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    Hydrophilic copolymers, their preparation and their use in separation techniques
    12.
    发明授权
    Hydrophilic copolymers, their preparation and their use in separation techniques 失效
    亲水共聚物，它们的制备及其在分离技术中的应用

    公开(公告)号：US4192784A

    公开(公告)日：1980-03-11

    申请号：US873026

    申请日：1978-01-27

    Applicant: Eric Brown ,  Egisto Boschetti ,  Monique M. Corgier ,  Joel Touet

    Inventor： Eric Brown ,  Egisto Boschetti ,  Monique M. Corgier ,  Joel Touet

    IPC: C08F20/00 ,  B01D15/08 ,  C08F20/52 ,  C08F220/58 ,  C08L33/24 ,  C08L33/26 ,  C12N11/08 ,  C08L89/00 ,  C08F20/54 ,  C08L3/00

    CPC classification number: C08F220/58 ,  C12N11/08 ,  Y10S524/916 ,  Y10S526/909 ,  Y10T428/2998

    Abstract: Water-insoluble, tridimensional cross-linked random copolymers, which contain in copolymerized form:(a) 25% to 98% by weight of N-[tris(hydroxymethyl)methyl]acrylamide or N-[tris(hydroxymethyl)methyl]methacrylamide or a mixture of these two compounds;(b) 2% to 50% by weight of one or more monomers having several polymerizable ethylenic double bonds and one or more hydroxy groups, and free from NH.sub.2 or COOH groups; and(c) 0% to 50% by weight of one or more monomers having a polymerizable ethylenic double bond and one or more amino or carboxy groups. These copolymers may be used, in the form of aqueous gels, as supports in techniques of separation such as gell permeation chromatography and in techniques of immobilization of natural substances.

    Abstract translation: 含有共聚形式的水不溶性三维交联无规共聚物：（a）25-98重量％的N- [三（羟甲基）甲基]丙烯酰胺或N- [三（羟甲基）甲基]甲基丙烯酰胺或 这两种化合物的混合物; （b）2重量％至50重量％的一种或多种具有几个可聚合的烯属双键和一个或多个羟基并且不含NH 2或COOH基团的单体; 和（c）0重量％至50重量％的一种或多种具有可聚合烯键式双键和一个或多个氨基或羧基的单体。 这些共聚物可以水凝胶的形式用作分离技术中的载体，例如凝胶渗透色谱法和固定天然物质的技术。

    Process for obtaining gels of N-methylol-acrylamide copolymers and application of said gels for the stepped gradient separation of seric lipoproteins
    13.
    发明授权
    Process for obtaining gels of N-methylol-acrylamide copolymers and application of said gels for the stepped gradient separation of seric lipoproteins 失效
    获得N-羟甲基丙烯酰胺共聚物凝胶的方法和用于梯度梯度分离线性脂蛋白的所述凝胶的应用

    公开(公告)号：US4189370A

    公开(公告)日：1980-02-19

    申请号：US917549

    申请日：1978-06-21

    Applicant: Egisto Boschetti

    Inventor： Egisto Boschetti

    IPC: G01N27/447 ,  G01N27/26 ,  G01N27/28

    CPC classification number: G01N27/44747

    Abstract: A process for preparing plates of a new gel polymer, said plates being adapted to the electrophoresis separation of the seric or plasmatic lipoproteins under a stepped gradient. The gel polymers are prepared by radical polymerization of N-methylol-acrylamide and of a bifunctional allylic or acrylic compound causing cross-linking to yield a tridimensional configuration polymer. The polymerization may optionally be catalyzed by peroxides and/or ultraviolet radiation. Anionic polysaccharides containing only COOH groups may be added to assist migration of lipoproteins in the gel.

    Abstract translation: 一种制备新凝胶聚合物的平板的方法，所述板适于在梯度梯度下电泳分离浆液或血浆脂蛋白。 凝胶聚合物通过N-羟甲基丙烯酰胺和双官能烯丙基或丙烯酸化合物的自由基聚合制备，引起交联以产生三维构型聚合物。 聚合可以任选地被过氧化物和/或紫外线辐射催化。 可以加入仅含有COOH基团的阴离子多糖以辅助凝胶中脂蛋白的迁移。

    DIVERSE CHEMICAL LIBRARIES BOUND TO SMALL PARTICLES WITH PARAMAGNETIC PROPERTIES
    17.
    发明申请
    DIVERSE CHEMICAL LIBRARIES BOUND TO SMALL PARTICLES WITH PARAMAGNETIC PROPERTIES 审中-公开
    分散化学图书馆附有具有参照性质的小颗粒

