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    Microscopy imaging apparatus and method for generating an image
    11.
    发明授权
    Microscopy imaging apparatus and method for generating an image 有权
    显微镜成像装置和产生图像的方法

    公开(公告)号：US07385709B2

    公开(公告)日：2008-06-10

    申请号：US10501637

    申请日：2003-01-15

    申请人： Karsten Plamann ,  Stéphane Bourquin ,  Mathieu Ducros ,  Jelena Mitic ,  Francois Vuille ,  Theo Lasser ,  Tiemo Anhut

    发明人： Karsten Plamann ,  Stéphane Bourquin ,  Mathieu Ducros ,  Jelena Mitic ,  Francois Vuille ,  Theo Lasser ,  Tiemo Anhut

    IPC分类号： G01B11/24

    CPC分类号： G02B21/06 ,  G02B21/002 ,  G02B21/367 ,  G02B27/58

    摘要： A method and a microscopy imaging apparatus for generating an optically sectioned image of a specimen are provided. The method comprises the steps of: illuminating the specimen with a modulating, spatially periodic illumination pattern; imaging said specimen on a conjugate image plane; acquiring a plurality of signals at respective positions on said image plane, each signal corresponding to the incident light intensity at that position and having an oscillatory component caused by the modulation of the illumination pattern; and measuring a characteristic of the oscillatory component of each of the signals, whereby the measured characteristics when combined in their relative positions generate an optically sectioned image of the specimen.

    摘要翻译： 提供了一种用于产生样本的光学截面图像的方法和显微镜成像设备。 该方法包括以下步骤：用调制的空间周期照明图案照射样本; 在共轭图像平面上成像所述样本; 在所述图像平面上的各个位置处获取多个信号，每个信号对应于该位置处的入射光强度并且具有由照明图案的调制引起的振荡分量; 并且测量每个信号的振荡分量的特性，由此当在其相对位置中组合时的测量特性产生样本的光学截面图像。

    Method and device for identifying luminescent molecules according to the fluorescence correlation spectroscopy method
    12.
    发明申请
    Method and device for identifying luminescent molecules according to the fluorescence correlation spectroscopy method 审中-公开
    根据荧光相关光谱法鉴定发光分子的方法和装置

    公开(公告)号：US20060226374A1

    公开(公告)日：2006-10-12

    申请号：US10567427

    申请日：2004-08-06

    申请人： Rudolf Rigler ,  Theo Lasser ,  Pierre-Andre Besse ,  Alexis Rochas ,  Alexandre Serov ,  Michael Gosch ,  Radivoje Popovic

    发明人： Rudolf Rigler ,  Theo Lasser ,  Pierre-Andre Besse ,  Alexis Rochas ,  Alexandre Serov ,  Michael Gosch ,  Radivoje Popovic

    IPC分类号： G01J1/58

    CPC分类号： G01J3/2803 ,  G01J3/4406 ,  G01N21/645 ,  G01N21/6458 ,  G01N2021/6417 ,  G01N2021/6463 ,  G02B21/0024

    摘要： The invention relates to a method and device for identifying luminescent molecules according to the fluorescence correlation spectroscopy method. The inventive method comprising the following steps: a) preparing a sample (12) containing luminescent molecules; b) illuminating the sample (12) using an optical excitation device (2,4,6,8) comprising at least one light source, at least one, in particular, diffractive optical element (7) for splitting light passing therethrough into multiple beams, and a focusing optics (8) for focusing multiple light beams passing therethrough into multiple confocal volume elements: c) capturing emission radiation from the multiple confocal volume elements by means of a locally resolving sensor matrix arrangement (20), whereby the sensor matrix arrangement is a sensor matrix, which is comprised of avalanche photodiodes AD is produced using IC technology, particularly CMOS technology, and is integrated in a sensor chip (20) with Greiger-mode wiring, and; d) processing the signals, which are provided by the avalanche photodiode matrix, by means of a signal processing and evaluation device preferably integrated in the sensor chip.

    摘要翻译： 本发明涉及根据荧光相关光谱法鉴定发光分子的方法和装置。 本发明的方法包括以下步骤：a）制备含有发光分子的样品（12） b）使用包括至少一个光源的光学激发装置（2,4,6,8）照亮样品（12），至少一个特别是衍射光学元件（7），用于将穿过其中的光分成多个光束 以及用于将通过其中的多个光束聚焦成多个共焦体积元件的聚焦光学器件（8）：c）通过局部分辨传感器矩阵布置（20）捕获来自多个共焦体积元件的发射辐射，由此传感器矩阵布置 是由雪崩光电二极管组成的传感器矩阵，AD采用IC技术，特别是CMOS技术制造，并集成在具有Greiger模式布线的传感器芯片（20）中; d）通过优选地集成在传感器芯片中的信号处理和评估装置处理由雪崩光电二极管矩阵提供的信号。

