公开(公告)号：US06893822B2

公开(公告)日：2005-05-17

申请号：US09910469

申请日：2001-07-19

Applicant: Markus Schweitzer ,  Richard R. Anderson ,  Michael D. Fiechtner ,  Jochen Müller ,  Stefan Raddatz ,  Christoph Brücher ,  Norbert Windhab ,  Jill M. Orwick ,  Eberhard Schneider ,  Marc Pignot ,  Stefan Kienle

Inventor： Markus Schweitzer ,  Richard R. Anderson ,  Michael D. Fiechtner ,  Jochen Müller ,  Stefan Raddatz ,  Christoph Brücher ,  Norbert Windhab ,  Jill M. Orwick ,  Eberhard Schneider ,  Marc Pignot ,  Stefan Kienle

IPC: G01N33/53 ,  B01J19/00 ,  B05D3/00 ,  C07H21/00 ,  C07H21/04 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12P19/34 ,  C12Q1/68 ,  G01N33/543 ,  G01N33/566 ,  G01N37/00

CPC classification number: C07H21/00 ,  B01J19/0046 ,  B01J2219/00608 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00722 ,  C12Q1/6837 ,  G01N33/54353 ,  C12Q2565/518 ,  C12Q2525/117 ,  C12Q2525/113

Abstract: The present invention relates to conjugates of synthetic binding units and nucleic acids. The present invention also relates to methods for sorting and immobilizing nucleic acids on support materials using such conjugates by specific molecular addressing of the nucleic acids mediated by the synthetic binding systems. Particularly, the present invention also relates to novel methods of utilizing conjugates of synthetic binding units and nucleic acids to in active electronic array systems to produce novel array constructs from the conjugates, and the use of such constructs in various nucleic acid assay formats. In addition, the present invention relates to various novel forms of such conjugates, improved methods of making solid phase synthesized conjugates, and improved methods of conjugating pre-synthesized synthetic binding units and nucleic acids. The present invention also relates to the use of conjugates of synthetic binding units and nucleic acids as substrates for various enzymatic reactions, including nucleic acid amplification reactions.

Abstract translation: 本发明涉及合成结合单元和核酸的缀合物。 本发明还涉及使用这种共轭物通过由合成结合系统介导的核酸的特异性分子寻址来分选和固定核酸的载体材料的方法。 特别地，本发明还涉及利用合成结合单元和核酸的缀合物在活性电子阵列体系中从缀合物产生新型阵列构建体的新方法，以及以各种核酸测定形式使用这种构建体。 此外，本发明涉及这种缀合物的各种新型形式，制备固相合成的缀合物的改进方法，以及与预合成的合成结合单元和核酸缀合的改进方法。 本发明还涉及合成结合单元和核酸的缀合物作为各种酶反应的底物的用途，包括核酸扩增反应。

公开(公告)号：US06556492B2

公开(公告)日：2003-04-29

申请号：US09907695

申请日：2001-07-18

Applicant: Wolfgang Ernst ,  Gunnar Krause ,  Justus Kuhn ,  Jens Lüpke ,  Jochen Müller ,  Peter Pöchmüller ,  Michael Schittenhelm

Inventor： Wolfgang Ernst ,  Gunnar Krause ,  Justus Kuhn ,  Jens Lüpke ,  Jochen Müller ,  Peter Pöchmüller ,  Michael Schittenhelm

IPC: G11C700

CPC classification number: G11C29/56

Abstract: The system enables testing fast synchronous semiconductor circuits, particularly semiconductor memory chips. Various test signals such as test data, data strobe signals, control/address signals are combined to form signal groups and controllable transmit driver and receiver elements allocated to them are in each case jointly activated or, respectively, driven by timing reference signals generated by programmable DLL delay circuits. A clock signal generated in a clock generator in the BOST semiconductor circuit is picked up at a tap in the immediate vicinity of the semiconductor circuit chip to be tested and fed back to a DLL circuit in the BOST chip where it is used for eliminating delay effects in the lines leading to the DUT and back to the BOST.

