公开(公告)号：US20240294886A1

公开(公告)日：2024-09-05

申请号：US18652554

申请日：2024-05-01

Applicant: Agilent Technologies, Inc.

Inventor： Michelle Cayouette ,  Jeffrey Fox ,  Connie Hansen ,  Holly Hogrefe ,  Weidong Wu

IPC: C12N9/12 ,  C12P19/34 ,  C12Q1/6869

CPC classification number: C12N9/1252 ,  C12P19/34 ,  C12Q1/6869 ,  C12Y207/07007

Abstract: Mutant polymerases are provided that have improved ability to incorporate modified nucleotides, including 3′—OH unblocked reversible terminators. The mutant polymerases may be used in a variety of applications, such as for polynucleotide sequencing, primer extension reactions, and template-independent enzymatic oligonucleotide synthesis.

公开(公告)号：US12079313B2

公开(公告)日：2024-09-03

申请号：US17612911

申请日：2020-05-21

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Dustin Bingham ,  Charles Manfredi

IPC: G06F21/10 ,  H04L67/141

CPC classification number: G06F21/105 ,  G06F21/1077 ,  H04L67/141

Abstract: Novel tools and techniques are provided for implementing software licensing management and authentication. In various examples, a computing system might receive a request for an unlock code for a requested service from a user using a client device on which a first software is executed, the request comprising a generated unique identifier associated with the requested service and/or the first software. The generated unique identifier comprises licensing information associated with the requested service and/or the first software. In response to receiving the generated unique identifier, the computing system might determine whether the user should have access to the requested service using the first software based at least in part on the licensing information. If so, the computing system might generate an unlock code associated with the requested service using the first software, might deduct cost associated with the licensing information, and might send the unlock code to the user.

公开(公告)号：US20240287673A1

公开(公告)日：2024-08-29

申请号：US18649133

申请日：2024-04-29

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Elizabeth Carr ,  Karen L. Seaward ,  Kevin P. Killeen

IPC: C23C16/24 ,  B01D15/22 ,  C23C16/04 ,  C23C16/32 ,  C23C16/40 ,  C23C16/44 ,  C23C16/455

CPC classification number: C23C16/24 ,  B01D15/22 ,  C23C16/045 ,  C23C16/325 ,  C23C16/401 ,  C23C16/403 ,  C23C16/405 ,  C23C16/44 ,  C23C16/45555 ,  Y10T428/13

Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.

公开(公告)号：US20240262112A1

公开(公告)日：2024-08-08

申请号：US18105110

申请日：2023-02-02

Applicant: Agilent Technologies, Inc.

Inventor： Andy Wu

IPC: B41J11/42 ,  B01L3/00

CPC classification number: B41J11/42 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0819

Abstract: A substrate orientation device includes a frame that supports a substrate on which liquid is dispensed, for example as may relate to (bio)chemical microarray fabrication. The frame is movable to different positions, such as for mounting the substrate to the frame, depositing droplets on the substrate, and applying a bulk liquid to the substrate. The substrate orientation device may be movable to different locations, such as different liquid dispensing devices, for example a printer and a flow cell.

公开(公告)号：US20240248580A1

公开(公告)日：2024-07-25

申请号：US18099166

申请日：2023-01-19

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Rainer JAEGER

IPC: G06F3/0482 ,  G06F3/04845

CPC classification number: G06F3/0482 ,  G06F3/04845

Abstract: In some examples, linear and non-linear range-based plot pane selection may include receiving data that is to be displayed. Based on an increase or a decrease in a size of a range selector, a selection of a range of plot panes may be received from a plurality of available plot panes to display the data. Based on the received selection of the range of plot panes, a display of the data may be generated in plot panes included in the range of plot panes. The size of the range selector may be non-linearly proportional to the available plot panes to display the data.

公开(公告)号：US20240209422A1

公开(公告)日：2024-06-27

申请号：US18423678

申请日：2024-01-26

Applicant: Agilent Technologies, Inc.

