公开(公告)号：US07505811B2

公开(公告)日：2009-03-17

申请号：US10298196

申请日：2002-11-18

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B5/05 ,  A61B6/00

CPC classification number: A61K49/00 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/0538 ,  A61B5/065 ,  A61B5/411 ,  A61B5/416 ,  Y10S607/901

Abstract: A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.

Abstract translation: 一种用于通过使检查组织对包含与选择性地与靶细胞结合的生物载体结合的物理元素的小颗粒的造影剂来检查组织是否存在靶细胞特别是癌细胞的方法，装置和探针。 能量脉冲被施加到被检查的组织。 检测由所施加的能量脉冲产生的被检查组织的阻抗和/或光学特性的变化并用于确定所检查组织中靶细胞的存在。 在所描述的优选实施例中，所施加的能量脉冲包括激光脉冲，并且与生物载体共轭的物理元件是具有在存在光时显着降低的阻抗的光敏半导体。 用于检测靶细胞的相同探针也可用于破坏如此靶向的细胞。

公开(公告)号：US20080249434A1

公开(公告)日：2008-10-09

申请号：US10582135

申请日：2006-03-02

Applicant: Dan Hashimshony ,  Orit Yarden ,  Gal Aharonowitz ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Orit Yarden ,  Gal Aharonowitz ,  Gil Cohen ,  Iddo Geltner

IPC: A61B10/02 ,  C12M1/00

CPC classification number: A61B10/0096 ,  A01N1/02 ,  A01N1/0273 ,  A61B90/39 ,  A61B2017/320064 ,  A61B2090/0807 ,  A61B2090/0811 ,  A61B2090/3908 ,  B01L3/508 ,  G01N1/312

Abstract: A device and method and provided for tissue handling, while maintaining the in-vivo tissue orientation. The device includes a structure, configured for receiving and holding a tissue specimen, wherein the tissue specimen includes tissue positional references; and device positional references, associated with the structure, for fixing the orientation of the tissue specimen, when held by the device, so as to reflect the tissue specimen positional references.

Abstract translation: 一种装置和方法，并提供用于组织处理，同时保持体内组织取向。 所述装置包括构造成用于接收和保持组织样本的结构，其中所述组织样本包括组织位置参考; 以及与所述结构相关联的用于固定所述组织样本的取向的装置位置参考，当被所述装置保持时，以便反映所述组织样本位置参考。

公开(公告)号：US20080039742A1

公开(公告)日：2008-02-14

申请号：US11745334

申请日：2007-05-07

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/103

CPC classification number: A61B5/415 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0091 ,  A61B5/01 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/053 ,  A61B5/055 ,  A61B5/06 ,  A61B5/068 ,  A61B5/4312 ,  A61B8/0858 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4472 ,  A61B34/20 ,  A61B34/30 ,  A61B2017/00026 ,  A61B2017/00057 ,  A61B2017/00061 ,  A61B2017/00106 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/061 ,  A61B2090/367 ,  Y10S607/901

Abstract: An integrated tool is provided, having a tissue-type sensor, for determining the tissue type at a near zone volume of a tissue surface, and a distance-measuring sensor, for determining the distance to an interface with another tissue type, for (i) confirming an existence of a clean margin of healthy tissue around a malignant tumor, which is being removed, and (ii) determining the depth of the clean margin. The integrated tool may further include a position tracking device and an incision instrument. The soft tissue may be held within a fixed frame, while the tumor is being removed. Additionally a method for malignant tumor removal is provided, comprising, fixing the soft tissue within a frame, performing imaging with the hand-held, integrated tool, from a plurality of locations and orientations around the soft tissue, reconstructing a three-dimensional image of the soft tissue and the tumor within, defining a desired clean margin on the reconstructed image, calculating a recommended incision path, displaying the recommended path on the reconstructed image, and cutting the tissue while determining its type, at the near zone volume of the incision surface. The method may further include continuously imaging with the cutting, continuously correcting the reconstructed image and the recommended incision path, and continuously determining the tissue type, at the near zone volume of the incision surface.

