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    Device for sampling plant material
    11.
    发明授权
    Device for sampling plant material 有权
    设备用于采样植物材料

    公开(公告)号：US07980148B2

    公开(公告)日：2011-07-19

    申请号：US11948491

    申请日：2007-11-30

    Applicant: Daniel S. Kline ,  Anthony David Barghini ,  Scott Wayne Beaver ,  James Coleman Lee ,  William Michael Lafferty

    Inventor： Daniel S. Kline ,  Anthony David Barghini ,  Scott Wayne Beaver ,  James Coleman Lee ,  William Michael Lafferty

    IPC: G01N1/04

    CPC classification number: G01N1/08 ,  G01N1/04 ,  G01N33/0098 ,  G01N2001/288

    Abstract: A device for collecting plant samples includes a punch and die mechanism for taking leaf plugs from plants. The punch itself includes a punch rod coaxially mounted inside a punch tube. In use, the punch tube has a distal end with two, diametrically opposed projections that interact with the formed aperture to cut a plug from a plant leaf. The punch rod then follows to remove a cut leaf plug from the formed aperture. Also included is a hydraulic subsystem for periodically delivering liquid on the punch and die mechanism to prevent plant debris from clogging the device.

    Abstract translation: 用于收集植物样品的装置包括用于从植物取出叶片的冲头和模具机构。 冲头本身包括同轴地安装在冲头管内的冲杆。 在使用中，冲头管具有远端，其具有与形成的孔相互作用的两个直径相对的突起，以从植物叶切割塞子。 接下来的打孔杆从形成的孔中移除切割的叶片。 还包括液压子系统，用于在冲头和模具机构上周期性地输送液体，以防止植物碎屑堵塞装置。

    Stackable sample holding plate with robot removable lid
    12.
    发明授权
    Stackable sample holding plate with robot removable lid 有权
    可堆放样品保持板，带机械手可拆卸盖

    公开(公告)号：US06918738B2

    公开(公告)日：2005-07-19

    申请号：US10095906

    申请日：2002-03-11

    Applicant: William Michael Lafferty ,  Scott Wayne Beaver ,  Charles Wilson Tweedy

    Inventor： William Michael Lafferty ,  Scott Wayne Beaver ,  Charles Wilson Tweedy

    IPC: B01L3/00 ,  G01N35/04 ,  B65G59/06 ,  B65H3/00 ,  C12M1/22 ,  C12M1/34 ,  C12M3/00

    CPC classification number: B01L3/5085 ,  B01L2200/02 ,  B01L2200/025 ,  B01L2300/042 ,  B01L2300/0829 ,  G01N2035/0425 ,  G01N2035/0427

    Abstract: A holding plate includes a flat base member with a surface that is formed with a plurality of stations (wells or depressions) for holding specimens. A panel extends downwardly from the edge of the surface to create a concavity for receiving a lid member therein. The panel also has a flange extending outwardly from the concavity. The flat lid member has a skirt with a rim that extends from the edge of the lid member to create a hollow for receiving a base member therein. In operation, a robot or mechanical device selectively engages the flange of the base member and the rim of the lid member to engage or disengage the base and lid members. This allows for individual movement of either the base member or the lid member. This also allows for collective movement of the engaged base and lid members for stacking and storage.

    Abstract translation: 保持板包括具有表面的平坦的基底构件，该表面形成有用于保持试样的多个站（孔或凹陷）。 面板从表面的边缘向下延伸以形成用于在其中接收盖构件的凹部。 面板还具有从凹部向外延伸的凸缘。 平盖部件具有裙部，该裙部具有从盖部件的边缘延伸的边缘，以形成用于在其中容纳基部部件的中空部。 在操作中，机器人或机械装置选择性地接合基部构件的凸缘和盖构件的边缘以接合或脱离底座和盖构件。 这允许基部构件或盖构件的单独移动。 这也允许接合的基座和盖构件的集体运动用于堆叠和存储。

    Gigamatrix holding tray having through-hole wells
    13.
    发明申请
    Gigamatrix holding tray having through-hole wells 审中-公开
    Gigamatrix保持盘具有通孔孔

