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公开(公告)号：US10548517B2
公开(公告)日：2020-02-04
申请号：US14934727
申请日：2015-11-06
Applicant: SAMSUNG ELECTRONICS CO., LTD. , IMEC VZW
Inventor： Seongho Cho , Peter Peumans , Woochang Lee
IPC: A61B5/1455 , A61B5/145
Abstract: A spectroscopic apparatus and method for analyzing a biological material are provided. The spectroscopic apparatus may analyze a biological material which has an internal non-uniform tissue depending on a position thereof. The apparatus may include at least one detector configured to obtain respective detection spectrums corresponding to a plurality of measurement regions that are at mutually different positions of the biological material, and an information processor to determine whether the measurement regions are normal by mutually comparing the detection spectrums, or converting contribution degrees of data for a specific component of the biological material by differentiating the detection spectrums.
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公开(公告)号：US10359363B2
公开(公告)日：2019-07-23
申请号：US15736414
申请日：2016-06-22
Applicant: IMEC VZW
Inventor： Peter Peumans , Liesbet Lagae , Willem Van Roy , Tim Stakenborg , Pol Van Dorpe
Abstract: A sensor device for quantifying luminescent targets. The device comprises a light source for exciting the targets, thus generating luminescence signals, and a detector for detecting these signals of the targets in a cell, resulting in a detected signal comprising a desired signal and a background signal. The detector has a spatial cell resolution and/or a time resolution that is so high that only a limited number of targets will be present in the cell when measuring at low concentration and/or that only a limited number of targets add to the cell in between two measurements. A change in the number of targets in the cell can be observed in the detected signal. The device comprises a processor configured to distinguish the desired and the background signal, and to combine the detected signals of the different cells and/or moments in time, to quantify the targets.
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公开(公告)号：US10267733B2
公开(公告)日：2019-04-23
申请号：US15312116
申请日：2015-05-22
Applicant: IMEC VZW
Inventor： Pol Van Dorpe , Liesbet Lagae , Peter Peumans , Andim Stassen , Philippe Helin , Bert Du Bois , Simone Severi
Abstract: The present disclosure relates to semiconductor devices for detecting fluorescent particles. At least one embodiment relates to an integrated semiconductor device for detecting fluorescent tags. The device includes a first layer, a second layer, a third layer, a fourth layer, and a fifth layer. The first layer includes a detector element. The second layer includes a rejection filter. The third layer is fabricated from dielectric material. The fourth layer is an optical waveguide configured and positioned such that a top surface of the fourth layer is illuminated with an evanescent tail of excitation light guided by the optical waveguide when the fluorescent tags are present. The fifth layer includes a microfluidic channel. The optical waveguide is configured and positioned such that the microfluidic channel is illuminated with the evanescent tail. The detector element is positioned such that light from activated fluorescent tags can be received.
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公开(公告)号：US10124338B2
公开(公告)日：2018-11-13
申请号：US15526922
申请日：2015-11-19
Applicant: IMEC VZW
Inventor： Chengxun Liu , Peter Peumans , Liesbet Lagae , Bivragh Majeed
Abstract: The present disclosure relates to microbubble generator devices for deflecting objects in a liquid, systems for sorting objects that utilize such devices, and methods for fabricating such devices. At least one embodiment relates to a micro-fluidic device for deflecting objects in a liquid. The device includes a substrate for providing an object-containing liquid thereon. The device also includes a microbubble generator that includes at least one microbubble generating element. The microbubble generator is located on a surface of the substrate and in direct contact with the object-containing liquid when the object-containing liquid is provided on the substrate. The at least one microbubble generating element is configured to deflect a single object in the object-containing liquid through generation of a plurality of microbubbles.
