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    Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry
    13.
    发明授权
    Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry 有权

    公开(公告)号：US06610978B2

    公开(公告)日：2003-08-26

    申请号：US09820321

    申请日：2001-03-27

    申请人： Hongfeng Yin ,  Thomas P. Doherty ,  Sally A Swedberg

    发明人： Hongfeng Yin ,  Thomas P. Doherty ,  Sally A Swedberg

    IPC分类号： H01J4900

    CPC分类号： H01J49/045 ,  H01J49/0018 ,  H01J49/105

    摘要： The present invention relates to microdevices for introducing a small volume of a fluid sample into an ionization chamber. The microdevices are constructed from a substrate having a first and second opposing surfaces, the substrate having a microchannel formed in the first surface, and a cover plate arranged over the first surface, the cover plate in combination with the microchannel defining a conduit for conveying the sample. A sample inlet port is provided in fluid communication with the microchannel, wherein the sample inlet port allows the fluid sample from an external source to be conveyed in a defined sample flow path that travels, in order, through the sample inlet port, the conduit and a sample outlet port and into the ionization chamber. Optionally, the fluid sample undergoes a chemical or biochemical reaction within an integrated portion of the microdevice before reaching the ionization chamber. A nebulizing means nebulizes the fluid sample in a nebulizing region adjacent to the sample outlet port. The invention also relates to a method for introducing a fluid sample using the microdevice.

    Preparative capillary electrophoresis with wide-bore capillary
    14.
    发明授权
    Preparative capillary electrophoresis with wide-bore capillary 失效
    具有宽孔毛细管的制备性毛细管电泳

    公开(公告)号：US5658446A

    公开(公告)日：1997-08-19

    申请号：US688351

    申请日：1996-07-30

    申请人： Hongfeng Yin ,  Douglass McManigill ,  Catherine A. Keely-Templin ,  Robert R. Holloway

    发明人： Hongfeng Yin ,  Douglass McManigill ,  Catherine A. Keely-Templin ,  Robert R. Holloway

    IPC分类号： G01N27/447 ,  G01N27/26

    CPC分类号： G01N27/44704

    摘要： A wide-bore capillary electrophoresis apparatus for the analysis of analyte ions is provided. The apparatus has a wide-bore capillary that has a restriction zone at one or more ends. The capillary has an inlet end and an outlet end and an opening at each of said ends. The restriction zone is capable of providing fluid communication between the wide bore and the opening at said end. The restriction zone includes a narrow bore extending to the opening and a transition zone providing gradual change of bore diameter from the wide bore to the narrow bore. The apparatus further has a buffer source to supply buffer to the inlet end of the capillary and a power supply for supplying power to drive buffer and analyte ions through the capillary. During CE, electrodes provide electrical communication between the power supply and the inlet end and the outlet end and apply a voltage differential between said ends.

    摘要翻译： 提供了一种用于分析离子的分析的宽孔毛细管电泳装置。 该装置具有在一个或多个端部处具有限制区的宽孔毛细管。 毛细管具有入口端和出口端以及在每个端部处的开口。 限制区域能够在所述端部的宽孔和开口之间提供流体连通。 限制区域包括延伸到开口的窄孔和过渡区，其提供从宽孔到窄孔的孔直径的逐渐变化。 该装置还具有缓冲源，以向毛细管的入口端供应缓冲器，以及用于通过毛细管向驱动缓冲器和分析物离子供电的电源。 在CE期间，电极在电源与入口端和出口端之间提供电气连通，并在所述端部之间施加电压差。

    Content presentation and management system associating base content and relevant additional content
    16.
    发明授权
    Content presentation and management system associating base content and relevant additional content 有权
    内容演示和管理系统将基础内容和相关附加内容相关联

    公开(公告)号：US07483891B2

    公开(公告)日：2009-01-27

    申请号：US10829814

    申请日：2004-04-21

    申请人： Hongche Liu ,  Anand Madhavan ,  Majid Mohazzab ,  Hongfeng Yin ,  Eric Leu

    发明人： Hongche Liu ,  Anand Madhavan ,  Majid Mohazzab ,  Hongfeng Yin ,  Eric Leu

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30648 ,  G06F17/30864 ,  Y10S707/99935 ,  Y10S707/99936 ,  Y10S707/99937

    摘要： A system for determining associations between base content and relevant content and for publishing the base content and relevant content on a client browser. The system includes a parsing module configured to parse the base content to form parsed base content; a unit-dictionary module including a plurality of query units; a unit-extraction module configured to extract query units included in the unit dictionary from the parsed base content, wherein the query units extracted from the base content are referred to as the extracted-query units; a unit-ranking module configured to rank the extracted-query units based on at least one of relevance scores and revenue-generation amounts for the query units; and a unit-matching module configured to generate at least one association between the base content and the relevant content based on whether the extracted-query units and at least one of query units and keywords associated with the relevant content are the same.

