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公开(公告)号：US20180193315A1
公开(公告)日：2018-07-12
申请号：US15907597
申请日：2018-02-28
Applicant: AbbVie Inc.
Inventor： Edward A. Kesicki , Arthur F. Kluge , Michael A. Patane , John H. Van Drie, JR. , Ce Wang , Maricel Torrent , Michael L. Curtin , Todd M. Hansen , Rick F. Clark , Robin R. Frey , Zhiqin Ji , Yujia Dai , William J. McClellan , Jane Gong , Gui-dong G. Zhu , Anthony Mastracchio , Michael R. Michaelides , Thomas D. Penning , Chunqiu C. Lai
IPC: A61K31/4184 , C07D403/06 , C07D498/10 , A61K31/4439 , A61K31/423 , C07D405/06 , C07D409/06 , C07D403/12 , C07D413/14 , C07D235/02 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D263/52 , C07D491/107 , C07D493/10 , C07D495/10 , C07D401/06
CPC classification number: A61K31/4184 , A61K31/423 , A61K31/4439 , C07D235/02 , C07D263/52 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D491/107 , C07D493/10 , C07D495/10 , C07D498/10
Abstract: Compounds having a structure of Formula (IX): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1-Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.
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公开(公告)号：US09957274B2
公开(公告)日：2018-05-01
申请号：US15588398
申请日：2017-05-05
Applicant: AbbVie Inc.
Inventor： Michael R. Michaelides , Michael L. Curtin , Huan-Qiu Li , Marina A Pliushchev , Ying Wang , Hongyu H. Zhao , Richard F. Clark , Alan S. Florjancic , Zhiqin Ji , Mariazel Torrent , Ramzi F. Sweis , Anil Vasudevan , Justin D. Dietrich
IPC: C07D207/14 , A61K31/40 , C07D487/04 , C07D403/10 , C07D405/04 , C07D413/10 , C07D403/12 , C07D401/12 , C07D403/04 , C07D403/14 , C07D417/14 , C07D471/04 , C07D401/04 , C07D401/14
CPC classification number: C07D487/04 , A61K31/40 , C07D207/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D413/10 , C07D417/14 , C07D471/04
Abstract: Compounds having a structure of Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein A1, A2, A3, A4, A5, n, and m are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various EED-related conditions or diseases, including cancer, by administration of such compounds are also provided.
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公开(公告)号：US20160168134A1
公开(公告)日：2016-06-16
申请号：US15048574
申请日：2016-02-19
Applicant: AbbVie Inc.
Inventor： Michael L. Curtin , Kenton Longenecker , Todd M. Hansen , Richard F. Clark , Bryan Sorensen , Howard R. Heyman , Zhiqin Ji
IPC: C07D405/14
CPC classification number: C07D405/14 , A61K45/06 , C07D401/14 , C07D409/14 , C07D417/14
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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公开(公告)号：US09193723B2
公开(公告)日：2015-11-24
申请号：US13891349
申请日：2013-05-10
Applicant: AbbVie Inc.
Inventor： Richard F. Clark , Bryan Sorensen , Augustine T. Osuma , Robin Frey , Kenton Longenecker , George Doherty , Michael L. Curtin , Michael R. Michaelides , Ramzi F. Sweis , Marina A. Pliushchev , Andy Judd , Todd M. Hansen , Howard R. Heyman
IPC: A61K31/437 , A61K31/4985 , A61K45/06 , A61K31/5377 , C07D471/04 , C07D487/04 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/55 , A61K31/407
CPC classification number: A61K31/437 , A61K31/407 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
Abstract translation: 公开了抑制NAMPT活性的化合物，含有该化合物的组合物和治疗其中NAMPT表达的疾病的方法。
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公开(公告)号：US20170253562A1
公开(公告)日：2017-09-07
申请号：US15287851
申请日：2016-10-07
Applicant: AbbVie Inc.
Inventor： Michael L. Curtin , Anil Vasudevan , Kevin Woller
IPC: C07D209/44 , C07D403/12 , C07D405/12 , C07D491/10 , A61K31/55 , A61K31/547 , A61K31/5377 , A61K31/501 , C07D491/107 , C07D491/048 , C07D487/04 , A61K31/551 , A61K31/4035 , A61K31/4178
CPC classification number: C07D209/44 , A61K31/4035 , A61K31/4178 , A61K31/501 , A61K31/5377 , A61K31/547 , A61K31/55 , A61K31/551 , A61K45/06 , C07D403/12 , C07D405/12 , C07D487/04 , C07D491/048 , C07D491/10 , C07D491/107 , A61K2300/00
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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Patent Agency Ranking
公开(公告)号：US20170065575A1
公开(公告)日：2017-03-09
申请号：US15357383
申请日：2016-11-21
Applicant: AbbVie Inc.
