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公开(公告)号：US10884008B2
公开(公告)日：2021-01-05
申请号：US15309550
申请日：2015-04-27
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Taro Nakazawa , Motohiro Yamazaki , Tatsuya Yamashita , Yoshitaka Kodama
Abstract: Provided are: a device for storing biochemical reagents wherein an amount of a reagent can be hermetically stored and dropped from a storage site without coming into contact with the outside air; and a biochemical analyzer using the device. The device (10) is constituted by: sticking a top sheet (32) to a base sheet (31) provided with a convex-shaped hollow pocket (16) in which a reagent can be housed; a reagent container as a PTP packaging sheet (30) wherein an opening of the pocket in the base sheet (31), in which a reagent is preliminarily housed, is hermetically sealed with the top sheet (32); and sticking the film sheet surface as the top sheet (32) of the PTP packaging sheet (30), in which the reagent is hermetically packaged, to a cartridge surface of a device body (20) to thereby hermetically seal the inside of the device body too.
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12.发明申请公开(公告)号：US20150210999A1
公开(公告)日：2015-07-30
申请号：US14416146
申请日：2013-06-11
Applicant: Hitachi High-Technologies Corporation
Inventor： Yukari Sahoyama , Motohiro Yamazaki , Yoshitaka Kodama , Takamichi Muramatsu
IPC: C12N15/10 , C12Q1/68 , G01N27/447 , B01L7/00
CPC classification number: C12N15/101 , B01L3/5027 , B01L7/52 , B01L2200/028 , B01L2200/10 , B01L2300/0816 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/686 , G01N27/44791 , C12Q2565/125 , C12Q2565/629 , C12Q2531/113
Abstract: To allow fully automated implementation of all steps of from pre-processing up to electrophoresis. Provided is a pre-processing/electrophoresis integrated cartridge including one or more block structures corresponding to the individual steps of pre-processing. Each block structure includes (1) a first block having a reaction tank, a reagent tank, a plurality of flow channels that connect the tanks, a plurality of control valves arranged in the flow channels, and a flow channel that connects a reaction tank in a block structure located at a preceding stage and a reaction tank in a block structure located at a next stage, and (2) a second block having a phoretic solution tank, a cathode buffer solution tank, a wash solution tank, a flow channel that connects a carrier tank in the block structure located at the preceding stage and the phoretic solution tank, and a control valve for the flow channel.
Abstract translation: 允许全自动实现从预处理到电泳的所有步骤。 提供了一种预处理/电泳集成盒，其包括对应于预处理的各个步骤的一个或多个块结构。 每个块结构包括（1）具有反应罐，试剂罐，连接罐的多个流动通道，布置在流动通道中的多个控制阀的第一块和将反应罐连接在一起的流动通道 位于前一级的块结构和位于下一阶段的块结构中的反应槽，以及（2）具有沉淀溶液罐，阴极缓冲溶液罐，洗涤溶液罐的第二块，流动槽 将位于前一级的块结构中的载体槽和溶液槽连接，并且将流路的控制阀连接起来。
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公开(公告)号：US11360047B2
公开(公告)日：2022-06-14
申请号：US16633641
申请日：2017-07-31
Applicant: Hitachi High-Technologies Corporation
Inventor： Katsuhiro Aritome , Ryusuke Kimura , Motohiro Yamazaki
IPC: G01N27/447 , G01N27/416
Abstract: An electrophoresis device has: a sample tray (112) on which there are placed a positive-electrode-side buffer solution container (103) containing a buffer solution and a phoresis medium container (102) containing a phoresis medium, and which is driven in a vertical direction and a horizontal direction; a thermostat oven unit (113) that holds a capillary array having a capillary head in which a plurality of capillaries are bundled in a single unit at one end thereof in a state where the capillary array being held in a state in which the capillary head protrudes downward, and that keeps the interior temperature constant; a solution-delivering mechanism (106) for delivering the phoresis medium in the phoresis medium container to the capillary array from the capillary head; and a power source for applying a voltage to both ends of the capillary array. Holes for insertion of the capillary head are provided in upper sections of the positive-electrode-side buffer solution container and the phoresis medium container. The thermostat oven unit is provided with a first lid member (207) that is positioned above the sample tray and seals the upper section of the positive-electrode-side buffer solution container while the phoresis medium is being delivered by the solution-delivering mechanism.
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公开(公告)号：US10705046B2
公开(公告)日：2020-07-07
申请号：US15560395
申请日：2015-03-27
Applicant: Hitachi High-Technologies Corporation
Inventor： Ryusuke Kimura , Motohiro Yamazaki , Hitoshi Miyata , Hiroyuki Higashino
IPC: G01N27/447
Abstract: Provided is an electrophoresis device that, by electrophoresis, feeds a sample into capillaries and optically detects the sample, the electrophoresis device being provided with capillaries, a capillary head provided at the distal end of the capillaries, a phoretic medium-filled container used for electrophoresis and filled with a phoretic medium, a guide member that covers the side surface of the phoretic medium-filled container, a seal member that seals from below the phoretic medium filled in the phoretic medium-filled container, and a plunger that presses the seal member.