    摘要翻译： 一种用于确定基础内容和相关内容之间的关联以及用于在客户端浏览器上发布基础内容和相关内容的系统。 所述系统包括解析模块，所述解析模块被配置为解析所述基本内容以形成解析的基本内容; 包括多个查询单元的单位字典模块; 单元提取模块，被配置为从解析的基本内容中提取包含在单元字典中的查询单元，其中从基本内容中提取的查询单元被称为提取查询单元; 单元分级模块，被配置为基于所述查询单元的相关性分数和收入生成量中的至少一个来对提取的查询单元进行排名; 以及单元匹配模块，被配置为基于所提取的查询单元以及与相关内容相关联的查询单元和关键字中的至少一个是相同的，来生成基本内容和相关内容之间的至少一个关联。

    Ion source frequency feedback device and method
    18.
    发明授权
    Ion source frequency feedback device and method 失效
    离子源频率反馈装置及方法

    公开(公告)号：US07372023B2

    公开(公告)日：2008-05-13

    申请号：US11333213

    申请日：2006-01-18

    申请人： Daniel Sobek ,  Jing Cai ,  Kevin Killeen ,  Hongfeng Yin

    发明人： Daniel Sobek ,  Jing Cai ,  Kevin Killeen ,  Hongfeng Yin

    IPC分类号： H01J49/10

    CPC分类号： H01J49/165

    摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip and counter-electrode interface and a feedback loop control device connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier, a DC de-coupler, a frequency to voltage converter, a controller, and a voltage-controlled high-voltage power supply that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.

    摘要翻译： 描述了用于分析仪器的离子源。 离子源包括毛细管尖端和对电极界面以及连接到毛细管尖端和对电极界面的反馈回路控制装置。 反馈回路控制装置包括跨阻抗放大器，直流去耦合器，频率 - 电压转换器，控制器和电压控制的高压电源，其提供针对毛细管尖端和计数器的对电极电压的尖端 电极接口。 反馈回路控制装置测量电离电流的调制频率，并提供端对电极电压的反馈调整，以维持电离效率。

    Behavioral targeting system
    19.
    发明申请
    Behavioral targeting system 有权
    行为定位系统

    公开(公告)号：US20070260596A1

    公开(公告)日：2007-11-08

    申请号：US11394343

    申请日：2006-03-29

    申请人： Joshua Koran ,  Christina Chung ,  Abhinav Gupta ,  George John ,  Hongfeng Yin ,  Long-Ji Lin ,  Richard Frankel

    发明人： Joshua Koran ,  Christina Chung ,  Abhinav Gupta ,  George John ,  Hongfeng Yin ,  Long-Ji Lin ,  Richard Frankel

    IPC分类号： G06F17/30

    CPC分类号： G06Q30/0255 ,  G06F17/3053 ,  G06F17/30702 ,  G06F17/30761 ,  G06F17/30914 ,  G06N5/02 ,  G06Q10/067 ,  G06Q30/02

    摘要： A behavioral targeting system determines user profiles from online activity. The system includes a plurality of models that define parameters for determining a user profile score. Event information, which comprises on-line activity of the user, is received at an entity. To generate a user profile score, a model is selected. The model comprises recency, intensity and frequency dimension parameters. The behavioral targeting system generates a user profile score for a target objective, such as brand advertising or direct response advertising. The parameters from the model are applied to generate the user profile score in a category. The behavioral targeting system has application for use in ad serving to on-line users.

    摘要翻译： 行为定位系统从在线活动确定用户个人资料。 该系统包括多个模型，其定义用于确定用户简档分数的参数。 事件信息，包括用户的在线活动，在一个实体被接收。 要生成用户配置文件分数，选择一个模型。 该模型包括新近度，强度和频率尺寸参数。 行为定位系统为目标目标生成用户简档分数，例如品牌广告或直接响应广告。 应用来自模型的参数以在类别中生成用户简档分数。 行为定位系统具有在在线用户的广告投放中使用的应用。

    Devices and methods using fluid-transporting features of differing dwell times
    20.
    发明申请
    Devices and methods using fluid-transporting features of differing dwell times 审中-公开
    使用不同停留时间的流体输送特征的装置和方法

    公开(公告)号：US20070113907A1

    公开(公告)日：2007-05-24

    申请号：US11283363

    申请日：2005-11-18

    申请人： Reid Brennen ,  Hongfeng Yin ,  Kevin Killeen ,  Arthur Schleifer

    发明人： Reid Brennen ,  Hongfeng Yin ,  Kevin Killeen ,  Arthur Schleifer

    IPC分类号： F15C1/06

    CPC分类号： G01N30/34 ,  B01F13/0059 ,  B01F13/0094 ,  B01L3/502746 ,  B01L2300/0867 ,  B01L2400/0418 ,  B01L2400/0487 ,  B01L2400/084 ,  Y10T137/2224

    摘要： A fluidic device is provided that includes a plurality of fluid-transporting features extending from a common inlet to a common outlet and a means for effecting fluid flow through the fluid-transporting features. The features are associated with differing fluid dwell times. The means for effecting fluid flow cooperates with the fluid-transporting features to merge fluids from the fluid-transporting features in a manner effective to produce an output stream from the common outlet that exhibits at least one desired characteristic generated as a result of the differing dwell times. Also provided is a method for producing a fluid stream exhibiting at least one desired characteristic. Optionally, the device and/or method are used in microfluidic applications.

    摘要翻译： 提供了一种流体装置，其包括从公共入口延伸到公共出口的多个流体输送特征以及用于使流体流过流体输送特征的装置。 这些特征与不同的流体停留时间有关。 用于实现流体流动的装置与流体输送特征协作，以有效地产生来自公共出口的输出流的方式合并来自流体输送特征的流体，其显示由于不同驻留而产生的至少一个期望特性 次 还提供了一种产生表现出至少一种期望特性的流体流的方法。 可选地，该装置和/或方法用于微流体应用中。