公开(公告)号：US20210091268A1

公开(公告)日：2021-03-25

申请号：US16848175

申请日：2020-04-14

Applicant: Lehigh University ,  Osaka University

Inventor： Volkmar Dierolf ,  Brandon Mitchell ,  Ruoqiao Wei ,  Yasufumi Fujiwara ,  Tomasz Gregorkiewicz ,  Shuhei Ichikawa ,  Jun Tatebayashi ,  Dolf Timmerman

IPC: H01L33/32 ,  H01L33/06 ,  H01L33/12 ,  H01L33/50 ,  H01L25/075 ,  H01L33/08

Abstract: A color tunable light emission diode in which the color tone of the emission color changes by controlling the injection current, which has an active layer sandwiched between a p-type layer and an n-type layer on a substrate, and the active color layer is formed by doping Eu and Mg to an AlGaInN-based material which is GaN, InN, AlN or a mixed crystal of any two or more of them; and a micro LED display, wherein its display unit is formed by integrating image pixels having the above color tunable light emission diode are provided; and a light emitting semiconductor device technology capable of providing an ultra-small and high definition micro LED display can be provided.

公开(公告)号：US10954487B2

公开(公告)日：2021-03-23

申请号：US16071969

申请日：2017-01-20

Applicant: Osaka University

Inventor： Masahiro Kinooka ,  Eiji Nagamori

IPC: C12N5/00 ,  C12M1/00 ,  C12N5/074 ,  C12M1/04 ,  C12M1/34 ,  C12N5/0735

Abstract: Provided is a cell culturing method in which physical stress is reduced and oxygen can be supplied. The invention relates to a cell culturing method including; arranging cells in a dispersed state in a culture medium which is a plastic fluid; and introducing air bubbles into said culture medium.

公开(公告)号：US10942127B2

公开(公告)日：2021-03-09

申请号：US15030183

申请日：2014-10-20

Applicant: OSAKA UNIVERSITY

Inventor： Hiroyuki Yoshikawa ,  Eiichi Tamiya ,  Shuhei Imura

IPC: C12Q1/26 ,  G01N21/17 ,  G01N21/82 ,  G01N33/58 ,  G01N33/535 ,  G01N21/78 ,  G01N21/77

Abstract: The present invention provide a method for detecting a test substance utilizing a color development caused by an enzyme reaction, or a color development caused by a specific interaction such as an antigen-antibody reaction and an enzyme reaction, the test substance being detected rapidly, sensitively and quantitatively without using a spectroscopic measurement device. The method for measuring a concentration of a test substance by the present invention comprises the steps of: generating a peroxide from the test substance; obtaining a polymerized substance by bringing an oxidoreductase for producing a polymerized substance and a substrate of the oxidoreductase for producing a polymerized substance into contact with the peroxide; and irradiating the polymerized substance with light to record a temporal variation information of an intensity of scattered light generated from an irradiation point.

公开(公告)号：US10928433B2

公开(公告)日：2021-02-23

申请号：US15758175

申请日：2016-06-15

Applicant: OSAKA UNIVERSITY

Inventor： Masayuki Abe ,  Hiroshi Toki

IPC: G01R29/08 ,  G01R29/24 ,  G06F17/12 ,  G06F17/13 ,  G06F30/00 ,  G01R19/25

Abstract: It is possible to comprehensively calculate a potential and a current of a transmission line in an electric circuit, a potential and a current of an element, and an electromagnetic field including noise generated from the electric circuit. A computer performs a circuit configuration inputting step of inputting a circuit configuration of a distributed constant circuit and a lumped constant circuit and an initial value of each variable, and a calculating step of obtaining a scalar potential and a current in a multi-conductor transmission line, a scalar potential and a voltage in an element, and an electromagnetic radiation amount by, under the circuit configuration and the initial value, solving a basic equation of a transmission theory using a boundary condition formula at x=0 and w which are the boundary between the distributed constant circuit and the lumped constant circuit.

公开(公告)号：US20210046190A1

公开(公告)日：2021-02-18

申请号：US16965807

申请日：2019-01-30

Applicant: OSAKA UNIVERSITY ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Masaki MORI ,  Hideshi ISHII ,  Masamitsu KONNO ,  Hidetoshi EGUCHI ,  Naotsugu HARAGUCHI ,  Reishi TOSHIYAMA ,  Nobuhiro NISHIYAMA ,  Hiroyasu TAKEMOTO

IPC: A61K47/64 ,  A61P35/00 ,  A61K31/513 ,  A61K31/704 ,  A61K33/243

Abstract: An object to be achieved by the present invention is to provide a technique for enhancing the anticancer effect of ubenimex; in particular, enhancing its anticancer effect on solid cancer. This object can be achieved by a compound containing a chain structure in which a plurality of ubenimex molecules is linked to a chain polymer.

