公开(公告)号：US09653877B1

公开(公告)日：2017-05-16

申请号：US14537574

申请日：2014-11-10

Applicant: STC.UNM

Inventor： Ladan Arissian ,  Jean-Claude Diels

IPC: G01N21/41 ,  H01S3/106

CPC classification number: H01S3/1112 ,  G01N21/41 ,  G01N21/4133 ,  G01N2201/06113 ,  H01S3/0014 ,  H01S3/0957 ,  H01S3/105 ,  H01S3/1062 ,  H01S3/1106

Abstract: Apparatus, systems, and methods of generating multi combs can be used in a variety of applications. In various embodiments, a passive resonator can be disposed in the laser cavity of a mode-locked laser to generate a nested frequency comb. The passive resonator can be a sample under investigation, where a characteristic of the sample is determined using the generated nested frequency comb. Additional apparatus, systems, and methods are disclosed.

公开(公告)号：US09634331B2

公开(公告)日：2017-04-25

申请号：US14126788

申请日：2012-06-15

Applicant: Alexey Serov ,  Barr Halevi ,  Kateryna Artyushkova ,  Plamen B Atanassov ,  Ulises A Martinez

Inventor： Alexey Serov ,  Barr Halevi ,  Kateryna Artyushkova ,  Plamen B Atanassov ,  Ulises A Martinez

IPC: B01J23/72 ,  B01J23/745 ,  B01J23/755 ,  B01J23/86 ,  B01J23/10 ,  B01J23/20 ,  B01J23/22 ,  B01J23/24 ,  B01J23/64 ,  B01J21/08 ,  H01M4/86 ,  B01J37/08 ,  B01J23/889 ,  B01J23/70 ,  B01J35/00 ,  H01M4/88 ,  H01M4/90

CPC classification number: H01M4/8652 ,  B01J23/70 ,  B01J23/8892 ,  B01J35/0033 ,  B01J37/084 ,  H01M4/8621 ,  H01M4/8885 ,  H01M4/9041 ,  H01M4/9083 ,  H01M4/9091 ,  H01M2004/8689

Abstract: A method of preparing M-N—C catalysts utilizing a sacrificial support approach and inexpensive and readily available polymer precursors as the source of nitrogen and carbon is disclosed. Exemplary polymer precursors include non-porphyrin precursors with no initial catalytic activity. Examples of suitable non-catalytic non-porphyrin precursors include, but are not necessarily limited to low molecular weight precursors that form complexes with iron such as 4-aminoantipirine, phenylenediamine, hydroxysuccinimide, ethanolamine, and the like.

公开(公告)号：US20170110602A1

公开(公告)日：2017-04-20

申请号：US15389936

申请日：2016-12-23

Applicant: STC.UNM

Inventor： Sang Eon Han ,  Brittany R. Hoard ,  Sang M. Han ,  Swapnadip Ghosh

IPC: H01L31/0236 ,  G02B1/00 ,  H01L31/20 ,  H01L31/0747 ,  H01L31/18

CPC classification number: H01L31/02363 ,  G02B1/005 ,  H01L31/0747 ,  H01L31/1804 ,  H01L31/202 ,  H01L31/208 ,  H03H9/10 ,  H03H9/145 ,  H03H9/25 ,  Y02E10/547 ,  Y02P70/521

Abstract: Provided is a method for fabricating a nanopatterned surface. The method includes forming a mask on a substrate, patterning the substrate to include a plurality of symmetry-breaking surface corrugations, and removing the mask. The mask includes a pattern defined by mask material portions that cover first surface portions of the substrate and a plurality of mask space portions that expose second surface portions of the substrate, wherein the plurality of mask space portions are arranged in a lattice arrangement having a row and column, and the row is not oriented parallel to a [110] direction of the substrate. The patterning the substrate includes anisotropically removing portions of the substrate exposed by the plurality of spaces.