Abstract translation: 提供了一种集成工具，具有用于确定组织表面的近区域体积处的组织类型的组织型传感器和用于确定与另一组织类型的界面的距离的距离测量传感器，用于（i ）确认正在被去除的恶性肿瘤周围存在健康组织的清洁边缘，以及（ii）确定清洁边缘的深度。 集成工具还可以包括位置跟踪装置和切口装置。 当肿瘤被移除时，软组织可以保持在固定框架内。 另外，提供了一种用于恶性肿瘤去除的方法，包括：将软组织固定在框架内，利用手持式集成工具从软组织周围的多个位置和取向进行成像，重建三维图像 软组织和肿瘤内，在重建图像上限定所需的清洁边缘，计算推荐切口路径，在重建图像上显示推荐路径，以及在确定其类型的同时切割组织，在切口的近区体积处 表面。 该方法可以进一步包括连续成像切割，连续校正重建图像和推荐切口路径，以及在切口表面的近区域体积处连续地确定组织类型。

公开(公告)号：US20070260156A1

公开(公告)日：2007-11-08

申请号：US11743027

申请日：2007-05-01

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B5/053

CPC classification number: A61K49/00 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/0538 ,  A61B5/065 ,  A61B5/411 ,  A61B5/416 ,  Y10S607/901

Abstract: A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.

Abstract translation: 一种用于通过使检查组织对包含与选择性地与靶细胞结合的生物载体结合的物理元素的小颗粒的造影剂来检查组织是否存在靶细胞特别是癌细胞的方法，装置和探针。 能量脉冲被施加到被检查的组织。 检测由所施加的能量脉冲产生的被检查组织的阻抗和/或光学特性的变化并用于确定所检查组织中靶细胞的存在。 在所描述的优选实施例中，所施加的能量脉冲包括激光脉冲，并且与生物载体共轭的物理元件是具有在存在光时显着降低的阻抗的光敏半导体。 用于检测靶细胞的相同探针也可用于破坏如此靶向的细胞。

公开(公告)号：US20070032747A1

公开(公告)日：2007-02-08

申请号：US11350102

申请日：2006-02-09

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/103 ,  A61B5/117

CPC classification number: A61B6/032 ,  A61B5/0059 ,  A61B5/015 ,  A61B5/0536 ,  A61B5/055 ,  A61B5/103 ,  A61B5/4312 ,  A61B5/6834 ,  A61B5/6843 ,  A61B5/6844 ,  A61B5/6885 ,  A61B5/6886 ,  A61B6/4417 ,  A61B6/5247 ,  A61B8/13

Abstract: The present invention relates to a device for tissue-characterization, designed for effective sensor-to-tissue contact. The device includes an element, having a rigid surface of a linear cross-section, on which at least one sensor is arranged, and a mechanism for applying a force to a soft tissue, the line of force being at an acute angle with the rigid surface, for stretching or stretching and pushing the soft tissue against the rigid surface, thus achieving effective contact between the tissue and the at least one sensor. In consequence, the accuracy of the sensing is improved. In accordance with another embodiment, a plurality of sensors is employed, arranged along a curved element, for providing three-dimensional information regarding the tissue, for example, by small-scale computerized tomography.

Abstract translation: 本发明涉及一种用于组织表征的设备，用于有效的传感器与组织接触。 该装置包括具有线性横截面的刚性表面的元件，至少一个传感器布置在该元件上，以及用于向软组织施加力的机构，该力与刚性线成锐角 表面，用于拉伸或拉伸并将软组织推靠在刚性表面上，从而实现组织与至少一个传感器之间的有效接触。 因此，传感的精度得到改善。 根据另一个实施例，采用多个传感器，沿弯曲元件布置，用于提供关于组织的三维信息，例如通过小规模计算机断层摄影。

公开(公告)号：US07082325B2

公开(公告)日：2006-07-25

申请号：US10891750

申请日：2004-07-15

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: A61B5/055

CPC classification number: G01R33/60 ,  A61B5/053 ,  A61B5/055 ,  A61B10/0266 ,  A61B90/39 ,  G01R33/3808

Abstract: A method and apparatus for examining a substance volume to characterize its type, particularly useful for examining tissue to characterize it as cancerous or non-cancerous. The method comprises: applying a polarizing magnetic field through the examined substance; applying RF pulses locally to the examined substance volume such as to invoke electrical impedance (EI) responses signals corresponding to the electrical impedance of the substance, and magnetic resonance (MR) responses signals corresponding to the MR properties of the substance; detecting the EI and MR response signals; and utilizing the detected response signals for characterizing the examined substance volume type.