Inventor： Todd M. Hansen , Kenton Longenecker , Howard R. Heyman , Michael L. Curtin , Richard F. Clark , Bryan Sorensen , Zhiqin Ji , Kevin Woller , George Doherty , Robin Frey
IPC: A61K31/4545 , A61K31/506 , A61K31/501 , A61K31/5377 , A61K31/496
CPC classification number: A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
Abstract translation: 公开了抑制NAMPT活性的化合物，含有该化合物的组合物和治疗其中NAMPT表达的疾病的方法。
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公开(公告)号：US20160235716A1
公开(公告)日：2016-08-18
申请号：US14857419
申请日：2015-09-17
Applicant: ABBVIE INC.
Inventor： Edward A. Kesicki , Arthur F. Kluge , Michael A. Patane , John H. Van Drie, JR. , Ce Wang , Maricel Torrent , Michael L. Curtin , Todd M. Hansen , Rick F. Clark , Robin R. Frey , Zhiqin Ji , Yujia Dai , William J. McClellan , Jane Gong , Gui-dong G. Zhu , Anthony Mastracchio , Michael R. Michaelides , Thomas D. Penning , Chunqiu C. Lai
IPC: A61K31/4184 , C07D403/06 , C07D405/06 , A61K31/423 , C07D401/06 , A61K31/4439 , C07D263/52 , C07D235/02 , C07D409/06
CPC classification number: A61K31/4184 , A61K31/423 , A61K31/4439 , C07D235/02 , C07D263/52 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D491/107 , C07D493/10 , C07D495/10 , C07D498/10
Abstract: Compounds having a structure of Formula (IX): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1- - - -Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.
Abstract translation: 具有式（IX）结构的化合物或其立体异构体，互变异构体或其药学上可接受的盐，其中R1，R2a，R2b，R3a，R3b，R4a，R4b，Q1- - -Q2，R6，R7，A，B ，W，x和y如本文所定义并提供。 还提供了包含这些化合物的药物组合物和通过施用这些化合物治疗各种HAT相关病症或疾病（包括癌症）的方法。
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公开(公告)号：US20160193209A1
公开(公告)日：2016-07-07
申请号：US15068131
申请日：2016-03-11
Applicant: AbbVie Inc.
Inventor： Ramzi F. Sweis , Michael L. Curtin , Marina A. Pliushchev , Todd M. Hansen , Kenton Longenecker
IPC: A61K31/506 , A61K31/496 , A61K31/497 , A61K31/4439 , A61K31/427
CPC classification number: A61K31/506 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/497 , C07D417/12 , C07D417/14
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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公开(公告)号：US20170320880A1
公开(公告)日：2017-11-09
申请号：US15588398
申请日：2017-05-05
Applicant: AbbVie Inc.
Inventor： Michael R. Michaelides , Michael L. Curtin , Huan-Qiu Li , Marina A. Pliushchev , Ying Wang , Hongyu H. Zhao , Richard F. Clark , Alan S. Florjancic , Zhiqin Ji , Mariazel Torrent , Ramzi F. Sweis , Anil Vasudevan , Justin D. Dietrich
IPC: C07D487/04 , C07D417/14 , C07D413/10 , C07D405/04 , C07D403/14 , C07D403/12 , C07D403/10 , C07D403/04 , C07D401/14 , C07D401/12 , C07D401/04 , C07D471/04 , C07D207/14
CPC classification number: C07D487/04 , A61K31/40 , C07D207/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D413/10 , C07D417/14 , C07D471/04
Abstract: Compounds having a structure of Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein A1, A2, A3, A4, A5, n, and m are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various EED-related conditions or diseases, including cancer, by administration of such compounds are also provided.
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公开(公告)号：US20160184281A1
公开(公告)日：2016-06-30
申请号：US14878836
申请日：2015-10-08
Applicant: AbbVie Inc.
Inventor： Richard F. Clark , Bryan Sorensen , Augustine T. Osuma , Robin Frey , Kenton Longenecker , George Doherty , Michael L. Curtin , Michael Michaelides , Ramzi Sweis , Marina Pliushchev , Andrew Judd , Todd Hansen , Howard R. Heyman
IPC: A61K31/437 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/55 , A61K31/5377 , A61K31/444
CPC classification number: A61K31/437 , A61K31/407 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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