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    SYSTEMS AND METHODS FOR PROVIDING BEAM SCAN PATTERNS FOR HIGH SPEED DOPPLER OPTICAL FREQUENCY DOMAIN IMAGING
    11.
    发明申请
    SYSTEMS AND METHODS FOR PROVIDING BEAM SCAN PATTERNS FOR HIGH SPEED DOPPLER OPTICAL FREQUENCY DOMAIN IMAGING 有权
    用于提供高速多普勒光学频域成像的光束扫描模式的系统和方法

    公开(公告)号：US20090036782A1

    公开(公告)日：2009-02-05

    申请号：US12183630

    申请日：2008-07-31

    申请人： Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

    发明人： Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0261 ,  A61B5/0066 ,  A61B5/0073

    摘要： An exemplary apparatus and/or an exemplary method can be provided using which, it is possible (e.g., with at least one first arrangement) to measure an amplitude and/or a phase of at least one electromagnetic radiation provided from a particular portion of a sample. Further, it is possible (e.g., using at least one second arrangement) to scan a location of the particular portion along a path from a first point of the sample to a second point of the sample. In addition, it is possible to control the scan (e.g., with the second arrangement) such that the scan may comprise at least one first segment having a positive velocity and at least one segment having a negative velocity. A first distance of the first segment and/or the second segment can be smaller than a second distance between the first and second points.

    摘要翻译： 可以提供示例性的装置和/或示例性方法，其可以（例如，利用至少一个第一布置）来测量从特定部分提供的至少一个电磁辐射的幅度和/或相位 样品。 此外，可以（例如，使用至少一个第二布置）沿着从样品的第一点到样品的第二点的路径扫描特定部分的位置。 此外，可以控制扫描（例如，利用第二布置），使得扫描可以包括具有正速度的至少一个第一段和至少一个具有负速度的段。 第一段和/或第二段的第一距离可以小于第一和第二点之间的第二距离。

    APPARATUS AND METHOD FOR RANGING AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS
    12.
    发明申请
    APPARATUS AND METHOD FOR RANGING AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS 有权
    通过平行检测光谱仪的低相干干涉LCI和光学相干TOMOGRAPHY OCT信号的范围和噪声降低的装置和方法

    公开(公告)号：US20080152353A1

    公开(公告)日：2008-06-26

    申请号：US11955986

    申请日：2007-12-13

    申请人： Johannes F. de Boer ,  Guillermo J. Tearney ,  Brett E. Bouma

    发明人： Johannes F. de Boer ,  Guillermo J. Tearney ,  Brett E. Bouma

    IPC分类号： G01B9/02

    CPC分类号： G01B9/02007 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02008 ,  G01B9/0201 ,  G01B9/02032 ,  G01B9/02044 ,  G01B9/02045 ,  G01B9/02079 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01N21/4795

    摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

    摘要翻译： 通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。 对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。 结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。 信号保持不变。 喷射噪声的降低增加了系统的动态范围和灵敏度。

    System and method for optical coherence imaging
    14.
    再颁专利
    System and method for optical coherence imaging 有权
    光学相干成像系统和方法

    公开(公告)号：USRE45512E1

    公开(公告)日：2015-05-12

    申请号：US13611926

    申请日：2012-09-12

    申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett E. Bouma

    发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett E. Bouma

    IPC分类号： G02B6/02 ,  G02B6/12 ,  G02B6/26 ,  G02B6/28 ,  G02B6/32 ,  G02B6/36 ,  G02B6/42 ,  G02B6/44 ,  H04J14/02

    CPC分类号： H04J14/0267 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  G02B6/2552 ,  G02B6/262 ,  G02B6/2856

    摘要： Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a second surface which includes a curved portion. The first axis can be provided at a particular angle that is more than 0° and less than 90° with respect to the second axis.