    Apparatus and method for detecting and measuring biomolecular interactions
    15.
    发明授权
    Apparatus and method for detecting and measuring biomolecular interactions 有权
    用于检测和测量生物分子相互作用的装置和方法

    公开(公告)号：US08938103B2

    公开(公告)日：2015-01-20

    申请号：US13581761

    申请日：2011-02-25

    申请人： Nicolas Durand ,  Iwan Märki ,  Theo Lasser

    发明人： Nicolas Durand ,  Iwan Märki ,  Theo Lasser

    IPC分类号： G06K9/00 ,  G01N21/64 ,  C12N15/82 ,  G01N35/00

    CPC分类号： G01N21/6452 ,  G01N21/6428 ,  G01N2035/00158

    摘要： A method and system for the rapid detection of biomolecular interactions, the system comprising a sensing platform which comprises a primary support structure including recesses designed to be located in front of a detection unit, said recesses containing one or several arrays of biosensors, said system furthermore comprising a reader unit for optical excitation and detection.

    摘要翻译： 一种用于快速检测生物分子相互作用的方法和系统，该系统包括感测平台，该感测平台包括主要支撑结构，其包括设计成位于检测单元前面的凹槽，所述凹部包含一个或多个生物传感器阵列，所述系统进一步 包括用于光学激发和检测的读取器单元。

    Microscopy imaging apparatus and method for generating an image
    16.
    发明申请
    Microscopy imaging apparatus and method for generating an image 有权
    显微镜成像装置和产生图像的方法

    公开(公告)号：US20050117172A1

    公开(公告)日：2005-06-02

    申请号：US10501637

    申请日：2003-01-15

    申请人： Karsten Plamann ,  Stephane Bourquin ,  Mathieu Ducros ,  Jelena Mitic ,  Francois Vuille ,  Theo Lasser ,  Tiemo Anhut

    发明人： Karsten Plamann ,  Stephane Bourquin ,  Mathieu Ducros ,  Jelena Mitic ,  Francois Vuille ,  Theo Lasser ,  Tiemo Anhut

    IPC分类号： G02B26/00 ,  F03D7/02 ,  G02B21/00 ,  G02B21/06 ,  G02B21/36 ,  G01B11/24

    CPC分类号： G02B21/06 ,  G02B21/002 ,  G02B21/367 ,  G02B27/58

    摘要： A method and a microscopy imaging apparatus for generating an optically sectioned image of a specimen are provided. The method comprises the steps of: illuminating the specimen with a modulating, spatially periodic illumination pattern; imaging said specimen on a conjugate image plane; acquiring a plurality of signals at respective positions on said image plane, each signal corresponding to the incident light intensity at that position and having an oscillatory component caused by the modulation of the illumination pattern; and measuring a characteristic of the oscillatory component of each of the signals, whereby the measured characteristics when combined in their relative positions generate an optically sectioned image of the specimen.

    摘要翻译： 提供了一种用于产生样本的光学截面图像的方法和显微镜成像设备。 该方法包括以下步骤：用调制的空间周期照明图案照射样本; 在共轭图像平面上成像所述样本; 在所述图像平面上的各个位置处获取多个信号，每个信号对应于该位置处的入射光强度并且具有由照明图案的调制引起的振荡分量; 并且测量每个信号的振荡分量的特性，由此当在其相对位置中组合时的测量特性产生样本的光学截面图像。

    Unstable laser resonator for generating a stable fundamental mode beam profile
    17.
    发明授权
    Unstable laser resonator for generating a stable fundamental mode beam profile 失效
    不稳定激光谐振器，用于产生稳定的基模光束轮廓

    公开(公告)号：US5406578A

    公开(公告)日：1995-04-11

    申请号：US93553

    申请日：1993-07-19

    申请人： Herbert Gross ,  Harry Bauer ,  Theo Lasser ,  Martin Wiechmann

    发明人： Herbert Gross ,  Harry Bauer ,  Theo Lasser ,  Martin Wiechmann

    IPC分类号： H01S3/082 ,  A61F9/00 ,  H01S3/08 ,  H01S3/113 ,  H01S3/11

    CPC分类号： H01S3/08081 ,  H01S2301/206 ,  H01S3/08063 ,  H01S3/086 ,  H01S3/113

    摘要： The reflecting surfaces within the resonator are minimized in an unstable laser resonator having a radially-dependent output end reflection profile and a passive Q-switch so that the least possible competing resonator geometries can be formed. For this purpose, a saturable absorber foil can be provided as a passive Q-switch element mounted so as to be inclined with respect to the optical axis. Furthermore, it is advantageous to use an output reflector having highly precise parallel boundary surfaces and to align this output reflector with high precision parallel to the end surfaces which delimit the laser medium.