Abstract translation: 用于检查物质体积以表征其类型的方法和装置，特别用于检查组织以将其表征为癌性或非癌性。 该方法包括：通过被检物质施加极化磁场; 将RF脉冲局部施加到所检查的物质体积，以便调用对应于物质的电阻抗的电阻抗（EI）响应信号，以及对应于物质的MR性质的磁共振（MR）响应信号; 检测EI和MR响应信号; 以及利用检测到的响应信号来表征所检查的物质体积类型。

公开(公告)号：US06463124B1

公开(公告)日：2002-10-08

申请号：US09596530

申请日：2000-06-19

Applicant: Effraim Weisman ,  Nathan Sela ,  Dan Hashimshony ,  Uriel Halavee ,  Guy Shinar ,  Gilad Marcus

Inventor： Effraim Weisman ,  Nathan Sela ,  Dan Hashimshony ,  Uriel Halavee ,  Guy Shinar ,  Gilad Marcus

IPC: H01J3506

CPC classification number: A61N5/1001 ,  A61N5/1002 ,  H01J35/065 ,  H01J35/32 ,  H01J2201/342 ,  H01J2235/06 ,  H01J2235/164

Abstract: An apparatus provides in-situ radiation treating utilizing a miniature energy transducer to produce x-rays, wherein the energy transducer includes a Schottky cathode tip. More specifically, the energy transducer includes a transducer body, an anode provided at a first end of the transducer body, and a cathode provided at a second end of the transducer body opposite the anode. The energy transducer is coupled to an energy source by a flexible insertion device. The energy source provides electrical and/or light signals to the energy transducer via the flexible insertion device. Light transmitted from the energy source to the energy transducer by the flexible insertion device is focused on a Schottky cathode tip of the cathode by the optical fiber provided in the hollow core of the anode. The application of the light signal to the cathode tip results in heating of the tip and along with the electric field generated by the acceleration voltage it leads to electron Schottky emission and electron acceleration towards the anode. In another preferred embodiment, an electrical current, transmitted from the energy source to the energy transducer by the flexible insertion device, is applied to the Schottky cathode tip of the cathode, causing thermo-emission. The electrons generated due to this process are accelerated towards the anode across a voltage difference between the anode and the cathode.

Abstract translation: 一种装置利用微型能量换能器提供原位辐射处理以产生X射线，其中能量换能器包括肖特基阴极尖端。 更具体地，能量换能器包括换能器主体，设置在换能器主体的第一端的阳极和设置在换能器本体的与阳极相对的第二端的阴极。 能量传感器通过柔性插入装置耦合到能量源。 能量源通过柔性插入装置向能量换能器提供电和/或光信号。 通过柔性插入装置从能量源传递到能量换能器的光通过设置在阳极中空芯中的光纤聚焦在阴极的肖特基阴极尖端上。 将光信号施加到阴极尖端导致尖端的加热以及由加速电压产生的电场，从而导致电子肖特基发射和朝向阳极的电子加速。 在另一个优选实施例中，通过柔性插入装置从能量源传递到能量换能器的电流被施加到阴极的肖特基阴极尖端，引起热发射。 由于该过程产生的电子在阳极和阴极之间的电压差上被朝向阳极加速。

公开(公告)号：US09750425B2

公开(公告)日：2017-09-05

申请号：US12483738

申请日：2009-06-12

Applicant: Dan Hashimshony ,  Orit Yarden ,  Gal Aharonowitz ,  Gil Cohen

Inventor： Dan Hashimshony ,  Orit Yarden ,  Gal Aharonowitz ,  Gil Cohen

IPC: A61B5/00 ,  G06F3/048 ,  G01M19/00 ,  A61B5/05 ,  A61B8/08 ,  G06F3/0481 ,  A61B34/00 ,  A61B5/01 ,  A61B5/053 ,  A61B5/06 ,  A61B8/12 ,  G06F19/00 ,  A61B34/20 ,  A61B34/30 ,  A61B90/00

CPC classification number: A61B5/05 ,  A61B5/0084 ,  A61B5/015 ,  A61B5/053 ,  A61B5/06 ,  A61B5/064 ,  A61B8/0858 ,  A61B8/12 ,  A61B34/20 ,  A61B34/25 ,  A61B34/30 ,  A61B2090/061 ,  A61B2562/0233 ,  A61B2562/046 ,  G06F3/0481 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3481 ,  G16H40/63 ,  G16H50/50

Abstract: A graphical user interface (GUI) including: (a) a group definition module adapted to accept a user input defining groups; (b) a data receiver operable to receive a plurality of individual measurement input datum indicative of status of a substrate; (c) a grouping module configured to assign each of said individual measurement input datum to one of said groups to produce grouped data; and (d) an output module adapted to output the grouped data.