Inventor： Steen Hauge Matthiesen

IPC: C12Q1/6832 ,  C12Q1/6841 ,  C12Q1/6876

CPC classification number: C12Q1/6832 ,  C12Q1/6841 ,  C12Q1/6876

Abstract: The invention provides methods and compositions for hybridizing at least one molecule to a target. The composition comprises at least one nucleic acid sequence, formamide, and a hybridization solution, wherein the concentration of formamide is less than or equal to 25%.

公开(公告)号：US20240201143A1

公开(公告)日：2024-06-20

申请号：US18430447

申请日：2024-02-01

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Martin Seifried ,  Sam Wouters ,  Irina Spuling

IPC: G01N30/20 ,  G01N30/02 ,  G01N30/14 ,  G01N30/32

CPC classification number: G01N30/20 ,  G01N30/14 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/326

Abstract: A sample separation device includes a separation path and a control unit. The separation path is between a fluid drive and a sample separation unit, and is configured to inject a fluidic sample in an injector path into a mobile phase in the separation path driven by the fluid drive to the sample separation unit for chromatographically separating the fluidic sample. The control unit is configured to control blocking the injector path or at least a partial path thereof, generating an overpressure in the blocked injector path or the partial path thereof by a pressure source, and subsequently fluidically coupling the injector path or the partial path thereof to a region of lower pressure than the overpressure to generate an expansion stroke for releasing unwanted components from the injector path.

公开(公告)号：US12015320B2

公开(公告)日：2024-06-18

申请号：US16869459

申请日：2020-05-07

Applicant: Agilent Technologies, Inc.

Inventor： Ronald J. Forni

IPC: H02K49/10 ,  F04C15/00 ,  F04C18/02 ,  F04C27/00 ,  H02K7/10

CPC classification number: H02K49/108 ,  F04C15/0069 ,  H02K7/10 ,  H02K49/104 ,  F04C18/0215 ,  F04C27/005 ,  F05C2225/00

Abstract: A magnetic coupling assembly includes a first balancing magnet positioned and surrounding drive magnets and, across a gap, a second balancing magnet and surrounding driven magnets. The drive magnets when rotated drive the driven magnets to rotate. The balancing magnets generate a repulsive force, which counterbalances an attractive force generated by the drive magnets and driven magnets. The assembly may be utilized in a pump for contactless coupling of a motor shaft to a pump shaft. The driven side of the assembly may be hermetically sealed, such as with a liquid crystal polymer boundary interposed in the gap.

公开(公告)号：US11992518B2

公开(公告)日：2024-05-28

申请号：US16455224

申请日：2019-06-27

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

IPC: A61K39/12 ,  A61K39/00 ,  A61K39/21 ,  A61K47/61 ,  A61K47/64 ,  C07K14/74 ,  A61K38/00

CPC classification number: A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K47/61 ,  A61K47/646 ,  C07K14/70539 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55516 ,  A61K2039/55583 ,  A61K2039/6087 ,  A61K2039/625 ,  C12N2740/16134 ,  C12N2740/16234 ,  Y02A50/30

Abstract: The present invention relates to methods for construction of pharmamers i.e. vaccine components characterized by their multimerization domain and the attached biologically active molecules, and their use in preparation of vaccines that contains the pharmamers alone or in combination with other molecules. The individual molecules of the construct can be bound to each other or the multimerization domain(s) by covalent or non-covalent bonds, directly or via linkers. The invention further relates to the use of such preparations in vaccine settings aimed to function as preventive/prophylactic or therapeutic vaccines in humans and animals.

公开(公告)号：US20240133412A1

公开(公告)日：2024-04-25

申请号：US17969584

申请日：2022-10-18

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Manuel VAN VENROOY ,  Patrick MATZ ,  Alan NORMAN

IPC: F16B21/06 ,  F16B21/04

CPC classification number: F16B21/065 ,  F16B21/04 ,  F16B2200/406

Abstract: In some examples, a vessel mounting system may include a first collar and a second collar. The second collar may include a clip engageable with an edge of the first collar to engage the second collar with the first collar.