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公开(公告)号：US20180188176A1
公开(公告)日：2018-07-05
申请号：US15737747
申请日：2016-06-29
Applicant: IMEC VZW
Inventor： Peter Peumans , Liesbet Lagae , Willem Van Roy , Tim Stakenborg , Pol Van Dorpe
CPC classification number: G01N21/6452 , G01N21/1717 , G01N21/6428 , G01N21/6456 , G01N21/648 , G01N2021/1731 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439
Abstract: A sensor device for quantifying luminescent targets configured in an at least one dimensional pattern. The sensor device comprises a detector for obtaining an at least one dimensional pattern of measured signals, wherein the detector is adapted for detecting the luminescence of the luminescent targets, resulting in a measured pattern. The sensor device moreover comprises a processor configured to correlate the measured pattern with at least one reference pattern, so as to generate a measurement signal representative for the quantification of luminescent targets. The at least one reference pattern is a recorded pattern or an expected pattern. A recorded pattern is a pattern which is obtained by the detector before the measured pattern is obtained.
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Patent Agency Ranking
公开(公告)号：US20170326552A1
公开(公告)日：2017-11-16
申请号：US15529441
申请日：2015-11-24
Applicant: IMEC VZW
Inventor： Peter Peumans , Liesbet Lagae , Paolo Fiorini
CPC classification number: B01L3/502715 , A61B5/150022 , A61B5/150061 , A61B5/150389 , A61B5/151 , A61B5/157 , A61B2562/028 , B01L3/5027 , B01L3/50273 , B01L2200/10 , B01L2300/041 , B01L2300/046 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/18 , B01L2400/0406 , B01L2400/049
Abstract: The present disclosure relates to a fluid analyzing device that includes a sensing device for analyzing a fluid sample. The sensing device includes a microchip configured for sensing the fluid sample, and a closed micro-fluidic component for propagating the fluid sample to the microchip. The fluid sample can be provided to the micro-fluidic component via an inlet of the fluid analyzing device. And a vacuum compartment, which is air-tight connected to the sensing device, can create in the micro-fluidic component a suction force suitable for propagating the fluid sample through the micro-fluidic component.
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公开(公告)号：US09816935B2
公开(公告)日：2017-11-14
申请号：US15113122
申请日：2015-01-23
Applicant: IMEC VZW
Inventor： Peter Peumans , Pol Van Dorpe
CPC classification number: G01N21/7746 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N2021/6439 , G01N2021/7716 , G01N2021/7786 , G02B6/00 , G02B6/1223 , G02B6/1228 , G02B6/125 , G02B6/4214 , G02B2006/12147
Abstract: The present disclosure relates to structures, systems, and methods for characterizing one or more fluorescent particles. At least one embodiment relates to an integrated waveguide structure. The integrated waveguide structure includes a substrate. The integrated waveguide structure also includes a waveguide layer arranged on top of the substrate. The waveguide layer includes one or more excitation waveguides, one or more emission waveguides, and a particle radiation coupler, which includes a resonator element. In addition, the integrated waveguide structure includes one or more sensing sites configured with respect to the one or more excitation waveguides and the one or more emission waveguides such that a fluorescent particle at one of the sensing sites is activated by an excitation radiation transmitted via the one or more excitation waveguides and radiation emitted by the fluorescent particle is coupled into at least one of the emission waveguides by the particle radiation coupler.
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公开(公告)号：US09617149B2
公开(公告)日：2017-04-11
申请号：US14567301
申请日：2014-12-11
Applicant: IMEC VZW
Inventor： Liesbet Lagae , Peter Peumans
IPC: B01L1/00 , B01L3/00 , B81C1/00 , G01N27/414 , A61B5/15 , F15C5/00 , F15C7/00 , G01N27/22 , B01L7/00
CPC classification number: B81C1/00539 , A61B5/1411 , A61B5/150022 , A61B5/150221 , A61B5/150274 , A61B5/150358 , A61B5/15087 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L2300/046 , B01L2300/0645 , B01L2300/0663 , B01L2300/0681 , B01L2300/0819 , B01L2300/0887 , B01L2300/123 , B01L2300/1833 , B01L2400/0406 , B01L2400/0415 , B01L2400/0688 , B01L2400/086 , B81C1/00238 , F15C5/00 , F15C7/00 , G01N27/227 , G01N27/4148 , Y10T29/494 , Y10T436/143333
Abstract: The present disclosure relates to a device for analyzing a fluid sample. In one aspect, the device includes a fluidic substrate that comprises a micro-fluidic component embedded in the fluidic substrate configured to propagate a fluid sample via capillary force through the device and a means for providing a fluid sample connected to the micro-fluidic component. The device also includes a lid attached to the fluidic substrate at least partly covering the fluidic substrate and at least partly closing the micro-fluidic component. The fluidic substrate may be a silicon fluidic substrate and the lid may be a CMOS chip. In another aspect, embodiments of the present disclosure relate to a method for fabricating such a device, and the method may include providing a fluidic substrate, providing a lid, and attaching, through a CMOS compatible bonding process, the fluidic substrate to the lid to close the fluidic substrate at least partly.