公开(公告)号：US07931345B2

公开(公告)日：2011-04-26

申请号：US12307797

申请日：2007-07-11

Applicant: Jochen Müller ,  Faouzi Attallah ,  Dieter Burkhard ,  Andreas Kohl

Inventor： Jochen Müller ,  Faouzi Attallah ,  Dieter Burkhard ,  Andreas Kohl

IPC: B60T13/16

CPC classification number: B60T8/4059

Abstract: A motor vehicle brake system having a hydraulic cable, via which a wheel brake module can be pressurized by a brake medium using brake pressure from a brake cylinder and to which a low pressure accumulator is connected for temporarily receiving excess brake medium, wherein the low pressure accumulator is connected to the hydraulic cable via a backflow line and a return pump interposed in the return line in order to return temporarily stored brake medium, the return pump being cyclically actuated for adjusting the pump capacity such that an activation occurs within each braking cycle during a portion of pump cycles that corresponds to the pump capacity, is intended to provide particularly high operational safety while also providing a comfortable pedal sensation.

Abstract translation: 一种具有液压电缆的机动车辆制动系统，通过该液压电缆可以利用来自制动缸的制动压力由制动介质对车轮制动模块进行加压，并且连接有低压蓄能器以临时容纳多余的制动介质，其中低压 蓄能器通过回流管路和回流泵连接到液压电缆，以便返回临时存储的制动介质，回流泵循环地致动以调节泵的容量，使得在每个制动循环期间发生激活 与泵容量相对应的泵循环的一部分旨在提供特别高的操作安全性，同时还提供舒适的踏板感觉。

公开(公告)号：US07832894B2

公开(公告)日：2010-11-16

申请号：US11922909

申请日：2006-06-22

Applicant: Günter Rudolph ,  Jochen Müller ,  Eva-Maria Menzel ,  Bryce Anton Moffat ,  Andreas Nolte

Inventor： Günter Rudolph ,  Jochen Müller ,  Eva-Maria Menzel ,  Bryce Anton Moffat ,  Andreas Nolte

IPC: F21V9/00

CPC classification number: G02B21/084 ,  F21K9/00 ,  F21K9/61 ,  F21Y2115/10 ,  G02B6/0003 ,  G02B21/10 ,  G02B21/12 ,  H01L25/0753 ,  H01L33/50 ,  H01L2924/0002 ,  H01L2924/00

Abstract: The invention relates to an illuminating device for microscopes, wherein the light source has, in particular, a white light illumination having total daylight spectrum and/or an excitation light source for fluorescent colors. The inventive illuminating device for a microscope consists of surface or spatially arranged light sources, which are connected to a control unit for generating any desired illuminating patterns and illuminating spectrums, and an illuminating optic to image these illuminating patterns on the object to be examined. The light sources consist of LEDs (11) which excite at least one luminescence color (14) which is adapted to the wavelength which is emitted by the LEDs (11). The LEDs (11) are arranged concentrically to the optical axis of the illuminating device, preferably, in or in the vicinity of the aperture diaphragm plane. The microscope illumination enables realization of flexible illumination structures and illumination spectrums for bright field, dark field, fluorescence, inclined and/or annularly-shaped illumination, and also white light illuminations having total daylight spectrum. Due to the advantages of the LEDs (economical, low power consumption, long service life and easy to control), such illumination devices are particularly suitable for use in the field, for example, in archaeology, geology and in protecting the environment.

Abstract translation: 本发明涉及一种用于显微镜的照明装置，其中光源具有特别是具有总日光光谱的白光照明和/或用于荧光颜色的激发光源。 用于显微镜的本发明的照明装置由表面或空间上布置的光源组成，其连接到用于产生任何期望的照明图案和照明光谱的控制单元，以及照明光学器件，用于将这些照明图案成像在待检查对象上。 光源由LED（11）组成，其激发适于由LED（11）发射的波长的至少一种发光颜色（14）。 LED（11）同心地布置在照明装置的光轴上，优选地在孔径光阑平面内或附近。 显微镜照明使得能够实现用于明场，暗场，荧光，倾斜和/或环形照明的柔性照明结构和照明光谱，以及具有总日光谱的白光照明。 由于LED的优点（经济，低功耗，长使用寿命和易于控制），这种照明装置特别适用于现场，例如考古学，地质学和保护环境。

