公开(公告)号：US20050176625A1

公开(公告)日：2005-08-11

申请号：US10512869

申请日：2003-05-12

Applicant: Tore Curstedt ,  Jan Johansson ,  Bengt Robertson

Inventor： Tore Curstedt ,  Jan Johansson ,  Bengt Robertson

IPC: A61K38/00 ,  A61P11/00 ,  C07K14/785 ,  A61K38/16 ,  A61K31/685

CPC classification number: C07K14/785 ,  A61K38/00

Abstract: The invention relates to reconstituted surfactants consisting of artificial phospholipids and peptides able to lower the air-liquid surface tension, more particularly to reconstituted surfactants, comprising special phospholipid mixtures and artificial peptides which are analogues of the natural surfactant SP-C protein for the treatment of respiratory distress syndrome (RDS) and other diseases relates to pulmonary surfactant dysfunctions.

Abstract translation: 本发明涉及由人造磷脂和能够降低空气 - 液体表面张力的肽组成的重构表面活性剂，更具体地说，涉及包含特殊磷脂混合物和人造肽的重构表面活性剂，其是天然表面活性剂SP-C蛋白的类似物，用于治疗 呼吸窘迫综合征（RDS）等疾病涉及肺表面活性物质功能障碍。

公开(公告)号：US5982000A

公开(公告)日：1999-11-09

申请号：US055023

申请日：1998-04-03

Applicant: Larry C. Leighton ,  Thomas W. Moller ,  Nils af Ekenstam ,  Jan Johansson

Inventor： Larry C. Leighton ,  Thomas W. Moller ,  Nils af Ekenstam ,  Jan Johansson

IPC: H01L23/482 ,  H01L29/78

CPC classification number: H01L23/4824 ,  H01L2924/0002 ,  H01L2924/3011

Abstract: A plurality of transistor cells (36) formed on a semiconductor substrate (32) are connected to form a radio frequency power transistor device (30), whereby individual conductive paths (38) are formed on one side of the substrate (32) to connect respective common gate terminals (34) of adjacent transistor cells (36) in series. A further conductive path (40) is formed on an opposite side of the substrate connecting respective drain terminals (35) of the transistor cells (36) in parallel. A resistive element (42) is interposed in the conductive path (38) connecting each adjacent pair of gate terminals (34). The conductivity of the respective resistive elements (42) is selected so as to adequately provide a conductive pathway for connecting the respective gate terminal outputs, while being sufficiently resistive such that each gate terminal 34 "sees" an electrical circuit termination.

Abstract translation: 形成在半导体衬底（32）上的多个晶体管单元（36）被连接以形成射频功率晶体管器件（30），由此在衬底（32）的一侧上形成各个导电通路（38）以连接 相邻晶体管单元（36）的各个公共栅极端子（34）串联。 另外的导电路径（40）形成在与晶体管单元（36）的各个漏极端子（35）并联连接的衬底的相对侧。 电阻元件（42）被插入连接每个相邻的一对栅极端子（34）的导电路径（38）中。 选择各个电阻元件（42）的导电性，以便充分地提供用于连接各个栅极端子输出的导电路径，同时具有足够的电阻性，使得每个栅极端子34“看到”电路端接。

公开(公告)号：US4803702A

公开(公告)日：1989-02-07

申请号：US893432

申请日：1986-08-05

Applicant: Shallop J. Chen ,  Jan Johansson

Inventor： Shallop J. Chen ,  Jan Johansson

IPC: H04M11/00 ,  G06F1/12 ,  G06F1/24 ,  H04L29/10 ,  H04M19/08 ,  H04L7/00

CPC classification number: H04M19/08 ,  G06F1/12 ,  G06F1/24

Abstract: A reset and synchronization interface circuit for use in a subscriber power controller includes a reset circuit portion and a synchronization circuit portion. The reset circuit portion is formed of a first comparator, a second comparator, and an output network for generating a reset signal. The first comparator compares an input signal with the reference voltage to produce a first output signal and a second output signal. The second comparator compares the first output signal from the first comparator with the reference voltage to produce a third output signal. The output network inverts and shifts the level of the third output signal to produce the reset signal. The synchronization circuit portion is formed of a third comparator and an AND logic gate for generating a modified synchronizing signal. The third comparator inverts a synchronizing clock signal to generate a complementary synchronizing clock signal. The AND logic gate combines logically the second output signal from the first comparator with the complementary synchronizing clock signal to produce the modified synchronizing signal.