公开(公告)号：US07904145B2

公开(公告)日：2011-03-08

申请号：US11745334

申请日：2007-05-07

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/05 ,  A61B5/04

CPC classification number: A61B5/415 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0091 ,  A61B5/01 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/053 ,  A61B5/055 ,  A61B5/06 ,  A61B5/068 ,  A61B5/4312 ,  A61B8/0858 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4472 ,  A61B34/20 ,  A61B34/30 ,  A61B2017/00026 ,  A61B2017/00057 ,  A61B2017/00061 ,  A61B2017/00106 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/061 ,  A61B2090/367 ,  Y10S607/901

Abstract: An integrated tool is provided, having a tissue-type sensor, for determining the tissue type at a near zone volume of a tissue surface, and a distance-measuring sensor, for determining the distance to an interface with another tissue type, for (i) confirming an existence of a clean margin of healthy tissue around a malignant tumor, which is being removed, and (ii) determining the depth of the clean margin. The integrated tool may further include a position tracking device and an incision instrument. The soft tissue may be held within a fixed frame, while the tumor is being removed. Additionally a method for malignant tumor removal is provided, comprising, fixing the soft tissue within a frame, performing imaging with the hand-held, integrated tool, from a plurality of locations and orientations around the soft tissue, reconstructing a three-dimensional image of the soft tissue and the tumor within, defining a desired clean margin on the reconstructed image, calculating a recommended incision path, displaying the recommended path on the reconstructed image, and cutting the tissue while determining its type, at the near zone volume of the incision surface. The method may further include continuously imaging with the cutting, continuously correcting the reconstructed image and the recommended incision path, and continuously determining the tissue type, at the near zone volume of the incision surface.

Abstract translation: 提供了一种集成工具，具有用于确定组织表面的近区域体积处的组织类型的组织型传感器和用于确定与另一组织类型的界面的距离的距离测量传感器，用于（i ）确认正在被去除的恶性肿瘤周围存在健康组织的清洁边缘，以及（ii）确定清洁边缘的深度。 集成工具还可以包括位置跟踪装置和切口装置。 当肿瘤被移除时，软组织可以保持在固定框架内。 另外，提供了一种用于恶性肿瘤去除的方法，包括：将软组织固定在框架内，利用手持式集成工具从软组织周围的多个位置和取向进行成像，重建三维图像 软组织和肿瘤内，在重建图像上限定所需的清洁边缘，计算推荐切口路径，在重建图像上显示推荐路径，以及在确定其类型的同时切割组织，在切口的近区体积处 表面。 该方法可以进一步包括连续成像切割，连续校正重建图像和推荐切口路径，以及在切口表面的近区域体积处连续地确定组织类型。

公开(公告)号：US07809425B2

公开(公告)日：2010-10-05

申请号：US11487431

申请日：2006-07-17

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: A61B5/055

CPC classification number: G01R33/60 ,  A61B5/053 ,  A61B5/055 ,  A61B10/0266 ,  A61B90/39 ,  G01R33/3808 ,  G06F19/00

Abstract: A method and apparatus are disclosed, for examining a substance of a given volume to characterize its type, with an integrated sensing head. The method comprises applying locally to the substance of the given volume a polarizing magnetic field, with a component defining a polarizing axis; applying locally RF pulses to the substance of the given volume, the RF pulses having a B component, orthogonal to the polarizing axis, such as to invoke EI response signals corresponding to the electrical impedance (EI) of the examined substance of the given volume, and magnetic resonance (MR) response signals corresponding to the MR properties of the examined substance of the given volume; detecting locally EI response signals from the substance of the given volume; and detecting locally MR response signals from the substance of the given volume. Two or more sensing heads may be used, both applying locally the RF pulses and detecting. Alternatively, one of the sensing heads may operate as a transmitter, while the other or others may operate as receivers.

Abstract translation: 公开了一种用于通过集成感测头来检查给定体积的物质来表征其类型的方法和装置。 该方法包括将局部施加给给定体积的物质的偏振磁场，其中限定偏振轴的分量; 将本地RF脉冲施加到给定体积的物质，RF脉冲具有与偏振轴正交的B分量，以便调用与给定体积的被检物质的电阻抗（EI）相对应的EI响应信号， 和对应于给定体积的检查物质的MR性质的磁共振（MR）响应信号; 从给定体积的物质中检测局部EI响应信号; 以及从给定体积的物质检测局部MR响应信号。 可以使用两个或更多个感测头，两个或更多个感测头都本地施加RF脉冲和检测。 或者，感测头中的一个可以作为发射器操作，而另一个或另外一个可以作为接收器操作。