公开(公告)号：US20180180541A1

公开(公告)日：2018-06-28

申请号：US15577091

申请日：2016-05-27

Applicant: NIPRO CORPORATION ,  HARADA ELECTRONICS INDUSTRY CO., LTD.

Inventor： Yoshihiko SANO ,  Masahide HARADA

IPC: G01N21/59 ,  G01N33/49

CPC classification number: G01N21/59 ,  G01N21/05 ,  G01N21/85 ,  G01N33/4915 ,  G01N2021/0364 ,  G01N2201/0612 ,  G01N2201/0621 ,  G01N2201/0639

Abstract: A transmitted light intensity measurement unit for measuring a concentration of fluid flowing through a duct comprises: a light source for supplying light into the duct from a light supply part on a surface of the duct; a light receiving element for receiving the light, which has been passed from the light supply part through the duct wall and the fluid inside the duct, at a light receiving part located on an opposite side in a diametrical direction of the duct relative to the light supply part, and outputs a signal indicating an intensity of the light; and a light-transmissive member disposed on at least one light path among a light pass between the light source and the light supply part and a light pass between the light receiving element and the light receiving part, abutting and closely contacting the duct wall by an elastic deformation of the duct wall.

公开(公告)号：US09987409B2

公开(公告)日：2018-06-05

申请号：US14722756

申请日：2015-05-27

Applicant: Nipro Corporation

Inventor： Kimihiro Mabuchi ,  Noriko Monden ,  Noriaki Kato ,  Yuuki Hatakeyama ,  Takashi Sunohara ,  Toshiaki Masuda

IPC: B01D39/00 ,  B01D39/14 ,  A61M1/16 ,  A61L2/08 ,  B01D65/02 ,  B01D67/00 ,  B01D71/68 ,  B01D69/08

CPC classification number: A61M1/168 ,  A61L2/087 ,  A61L2202/22 ,  A61M1/16 ,  A61M1/1682 ,  A61M1/169 ,  A61M2209/06 ,  B01D65/022 ,  B01D67/0011 ,  B01D67/0097 ,  B01D69/08 ,  B01D71/68 ,  B01D2321/34 ,  B01D2323/34 ,  B01D2325/36 ,  B01D2325/38

Abstract: The invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The blood purifier comprises selectively permeable separation membranes as a main component and is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.

公开(公告)号：US20180148680A1

公开(公告)日：2018-05-31

申请号：US15574530

申请日：2016-05-24

Applicant: Norihisa SASAYAMA ,  Masakatsu TAKEUCHI ,  Atsushi TAGUCHI ,  Nipro Corporation

Inventor： Norihisa Sasayama ,  Masakatsu Takeuchi ,  Atsushi Taguchi

IPC: C12M1/00 ,  B01D63/16 ,  B01D63/04 ,  C12M1/36

CPC classification number: C12M47/02 ,  B01D61/243 ,  B01D63/02 ,  B01D63/04 ,  B01D63/16 ,  B01D2313/06 ,  B01D2313/10 ,  B01D2313/12 ,  B01D2315/02 ,  B01D2315/18 ,  C12M1/10 ,  C12M3/02 ,  C12M3/043 ,  C12M3/06 ,  C12M3/065 ,  C12M23/14 ,  C12M23/42 ,  C12M23/44 ,  C12M23/50 ,  C12M29/04 ,  C12M29/16 ,  C12M41/48

Abstract: A means capable of simply and efficiently concentrating a cell suspension. A concentrator has a culture vessel having a first port and a second port, a server bag having a port, a case having a hollow fiber bundle in the internal space, a filtering device having an inlet port, a first outlet port, and a second outlet port, a collection vessel having a port, a liquid supply circuit connected to the first port, the inlet port, and the server bag's port so that flow passages are switchable, a liquid discharge circuit connected to the second port, the first outlet port, the second outlet port, and the collection vessel's port so that flow passages are switchable, a liquid supply mechanism having a switching mechanism, a supply pump, and a discharge pump, and a rotation mechanism rotating the filtering device.