公开(公告)号：US20100121548A1

公开(公告)日：2010-05-13

申请号：US12597532

申请日：2008-04-22

Applicant: Jochen Müller ,  Jochen Zimmermann ,  Robert Schmidt ,  Dieter Burkhard

Inventor： Jochen Müller ,  Jochen Zimmermann ,  Robert Schmidt ,  Dieter Burkhard

IPC: B60T8/36

CPC classification number: B60T8/36 ,  B60T8/3655 ,  B60T8/4872 ,  B60T13/686

Abstract: A correction method in which characteristic curves and/or correction values are produced, by way of which the drive current for one or more electrically activated hydraulic values operated in an analog fashion is measured during a pressure regulation in such a way that, during the operation of an anti-lock regulation, one or a respective characteristic curve is first prescribed and then the prescribed characteristic curve is corrected, particularly in a learning process, wherein, after a pressure build-up phase, the current pressure model value (Pmod) is compared to and/or analyzed using a model locking pressure level (Pmax).

Abstract translation: 产生特性曲线和/或校正值的校正方法，通过该校正方法，在压力调节期间测量以模拟方式操作的一个或多个电激活液压值的驱动电流，使得在操作期间 首先规定一个或相应的特性曲线，然后校正规定的特性曲线，特别是在学习过程中，其中在压力建立阶段之后，当前压力模型值（Pmod）为 与模型锁定压力水平（Pmax）进行比较和/或分析。

公开(公告)号：US07129229B2

公开(公告)日：2006-10-31

申请号：US10344092

申请日：2001-08-10

Applicant: Stefan Raddatz ,  Jochen Müller-Ibeler ,  Markus Schweitzer ,  Christoph Brücher ,  Norbert Windhab ,  John R. Havens ,  Thomas J. Onofrey ,  Charles H. Greef ,  Daguang Wang

Inventor： Stefan Raddatz ,  Jochen Müller-Ibeler ,  Markus Schweitzer ,  Christoph Brücher ,  Norbert Windhab ,  John R. Havens ,  Thomas J. Onofrey ,  Charles H. Greef ,  Daguang Wang

IPC: A61K31/66 ,  C07F9/02

CPC classification number: A61K31/66 ,  C07F9/2408 ,  C07F9/2429

Abstract: This invention relates to attachment chemistries for binding macromolecules to a substrate surface or to other conjugation targets. More particularly, this invention relates to attachment chemistries involving branched or linear structures having one or more hydrazide attachment moieties for binding the macromolecules to a substrate surface, or for other conjugation reactions. Novel modifying reagents are provided for the introduction of protected hydrazide attachment moieties or precursor forms of such hydrazides to the macromolecule, either as a single hydrazide or as multiple hydrazides.

Abstract translation: 本发明涉及用于将大分子结合到底物表面或其它共轭靶的附着化学物质。 更具体地说，本发明涉及包含具有一个或多个用于将大分子结合到底物表面或其它共轭反应的一个或多个酰肼连接部分的支链或线性结构的附着化学物质。 提供了新的改性试剂，用于将受保护的酰肼连接部分或这种酰肼的前体形式引入高分子，作为单酰肼或多个酰肼。

公开(公告)号：US07062690B2

公开(公告)日：2006-06-13

申请号：US09907786

申请日：2001-07-18

Applicant: Wolfgang Ernst ,  Gunnar Krause ,  Justus Kuhn ,  Jens Lüpke ,  Jochen Müller ,  Peter Pöchmüller ,  Michael Schittenhelm

Inventor： Wolfgang Ernst ,  Gunnar Krause ,  Justus Kuhn ,  Jens Lüpke ,  Jochen Müller ,  Peter Pöchmüller ,  Michael Schittenhelm

IPC: G01R31/28

CPC classification number: G11C29/48 ,  G01R31/31905 ,  G11C29/56

Abstract: A system and a method for testing fast synchronous digital circuit with an additional built outside self test semiconductor chip disposed between a test device and circuit under test. The chip has a switching/detection unit that tests the chip based on external criteria between a first normal operating mode in which the chip tests the circuit to be tested, and a second operating mode in which programmable registers of the register unit of a receiver of the chip are programmed by the external test device. The registers store constants and variables for generating the test signals and for evaluating them. The chip generates test signals and transceiver for sending the test signals and receiving response signals generated thereby.