公开(公告)号：US09610371B2

公开(公告)日：2017-04-04

申请号：US14669313

申请日：2015-03-26

Applicant: STC.UNM

Inventor： Jeffrey P. Norenberg

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/08 ,  A61K31/7068 ,  A61K38/31 ,  A61K45/06

CPC classification number: A61K51/08 ,  A61K31/7068 ,  A61K38/31 ,  A61K45/06 ,  A61K51/083 ,  A61K51/088 ,  A61K2300/00

Abstract: A subject afflicted with a cancer or precancerous condition is treated by administering an agent that increases expression of somatostatin receptors, and a cytotoxic recognition ligand. In an alternative embodiment, somatostatin analogs, which are radiolabeled are used to treat cancer or precancerous conditions.

公开(公告)号：US09606129B2

公开(公告)日：2017-03-28

申请号：US14677053

申请日：2015-04-02

Applicant: STC.UNM

Inventor： Ke Jian Liu ,  Wenlan Liu ,  Graham Timmins ,  Rong Pan

IPC: A61K39/395 ,  G01N33/68

CPC classification number: G01N33/6893 ,  G01N2333/4703 ,  G01N2800/2871 ,  G01N2800/52

Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.

公开(公告)号：US09546186B2

公开(公告)日：2017-01-17

申请号：US14451916

申请日：2014-08-05

Applicant: STC.UNM

Inventor： Jeffrey P. Norenberg ,  Richard S. Larson

IPC: A61K51/00 ,  A61M36/14 ,  C07F5/00 ,  C07F9/94 ,  A61K49/10 ,  A61K51/04

CPC classification number: C07F5/003 ,  A61K47/22 ,  A61K49/106 ,  A61K51/0474 ,  A61K51/0482 ,  A61K51/0485 ,  A61K51/0497 ,  C07F9/94

Abstract: The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。 该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：US09541374B2

公开(公告)日：2017-01-10

申请号：US14230582

申请日：2014-03-31

Applicant: Steven R.J. Brueck ,  Yuliya Kuznetsova ,  Alexander Neumann

Inventor： Steven R.J. Brueck ,  Yuliya Kuznetsova ,  Alexander Neumann

IPC: G02B21/06 ,  G02B21/00 ,  G01B9/02 ,  G02B21/36 ,  G06T3/40 ,  G02B21/18 ,  G01B9/04 ,  G01N21/65

CPC classification number: G01B9/02015 ,  G01B9/04 ,  G01N21/65 ,  G01N2021/653 ,  G02B21/0056 ,  G02B21/06 ,  G02B21/18 ,  G02B21/365 ,  G06T3/4061

Abstract: In accordance with the aspects of the present disclosure, a method and apparatus is disclosed for three-dimensional imaging interferometric microscopy (IIM), which can use at least two wavelengths to image a three-dimensional object. The apparatus can include a first, a second, and a third optical system. The first optical system is disposed to provide a substantially coherent illumination to the 3D object, wherein the illumination is characterized by a plurality of wavelengths. The second optical system includes an optical image recording device and one or more additional optical components characterized by a numerical aperture NA. The third optical system provides interferometric reintroduction of a portion of the coherent illumination as a reference beam into the second optical system. An image recording device records each sub-image formed as a result of interference between the illumination that is scattered by the 3D object and the reference beam.

Abstract translation: 根据本公开的方面，公开了用于三维成像干涉显微镜（IIM）的方法和装置，其可以使用至少两个波长来成像三维物体。 该装置可以包括第一，第二和第三光学系统。 第一光学系统设置成向3D对象提供基本相干的照明，其中照明由多个波长表征。 第二光学系统包括光学图像记录装置和由数值孔径NA表征的一个或多个附加光学部件。 第三光学系统将相干照明的一部分的干涉重新引入作为参考光束进入第二光学系统。 图像记录装置记录由作为3D对象散射的照明与参照光束之间的干涉而形成的各子图像。