    公开(公告)号：US20110111978A1

    公开(公告)日：2011-05-12

    申请号：US13004281

    申请日：2011-01-11

    Applicant: Egisto Boschetti ,  Lee Lomas

    Inventor： Egisto Boschetti ,  Lee Lomas

    IPC: C40B30/04 ,  C40B50/14 ,  B82Y5/00

    CPC classification number: C07K1/047 ,  C07K1/22

    Abstract: The present invention provides diverse chemical libraries bound to small particle with paramagnetic properties. Typically, the chemical structures comprise a plurality of different chemical moieties, the particles are paramagnetic and have a diameter between about 100 nm and about 10 microns, the chemical structures bound to each particular particle have substantially the same structure and the combinatorial library comprises at least 100,000 different chemical structures.

    Abstract translation: 本发明提供了与具有顺磁性质的小颗粒结合的不同化学文库。 通常，化学结构包括多个不同的化学部分，颗粒是顺磁性的并且具有约100nm至约10微米之间的直径，与每个特定颗粒结合的化学结构具有基本上相同的结构，组合文库至少包含 100,000种不同的化学结构。

    Multi-compartment filter and method of filtering using same
    19.
    发明授权
    Multi-compartment filter and method of filtering using same 有权
    多室过滤器和使用其的过滤方法

    公开(公告)号：US07815783B2

    公开(公告)日：2010-10-19

    申请号：US11073999

    申请日：2005-03-08

    Applicant: Egisto Boschetti ,  Lee O. Lomas ,  Pierre Girot

    Inventor： Egisto Boschetti ,  Lee O. Lomas ,  Pierre Girot

    IPC: G01N27/453 ,  B01D57/02

    CPC classification number: G01N27/44704 ,  B01D57/02 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J2220/54 ,  C07K1/24 ,  C07K1/34 ,  G01N27/44795

    Abstract: Each embodiment includes a central sample reservoir and a plurality of satellite reservoirs. In a first embodiment, a first electrode in electrical contact with the central reservoir is charged and second electrodes in electrical contact with the satellite reservoirs are sequentially charged, thereby pI filtering molecules in the central reservoir into the satellite reservoirs. In a second embodiment, the central reservoir is configured to rotate so that molecules in a sample in the central reservoir are centrifugally pI-filtered into the satellite reservoirs. In a third embodiment, first and second electrodes proximate opposite first and second satellite reservoirs, respectively, are charged. Some molecules in a sample are pI filtered into the first and second satellite reservoirs. Third and fourth electrodes proximate opposite third and fourth satellite reservoirs, respectively, are then charged. Some molecules in a sample are pI filtered into the third and fourth satellite reservoirs.

    Abstract translation: 每个实施例包括中央样品储存器和多个卫星储存器。 在第一实施例中，与中央储存器电接触的第一电极被充电，并且与卫星储存器电接触的第二电极被顺序地充电，从而将中央储存器中的分子过滤到卫星储存器中。 在第二实施例中，中央储存器被配置为旋转，使得中央储存器中的样品中的分子被离心地pI过滤到卫星储存器中。 在第三实施例中，分别与第一和第二卫星储存器相邻的第一和第二电极被充电。 样品中的一些分子被pI过滤到第一和第二卫星储层中。 然后分别靠近相对的第三和第四卫星储存器的第三和第四电极被充电。 样品中的一些分子被pI过滤到第三和第四卫星储层中。

    Protein interaction difference mapping
    20.
    发明授权
    Protein interaction difference mapping 有权
    蛋白质相互作用差异作图

    公开(公告)号：US07348184B2

    公开(公告)日：2008-03-25

    申请号：US10626493

    申请日：2003-07-23

    Applicant: William E. Rich ,  Egisto Boschetti ,  Lee O. Lomas ,  Tai-Tung Yip

    Inventor： William E. Rich ,  Egisto Boschetti ,  Lee O. Lomas ,  Tai-Tung Yip

    IPC: G01N33/543

    CPC classification number: C40B30/04 ,  G01N33/54306 ,  G01N33/6803

    Abstract: This invention provides methods and materials for mapping interaction characteristics between components of a multicomponent biological complex. The methods involve capturing a multicomponent complex on a solid support and washing the support with a series of elution washes forming a gradient of solute concentrations, and determining whether a particular elution wash eluted a particular component.

    Abstract translation: 本发明提供了用于映射多组分生物复合物的组分之间的相互作用特征的方法和材料。 该方法包括在固体支持物上捕获多组分复合物，并用洗脱洗涤洗涤洗脱洗涤洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱特定组分。

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