公开(公告)号：US20210038763A1

公开(公告)日：2021-02-11

申请号：US17078115

申请日：2020-10-23

Applicant: OSAKA UNIVERSITY ,  KOKEN CO., LTD

Inventor： Ken NAKATA ,  Yukihiro SATO ,  Daisuke IKEDA ,  Ichiro FUJIMOTO

IPC: A61L27/24 ,  A61L27/58 ,  A61L27/56

Abstract: Provided is a collagen sponge which has compressive strength (stress) equivalent to that of a tissue into which the collagen sponge is to be implanted, has no unevenness in structure and stress, and has a pore structure for allowing cells to infiltrate thereinto. The collagen sponge is obtained by subjecting a collagen dispersion, a collagen solution, or a mixture thereof having a collagen concentration of 50 mg/ml or more to freeze-drying and insolubilization treatment thereafter. The collagen sponge thus obtained has a stress of from 10 kPa to 30 kPa when loaded with 10% strain, has in its surface and inside a pore structure having a mean pore diameter ranging from 50 μm to 400 μm, and has a pore diameter standard deviation equal to or less than 80% of the mean pore diameter.

公开(公告)号：US10889805B2

公开(公告)日：2021-01-12

申请号：US15557477

申请日：2016-03-09

Applicant: National Institutes of Biomedical Innovation, Health and Nutrition ,  Osaka University

Inventor： Hiroyuki Mizuguchi ,  Kazuo Takayama

IPC: C12N5/00 ,  C12N1/00 ,  C12N5/10 ,  G01N33/50 ,  C12N5/071 ,  C12Q1/02

Abstract: Provided is a selective method for inducing differentiation from pluripotent stem cells to enterocyte-like cells. Also provided is an excellent enterocyte-like cell expressing drug-metabolizing enzymes and drug transporters. More specifically, provided is an enterocyte-like cell having properties closer to those of primary enterocytes, which are difficult to acquire. The foregoing is achieved by adding an ALK5 inhibitor (SB431542), Wnt3a, and EGF to a culture system of definitive endoderm cells obtained by differentiation induction from pluripotent stem cells and extending a culture time. The foregoing is also achieved by introducing CDX2 gene and/or FOXA2 gene into the pluripotent stem cells or the definitive endoderm cells. The foregoing is also achieved by overlaying a basement membrane matrix on the enterocyte-like cells.

公开(公告)号：US20210003546A1

公开(公告)日：2021-01-07

申请号：US16977918

申请日：2019-03-08

Applicant: MANDOM CORPORATION ,  OSAKA UNIVERSITY ,  NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION

Inventor： Manami Toriyama ,  Fumitaka Fujita ,  Fumihiro Okada ,  Ken Ishii

IPC: G01N33/483 ,  G01N33/569

Abstract: Provided is a method whereby an objective indicator of an immune-related disease can be rapidly and easily detected, the method comprising detecting, as an indicator of an immune-related disease, a difference in the result of observing a primary cilium of an immune-related cell between a subject specimen and a normal specimen.

公开(公告)号：US20210003498A1

公开(公告)日：2021-01-07

申请号：US16936138

申请日：2020-07-22

Applicant: The University of Tokyo ,  Osaka University

Inventor： Sadao Ota ,  Ryoichi Horisaki ,  Kazuki Hashimoto

IPC: G01N21/01 ,  G01B11/00 ,  G01N21/64 ,  H03M7/30 ,  G01N21/53 ,  G01N21/59

Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.

公开(公告)号：US20200369578A1

公开(公告)日：2020-11-26

申请号：US16636236

申请日：2018-08-03

Applicant: OSAKA UNIVERSITY

Inventor： Yoshifumi SHIRAKAMI ,  Hayato IKEDA ,  Yasukazu KANAI ,  Eku SHIMOSEGAWA ,  Jun HATAZAWA ,  Tadashi WATABE ,  Kazuko KANEDA

IPC: C07B59/00 ,  C07F13/00

Abstract: The invention relates to a method of producing the radiolabeled aryl compound (I) Ar—X, or a salt thereof, wherein X is 211At, 210At, 123I, 124I, 125I, or 131I. The method involves reacting the aryl boronic acid compound (II) Ar—Y, or a salt thereof, wherein Y is a borono group (—B(OH)2) or an ester group thereof, with a radionuclide selected from 211At, 210At, 123I, 124I, 125I and 131I, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.