公开(公告)号：US09515323B2

公开(公告)日：2016-12-06

申请号：US14376146

申请日：2013-02-01

Applicant: STC.UNM

Inventor： Alexey Serov ,  Barr Halevi ,  Kateryna Artyushkova ,  Plamen B Atanassov

IPC: B01J38/02 ,  B01J27/057 ,  B01J27/20 ,  B01J27/24 ,  H01M4/90 ,  B01J37/08 ,  B01J23/70 ,  H01M8/02 ,  H01M8/10 ,  H01M4/86 ,  H01M4/88

CPC classification number: H01M4/90 ,  B01J23/70 ,  B01J37/08 ,  H01M4/8605 ,  H01M4/88 ,  H01M8/02 ,  H01M8/1007 ,  Y02E60/521

Abstract: A method of preparation of metal-chalcogen-nitrogen-carbon (M-Ch-N—C) catalytic material utilizing a sacrificial support approach and using inexpensive and readily available precursors is described. Furthermore, the catalytic materials synthesized using the disclosed methods include multiple types of active sites.

Abstract translation: 描述了利用牺牲支撑方法制备金属 - 硫属 - 氮 - 碳（M-Ch-N-C）催化材料并使用便宜且容易获得的前体的方法。 此外，使用所公开的方法合成的催化材料包括多种类型的活性位点。

公开(公告)号：US09492625B2

公开(公告)日：2016-11-15

申请号：US13505402

申请日：2010-11-12

Applicant: Hugh D. C. Smyth ,  Parthiban Selvam ,  Charles Randall Truman

Inventor： Hugh D. C. Smyth ,  Parthiban Selvam ,  Charles Randall Truman

IPC: A61M15/00 ,  A61M11/00

CPC classification number: A61M15/0028 ,  A61M11/003 ,  A61M15/0031 ,  A61M15/0038 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2206/16

Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.

Abstract translation: 一种干粉吸入器，其包括限定用于接收一定剂量的粉末药物的室的壳体，与所述室流体连通的吸入口，至少一个气流入口，其提供所述腔室与所述壳体的外部之间的流体连通，以及颤动元件 并且与一定剂量的粉末状药物相关联。 颤振元件具有靠近至少一个气流入口的张紧的远端和与入口的远端和下游相对的自由近端。 颤振元件构造成响应于通过腔室的气流而振动并使粉末状药物的剂量雾化。

公开(公告)号：US09482608B1

公开(公告)日：2016-11-01

申请号：US14659579

申请日：2015-03-16

Applicant: Ravinder Jain ,  Mani Hossein-Zadeh

Inventor： Ravinder Jain ,  Mani Hossein-Zadeh

IPC: G01J5/02 ,  G01N21/3504 ,  G01N21/27

CPC classification number: G01N21/3504 ,  G01N21/27 ,  G01N21/7746 ,  G01N2021/7789 ,  G01N2201/06113 ,  G01N2201/0686 ,  H01S3/0627 ,  H01S3/083 ,  H01S3/094057 ,  H01S3/0941 ,  H01S3/1312 ,  H01S3/1608 ,  H01S3/173

Abstract: The present invention concerns an optical molecular sensing device and related method. The optical molecular sensing device has an optical resonator adapted to be connected to an excitation source. The excitation source may be a laser operating at a 2.7-2.8 um spectral range. The optical molecular sensing device has an emission spectrum comprised of a plurality wavelengths. Also included are a detection unit and a RF frequency counter to detect at least one RF beat note resulting from detecting the emission spectrum of the optical resonator. A change in frequency of the RF beat note indicates the presence of a target molecule.

Abstract translation: 本发明涉及光学分子感测装置及相关方法。 光学分子感测装置具有适于连接到激发源的光学谐振器。 激发源可以是在2.7-2.8um光谱范围内操作的激光器。 光学分子感测装置具有由多个波长组成的发射光谱。 还包括检测单元和RF频率计数器，用于检测由检测光学谐振器的发射光谱而产生的至少一个RF拍音。 RF拍音的频率变化表示存在目标分子。