公开(公告)号：US09968769B2

公开(公告)日：2018-05-15

申请号：US14386461

申请日：2013-01-29

Applicant: NIPRO CORPORATION

Inventor： Norihisa Sasayama ,  Yui Hagiwara ,  Naoko Ishihara

IPC: A61M5/32 ,  A61M39/10 ,  A61M5/315 ,  A61M1/02 ,  A61M5/178

CPC classification number: A61M39/10 ,  A61M1/029 ,  A61M5/178 ,  A61M5/31515 ,  A61M5/3202 ,  A61M5/3275 ,  A61M2005/3268

Abstract: To prevent a user from accidentally pricking the user with a hollow needle when separating blood components using a syringe and a connection device. A blood component separation apparatus has three syringes and a connection device. The connection device is attached to one syringe and is inserted into other syringes. The connection device has a first member to which a base end of a hollow needle is joined and a second member which is connected to the first member in such a manner as to be able to move relative to the first member. The second member is moved back and forth between a first position where a tip of the hollow needle is accommodated and a second position where the tip of the hollow needle is exposed. The second member has elastic portions which are elastically deformed in the movement from the first position to the second position. The elastically deformed elastic portions elastically energize the second member at the second position to the first position side with respect to the first member.

公开(公告)号：US20180127696A1

公开(公告)日：2018-05-10

申请号：US15574516

申请日：2016-05-24

Applicant: NIPRO CORPORATION

Inventor： Masakatsu TAKEUCHI ,  Atsushi TAGUCHI

IPC: C12M3/04 ,  C12M1/10 ,  C12M1/00 ,  C12M1/06 ,  C12M1/38 ,  B01L3/00 ,  C12M3/00 ,  C12M3/02

CPC classification number: C12M3/043 ,  B01L3/50 ,  B01L3/563 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2300/046 ,  C12M1/007 ,  C12M1/065 ,  C12M1/10 ,  C12M1/38 ,  C12M3/02 ,  C12M23/14 ,  C12M23/34 ,  C12M23/42 ,  C12M23/44 ,  C12M23/50 ,  C12M29/00 ,  C12M41/48

Abstract: A compact culture device capable of performing large-scale culture in an aseptic state. A culture device has a culture bag which has ports through which a liquid flows and enables cell culture, a bag holding portion having holding plates holding the culture bag and rotating shafts, a rotation mechanism supporting and rotating the rotating shaft, a liquid supply/discharge mechanism supplying and discharging a liquid to/from the culture bag, and a rotation control portion controlling the rotation of the rotation mechanism. The rotation control portion brings the bag holding portion into a first position in parallel with the approximately horizontal direction according to a first information, brings the bag holding portion into a second position when a culture medium in the culture bag is caused to flow out of the port according to a second information, and brings the bag holding portion into a third position in parallel with the approximately vertical direction at least when a cell suspension in the culture bag is caused to flow out of the port according to a third information.

公开(公告)号：US20180117264A1

公开(公告)日：2018-05-03

申请号：US15573695

申请日：2016-04-26

Applicant: NIPRO CORPORATION

Inventor： Teruhisa HIROBE

IPC: A61M5/34 ,  A61M5/32

CPC classification number: A61M5/34 ,  A61J1/201 ,  A61J1/2096 ,  A61M5/2033 ,  A61M5/28 ,  A61M5/3202 ,  A61M5/3287

Abstract: A drug delivering apparatus includes a drug container, a pre-filled syringe including a cylindrical container having a nozzle portion and an injection needle attachment portion, and a connecting tool configured to allow communication between the inside of the cylindrical container and the inside of the drug container. The connecting tool further includes a nozzle insertion portion. The pre-filled syringe further includes a cap member configured to be detachably fitted on the injection needle attachment portion, the cap member having an opening into which the nozzle insertion portion can be inserted. The injection needle attachment portion has a guiding groove in the inner periphery thereof. In the state where the cap member is fitted on the injection attachment portion, at least a part of the edge of the opening is located on the inner side relative to the bottom portion of the guiding groove.

公开(公告)号：US20180000373A1

公开(公告)日：2018-01-04

申请号：US15543346

申请日：2016-01-12

Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY ,  NIPRO CORPORATION ,  HARADA ELECTRONICS INDUSTRY CO., LTD.

