00 ,  C07K14/70546

Abstract: The present invention is directed to protocells, which have a core and a lipid bilayer surrounding the core, with at least one CD47 molecule or an active fragment thereof in or conjugated to the lipid bilayer. The CD47 present on the lipid bilayer allows the protocell to evade phagocytosis by macrophages, and can be conjugated to the lipid bilayer via a crosslinker. The protocell can be loaded with a diagnostic or therapeutic cargo, such as a polypeptide, a nucleic acid, or a drug. The protocell can also include a targeting species for targeted delivery of the cargo to a cell. The protocell can also include an endosomolytic peptide, which promotes endosomal escape after uptake by the targeted cell. The protocells with CD47 on the lipid bilayer provide better circulation after in vivo administration compared to protocells without CD47, and are therefore particularly useful as a cargo delivery vehicle.

公开(公告)号：US09898249B2

公开(公告)日：2018-02-20

申请号：US14433146

申请日：2013-10-08

Applicant: STC.UNM

Inventor： Panaiotis

IPC: G10H1/36 ,  G06F3/16 ,  G06F3/01 ,  G06F9/44

CPC classification number: G06F3/167 ,  G06F3/011 ,  G06F3/017 ,  G06F8/38

Abstract: The invention is directed to a system and methods allowing a user to interact with one or more data applications—including for example, games, music, music composition and tactile stimulation—to simulate real-time multisensory output. The invention includes a music program, a music texture program and a simulation program.

公开(公告)号：US09869669B2

公开(公告)日：2018-01-16

申请号：US14380350

申请日：2013-03-15

Applicant: STC.UNM

Inventor： Sang M. Han ,  Cornelius F. Ivory ,  Mani Hossein-Zadeh

IPC: B01L3/00 ,  G01N21/75 ,  G01N33/53 ,  G01N21/77 ,  G01N33/543

CPC classification number: G01N33/5302 ,  B01L3/502753 ,  G01N21/75 ,  G01N21/7746 ,  G01N33/54373 ,  G01N33/5438 ,  G01N2021/755

Abstract: Provided is a sensor platform that includes a substrate, a plurality of nanochannels disposed on the substrate, and a plurality of electrodes, a waveguide disposed on the substrate and an analysis chamber and a reference chamber disposed on the substrate. Each electrode extends substantially across a width of the plurality of nanochannels. At least one analysis optical resonator is disposed in the analysis chamber and is optically coupled to at least a portion of the waveguide. The at least one analysis optical resonator is in fluid communication with at least one of the plurality of nanochannels. At least one reference optical resonator is disposed in the reference chamber and is optically coupled to at least a portion of the waveguide. The at least one reference optical resonator is in fluid communication with at least one other of the plurality of nanochannels.

公开(公告)号：US20170364709A1

公开(公告)日：2017-12-21

申请号：US15534116

申请日：2015-12-15

Applicant: STC.UNM

Inventor： James PLUSQUELLIC

IPC: G06F21/73 ,  G06F21/60 ,  G06F21/71 ,  G06F21/70 ,  G06F17/18

CPC classification number: G06F21/73 ,  G06F17/18 ,  G06F21/604 ,  G06F21/70 ,  G06F21/71 ,  G09C1/00 ,  H04L9/3278

Abstract: A Hardware-Embedded Delay Physical Unclonable Function (“HELP PUF”) leverages entropy by monitoring path stability and measuring path delays from core logic macros. Reliability and security enhancing techniques for the HELP PUF reduce bit flip errors during regeneration of the bitstring across environmental variations and improve cryptographic strength along with the corresponding difficulty of carrying out model building attacks. A voltage-based enrollment process screens unstable paths on normally synthesized (glitchy) functional units and reduces bit flip errors by carrying out enrollment at multiple supply voltages controlled using on-chip voltage regulators.

公开(公告)号：US09763967B2

公开(公告)日：2017-09-19

申请号：US14561787

申请日：2014-12-05

Applicant: Ball State Innovation Corporation ,  STC.UNM

Inventor： Susan A. McDowell ,  Robert E. Sammelson ,  Larry A. Sklar ,  Mark K. Haynes

IPC: A61K31/415 ,  A61K31/63 ,  A61K31/635

CPC classification number: A61K31/635

Abstract: The present disclosure relates to molecules which function as selective modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases and, in particular, CDC42 GTPase, and their use to treat bacterial infection including systemic infection from sources such as Staphylococcus aureus and Streptococcus pyogenes.

公开(公告)号：US20170256405A1

公开(公告)日：2017-09-07

申请号：US15599376

申请日：2017-05-18

Applicant: STC.UNM

Inventor： Seung-Chang Lee ,  Steven R.J. Brueck

IPC: H01L21/02 ,  H01L29/267

CPC classification number: H01L21/02513 ,  C30B7/005 ,  C30B23/025 ,  C30B25/04 ,  C30B25/18 ,  C30B25/183 ,  C30B29/40 ,  C30B29/42 ,  H01L21/02381 ,  H01L21/02433 ,  H01L21/02455 ,  H01L21/02458 ,  H01L21/02505 ,  H01L21/02538 ,  H01L21/02546 ,  H01L21/02636 ,  H01L21/02642 ,  H01L21/02647 ,  H01L29/0665 ,  H01L29/0688 ,  H01L29/267

Abstract: Exemplary embodiments provide materials and methods of forming high-quality semiconductor devices using lattice-mismatched materials. In one embodiment, a composite film including one or more substantially- single- particle-thick nanoparticle layers can be deposited over a substrate as a nanoscale selective growth mask for epitaxially growing lattice-mismatched materials over the substrate.

公开(公告)号：US20170247754A1

公开(公告)日：2017-08-31

申请号：US15443138

申请日：2017-02-27

Applicant: STC.UNM

Inventor： Jeremy Edwards ,  Payman Zarkesh-Ha ,  Steven R.J. Brueck

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6874 ,  G01N27/414 ,  G01N27/4145 ,  Y10T436/143333 ,  C12Q2531/125 ,  C12Q2535/122

Abstract: This disclosure describes, in one aspect, a method for preparing DNA molecule for sequencing. Generally, the method includes fragmenting the DNA molecule into double-stranded fragments; amplifying at least a portion of the double-stranded fragments; circularizing the fragments so that the first end of the fragment comprises a first loop connecting the strands and the second end of the fragment comprises a second loop connecting the strands; annealing a first sequencing primer to the first loop oriented to sequence at least a portion of one strand of the fragment; and annealing a second sequencing primer to the second loop oriented to sequence at least a portion of the other strand of the fragment. In another aspect, this disclosure describes a method for sequencing a DNA molecule. Generally, the method includes fragmenting the DNA molecule into double-stranded fragments; amplifying at least a portion of the double-stranded fragments; circularizing the fragments so that the first end of the fragment comprises a first loop connecting the strands and the second end of the fragment comprises a second loop connecting the strands; and sequencing at least one of the DNA strands.