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公开(公告)号：US08437834B2
公开(公告)日：2013-05-07
申请号：US13247403
申请日：2011-09-28
申请人： Robert M. Carr, Jr.
发明人： Robert M. Carr, Jr.
CPC分类号： A61B5/6842 , A61B90/39 , A61B2090/3908 , A61B2090/3987
摘要： Tissue markers, systems for marking tissue, and methods of using tissue markers. A tissue marker may have a body with a first surface and a second surface, a plurality of coupling sites, and a plurality of elongate members. The tissue marker may include a remotely visible material. The tissue marker may have a delivery configuration that is different from a deployed configuration.
摘要翻译： 组织标记，用于标记组织的系统和使用组织标记的方法。 组织标记可以具有带有第一表面和第二表面的主体，多个联接位置和多个细长构件。 组织标记可以包括远程可见的材料。 组织标记可以具有不同于展开配置的传送配置。
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公开(公告)号：US08709069B2
公开(公告)日：2014-04-29
申请号：US11408330
申请日：2006-04-21
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/07 , A61F2240/005 , A61F2250/0039 , Y10T83/75
摘要： A vascular graft with trim lines is described, the trim lines providing a guide for precision shaping of the cuff. The trim lines may be printed or otherwise disposed on a surface of the cuff or included on a template designed for disposition over the cuff. The trim lines may also be disposed on a side of a pocket into which the cuff is positioned for trimming. Also described is an apparatus and method for precise trimming of a vascular graft.
摘要翻译： 描述了具有修剪线的血管移植物，修剪线为袖带的精密成形提供了指导。 修剪线可以被印刷或以其他方式设置在袖带的表面上或包括在设计用于配置在袖带上的模板上。 修剪线也可以设置在口袋的一侧，袖口定位在其中以进行修整。 还描述了一种用于精细修剪血管移植物的装置和方法。
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公开(公告)号：US07909886B2
公开(公告)日：2011-03-22
申请号：US11277406
申请日：2006-03-24
CPC分类号： A61L2/0088 , A61F2/0063 , A61F2/0077 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/2475 , A61F2/442 , A61F2002/30062 , A61F2002/30929 , A61F2210/0004 , A61F2310/00365 , A61L27/24 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3687 , A61L27/58 , Y10S623/915 , Y10S623/917
摘要： This invention is directed to prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis is treated so that it is rendered non-antigenic so as not to elicit a significant humoral immune response. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译： 本发明涉及假体，其在植入哺乳动物患者时用作身体部位或组织结构的功能性替代物，并将经受受控的生物降解，伴随患者活细胞的生物模型发生。 治疗假体使其变得非抗原性，以便不引起显着的体液免疫应答。 因此，在其各种实施方案中，本发明的假体具有双重性质。 首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。
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公开(公告)号：US06893653B2
公开(公告)日：2005-05-17
申请号：US10615623
申请日：2003-07-08
IPC分类号： A61F13/00 , A01N1/02 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/28 , A61K35/12 , A61L27/24 , A61L27/36 , C12N5/08 , A61F38/17
CPC分类号： A61L27/3687 , A61K35/12 , A61K38/39 , A61L27/24 , A61L27/3695 , A61L2430/40 , Y10S623/917 , Y10S623/92
摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
摘要翻译： 本发明涉及已被处理以去除非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质组分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱处理组织，螯合剂，酸和盐从胶原组织基质中去除非胶原组分，同时控制溶胀和溶解量，使得所得到的胶原基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主的植入，修复或使用。
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公开(公告)号：US06572650B1
公开(公告)日：2003-06-03
申请号：US09719072
申请日：2001-06-11
IPC分类号： A61F206
CPC分类号： A61L27/507 , A61L27/24 , A61L27/3629 , A61L27/40 , B29C53/40 , B29C53/562
摘要： The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