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公开(公告)号：US20170082544A1
公开(公告)日：2017-03-23
申请号：US15312116
申请日：2015-05-22
Applicant: IMEC VZW
Inventor： Pol Van Dorpe , Liesbet Lagae , Peter Peumans , Andim Stassen , Philippe Helin , Bert Du Bois , Simone Severi
IPC: G01N21/64
CPC classification number: G01N21/6428 , G01N21/6454 , G01N21/648 , G01N21/7703 , G01N2201/0873
Abstract: The present disclosure relates to semiconductor devices for detecting fluorescent particles. At least one embodiment relates to an integrated semiconductor device for detecting fluorescent tags. The device includes a first layer, a second layer, a third layer, a fourth layer, and a fifth layer. The first layer includes a detector element. The second layer includes a rejection filter. The third layer is fabricated from dielectric material. The fourth layer is an optical waveguide configured and positioned such that a top surface of the fourth layer is illuminated with an evanescent tail of excitation light guided by the optical waveguide when the fluorescent tags are present. The fifth layer includes a microfluidic channel. The optical waveguide is configured and positioned such that the microfluidic channel is illuminated with the evanescent tail. The detector element is positioned such that light from activated fluorescent tags can be received.
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公开(公告)号：US20170003227A1
公开(公告)日：2017-01-05
申请号：US15113122
申请日：2015-01-23
Applicant: IMEC VZW
Inventor： Peter Peumans , Pol Van Dorpe
CPC classification number: G01N21/7746 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N2021/6439 , G01N2021/7716 , G01N2021/7786 , G02B6/00 , G02B6/1223 , G02B6/1228 , G02B6/125 , G02B6/4214 , G02B2006/12147
Abstract: The present disclosure relates to structures, systems, and methods for characterizing one or more fluorescent particles. At least one embodiment relates to an integrated waveguide structure. The integrated waveguide structure includes a substrate. The integrated waveguide structure also includes a waveguide layer arranged on top of the substrate. The waveguide layer includes one or more excitation waveguides, one or more emission waveguides, and a particle radiation coupler, which includes a resonator element. In addition, the integrated waveguide structure includes one or more sensing sites configured with respect to the one or more excitation waveguides and the one or more emission waveguides such that a fluorescent particle at one of the sensing sites is activated by an excitation radiation transmitted via the one or more excitation waveguides and radiation emitted by the fluorescent particle is coupled into at least one of the emission waveguides by the particle radiation coupler.
Abstract translation: 本公开涉及用于表征一种或多种荧光颗粒的结构，系统和方法。 至少一个实施例涉及一种集成波导结构。 集成波导结构包括基板。 集成波导结构还包括布置在基板顶部上的波导层。 波导层包括一个或多个激发波导，一个或多个发射波导和包括谐振元件的粒子辐射耦合器。 此外，集成波导结构包括相对于一个或多个激励波导和一个或多个发射波导配置的一个或多个感测位置，使得感测位置之一处的荧光颗粒被激发通过经由 一个或多个激发波导和由荧光颗粒发射的辐射通过粒子辐射耦合器耦合到至少一个发射波导中。
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