公开(公告)号：US06914811B2

公开(公告)日：2005-07-05

申请号：US10651857

申请日：2003-08-29

Applicant: Jochen Müller

Inventor： Jochen Müller

IPC: G11C17/18 ,  G11C16/04

CPC classification number: G11C17/18

Abstract: A method and a configuration for driving one-time operable isolation elements on a semiconductor chip store an item of isolation information for each isolation element to be operated on the chip. In which case, as soon as the isolation information item is present for an isolation element, a one-time operation on the isolation element is begun.

Abstract translation: 用于驱动半导体芯片上的一次可操作隔离元件的方法和配置存储要在芯片上操作的每个隔离元件的隔离信息项。 在这种情况下，一旦隔离元件存在隔离信息项，就开始隔离元件上的一次性操作。

公开(公告)号：US06862702B2

公开(公告)日：2005-03-01

申请号：US09907776

申请日：2001-07-18

Applicant: Wolfgang Ernst ,  Gunnar Krause ,  Justus Kuhn ,  Jens Lüpke ,  Jochen Müller ,  Peter Pöchmüller ,  Michael Schittenhelm

Inventor： Wolfgang Ernst ,  Gunnar Krause ,  Justus Kuhn ,  Jens Lüpke ,  Jochen Müller ,  Peter Pöchmüller ,  Michael Schittenhelm

IPC: G11C29/56 ,  G11C29/00

CPC classification number: G11C29/56

Abstract: The novel address counter can be used in combination with an existing test unit—serving for testing digital circuits—for addressing synchronous high-frequency digital circuits, in particular fast memory devices. Address offset values are provided in programmable offset registers, with a multiplexer circuit and a selection and combination circuit, on the basis of input signals which are fed in at low frequency and in parallel by the test unit. Simple address changes and address jumps can be realized at a high clock frequency in a very flexible manner.

Abstract translation: 新颖的地址计数器可以与用于测试数字电路的现有测试单元结合使用 - 用于寻址同步高频数字电路，特别是快速存储器件。 在可编程偏移寄存器中提供地址偏移值，其中多路复用器电路和选择和组合电路基于由测试单元以低频和并联馈送的输入信号。 可以以非常灵活的方式在高时钟频率下实现简单的地址改变和地址跳转。

公开(公告)号：US06853206B2

公开(公告)日：2005-02-08

申请号：US10736356

申请日：2003-12-15

Applicant: Michael Hübner ,  Gunnar Krause ,  Justus Kuhn ,  Jochen Müller ,  Peter P{hacek over (o)}chmüller ,  Jürgen Weidenhöfer

Inventor： Michael Hübner ,  Gunnar Krause ,  Justus Kuhn ,  Jochen Müller ,  Peter P{hacek over (o)}chmüller ,  Jürgen Weidenhöfer

IPC: G01R31/3185 ,  G01R31/319 ,  G11C29/00 ,  G11C29/48 ,  G01R31/02 ,  G01R31/28

CPC classification number: G01R31/319 ,  G01R31/318505 ,  G01R31/318511 ,  G01R31/31905 ,  G11C29/006 ,  G11C29/48

Abstract: A test configuration for testing a plurality of integrated circuits, in particular fast semiconductor memory modules located on a wafer, in parallel. The test configuration includes a carrier board for bringing up electrical signal lines belonging to a test system, contact-making needles for producing electrical connections with contact areas on the circuits to be tested, and a plurality of active modules that are arranged on the carrier board. The active modules are each assigned to one of the circuits to be tested in parallel, and are each case inserted into the signal path between the test system and the associated circuit to be tested. In a preferred embodiment, the active modules are arranged at least partly overlapping, based on a direction at right angles to the plane of the carrier board.

Abstract translation: 用于同时测试位于晶片上的多个集成电路，特别是快速半导体存储器模块的测试配置。 测试配置包括用于提升属于测试系统的电信号线的承载板，用于产生与要测试的电路上的接触区域的电连接的接触针，以及布置在承载板上的多个有源模块 。 有源模块分别被分配给要并联测试的电路之一，并且每一个都被插入测试系统和要测试的相关电路之间的信号路径中。 在优选实施例中，有源模块基于与载板的平面成直角的方向至少部分地重叠布置。