-
11.发明申请公开(公告)号：US20150232505A1
公开(公告)日：2015-08-20
申请号：US14627559
申请日：2015-02-20
Applicant: Genzyme Corporation
Inventor： Konstantin Konstantinov , Rahul Godawat , Veena Warikoo , Sujit Jain
CPC classification number: C07K1/16 , B01D15/1807 , B01D15/1864 , B01D15/1871 , B01D15/327 , B01D15/34 , B01D15/362 , B01D15/363 , B01D15/3809 , B01D15/3814 , B01D15/422 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/00 , C07K2317/14 , C12M23/52 , C12M47/10 , C12M47/12 , C12N9/00 , C12N9/2402 , C12N9/2465 , C12P21/00 , C12P21/005 , C12Y302/01022 , C12Y302/01045
Abstract: Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance. Also provided are systems that are capable of continuously producing a therapeutic protein drug substance.
Abstract translation: 本文提供了用于生产治疗性蛋白质药物物质的一体化连续生物制造方法。 还提供能够连续生产治疗性蛋白质药物物质的系统。
-
12.发明申请公开(公告)号：US20150202595A1
公开(公告)日：2015-07-23
申请号：US14598401
申请日：2015-01-16
Applicant: Genzyme Corporation
Inventor： Rahul Godawat , Veena Warikoo , Rohan Patil , Konstantin Konstantinov , Venkat Kishore Ryakala
IPC: B01J20/34 , B01J20/281 , B01J41/20 , B01D15/36 , C07K1/16 , C07K1/22 , B01D15/38 , B01J41/12 , B01J20/26
CPC classification number: B01J20/3441 , A61L2/081 , B01D15/1864 , B01D15/20 , B01D15/327 , B01D15/34 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/265 , B01J20/281 , B01J39/26 , B01J41/12 , B01J41/20 , C07K1/16 , C07K1/18 , C07K1/22 , Y10T29/49826
Abstract: Provided herein are methods of reducing bioburden of (e.g., sterilizing) a chromatography resin that include exposing a container including a composition including a chromatography resin and at least one antioxidant agent and/or chelator to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one antioxidant agent and/or chelator are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and at least one chelator and/or antioxidant agent, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.
Abstract translation: 本文提供了降低色谱树脂的生物负载（例如灭菌）的方法，其包括将包含包含色谱树脂和至少一种抗氧化剂和/或螯合剂的组合物的容器暴露于足以减少生物负载的γ射线剂量 的容器和色谱树脂，其中至少一种抗氧化剂和/或螯合剂的存在量足以改善在暴露于γ-照射剂量之后/之后色谱树脂的结合能力的损失。 还提供减少的生物负载层析柱，包括还原的生物负载层析树脂，包含色谱树脂和至少一种螯合剂和/或抗氧化剂的组合物，使用这些还原的生物负载层析色谱柱之一进行减少的生物负载层析色谱的方法，以及整合的封闭 ，以及用于减少纯化重组蛋白的生物负载生产的连续方法。
-
13.发明申请公开(公告)号：US20140255994A1
公开(公告)日：2014-09-11
申请号：US14195481
申请日：2014-03-03
Applicant: Genzyme Corporation
Inventor： Konstantin Konstantinov , Rahul Godawat , Veena Warikoo , Sujit Jain
CPC classification number: C07K1/16 , B01D15/1807 , B01D15/1864 , B01D15/1871 , B01D15/327 , B01D15/34 , B01D15/362 , B01D15/363 , B01D15/3809 , B01D15/3814 , B01D15/422 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/00 , C07K2317/14 , C12M23/52 , C12M47/10 , C12M47/12 , C12N9/00 , C12N9/2402 , C12N9/2465 , C12P21/00 , C12P21/005 , C12Y302/01022 , C12Y302/01045
Abstract: Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance. Also provided are systems that are capable of continuously producing a therapeutic protein drug substance.
Abstract translation: 本文提供了用于生产治疗性蛋白质药物物质的一体化连续生物制造方法。 还提供能够连续生产治疗性蛋白质药物物质的系统。
-
公开(公告)号：US20210268477A1
公开(公告)日：2021-09-02
申请号：US17149613
申请日：2021-01-14
Applicant: Genzyme Corporation
Inventor： Rahul Godawat , Veena Warikoo , Rohan Patil , Konstantin Konstantinov , Venkat Kishore Ryakala
IPC: B01J20/34 , B01D15/18 , B01D15/20 , B01D15/32 , B01D15/34 , B01D15/36 , B01J39/26 , B01D15/38 , B01J20/26 , B01J20/281 , B01J41/12 , B01J41/20 , C07K1/16 , C07K1/22 , A61L2/08 , C07K1/18
Abstract: Provided herein are methods of reducing bioburden of (e.g., sterilizing) a chromatography resin that include exposing a container including a composition including a chromatography resin and at least one antioxidant agent and/or chelator to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one antioxidant agent and/or chelator are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and at least one chelator and/or antioxidant agent, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.
-
公开(公告)号：US20180369786A1
公开(公告)日：2018-12-27
申请号：US16107110
申请日：2018-08-21
Applicant: Genzyme Corporation
Inventor： Rahul Godawat , Veena Warikoo , Rohan Patil , Konstantin Konstantinov , Venkat Kishore Ryakala
IPC: B01J20/34 , B01D15/36 , B01D15/34 , B01D15/32 , B01D15/20 , B01D15/18 , C07K1/18 , A61L2/08 , B01D15/38 , B01J20/26 , B01J20/281 , C07K1/22 , B01J41/12 , B01J41/20 , C07K1/16 , B01J39/26
Abstract: Provided herein are methods of reducing bioburden of (e.g., sterilizing) a chromatography resin that include exposing a container including a composition including a chromatography resin and at least one antioxidant agent and/or chelator to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one antioxidant agent and/or chelator are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and at least one chelator and/or antioxidant agent, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.