    摘要翻译： 提供了用于传送至少一个电磁辐射的装置和方法。 特别地，可以提供至少一个具有沿着第一轴线延伸的至少一个端部的光纤。 此外，可以与光纤光学协作地提供透光的光学装置。 光学装置可以具有第一表面，其具有垂直于第二轴线的部分，以及包括弯曲部分的第二表面。 第一轴可以相对于第二轴线以大于0°且小于90°的特定角度设置。

    Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution
    15.
    发明授权
    Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution 有权
    以特定分辨率提供至少一个解剖结构的微观图像的系统，方法和计算机可访问介质

    公开(公告)号：US08896838B2

    公开(公告)日：2014-11-25

    申请号：US13042278

    申请日：2011-03-07

    申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  Joseph A. Gardecki ,  Linbo Liu

    发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  Joseph A. Gardecki ,  Linbo Liu

    IPC分类号： G01B9/02 ,  A61B5/00

    CPC分类号： A61B5/0066 ,  A61B5/0044 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/02091 ,  G02B6/32

    摘要： Exemplary embodiments of probes, apparatus, systems and methods can be provided which provide at least one electro-magnetic radiation to at least one sample. For example, a plurality of axicon lenses can be provided which are configured to provide the electro-magnetic radiation(s) having at least partially annulus shape. In addition or alternatively, at least one optical arrangement can be provided which is configured to forward at least one radiation to the sample therethrough having at least partially circularly-symmetric pattern. For example, at least one first portion of the radiation transmitted through a circular section of the pattern can have an optical path-length that is different from an optical path-length of at least one second portion of the radiation transmitted through at least one other section of the pattern.

    摘要翻译： 可以提供探针，装置，系统和方法的示例性实施例，其向至少一个样品提供至少一个电磁辐射。 例如，可以提供多个旋转透镜，其构造成提供具有至少部分环形形状的电磁辐射。 另外或替代地，可以提供至少一个光学布置，其被配置为将至少一个辐射转发到具有至少部分圆对称图案的样品。 例如，透过图案的圆形部分的辐射的至少一个第一部分可以具有不同于透过至少一个其它的辐射的至少一个第二部分的光程长度的光程长度 部分图案。

    Devices and methods for imaging particular cells including eosinophils
    17.
    发明申请
    Devices and methods for imaging particular cells including eosinophils 审中-公开
    用于成像特定细胞（包括嗜酸性粒细胞）的装置和方法

    公开(公告)号：US20110137178A1

    公开(公告)日：2011-06-09

    申请号：US12899524

    申请日：2010-10-06

    申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  Dongkyun Kang ,  Hongki Yoo

    发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  Dongkyun Kang ,  Hongki Yoo

    IPC分类号： A61B6/00

    CPC分类号： A61B5/411 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/037 ,  A61B5/4233 ,  A61B5/68 ,  A61B5/6852 ,  A61B5/6853 ,  G02B21/0064 ,  G02B21/0076

    摘要： An exemplary embodiment of apparatus and method according to the present disclosure can be provided. For example, using at least one first arrangement, it is possible to direct at least one first electro-magnetic radiation to at least one portion of tissue within a body. Using at least one second arrangement, it is possible to receive at least one second electro-magnetic radiation provided from the portion, which is based on the first electro-magnetic radiation. Further, using at least one third arrangement, it is possible to differentiate at least one particular cell which is eosinophil, mast cell, basophil, monocyte and/or nutrophil from other cells in the portion based on the second electro-magnetic radiation.

    摘要翻译： 可以提供根据本公开的装置和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一电磁辐射引导到身体内的组织的至少一部分。 使用至少一个第二布置，可以接收从基于第一电磁辐射的部分提供的至少一个第二电磁辐射。 此外，使用至少三分之一布置，可以基于第二电磁辐射将部分中的至少一种特定的嗜酸性粒细胞，肥大细胞，嗜碱性粒细胞，单核细胞和/或营养细胞与其他细胞区分开。