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公开(公告)号：US09921160B2
公开(公告)日：2018-03-20
申请号：US15324149
申请日：2015-06-23
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Takashi Anazawa , Yoshitaka Kodama , Motohiro Yamazaki , Kunio Harada
CPC classification number: G01N21/6454 , B01L3/5027 , B01L2300/0861 , B01L2300/0877 , B01L2300/168 , G01N21/01 , G01N21/05 , G01N21/645 , G01N21/6452 , G01N2021/6463 , G01N2201/06113
Abstract: A laser beam 6 irradiated from a side face of a microchip 1 in which plural channels 2 fill ed with a member of a refractive index n2 in an inner portion of a member of a refractive index n1 (n2 lower base, and is deviated swiftly from a channel array. Hence, the laser beam 6 is made to be deviated gradually from the channel array by irradiating the laser beam 6 from the side face of the microchip 1 by being inclined relative to the same plane in a direction of being directed from the lower base to the upper base. As a result, a larger number of the channels 2 can efficiently be subjected to laser beam irradiation.
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Patent Agency Ranking
公开(公告)号：US20170138974A1
公开(公告)日：2017-05-18
申请号：US15309550
申请日：2015-04-27
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Taro Nakazawa , Motohiro Yamazaki , Tatsuya Yamashita , Yoshitaka Kodama
IPC: G01N35/10
CPC classification number: G01N35/1002 , B01L3/502715 , B01L3/523 , B01L7/52 , B01L2200/027 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/1822 , B01L2400/0481 , B01L2400/0633 , B01L2400/0683 , G01N2035/00158 , G01N2035/1041
Abstract: Provided are: a device for storing biochemical reagents wherein an amount of a reagent can be hermetically stored and dropped from a storage site without coming into contact with the outside air; and a biochemical analyzer using the device. The device (10) is constituted by: sticking a top sheet (32) to a base sheet (31) provided with a convex-shaped hollow pocket (16) in which a reagent can be housed; a reagent container as a PTP packaging sheet (30) wherein an opening of the pocket in the base sheet (31), in which a reagent is preliminarily housed, is hermetically sealed with the top sheet (32); and sticking the film sheet surface as the top sheet (32) of the PTP packaging sheet (30), in which the reagent is hermetically packaged, to a cartridge surface of a device body (20) to thereby hermetically seal the inside of the device body too.
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公开(公告)号：US09605300B2
公开(公告)日：2017-03-28
申请号：US14652922
申请日：2013-12-04
Applicant: Hitachi High-Technologies Corporation
Inventor： Toru Yokoyama , Motohiro Yamazaki
IPC: G01J3/30 , C12Q1/68 , G06F19/18 , G01N27/447 , G01N21/64
CPC classification number: C12Q1/68 , C12Q1/6827 , G01N21/6428 , G01N21/6456 , G01N27/447 , G01N27/44726 , G01N2021/6417 , G01N2021/6439 , G01N2021/6441 , G06F19/18 , C12Q2565/629 , C12Q2565/634
Abstract: A technique for performing spectral calibration simultaneously with electrophoresis of an actual sample to be analyzed, without performing electrophoresis using a special matrix standard which is time-consuming and costly, is provided. The device for genotypic analysis is characterized by obtaining reference fluorescence spectra using a size standard and an allelic ladder, which provide information concerning known DNA fragments used for electrophoresis of an actual sample, and is characterized by performing spectral calibration for a capillary in which the allelic ladder is not used by detecting a shift amount of the fluorescence spectra of the size standard and shifting the reference fluorescence spectra using the shift amount to determine fluorescence spectra.
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公开(公告)号：US11150214B2
公开(公告)日：2021-10-19
申请号：US16484696
申请日：2018-03-08
Applicant: Hitachi High-Technologies Corporation
Inventor： Wataru Sato , Motohiro Yamazaki
IPC: G01N27/447
Abstract: The capillary electrophoresis apparatus according to the present invention can maintain the temperature in the longitudinal direction of each of a plurality of capillaries uniformly, such that the separation performance of the capillary electrophoresis apparatus can be stabilized, and the analysis performance can be improved. A capillary electrophoresis apparatus according to the present invention includes: a thermostat having a heat source, a first heat conduction member, and a detection window for detecting a sample, the thermostat being configured to maintain a capillary at a predetermined temperature; a capillary holder having a second heat conduction member for sandwiching the capillary between the second heat conduction member and the first heat conduction member, the capillary holder being configured to hold the capillary; and a detection unit configured to detect a sample to be electrophoresed in the capillary, wherein in the heat source, a heat generation amount of at least one of a periphery of the detection window and an end of the capillary is higher than a heat generation amount of another portion.
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公开(公告)号：USD835293S1
公开(公告)日：2018-12-04
申请号：US29586483
申请日：2016-12-05
Applicant: Hitachi High-Technologies Corporation
Designer： Ai Masuda , Hiroyuki Noda , Hiroyuki Higashino , Jin Matsumura , Motohiro Yamazaki
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公开(公告)号：US10041884B2
公开(公告)日：2018-08-07
申请号：US14890246
申请日：2014-05-09
Applicant: Hitachi High-Technologies Corporation
Inventor： Michiru Fujioka , Motohiro Yamazaki , Toru Yokoyama
Abstract: Provided is a nucleic acid analyzer, which does not require manual processes by a highly trained operator such as a researcher and is easy to use, small-sized, capable of accepting multiple samples, and performs speedy analysis, and a nucleic acid analysis method using the analyzer. The analyzer and method perform detection in a plurality of exposure times, provide a program for determining a threshold for signal detection, and determine whether a faint signal peak is a false signal peak.
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