公开(公告)号：US5492821A

公开(公告)日：1996-02-20

申请号：US791915

申请日：1991-11-13

Applicant: Matthew R. Callstrom ,  Mark D. Bednarski ,  Patrick R. Gruber

Inventor： Matthew R. Callstrom ,  Mark D. Bednarski ,  Patrick R. Gruber

IPC: A61K47/48 ,  C07H5/06 ,  C07H13/04 ,  C07H15/12 ,  C07K16/12 ,  C07K16/44 ,  C08F8/30 ,  C08F8/34 ,  C12N11/06 ,  C12N11/08 ,  G01N33/545 ,  G01N33/58 ,  C12N9/00 ,  C12N9/96

CPC classification number: C07H5/06 ,  A61K47/48176 ,  A61K47/4843 ,  A61K47/48692 ,  C07H13/04 ,  C07H15/12 ,  C07K16/1292 ,  C07K16/44 ,  C08F8/30 ,  C08F8/34 ,  C12N11/06 ,  C12N11/08 ,  G01N33/545 ,  G01N33/581 ,  Y10S530/816

Abstract: This invention is directed to water soluble protein polymer conjugates which are stabile in hostile environments. The conjugate comprises a protein which is linked to an acrylic polymer at multiple points through saccharide linker groups.

Abstract translation: 本发明涉及在恶劣环境中稳定的水溶性蛋白质聚合物缀合物。 缀合物包含通过糖连接基团在多个点与丙烯酸聚合物连接的蛋白质。

公开(公告)号：US5475080A

公开(公告)日：1995-12-12

申请号：US34099

申请日：1993-03-22

Applicant: Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Christopher M. Ryan ,  Eric S. Hall ,  Robin S. Eichen Conn

Inventor： Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Christopher M. Ryan ,  Eric S. Hall ,  Robin S. Eichen Conn

IPC: C08K3/16 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/88 ,  C08G63/90 ,  C08J5/18 ,  C08K3/22 ,  C08K3/26 ,  C08K3/30 ,  C08K3/34 ,  C08K5/10 ,  C08K5/13 ,  C08K5/1515 ,  C08K5/1575 ,  C08K5/29 ,  C08K5/51 ,  C08K5/524 ,  C08K5/54 ,  C08L67/00 ,  C08L67/04 ,  C08L101/00 ,  C08L101/16 ,  C09D167/04 ,  D01F6/62 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62

CPC classification number: C08J5/18 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/90 ,  C08L67/04 ,  C09D167/04 ,  D01F6/625 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62 ,  C08G2230/00 ,  C08J2367/04 ,  C08L101/00 ,  Y10T428/31504 ,  Y10T428/31786 ,  Y10T428/3179 ,  Y10T428/31808 ,  Y10T428/31819 ,  Y10T428/31993

Abstract: A lactide polymer coating resulting in a strong, repulpable, high gloss, paper coating. The lactide polymer comprises a plurality of poly(lactide) polymer chains, residual lactide in concentration of less than about 5 percent and water in concentration of less than about 2000 parts-per-million. A process for coating paper with the lactide polymer composition is also disclosed.

Abstract translation: 丙交酯聚合物涂层产生强烈的，可重新涂抹的，高光泽的纸张涂层。 丙交酯聚合物包含多个聚（丙交酯）聚合物链，浓度小于约5％的残余丙交酯和浓度小于约百万分之二千份的水。 还公开了用丙交酯聚合物组合物涂布纸的方法。

公开(公告)号：US5446123A

公开(公告)日：1995-08-29

申请号：US233000

申请日：1994-04-25

Applicant: Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Eric S. Hall ,  Robin S. Eichen Conn ,  Christopher M. Ryan

Inventor： Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Eric S. Hall ,  Robin S. Eichen Conn ,  Christopher M. Ryan

IPC: C08K3/16 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/88 ,  C08G63/90 ,  C08J5/18 ,  C08K3/22 ,  C08K3/26 ,  C08K3/30 ,  C08K3/34 ,  C08K5/10 ,  C08K5/13 ,  C08K5/1515 ,  C08K5/1575 ,  C08K5/29 ,  C08K5/51 ,  C08K5/524 ,  C08K5/54 ,  C08L67/00 ,  C08L67/04 ,  C08L101/00 ,  C08L101/16 ,  C09D167/04 ,  D01F6/62 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62

CPC classification number: C08J5/18 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/90 ,  C08L67/04 ,  C09D167/04 ,  D01F6/625 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62 ,  C08G2230/00 ,  C08J2367/04 ,  C08L101/00 ,  Y10T428/31504 ,  Y10T428/31786 ,  Y10T428/3179 ,  Y10T428/31808 ,  Y10T428/31819 ,  Y10T428/31993