    公开(公告)号：US20050046833A1

    公开(公告)日：2005-03-03

    申请号：US10964940

    申请日：2004-10-14

    Applicant: William Michael Lafferty

    Inventor： William Michael Lafferty

    IPC: G01N21/64 ,  B01L3/00 ,  C03B37/15 ,  C03B37/16 ,  C12M1/34 ,  C12N15/12 ,  C12Q1/68 ,  G01N1/10 ,  G01N21/03 ,  G06K9/00

    CPC classification number: C03B37/16 ,  B01J2219/00641 ,  B01L3/50857 ,  B01L2200/025 ,  B01L2300/0819 ,  B01L2300/0838 ,  B01L2400/0406 ,  C03B37/15

    Abstract: A GigaMatrix plate for holding a large number of small-volume fluid samples includes a base for supporting a plurality of substantially parallel, elongated capillary tubes. Each tube defines a lumen that extends through the base, and each lumen has an aspect ratio greater than about 5:1. Dimensionally, each lumen has an inner diameter that is less than approximately five hundred microns and it has a length greater than about five millimeters. Further, each tube acts to optically distinguish light that is directed toward it from the sample whenever the sample fluoresces inside the tube lumen. Also, however, light from the sample that is directed axially through the tube is emitted therefrom for optical detection of the tube and the sample therein.

    Abstract translation: 用于容纳大量小体积流体样品的Giga矩阵板包括用于支撑多个基本平行的细长毛细管的基座。 每个管限定延伸穿过基部的内腔，并且每个内腔具有大于约5:1的纵横比。 在尺寸上，每个内腔具有小于约五百微米的内径，并且其长度大于约五毫米。 此外，每当管子在管腔内发出荧光时，每个管用于将来自样品的光定向到光学上。 然而，从轴向通过管的样品的光也被发射出来，用于光学检测管和样品。

    System for sampling and tracking plant material
    14.
    发明授权
    System for sampling and tracking plant material 有权
    系统采样和跟踪植物材料

    公开(公告)号：US08758683B2

    公开(公告)日：2014-06-24

    申请号：US11835986

    申请日：2007-08-08

    Applicant: William Michael Lafferty ,  Scott Wayne Beaver ,  Charles Wilson Tweedy ,  Elizabeth Ann George ,  Walter James Frandsen, Jr.

    Inventor： William Michael Lafferty ,  Scott Wayne Beaver ,  Charles Wilson Tweedy ,  Elizabeth Ann George ,  Walter James Frandsen, Jr.

    IPC: G01N1/04 ,  G01N1/28 ,  G01N35/02

    CPC classification number: G01N1/04 ,  G01N1/286 ,  G01N35/021 ,  G01N2001/288 ,  G06Q10/087

    Abstract: A system and method for processing, i.e., sampling and tracking, plant material requires the ability to identify each plant in a plurality of plants. Initially, samples are taken from selected plants and are collected in respective storage locations in a magazine. During sampling, the identity of the plant source for each plant sample is stored. Further, the identity of each storage location receiving a plant sample is stored. Subsequently, the samples are transferred from the storage locations and are placed in respective wells of a receiving member for further downstream processing. Again, the identity of each well receiving a plant sample is stored. As a result, a plant sample in a well can be traced back to its plant source.

    Abstract translation: 用于处理，即采样和跟踪植物材料的系统和方法需要识别多个植物中的每个植物的能力。 最初，样品从选定的植物中取出并收集在杂志的相应存储位置。 在采样期间，存储每个植物样品的植物来源的身份。 此外，存储接收植物样本的每个存储位置的身份。 随后，将样品从存储位置转移并放置在接收构件的相应孔中用于进一步的下游处理。 再次，存储接收植物样品的每个孔的身份。 因此，井中的植物样品可以追溯到其植物来源。

    Method and Apparatus for Addressable Flow Cells in Single Molecule Sequencing
    15.
    发明申请
    Method and Apparatus for Addressable Flow Cells in Single Molecule Sequencing 审中-公开
    单分子测序中可寻址流动池的方法和装置