Inventor： Shigeru TADANO ,  Yoshihiko SANO ,  Masahide HARADA

IPC: A61B5/0492 ,  A61B5/00

Abstract: A myoelectric sensor for detecting myoelectric signals which accompany body movement includes: a wearing band that is elastic, expandable, and circular, and that is worn around a limb to surround the limb tightly; myoelectric detection units a plurality of which are disposed in the circumferential direction on the wearing band with intervals therebetween so as to cause each of a plurality of myoelectric detection electrodes to be in close contact with the surface of the limb, and which detect myoelectric signals from corresponding positions on the limb using the myoelectric detection electrodes; and connection cables that electrically connect mutually adjacent myoelectric detection units and thereby transmit the myoelectric signals. The connection cables each include a bent portion, the bent shape of which changes in response to changes in the distance between the mutually adjacent myoelectric detection units.

公开(公告)号：US09814487B2

公开(公告)日：2017-11-14

申请号：US14361197

申请日：2012-11-30

Applicant: NIPRO CORPORATION

Inventor： Yoshiharu Iwase ,  Yutaka Eizumi ,  Kenji Kurokawa

IPC: B24B19/00 ,  A61B17/34 ,  A61B10/02 ,  B24B19/02 ,  A61B8/08 ,  A61B17/00 ,  A61B90/00

CPC classification number: A61B17/3417 ,  A61B8/0841 ,  A61B10/0233 ,  A61B2017/00526 ,  A61B2090/3925 ,  B24B19/009 ,  B24B19/02 ,  B24B19/022 ,  B24B19/028

Abstract: A puncture needle includes a needle tube 1 provided with a spiral groove 3 and wall surfaces 3a and 3b of the spiral groove 3 serve as a surface for reflecting ultrasonic waves. The spiral groove is formed on the peripheral surface of the needle tube such that a grinding stone 2 is brought into contact with the peripheral surface of the needle tube while the needle tube 1 is being moved in its axial direction and rotated.The wall surfaces of the spiral groove formed on the needle tube serve as a reflection surface to change the orientation of the reflection surface in the axial direction of the needle tube according to change in position of the spiral. Therefore, even if a direction in which an ultrasonic wave is applied to the puncture needle is fixed, any portion of the reflection surface changing in orientation can become a surface for reflecting well ultrasonic waves, so that good ultrasonic waves can be obtained. The slant angles of the reflection surfaces in the axial direction of the needle tube can be changed by adjusting the moving speed in the axial direction of the needle tube or the rotation speed.

公开(公告)号：US20170252520A1

公开(公告)日：2017-09-07

申请号：US15058628

申请日：2016-03-02

Applicant: NIPRO CORPORATION ,  Food and Drug Administration

Inventor： Yoshio Higaki ,  Oleg Vesnovsky

IPC: A61M5/32 ,  A61B17/34

CPC classification number: A61M5/3286 ,  A61B17/3417 ,  A61B2017/3454 ,  A61M2205/195

Abstract: The present disclosure relates, according to some embodiments, to a puncture needle that can prevent the occurrence of coring. A puncture needle according to the present disclosure includes a cannula provided with a lumen. The cannula has a blade surface. The blade surface has: a sharp region located on a tip side of the blade surface and provided with a sharp edge on inner and outer circumferences of the blade surface; and a blunt region located on a base end side of the blade surface and provided with a blunt edge on the inner and outer circumferences of the blade surface. A tip of the blade surface is provided with a thick portion formed by a boundary between two surfaces, and the boundary forms an edge.

公开(公告)号：US09751795B2

公开(公告)日：2017-09-05

申请号：US13846428

申请日：2013-03-18

Applicant: NIPRO CORPORATION

Inventor： Hideo Kuwabara ,  Hideki Yamauchi ,  Yoshitaka Ishimi ,  Shinichiro Senga

IPC: C03B23/09 ,  C03B29/02 ,  C03C23/00 ,  A61J1/14

CPC classification number: C03B23/099 ,  A61J1/14 ,  C03B23/006 ,  C03B23/0093 ,  C03B23/09 ,  C03B29/02 ,  C03C23/007

Abstract: A method for producing a vial with low alkali elution by removing a deteriorated region caused by processing on an internal surface of a vial is disclosed. The method involves forming vials from borosilicate glass tubes including a first step of forming a borosilicate glass tube into a cup-shaped body by formation of a bottom of a vial, and a second step of forming the cup-shaped body into the vial by formation of a mouth of the cup-shaped body.