Abstract: A lactide polymer composition combining compositional and purity limitations and catalyst optimization or addition of stabilizing agents resulting in a melt-stable polymer is disclosed. The melt-stable lactide polymer comprises a plurality of polylactide polymer chains, residual lactide in concentration of less than 2 percent and water in concentration of less than 1000 parts-per-million. A stabilizing agent in an amount sufficient to reduce depolymerization of the lactide polymer during melt-processing or alternatively, control of catalyst level at a molar ratio of monomer to catalyst greater than 3000:1 is also included in the melt-stable composition. A process for manufacture of a melt-stable lactide polymer composition includes polymerizing a lactide mixture and adding stabilizing agents sufficient to reduce depolymerization of the polylactide during melt-processing, followed by devolatilizing the polylactide to remove monomer and water.

Abstract translation: 公开了结合组合和纯度限制和催化剂优化或添加产生熔融稳定聚合物的稳定剂的丙交酯聚合物组合物。 熔融稳定的丙交酯聚合物包含多个聚丙交酯聚合物链，浓度小于2％的残余丙交酯和浓度小于1000ppm的水。 在熔融加工过程中足以减少丙交酯聚合物解聚的稳定剂，或者以单体与催化剂的摩尔比大于3000:1的催化剂含量的控制也包括在熔融稳定组合物中。 制备熔融稳定的丙交酯聚合物组合物的方法包括聚合丙交酯混合物并加入足以在熔融加工期间减少聚丙交酯的解聚的稳定剂，然后使聚交酯脱挥发去除单体和水。

公开(公告)号：US5338822A

公开(公告)日：1994-08-16

申请号：US955690

申请日：1992-10-02

Applicant: Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Eric S. Hall ,  Robin S. Eichen Conn ,  Christopher M. Ryan

Inventor： Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Eric S. Hall ,  Robin S. Eichen Conn ,  Christopher M. Ryan

IPC: C08K3/16 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/88 ,  C08G63/90 ,  C08J5/18 ,  C08K3/22 ,  C08K3/26 ,  C08K3/30 ,  C08K3/34 ,  C08K5/10 ,  C08K5/13 ,  C08K5/1515 ,  C08K5/1575 ,  C08K5/29 ,  C08K5/51 ,  C08K5/524 ,  C08K5/54 ,  C08L67/00 ,  C08L67/04 ,  C08L101/00 ,  C08L101/16 ,  C09D167/04 ,  D01F6/62 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62

CPC classification number: C08J5/18 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/90 ,  C08L67/04 ,  C09D167/04 ,  D01F6/625 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62 ,  C08G2230/00 ,  C08J2367/04 ,  C08L101/00 ,  Y10T428/31504 ,  Y10T428/31786 ,  Y10T428/3179 ,  Y10T428/31808 ,  Y10T428/31819 ,  Y10T428/31993

Abstract: A lactide polymer composition combining compositional and purity limitations and catalyst optimization or addition of stabilizing agents resulting in a melt-stable polymer is disclosed. The melt-stable lactide polymer comprises a plurality of polylactide polymer chains, residual lactide in concentration of less than 2 percent and water in concentration of less than 1000 parts-per-million. A stabilizing agent in an amount sufficient to reduce depolymerization of the lactide polymer during melt-processing or alternatively, control of catalyst level at a molar ratio of monomer to catalyst greater than 3000:1 is also included in the melt-stable composition. A process for manufacture of a melt-stable lactide polymer composition includes polymerizing a lactide mixture and adding stabilizing agents sufficient to reduce depolymerization of the polylactide during melt-processing, followed by devolatilizing the polylactide to remove monomer and water.

Abstract translation: 公开了结合组合和纯度限制和催化剂优化或添加产生熔融稳定聚合物的稳定剂的丙交酯聚合物组合物。 熔融稳定的丙交酯聚合物包含多个聚丙交酯聚合物链，浓度小于2％的残余丙交酯和浓度小于1000ppm的水。 在熔融加工过程中足以减少丙交酯聚合物解聚的稳定剂，或者以单体与催化剂的摩尔比大于3000:1的催化剂含量的控制也包括在熔融稳定组合物中。 制备熔融稳定的丙交酯聚合物组合物的方法包括聚合丙交酯混合物并加入足以在熔融加工期间减少聚丙交酯的解聚的稳定剂，然后使聚交酯脱挥发去除单体和水。