    公开(公告)号：US20110311963A1

    公开(公告)日：2011-12-22

    申请号：US13049660

    申请日：2011-03-16

    Applicant: W. MICHAEL LAFFERTY ,  JOSEPH BEECHEM ,  HONGYE SUN ,  MICHAEL METZKER

    Inventor： W. MICHAEL LAFFERTY ,  JOSEPH BEECHEM ,  HONGYE SUN ,  MICHAEL METZKER

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  C12Q2523/319 ,  C12Q2525/186 ,  C12Q2565/513

    Abstract: A method of sequencing a plurality of template nucleotide sequences includes immobilizing the plurality of template nucleotide sequences on a substrate. A first subset of the plurality of template nucleotide sequences is immobilized in a first field of view and a second subset of the plurality of template nucleotide sequences is immobilized in a second field of view. The first and second subsets are hybridized to a caged primer. The caged primer includes a caging group. The method further includes lysing the caging group from the caged primer in the first field of view and observing the first field of view to detect sequencing of the first subset of the plurality of template nucleotide sequences.

    Abstract translation: 对多个模板核苷酸序列进行测序的方法包括将多个模板核苷酸序列固定在底物上。 多个模板核苷酸序列的第一子集被固定在第一视场中，并且多个模板核苷酸序列的第二子集被固定在第二视野中。 第一和第二子集与笼式引物杂交。 笼状引物包括笼养组。 该方法还包括在第一视场中从笼式引物裂解笼基组，并观察第一视野以检测多个模板核苷酸序列的第一子集的测序。

    GigaMatrix holding tray having through-hole wells
    17.
    发明授权
    GigaMatrix holding tray having through-hole wells 有权

    公开(公告)号：US07019827B2

    公开(公告)日：2006-03-28

    申请号：US10084552

    申请日：2002-02-25

    Applicant: William Michael Lafferty

    Inventor： William Michael Lafferty

    IPC: G01N1/10

    CPC classification number: C03B37/16 ,  B01J2219/00641 ,  B01L3/50857 ,  B01L2200/025 ,  B01L2300/0819 ,  B01L2300/0838 ,  B01L2400/0406 ,  C03B37/15

    Abstract: A GigaMatrix plate for holding a large number of small-volume fluid samples includes a base for supporting a plurality of substantially parallel, elongated capillary tubes. Each tube defines a lumen that extends through the base, and each lumen has an aspect ratio greater than about 5:1. Dimensionally, each lumen has an inner diameter that is less than approximately five hundred microns and it has a length greater than about five millimeters. Further, each tube acts to optically distinguish light that is directed toward it from the sample whenever the sample fluoresces inside the tube lumen. Also, however, light from the sample that is directed axially through the tube is emitted therefrom for optical detection of the tube and the sample therein.

    Capillary array-based enzyme screening
    18.
    发明授权
    Capillary array-based enzyme screening 有权
    基于毛细管阵列的酶筛选

    公开(公告)号：US06972183B1

    公开(公告)日：2005-12-06

    申请号：US09444112

    申请日：1999-11-22

    Applicant: William Michael Lafferty ,  Jay M. Short ,  Martin Keller

    Inventor： William Michael Lafferty ,  Jay M. Short ,  Martin Keller

    IPC: C12N15/10 ,  G01N33/573

    CPC classification number: C12N15/1086

    Abstract: A process for screening an expression library to identify clones expressing enzymes having a desired activity is provided. The process involves first generating from genomic DNA samples of one or more microorganisms an expression library comprising a plurality of recombinant cell clones, and then introducing into capillaries in a capillary array a substrate and at least a subset of the clones, either individually or as a mixture. Interaction of the substrate and a clone expressing an enzyme having the desired activity produces an optically detectable signal, which can then be spatially detected to identify capillaries containing clones producing such a signal. The signal-producing clones can then be recovered from the identified capillaries.

    Abstract translation: 提供了筛选表达文库以鉴定表达具有所需活性的酶的克隆的方法。 该方法包括首先从一种或多种微生物的基因组DNA样品产生包含多个重组细胞克隆的表达文库，然后将毛细管阵列中的毛细管阵列引入基质和克隆的至少一个子集，单独地或作为 混合物。 底物和表达具有所需活性的酶的克隆的相互作用产生光学上可检测的信号，然后可以在空间上检测，以鉴定含有产生这种信号的克隆的毛细血管。 然后可以从识别的毛细血管中回收信号产生克隆。

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