METHOD FOR DETECTING A PERIODICALLY PULSING OPERATING PARAMETER
    15.
    发明申请
    METHOD FOR DETECTING A PERIODICALLY PULSING OPERATING PARAMETER 有权
    检测周期性脉冲操作参数的方法

    公开(公告)号:US20100268437A1

    公开(公告)日:2010-10-21

    申请号:US12741174

    申请日:2008-12-18

    申请人: Stefan Bauer

    发明人: Stefan Bauer

    IPC分类号: F02D45/00 G06F15/00

    摘要: In a method for detecting a periodically pulsing operating parameter of an internal combustion engine (10) having the steps of acquiring a measured variable of the periodically pulsing operating parameter of the internal combustion engine (10) in order to generate a periodically pulsing measuring signal, discretization of the measuring signal in the time range with a fixed time increment, wherein in each case a number of discrete measured values is obtained corresponding to the number of time increments of the period over a period of the measuring signal, wherein the measured values in each case are considered as representative of the measuring signal in the respective time increment, and developing an average value over the period of the measuring signal, in that an average value is calculated from the discrete measured values, improved average value development for acquired pulsing operating parameters of an internal combustion engine is enabled, in that in at least one of the discrete measured values an approximation is made of the course of the measuring signal over the associated time increment (61) with a polynomial in order to obtain the discrete measured value.

    摘要翻译: 在用于检测内燃机(10)的周期性脉动操作参数的方法中,具有获取内燃机(10)的周期性脉动操作参数的测量变量以产生周期性脉冲测量信号的步骤, 以固定的时间增量在时间范围内离散化测量信号,其中在每种情况下获得与测量信号的周期中的周期的时间增量的数量相对应的多个离散测量值,其中测量值在 每种情况被认为是在相应的时间增量中代表测量信号,并且在测量信号的周期内开发平均值,其中根据离散测量值计算平均值,用于获得的脉冲操作的改进的平均值开发 启用内燃机的参数,因为在至少一个离心机中 测量值通过多项式对相关时间增量(61)上的测量信号的过程进行近似,以获得离散的测量值。

    Nucleic acids for high throughput screening of CpG-based immuno-agonist/antagonist
    19.
    发明授权
    Nucleic acids for high throughput screening of CpG-based immuno-agonist/antagonist 失效
    用于高通量筛选基于CpG的免疫激动剂/拮抗剂的核酸

    公开(公告)号:US06943240B2

    公开(公告)日:2005-09-13

    申请号:US09954987

    申请日:2001-09-17

    CPC分类号: C07K14/705

    摘要: The invention pertains to murine TLR9 and related TLR9s which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR9. The invention further relates to methods of using such murine and non-murine TLR9 nucleic acids and polypeptides, especially in methods for screening for agonists and antagonists of immunostimulatory CpG nucleic acids. Also included are murine TLR9 inhibitors which inhibit murine TLR9 activity by inhibiting the expression or function of murine TLR9. In a further aspect the present invention pertains to murine TLR7 and murine TLR8, as well as related TLR7 and TLR8 molecules which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR7 and TLR8. Methods are included for screening for ligands of TLR7 and TLR8, as well as for inhibitors and agonists and antagonists of signaling mediated by TLR7 and TLR8.

    摘要翻译: 本发明涉及鼠TLR9和相关TLR9,其包括鼠特异性氨基酸,以及编码这些多肽的核酸。 本发明还包括鼠TLR9的片段和生物学功能变体。 本发明还涉及使用这种鼠和非鼠TLR9核酸和多肽的方法,特别是用于筛选免疫刺激性CpG核酸的激动剂和拮抗剂的方法。 还包括通过抑制鼠TLR9的表达或功能来抑制鼠TLR9活性的鼠TLR9抑制剂。 在另一方面,本发明涉及鼠TLR7和鼠TLR8,以及包括鼠特异性氨基酸的相关TLR7和TLR8分子,以及编码那些多肽的核酸。 本发明还包括鼠TLR7和TLR8的片段和生物功能变体。 包括用于筛选TLR7和TLR8配体的方法,以及由TLR7和TLR8介导的抑制剂和激动剂和信号通路拮抗剂。

    Process for high throughput screening of CpG-based immuno-agonist/antagonist
    20.
    发明申请
    Process for high throughput screening of CpG-based immuno-agonist/antagonist 失效
    基于CpG的免疫激动剂/拮抗剂的高通量筛选方法

    公开(公告)号:US20050181422A1

    公开(公告)日:2005-08-18

    申请号:US11084777

    申请日:2005-03-18

    CPC分类号: C07K14/705

    摘要: The invention pertains to murine TLR9 and related TLR9s which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR9. The invention further relates to methods of using such murine and non-murine TLR9 nucleic acids and polypeptides, especially in methods for screening for agonists and antagonists of immunostimulatory CpG nucleic acids. Also included are murine TLR9 inhibitors which inhibit murine TLR9 activity by inhibiting the expression or function of murine TLR9. In a further aspect the present invention pertains to murine TLR7 and murine TLR8, as well as related TLR7 and TLR8 molecules which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR7 and TLR8. Methods are included for screening for ligands of TLR7 and TLR8, as well as for inhibitors and agonists and antagonists of signaling mediated by TLR7 and TLR8.

    摘要翻译: 本发明涉及鼠TLR9和相关TLR9,其包括鼠特异性氨基酸,以及编码这些多肽的核酸。 本发明还包括鼠TLR9的片段和生物学功能变体。 本发明还涉及使用这种鼠和非鼠TLR9核酸和多肽的方法,特别是用于筛选免疫刺激性CpG核酸的激动剂和拮抗剂的方法。 还包括通过抑制鼠TLR9的表达或功能来抑制鼠TLR9活性的鼠TLR9抑制剂。 在另一方面,本发明涉及鼠TLR7和鼠TLR8,以及包括鼠特异性氨基酸的相关TLR7和TLR8分子,以及编码那些多肽的核酸。 本发明还包括鼠TLR7和TLR8的片段和生物功能变体。 包括用于筛选TLR7和TLR8配体的方法,以及由TLR7和TLR8介导的抑制剂和激动剂和信号通路拮抗剂。