公开(公告)号：US08546627B2

公开(公告)日：2013-10-01

申请号：US13441468

申请日：2012-04-06

Applicant: Patrick R. Gruber ,  Matthew W. Peters ,  Josefa M. Griffith ,  Yassin Al Obaidi ,  Leo E. Manzer ,  Joshua D. Taylor ,  David E. Henton

Inventor： Patrick R. Gruber ,  Matthew W. Peters ,  Josefa M. Griffith ,  Yassin Al Obaidi ,  Leo E. Manzer ,  Joshua D. Taylor ,  David E. Henton

IPC: C10L1/04 ,  C07C2/04 ,  C07C15/08 ,  C07C69/82

CPC classification number: C10L1/08 ,  C07C1/24 ,  C07C2/08 ,  C07C2/76 ,  C07C5/03 ,  C07C9/14 ,  C07C9/15 ,  C07C51/265 ,  C10G3/00 ,  C10G50/00 ,  C10G69/126 ,  C10G2300/1011 ,  C10G2300/42 ,  C10G2400/02 ,  C10G2400/04 ,  C10G2400/08 ,  C10G2400/30 ,  C10L1/04 ,  C10L1/06 ,  C10L2200/043 ,  C10L2200/0469 ,  C10L2270/04 ,  C10L2290/26 ,  C10L2290/543 ,  C12P5/00 ,  C12P7/04 ,  C12P7/06 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/13 ,  Y02E50/17 ,  Y02P30/20 ,  Y02T50/678 ,  C07C11/02 ,  C07C15/00 ,  C07C63/26 ,  C07C11/09

Abstract: The present invention is directed to renewable compositions derived from fermentation of biomass, and integrated methods of preparing such compositions.

公开(公告)号：US20130183730A9

公开(公告)日：2013-07-18

申请号：US13302775

申请日：2011-11-22

Applicant: William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins ,  Peter Meinhold ,  Reid M. Renny Feldman ,  Uvini Gunawardena ,  Jun Urano

Inventor： William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins ,  Peter Meinhold ,  Reid M. Renny Feldman ,  Uvini Gunawardena ,  Jun Urano

IPC: C12P7/16

CPC classification number: C12M43/00 ,  C07C29/80 ,  C07C29/86 ,  C12C11/11 ,  C12M45/20 ,  C12P7/04 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/17 ,  Y10T29/49826 ,  C07C31/12

Abstract: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.

公开(公告)号：US08450543B2

公开(公告)日：2013-05-28

申请号：US12986918

申请日：2011-01-07

Applicant: Matthew W. Peters ,  Joshua D. Taylor ,  David E. Henton ,  Leo E. Manzer ,  Patrick R. Gruber ,  Josefa M. Griffith ,  Yassin Al Obaidi

Inventor： Matthew W. Peters ,  Joshua D. Taylor ,  David E. Henton ,  Leo E. Manzer ,  Patrick R. Gruber ,  Josefa M. Griffith ,  Yassin Al Obaidi

IPC: C07C1/24

CPC classification number: C07C1/24 ,  C07C9/16 ,  C07C11/02 ,  C07C11/167 ,  C07C15/02 ,  C07C15/04 ,  C07C15/08 ,  C07C37/20 ,  C07C37/50 ,  C07C45/28 ,  C07C45/53 ,  C07C51/16 ,  C07C67/00 ,  C07C67/08 ,  C07C407/00 ,  C07D301/19 ,  C10G3/00 ,  C10G29/205 ,  C10G50/00 ,  C10G69/12 ,  Y02P20/52 ,  C07C11/04 ,  C07C11/08

Abstract: Isobutene, isoprene, and butadiene are obtained from mixtures of C4 and/or C5 olefins by dehydrogenation. The C4 and/or C5 olefins can be obtained by dehydration of C4 and C5 alcohols, for example, renewable C4 and C5 alcohols prepared from biomass by thermochemical or fermentation processes. Isoprene or butadiene can be polymerized to form polymers such as polyisoprene, polybutadiene, synthetic rubbers such as butyl rubber, etc. in addition, butadiene can be converted to monomers such as methyl methacrylate, adipic acid, adiponitrile, 1,4-butadiene, etc. which can then be polymerized to form nylons, polyesters, polymethylmethacrylate etc.