摘要翻译： 本发明涉及从源自动物来源的清洁的组织材料制备的生物工程化的血管移植物支撑假体。 本发明的生物工程化移植假体是使用保持加工的组织基质的细胞相容性，强度和生物可塑性的方法来制备的。 生物工程移植假体用于哺乳动物宿主植入，修复或使用。
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公开(公告)号：US5733337A
公开(公告)日：1998-03-31
申请号：US417868
申请日：1995-04-07
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/04 , A61F2/06 , A61F2/08 , A61F2/10 , A61F2/24 , A61F2/28 , A61F2/44 , A61L2/18 , A61L27/24 , A61L27/36 , A61L27/58
CPC分类号： A61L27/3691 , A61L2/18 , A61L27/24 , A61L27/3604 , A61L27/3687 , A61L27/58 , A61F2/0077
摘要： This invention is directed to prosthesis, which, when implanted into a mammalian patient, serve as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译： 本发明涉及假体，其在植入哺乳动物患者时用作身体部位或组织结构的功能性替代物，并且将经受受控的生物降解，伴随着患者活细胞的生物模型发生。 因此，在其各种实施方案中，本发明的假体具有双重性质。 首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。
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公开(公告)号：US07214242B2
公开(公告)日：2007-05-08
申请号：US10378178
申请日：2003-03-03
IPC分类号： A61F2/06
CPC分类号： A61L27/3629 , A61L27/24 , A61L27/3641 , A61L27/3687 , A61L27/40 , A61L27/507 , B29C53/40 , B29C53/562
摘要： The invention is directed to bioengineered tubular graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
摘要翻译： 本发明涉及从源自动物来源的清洁的组织材料制备的生物工程管状移植假体。 本发明的生物工程化移植假体是使用保持加工的组织基质的细胞相容性，强度和生物可塑性的方法来制备的。 生物工程移植假体用于哺乳动物宿主植入，修复或使用。
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公开(公告)号：US07041131B2
公开(公告)日：2006-05-09
申请号：US10411816
申请日：2003-04-11
IPC分类号： A61F2/06
CPC分类号： A61L27/507 , A61L27/24 , A61L27/3629 , A61L27/40 , B29C53/40 , B29C53/562
摘要： The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
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公开(公告)号：US06890351B2
公开(公告)日：2005-05-10
申请号：US09949043
申请日：2001-09-07
CPC分类号： A61L27/58 , A61F2/02 , A61F2/06 , A61F2002/30062 , A61F2002/3024 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/24 , A61L27/34 , Y10S623/917 , C08L89/06
摘要： A bioremodelable prosthesis for treating a patient with a diseased or damaged organs comprising a first layer that contains acid-extracted fibrillar or non-fibrillar collagen, and a second layer derived from the tunica submucosa of the small intestine that provides structural stability, is pliable and is semi-permeable,pe1 59564443.npc wherein the prosthesis undergoes controlled biodegradation occurring with adequate living cell replacement such that the original prosthesis is replaced by the patient's living cells.
摘要翻译： 用于治疗患有或受损器官的患者的生物可修改假体，其包括含有酸提取的纤维状或非纤维状胶原的第一层，以及衍生自提供结构稳定性的小肠粘膜下层的第二层，是柔韧的，并且 是半渗透性的，其中假体经受受控的生物降解，其具有足够的活细胞置换，使得原始假体被患者的活细胞代替。
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20.发明授权Reconstituted collagen fiber segment compositions and methods of preparation thereof 失效重组胶原纤维节段组合物及其制备方法
公开(公告)号：US5997896A
公开(公告)日：1999-12-07
申请号：US973571
申请日：1998-05-11
CPC分类号： A61L27/24 , A61K38/1841 , A61K38/39 , A61F2310/00365
摘要： The invention provides injectable collagen compositions that are reconstituted collagen fiber segments made from acid extracted collagen with telopeptides in a biocompatible carrier, with the collagen concentration in the composition ranging up to 200 mg/mL.
摘要翻译： PCT No.PCT / US96 / 09861 Sec。 371日期：1998年5月11日 102（e）日期1998年5月11日PCT提交1996年6月7日PCT公布。 出版物WO96 / 40216 PCT 日期：1996年12月19日本发明提供了可注射的胶原组合物，其是由生物相容性载体中的具有端肽的酸提取胶原构成的重组胶原纤维片段，组合物中的胶原浓度范围高达200mg / mL。
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