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公开(公告)号：US20180344631A1
公开(公告)日：2018-12-06
申请号：US16059522
申请日：2018-08-09
Applicant: 3M Innovative Properties Company
Inventor： Ying Zhang , Kristen J. Hansen , Amy S. Determan
CPC classification number: A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
Abstract: A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.
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12.发明申请公开(公告)号：US20170247581A1
公开(公告)日：2017-08-31
申请号：US15507354
申请日：2015-09-01
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Ying Zhang , Albert I. Everaerts , Dong-Wei Zhu , Ross E. Behling , Gregg A. Caldwell
IPC: C09J11/06 , C09J5/00 , H01B1/02 , C09D133/08
CPC classification number: C09J11/06 , C08K5/07 , C08K5/3435 , C08K5/3475 , C09D133/08 , C09J5/00 , C09J201/00 , C09J201/025 , C09J2433/00 , H01B1/02 , H01B1/026
Abstract: The present invention is an adhesive composition for stabilizing an electrical conductor. The adhesive composition includes a base polymer and an additive for absorbing UV light, such as a benzotriazole or a benzophenone. When the adhesive composition is in contact with the electrical conductor, the electrical conductor has less than about a 20% change in electrical resistance over a period of about 500 hours.
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公开(公告)号：US20140046292A1
公开(公告)日：2014-02-13
申请号：US13791170
申请日：2013-03-08
Applicant: Radius Health, Inc. , 3M Innovative Properties Company, a wholly owned subsidiary of 3M Company
Inventor： Gary Hattersley , Kris J. Hansen , Amy S. Determan , Ying Zhang
Abstract: The present invention provides compositions, devices, methods and processes related to the intradermal delivery of PTHrP and PTHrP analogues, particularly [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.
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公开(公告)号：US12060502B2
公开(公告)日：2024-08-13
申请号：US17057841
申请日：2019-05-23
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Encai Hao , Zhicheng Tian , Dong-Wei Zhu , Zhaohui Yang , James P. Dizio , Ying Zhang , Junkang J. Liu , Kent C. Hackbarth
IPC: C09J151/08 , C08F220/18 , C08F283/12 , C08L33/08 , C09J11/08 , C09J133/08 , H10K50/844 , H10K50/00 , H10K50/10 , H10K50/80 , H10K50/842 , H10K59/10 , H10K59/12
CPC classification number: C09J151/08 , C08F220/1808 , C08F283/12 , C08L33/08 , C09J11/08 , C09J133/08 , C09J151/085 , H10K50/844 , H10K50/00 , H10K50/10 , H10K50/8426 , H10K50/868 , H10K59/10 , H10K59/12 , C08F220/1808 , C08F220/56 , C08F220/1808 , C08F218/08 , C08F220/56 , C08F283/12 , C08F220/1808 , C08F220/56 , C08F283/12 , C08F220/1808 , C08F220/56 , C08F218/08
Abstract: Phase separated articles that include a matrix phase including an acrylate copolymer; and a silicone elastomer phase stably dispersed in the matrix phase are described. The matrix phase may be derived from precursors comprising from 60 to 95 parts by weight of an alkyl acrylate having an alkyl group having 1 to 14 carbon atoms. Methods of forming phase separated articles, and articles including phase separated articles are also described.
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15.发明公开公开(公告)号：US20230151133A1
公开(公告)日：2023-05-18
申请号：US18150468
申请日：2023-01-05
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Vasav Sahni , Saswata Chakraborty , Wayne S. Mahoney , Jason D. Clapper , Jacob P. Johnson , Ying Zhang , Albert I. Everaerts , Bryan V. Hunt , Richard B. Ross
IPC: C08F255/10 , C08L23/22 , C09J123/22 , C09J153/02
CPC classification number: C08F255/10 , C08L23/22 , C09J123/22 , C09J153/025 , C08L2205/03
Abstract: A composition is described comprising a styrene-isobutylene block copolymer; and at least one ethylenically unsaturated monomer. After curing the composition comprises polymerized units of the ethylenically unsaturated monomer. In some embodiments the ethylenically unsaturated groups are selected from (meth)acryl or vinyl ether. The composition is suitable for use as a (e.g. pressure sensitive) adhesive. Articles, methods of making an article, and methods of bonding are also described.
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Patent Agency Ranking
公开(公告)号：USD875953S1
公开(公告)日：2020-02-18
申请号：US29654852
申请日：2018-06-28
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Designer： Dan Wang , Steven B. Heinecke , Richard L. Jacobson , Ying Zhang
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公开(公告)号：US20200048511A1
公开(公告)日：2020-02-13
申请号：US16486037
申请日：2018-02-12
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Ying Zhang , Vasav Sahni , Albert I. Everaerts
IPC: C09J123/22 , C09J7/40 , C09J7/38 , B32B7/12
Abstract: The present invention is an adhesive composition for use in passivating metallic conductors in an electronic device including at least one low molecular weight polyisobutylene polymer having a weight average molecular weight of about 75,000 or lower, at least one high molecular weight polyisobutylene polymer having a weight average molecular weight of about 120,000 or higher, and optionally, at least one tackifier. Each of the polyisobutylenes and the optional tackifier has a halogen ion content of no more than 1 ppm.
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公开(公告)号：US20220081593A1
公开(公告)日：2022-03-17
申请号：US17417169
申请日：2019-12-23
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jungkang Liu , Athanasios Touris , Shijing Cheng , Wengsheng Xia , Ying Zhang
Abstract: Adhesive articles include a substrate; and a hot melt processable pressure sensitive adhesive on the substrate. The hot melt processable pressure sensitive adhesive is a (meth)acrylate-based copolymer that is the reaction product of a reaction mixture that is free of acidic or basic monomers, and includes an alkyl (meth)acrylate, a hydroxyl-functional (meth)acrylate, and a photocrosslinker. The (meth)acrylate-based polymer is prepared in a thermoplastic package.
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公开(公告)号：US10154957B2
公开(公告)日：2018-12-18
申请号：US15480813
申请日：2017-04-06
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Ying Zhang , Percy T. Fenn , Peter R. Johnson
IPC: A61K38/29 , A61M37/00 , A61K9/00 , A61K31/4172 , A61K47/18 , A61K38/23 , A61K38/28 , A61K38/47 , A61K31/198 , A61L31/10 , A61L31/16 , A61K38/22 , A61K47/22
Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.
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20.发明申请公开(公告)号：US20170209367A1
公开(公告)日：2017-07-27
申请号：US15480813
申请日：2017-04-06
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Ying Zhang , Percy T. Fenn , Peter R. Johnson
CPC classification number: A61K9/0021 , A61K9/0087 , A61K31/198 , A61K31/4172 , A61K38/225 , A61K38/23 , A61K38/28 , A61K38/29 , A61K38/47 , A61K47/183 , A61K47/22 , A61L31/10 , A61L31/16 , A61L2300/214 , A61L2300/252 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , C12Y302/01007 , A61K2300/00
Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.
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