Abstract translation: 异丁烯，异戊二烯和丁二烯通过脱氢从C4和/或C5烯烃的混合物中获得。 C4和/或C5烯烃可以通过C4和C5醇的脱水获得，例如通过热化学或发酵方法由生物质制备的可再生的C4和C5醇。 异戊二烯或丁二烯可以聚合形成聚合物，如聚异戊二烯，聚丁二烯，合成橡胶如丁基橡胶等。此外，丁二烯可以转化成单体如甲基丙烯酸甲酯，己二酸，己二腈，1,4-丁二烯等 然后将其聚合形成尼龙，聚酯，聚甲基丙烯酸甲酯等

公开(公告)号：US20120238787A1

公开(公告)日：2012-09-20

申请号：US13441459

申请日：2012-04-06

Applicant: Patrick R. Gruber ,  Matthew W. Peters ,  Jesefa M. Griffith ,  Yassin Al Obaidi ,  Leo E. Manzer ,  Joshua D. Taylor ,  David E. Henton

Inventor： Patrick R. Gruber ,  Matthew W. Peters ,  Jesefa M. Griffith ,  Yassin Al Obaidi ,  Leo E. Manzer ,  Joshua D. Taylor ,  David E. Henton

IPC: C12P7/16 ,  C07C11/00 ,  C10L1/16

CPC classification number: C10L1/08 ,  C07C1/24 ,  C07C2/08 ,  C07C2/76 ,  C07C5/03 ,  C07C9/14 ,  C07C9/15 ,  C07C51/265 ,  C10G3/00 ,  C10G50/00 ,  C10G69/126 ,  C10G2300/1011 ,  C10G2300/42 ,  C10G2400/02 ,  C10G2400/04 ,  C10G2400/08 ,  C10G2400/30 ,  C10L1/04 ,  C10L1/06 ,  C10L2200/043 ,  C10L2200/0469 ,  C10L2270/04 ,  C10L2290/26 ,  C10L2290/543 ,  C12P5/00 ,  C12P7/04 ,  C12P7/06 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/13 ,  Y02E50/17 ,  Y02P30/20 ,  Y02T50/678 ,  C07C11/02 ,  C07C15/00 ,  C07C63/26 ,  C07C11/09

Abstract: The present invention is directed to renewable compositions derived from fermentation of biomass, and integrated methods of preparing such compositions.

公开(公告)号：US20120040080A1

公开(公告)日：2012-02-16

申请号：US13269457

申请日：2011-10-07

Applicant: Andrew C. Hawkins ,  David A. Glassner ,  Thomas Buelter ,  James Wade ,  Peter Meinhold ,  Matthew W. Peters ,  Patrick R. Gruber ,  William A. Evanko ,  Aristos A. Aristidou

Inventor： Andrew C. Hawkins ,  David A. Glassner ,  Thomas Buelter ,  James Wade ,  Peter Meinhold ,  Matthew W. Peters ,  Patrick R. Gruber ,  William A. Evanko ,  Aristos A. Aristidou

IPC: A23K1/06 ,  C12S3/14 ,  C12S3/18 ,  C12S3/00

CPC classification number: C12P7/16 ,  C07K14/245 ,  C10G1/04 ,  C10G2300/1014 ,  C10G2300/4025 ,  C10L1/02 ,  C10L2200/0469 ,  C10L2290/26 ,  C12N9/0006 ,  C12N9/0036 ,  C12N9/2414 ,  C12N9/2417 ,  C12N9/2428 ,  C12N9/2434 ,  C12P7/04 ,  C12P7/24 ,  C12P7/62 ,  C12Y106/01002 ,  C12Y302/01001 ,  C12Y302/01003 ,  Y02E50/10 ,  Y02E50/16 ,  Y02P30/20

Abstract: Methods for producing a biofuel precursor are provided. Also provided are biocatalysts that convert a feedstock to a biofuel precursor.

Abstract translation: 提供生产生物燃料前体的方法。 还提供了将原料转化为生物燃料前体的生物催化剂。

公开(公告)号：US08101808B2

公开(公告)日：2012-01-24

申请号：US12342992

申请日：2008-12-23

Applicant: William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins

Inventor： William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins

IPC: C07C29/76

CPC classification number: C12M43/00 ,  C07C29/80 ,  C07C29/86 ,  C12C11/11 ,  C12M45/20 ,  C12P7/04 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/17 ,  Y10T29/49826 ,  C07C31/12

Abstract: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.

Abstract translation: 本发明涉及从稀释的水溶液如发酵液中回收C3-C6醇的方法。 这样的方法提供了用于发酵的改进的体积生产率并允许酒精回收。 由于通过同时发酵和回收过程增加了醇产物的有效浓度，所以这种方法还允许在用过的发酵液的生产和干燥中减少能量消耗，这增加了每一批发酵液干燥产生和回收的醇的量。 因此，本发明允许以低资本生产和回收C3-C6醇，降低运行成本。