-
Patent Agency Ranking
公开(公告)号：US10071364B2
公开(公告)日：2018-09-11
申请号：US14598401
申请日：2015-01-16
Applicant: Genzyme Corporation
Inventor： Rahul Godawat , Veena Warikoo , Rohan Patil , Konstantin Konstantinov , Venkat Kishore Ryakala
IPC: A61L2/08 , B01J20/34 , B01D15/36 , B01D15/38 , B01J20/26 , B01J20/281 , B01J41/12 , B01J41/20 , C07K1/16 , C07K1/22 , C07K1/18 , B01D15/18 , B01D15/20 , B01D15/32 , B01D15/34 , B01J39/26
CPC classification number: B01J20/3441 , A61L2/081 , B01D15/1864 , B01D15/20 , B01D15/327 , B01D15/34 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/265 , B01J20/281 , B01J39/26 , B01J41/12 , B01J41/20 , C07K1/16 , C07K1/18 , C07K1/22 , Y10T29/49826
Abstract: Provided herein are methods of reducing bioburden of (e.g., sterilizing) a chromatography resin that include exposing a container including a composition including a chromatography resin and at least one antioxidant agent and/or chelator to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one antioxidant agent and/or chelator are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and at least one chelator and/or antioxidant agent, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.
-
17.发明申请公开(公告)号：US20180051054A1
公开(公告)日：2018-02-22
申请号：US15677888
申请日：2017-08-15
Applicant: Genzyme Corporation
Inventor： Tarl Vetter , Michael Coolbaugh , Veena Warikoo , Konstantin Konstantinov
CPC classification number: C07K1/34 , B01D15/1864 , B01D61/145 , B01D2315/16 , C07K16/00 , C07K2317/21 , C07K2317/31
Abstract: Provided herein are methods of processing a fluid that include the use of one or both of a circuit system including a tangential flow filtration (TFF) unit and a circuit system including a tangential flow virus filtration (TFVF) unit. Also provided are integrated and continuous processes for manufacturing a therapeutic protein drug substance that include a step of processing a fluid including the recombinant therapeutic protein using any of the methods provided herein.
-
公开(公告)号：US09650413B2
公开(公告)日：2017-05-16
申请号：US14627559
申请日：2015-02-20
Applicant: Genzyme Corporation
Inventor： Konstantin Konstantinov , Rahul Godawat , Veena Warikoo , Sujit Jain
CPC classification number: C07K1/16 , B01D15/1807 , B01D15/1864 , B01D15/1871 , B01D15/327 , B01D15/34 , B01D15/362 , B01D15/363 , B01D15/3809 , B01D15/3814 , B01D15/422 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/00 , C07K2317/14 , C12M23/52 , C12M47/10 , C12M47/12 , C12N9/00 , C12N9/2402 , C12N9/2465 , C12P21/00 , C12P21/005 , C12Y302/01022 , C12Y302/01045
Abstract: Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance. Also provided are systems that are capable of continuously producing a therapeutic protein drug substance.
-
公开(公告)号：US20150203532A1
公开(公告)日：2015-07-23
申请号：US14629356
申请日：2015-02-23
Applicant: Genzyme Corporation
Inventor： Rahul Godawat , Veena Warikoo , Rohan Patil , Konstantin Konstantinov , Venkat Kishore Ryakala , Mahsa Rohani
CPC classification number: C07K1/16 , A61L2/081 , B01D15/1807 , B01D15/1864 , B01D15/20 , B01D15/363 , B01D15/3809 , B01D15/426 , C07K1/165 , C07K1/22 , C12N9/2465 , C12Y302/01022
Abstract: Provided herein are methods of performing chromatography with gamma-irradiated chromatography resin that include providing a chromatography column including a gamma-irradiated chromatography resin; performing a first cycle of chromatography through the column, where the cycle includes exposing the chromatography resin to a denaturing buffer; and performing at least one additional cycle of chromatography through the column. Also provided are integrated, closed or substantially closed, and continuous processes for manufacturing of a recombinant protein that include the use of at least one chromatography column including gamma-irradiated chromatography resin, where the gamma-irradiated chromatography resin is exposed to denaturing buffer during each cycle in the process, and reduced bioburden buffer is used in the process.
-
公开(公告)号：US20150203531A1
公开(公告)日：2015-07-23
申请号：US14629315
申请日：2015-02-23
Applicant: Genzyme Corporation
Inventor： Rahul Godawat , Veena Warikoo , Rohan Patil , Konstantin Konstantinov , Venkat Kishore Ryakala
CPC classification number: B01J20/3441 , A61L2/081 , B01D15/1864 , B01D15/20 , B01D15/327 , B01D15/34 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/265 , B01J20/281 , B01J39/26 , B01J41/12 , B01J41/20 , C07K1/16 , C07K1/18 , C07K1/22 , Y10T29/49826
Abstract: Provided herein are methods of reducing bioburden of (e.g., sterilizing) a chromatography resin that include exposing a container including a composition including a chromatography resin and at least one antioxidant agent and/or chelator to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one antioxidant agent and/or chelator are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and at least one chelator and/or antioxidant agent, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.
-
-
-
-
-
-
-
-
-
Search Results
34
records
(took 0.036 seconds)
