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    Methods utilizing scanning probe microscope tips and products thereof or produced thereby
    11.
    发明授权
    Methods utilizing scanning probe microscope tips and products thereof or produced thereby 有权
    使用扫描探针显微镜尖端及其产品或由其制造的方法

    公开(公告)号：US08187673B2

    公开(公告)日：2012-05-29

    申请号：US11933251

    申请日：2007-10-31

    申请人： Chad A. Mirkin ,  Richard Piner ,  Seunghun Hong

    发明人： Chad A. Mirkin ,  Richard Piner ,  Seunghun Hong

    IPC分类号： B05D3/00

    CPC分类号： B82B3/00 ,  B05D1/007 ,  B05D1/185 ,  B05D1/26 ,  G01Q80/00 ,  G03F7/0002 ,  G03F7/165 ,  Y10S977/849 ,  Y10S977/853 ,  Y10S977/854 ,  Y10S977/855 ,  Y10S977/856 ,  Y10S977/857 ,  Y10S977/86 ,  Y10S977/88 ,  Y10S977/884 ,  Y10S977/885 ,  Y10S977/886 ,  Y10S977/895 ,  Y10T428/24802

    摘要： The invention provides a lithographic method referred to as “dip pen” nanolithography (DPN). DPN utilizes a scanning probe microscope (SPM) tip (e.g., an atomic force microscope (AFM) tip) as a “pen,” a solid-state substrate (e.g., gold) as “paper,” and molecules with a chemical affinity for the solid-state substrate as “ink.” Capillary transport of molecules from the SPM tip to the solid substrate is used in DPN to directly write patterns consisting of a relatively small collection of molecules in submicrometer dimensions, making DPN useful in the fabrication of a variety of microscale and nanoscale devices. The invention also provides substrates patterned by DPN, including submicrometer combinatorial arrays, and kits, devices and software for performing DPN. The invention further provides a method of performing AFM imaging in air. The method comprises coating an AFM tip with a hydrophobic compound, the hydrophobic compound being selected so that AFM imaging performed using the coated AFM tip is improved compared to AFM imaging performed using an uncoated AFM tip. Finally, the invention provides AFM tips coated with the hydrophobic compounds.

    摘要翻译： 本发明提供了称为“浸笔”纳米光刻（DPN）的光刻方法。 DPN使用扫描探针显微镜（SPM）尖端（例如，原子力显微镜（AFM）尖端）作为“笔”，固态基底（例如，金）作为“纸”，并且具有化学亲和力的分子 固体底物作为“墨水”。DPN中使用分子从SPM尖端到固体基质的毛细管转运，以直接写入由亚微米尺寸的相对小的分子集合组成的图案，使得DPN可用于制造 各种微米级和纳米级器件。 本发明还提供由DPN图案化的衬底，包括亚微米组合阵列，以及用于执行DPN的试剂盒，装置和软件。 本发明还提供了一种在空气中进行AFM成像的方法。 该方法包括用疏水性化合物涂覆AFM尖端，选择疏水性化合物，使得与使用未涂覆的AFM尖端进行的AFM成像相比，使用涂覆的AFM尖端进行的AFM成像得到改善。 最后，本发明提供涂覆有疏水化合物的AFM尖端。

    Beam Pen Lithography
    12.
    发明申请
    Beam Pen Lithography 有权
    光笔平版印刷

    公开(公告)号：US20110305996A1

    公开(公告)日：2011-12-15

    申请号：US13202142

    申请日：2010-02-18

    申请人： Chad A. Mirkin ,  Gengfeng Zheng ,  Fengwei Huo

    发明人： Chad A. Mirkin ,  Gengfeng Zheng ,  Fengwei Huo

    IPC分类号： G03F7/20 ,  B05D3/12 ,  G03F7/26 ,  G01N21/01 ,  G01Q70/06

    CPC分类号： G03F7/2051 ,  G03F7/70291 ,  G03F7/70383 ,  G03F7/70466 ,  G03F7/70525 ,  G03F7/70958

    摘要： The disclosure relates to methods of beam pen lithography using a tip array having a plurality of transparent, elastomeric, reversibly-deformable tips coated with a blocking layer and apertures defined in the blocking layer to expose tip ends of the tips in the array. The tip array can be used to perform a photolithography process in which the tips are illuminated with a radiation that is channeled through the tips and out the apertures to expose a photosensitive substrate. Also disclosed are tip arrays formed of polymers and gels, apparatus including the tip arrays and radiation sources, and related apparatus for selectively masking tips in the tip array from radiation emitted from the radiation source.

    摘要翻译： 本公开涉及使用具有多个透明，弹性，可逆变形的尖端的尖端阵列的光笔笔光刻方法，所述尖端涂覆有阻挡层和限定在阻挡层中的孔，以暴露阵列中尖端的尖端。 尖端阵列可以用于执行光刻工艺，其中尖端被通过尖端引导的辐射照射并且出射孔以暴露感光基底。 还公开了由聚合物和凝胶形成的尖端阵列，包括尖端阵列和辐射源的装置以及用于从辐射源发射的辐射中选择性地遮蔽尖端阵列中的尖端的相关装置。

    CONTROLLED AGENT RELEASE AND SEQUESTRATION
    13.
    发明申请
    CONTROLLED AGENT RELEASE AND SEQUESTRATION 审中-公开
    控制代理释放和序列

    公开(公告)号：US20100294952A1

    公开(公告)日：2010-11-25

    申请号：US12687595

    申请日：2010-01-14

    申请人： Chad A. Mirkin ,  Matthew R. Jones ,  Jill E. Millstone ,  David A. Giljohann ,  Dwight S. Seferos ,  Kaylie L. Young

    发明人： Chad A. Mirkin ,  Matthew R. Jones ,  Jill E. Millstone ,  David A. Giljohann ,  Dwight S. Seferos ,  Kaylie L. Young

    IPC分类号： A61N5/06

    CPC分类号： A61N5/062 ,  A61N2005/0659

    摘要： Disclosed are nanostructures having nanoprisms and agents, such as diagnostic and/or therapeutic agents. Nanoprisms with a surface plasmon resonance in the near-infrared convert irradiation, such as from a laser into heat selectively to allow the dissociation, such as dehybridization of oligonucleotide duplexes, of agents associated with the nanoprism surface. These nanostructures show morphological, chemical, and functional stability under hours of irradiation. Further disclosed are methods of selectively releasing agents from nanostructures after directed surface plasmon resonance mediated heating of the nanoprisms. Released agents, such as oligonucleotides, are unharmed by this process and can be repeatedly released and sequestered under spatiotemporal control.

    摘要翻译： 公开了具有纳米棱镜和试剂的纳米结构，例如诊断和/或治疗剂。 在近红外转换照射中具有表面等离子体共振的纳米棱镜，例如从激光选择性地加热以允许与纳米棱镜表面相关的试剂的解离，例如寡核苷酸双链体的脱杂交。 这些纳米结构在照射几小时内显示形态，化学和功能稳定性。 进一步公开的是在定向表面等离子体共振介导的纳米棱镜加热之后从纳米结构中选择性释放试剂的方法。 释放的试剂，如寡核苷酸，不受这个过程的伤害，并且可以在时空控制下重复释放和螯合。