    摘要翻译： 谐振器内的反射表面在具有径向相关输出端反射曲线和无源Q开关的不稳定激光谐振器中被最小化，使得可以形成最小可能的竞争谐振器几何形状。 为此，可以提供可饱和吸收箔作为被安装成相对于光轴倾斜的无源Q开关元件。 此外，使用具有高度精确的平行边界表面的输出反射器是有利的，并且使得该输出反射器与限定激光介质的端面平行的高精度对准。

    DUAL BEAM HETERODYNE FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY
    19.
    发明申请
    DUAL BEAM HETERODYNE FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY 审中-公开
    双光束异质性FOURIER域光学相干TOMOGRAPHY

    公开(公告)号：US20100141956A1

    公开(公告)日：2010-06-10

    申请号：US12523398

    申请日：2008-01-21

    申请人： Rainer Leitgeb ,  Martin Villiger ,  Roland Michaey ,  Theo Lasser ,  Adrian Bachmann

    发明人： Rainer Leitgeb ,  Martin Villiger ,  Roland Michaey ,  Theo Lasser ,  Adrian Bachmann

    IPC分类号： G01B9/02

    CPC分类号： G01N21/4795 ,  G01B9/02003 ,  G01B9/02044 ,  G01B9/02057 ,  G01B9/02069 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/70

    摘要： The present invention relates to an apparatus and a method combining achromatic complex FDOCT signal reconstruction with a common path and dual beam configuration. The complex signal reconstruction allows resolving the complex ambiguity of the Fourier transform and to enhance the achievable depth range by a factor of two. The dual beam configuration shares the property of high phase stability with common path FDOCT. This is of importance for a proper complex signal reconstruction and is in particular useful in combination with handheld probes such as in endoscopy and catheter applications. The advantages of the present invention are in particular the flexibility to choose arbitrarily positioned interfaces in the sample arm as reference together with the possibility to compensate for dispersion.

    摘要翻译： 本发明涉及一种将消色差复合FDOCT信号重建与公共路径和双波束配置相结合的装置和方法。 复信号重建允许解析傅里叶变换的复杂模糊度，并将可实现的深度范围提高2倍。 双波束配置具有共同路径FDOCT的高相位稳定性。 这对于适当的复杂信号重建是重要的，并且特别适用于诸如在内窥镜检查和导管应用中的手持探针。 本发明的优点特别是在样品臂中选择任意定位的界面作为参考的灵活性以及补偿分散的可能性。

    OPTICAL IMAGING SYSTEM WITH EXTENDED DEPTH OF FOCUS
    20.
    发明申请
    OPTICAL IMAGING SYSTEM WITH EXTENDED DEPTH OF FOCUS 审中-公开
    光学成像系统具有更广泛的聚焦深度

    公开(公告)号：US20090128824A1

    公开(公告)日：2009-05-21

    申请号：US12162088

    申请日：2007-01-20

    申请人： Rainer Leitgeb ,  Theo Lasser ,  Adrian Bachmann ,  Lukas Steinmann ,  Martin Villiger

    发明人： Rainer Leitgeb ,  Theo Lasser ,  Adrian Bachmann ,  Lukas Steinmann ,  Martin Villiger

    IPC分类号： G01N21/47

    CPC分类号： G01N21/4795 ,  G01B9/02002 ,  G01B9/02035 ,  G01B9/02044 ,  G01B9/02091 ,  G01B2290/70

    摘要： The invention concerns an optical imaging apparatus comprising (o) a light source (1), (p) sample holding means, (q) an interferometer, (r) reference means, (s) an objective (8) which is adapted to have its sample side focal plane crossing a sample held in said sample holding means, (t) optical or electro-optical means (2, 3, 5, 16) adapted to produce a ring shaped or multi-spot light source in the front focal plane (17) or any conjugated plane (17′) of said objective (8), at least one detector. The invention also includes a method for using said apparatus where the sample is illuminated by an interference pattern and the depth information is obtained by using optical Coherence Tomography.

    摘要翻译： 本发明涉及一种光学成像设备，包括（o）光源（1），（p）样品保持装置，（q）干涉仪，（r）参考装置，（s）物镜（8） 其样品侧焦平面与保持在所述样品保持装置中的样品交叉;（t）适于在前焦平面中产生环形或多点光源的光学或电光装置（2,3,5,16） （17）或所述物镜（8）的任何共轭平面（17'），至少一个检测器。 本发明还包括使用所述装置的方法，其中样本被干涉图案照射，并且通过使用光学相干断层扫描获得深度信息。