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11.发明申请公开(公告)号：US20140141440A1
公开(公告)日：2014-05-22
申请号：US14084030
申请日：2013-11-19
申请人： BASF SE
发明人： Oskar Zelder , Birgit Hoff , Hartwig Schröder , Andrea Molt , Holger Hartmann , Klaus Ditrich , Michael Breuer , Rüdiger Reingruber , Jakob Weber
IPC分类号： C12P17/04
摘要： The invention pertains to/the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
摘要翻译： 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。
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公开(公告)号：US20170145451A1
公开(公告)日：2017-05-25
申请号：US15323515
申请日：2015-07-02
申请人： BASF SE
发明人： Kai-Uwe Baldenius , Michael Breuer , Klaus Ditrich , Vaidotas Navickas , Francesco Mutti , Tanja Knaus , Nicholas Turner
CPC分类号： C12P13/001 , C12N9/0006 , C12N9/0016 , C12N9/0018 , C12Y101/01001 , C12Y104/01009 , C12Y104/0102
摘要： The present invention relates to a novel biocatalytic method for the production of primary and secondary amines, comprising coupled enzymatic oxidation and reduction processes simultaneously regenerating the required cofactor; making use of two enzymes—i.e. an alcohol dehydrogenase and an amine dehydrogenase—operating simultaneously in a one pot process (i.e. biocatalytic cascade). Furthermore, the overall process is redox neutral, since the hydride generated from the first oxidative step is internally recycled in the second reductive step. The invention also relates to recombinant expression systems and microorganisms procuring the required enzyme activities; and bioreactors for performing such methods.
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13.发明授权公开(公告)号：US09447404B2
公开(公告)日：2016-09-20
申请号：US14560263
申请日：2014-12-04
申请人： BASF SE
发明人： Michael Breuer , Bernhard Hauer , Dieter Jendrossek , Gabrielle Siedenburg , Juergen Pleiss , Demet Sirim , Silvia Fadenrecht
CPC分类号： C12N9/88 , C12N9/90 , C12P5/007 , C12P7/02 , C12P7/22 , C12Y406/01 , C12Y504/99017 , Y02P20/52
摘要： The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
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公开(公告)号：US20220259580A1
公开(公告)日：2022-08-18
申请号：US17416480
申请日：2019-12-09
申请人： BASF SE
发明人： Kai-Uwe Baldenius , Michael Breuer , Corinna Ruffer , Melanie Weingarten , Reinhard Zschoche , Stefan Seemayer , Bernd Nidetzky , Katharina Schmoelzer , Michael Puhl
摘要： The present disclosure relates to methods for producing human milk oligosaccharide (HMO) core structures using glycosidases from family GH20 hexosaminidases. In particular, the present disclosure provides methods for producing lacto-N-triose II (LNT II) and/or lacto-N-tetraose (LNT) by reacting glucosamine-oxazoline and/or lacto-N-biose-oxazoline with lactose catalysed by an enzyme of the glycoside hydrolase family 20 (GH20) according to the classification of the Carbohydrate-Active-Enzymes (CAZy) database. Specific optimized enzymes are identified to catalyse the reactions.
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公开(公告)号：US09631212B2
公开(公告)日：2017-04-25
申请号：US14441215
申请日：2013-11-13
申请人： BASF SE
发明人： Oskar Zelder , Birgit Hoff , Hartwig Schroeder , Andrea Molt , Holger Hartmann , Klaus Ditrich , Michael Breuer , Rüdiger Reingrubber , Jakob Weber
IPC分类号： C12N15/80 , C12P17/04 , C12N15/67 , C07D307/93 , C12N15/52 , C07K14/37 , A01N37/46 , A01N63/04 , A01N37/42
CPC分类号： C12P17/04 , A01N37/42 , A01N37/46 , A01N63/04 , C07D307/93 , C07K14/37 , C12N15/52 , C12N15/67 , C12N15/80
摘要： The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
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公开(公告)号：US10954538B2
公开(公告)日：2021-03-23
申请号：US15999299
申请日：2017-02-20
申请人： BASF SE
IPC分类号： C12P17/04
摘要： The present invention relates to processes for the preparation of sclareolide and related compounds by the biocatalytic cyclization of polyunsaturated carboxylic acid compounds, in particular of homofarnesylic acid and related compounds; and to a process for the preparation of ambroxide via the biocatalytic cyclization of homofarnesylic acid to sclareolide.
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17.发明授权公开(公告)号：US10717973B2
公开(公告)日：2020-07-21
申请号：US16212287
申请日：2018-12-06
申请人： BASF SE
发明人： Michael Breuer , Bernhard Hauer , Dieter Jendrossek , Gabriele Siedenburg , Juergen Pleiss , Demet Sirim , Silvia Fadenrecht
摘要： The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
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公开(公告)号：US10533201B2
公开(公告)日：2020-01-14
申请号：US15509993
申请日：2015-06-30
申请人： BASF SE
发明人： Vaidotas Navickas , Kai-Uwe Baldenius , Michael Breuer , Patricia Wildberger , Martin Pfeiffer , Bernd Nidetzky
摘要： The present invention relates to methods of producing sugar phosphates by enzymatic transphosphorylation, wherein the phosphoryl transfer from phosphate donor substrates to sugar substrates is catalyzed by an enzyme having alpha-glucose-1-phosphatase activity. Furthermore, the present invention relates to a biocatalyst having sucrose phosphorylase as well as alpha-glucose-1-phosphatase activity and its use. The production of an enzyme having alpha-glucose-1-phosphatase activity and its use in the transphosphorylation of sugar substrates is also presented herein.
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公开(公告)号：US10428361B2
公开(公告)日：2019-10-01
申请号：US15559962
申请日：2016-02-19
申请人： BASF SE
发明人： Vaidotas Navickas , Michael Breuer , Michael Puhl , Melanie Weingarten , Kai-Uwe Baldenius , Wolfgang Siegel
摘要： The present invention relates to biocatalytic methods, comprising purely enzymatic, mixed enzymatic-fermentative and purely fermentative methods, for the direct single-step conversion of L-fucitol to L-fucose, in order to easily obtain L-fucose at high amounts and levels of purity. Suitable recombinant microorganisms and fungi are further disclosed and also the use thereof in said method for the single-step conversion to L-fucose.
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20.发明授权公开(公告)号：US10190112B2
公开(公告)日：2019-01-29
申请号：US15234529
申请日：2016-08-11
申请人： BASF SE
发明人： Michael Breuer , Bernhard Hauer , Dieter Jendrossek , Gabriele Siedenburg , Juergen Pleiss , Demet Sirim , Silvia Fadenrecht
摘要： The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
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