Abstract translation: 用于用户功率控制器的复位和同步接口电路包括复位电路部分和同步电路部分。 复位电路部分由第一比较器，第二比较器和用于产生复位信号的输出网络形成。 第一比较器将输入信号与参考电压进行比较，以产生第一输出信号和第二输出信号。 第二比较器将来自第一比较器的第一输出信号与参考电压进行比较，以产生第三输出信号。 输出网络反转并移位第三输出信号的电平以产生复位信号。 同步电路部分由第三比较器和与逻辑门组成，用于产生修改的同步信号。 第三比较器反相同步时钟信号以产生互补同步时钟信号。 与逻辑门逻辑地组合来自第一比较器的第二输出信号和互补同步时钟信号，以产生修改的同步信号。

公开(公告)号：US4616801A

公开(公告)日：1986-10-14

申请号：US572712

申请日：1984-01-20

Applicant: Goeran Cewers ,  Jan Johansson ,  Sven-Gunnar Olsson

Inventor： Goeran Cewers ,  Jan Johansson ,  Sven-Gunnar Olsson

IPC: A61M5/00 ,  A61M5/168 ,  A61M5/175 ,  F16L55/14 ,  F16K51/00

CPC classification number: A61M5/16813

Abstract: In order to be able to regulate in a simple and reliable manner the quantity of liquid that is administered to a patient through a hose in an infusion device, there is provided, according to the invention, a motor-driven eccentric, which presses the hose against a blocking device and clamps it off to a greater or lesser degree. The blocking device forms a part of at least one guide for the hose and can assume two positions. In one of the positions the guide is released; in the other position it is closed. A lever mounted with freedom to rotate, which can be spring-loaded, is particularly well suited for the blocking device. In addition, a clamping lever which can be activated through an electromagnetic latch, can be provided as an emergency stop.

Abstract translation: 为了能够以简单和可靠的方式调节通过输液装置中的软管施用于患者的液体量，根据本发明，提供了一种电动偏心器，其将软管按压 抵抗阻塞装置并将其夹紧到或多或少的程度。 阻塞装置形成软管的至少一个引导件的一部分，并且可以采取两个位置。 在其中一个位置，指南被释放; 在另一个位置，它是关闭的。 安装有自由旋转的杠杆，其可以是弹簧加载的，特别适用于阻挡装置。 此外，可以提供可以通过电磁闩锁启动的夹紧杆作为紧急停止。

公开(公告)号：US09157070B2

公开(公告)日：2015-10-13

申请号：US13639763

申请日：2011-04-12

Applicant: Jan Johansson ,  Anna Rising ,  My Hedhammar ,  Ulrika Johansson ,  Mona Widhe

Inventor： Jan Johansson ,  Anna Rising ,  My Hedhammar ,  Ulrika Johansson ,  Mona Widhe

IPC: C12N5/00 ,  C12N5/071 ,  A61L27/22 ,  A61L27/38 ,  A61L27/56 ,  C07K14/005 ,  C07K14/435 ,  D01F4/02 ,  C12N5/0735 ,  C12N5/0797 ,  C12N5/0789 ,  C12N5/077

CPC classification number: C12N5/0068 ,  A61L27/227 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/56 ,  C07K14/005 ,  C07K14/43518 ,  C12N5/0606 ,  C12N5/0623 ,  C12N5/0629 ,  C12N5/0647 ,  C12N5/0656 ,  C12N5/067 ,  C12N5/0676 ,  C12N5/0691 ,  C12N2500/82 ,  C12N2533/50 ,  C12N2539/00 ,  D01F4/02

Abstract: A method and a combination for the cultivation of eukaryotic cells are provided, as well as a method for preparation of eukaryotic cells. The methods comprise providing a sample of eukaryotic cells to be cultured, applying said sample to a cell scaffold material; and maintaining said cell scaffold material having cells applied thereto under conditions suitable for cell culture. The combination comprises eukaryotic cells and a cell scaffold material. The cell scaffold material comprises a polymer of a spider silk protein.

Abstract translation: 提供了用于培养真核细胞的方法和组合，以及用于制备真核细胞的方法。 所述方法包括提供待培养的真核细胞样品，将所述样品施用于细胞支架材料; 以及在适于细胞培养的条件下保持所述细胞支架材料具有施加于其上的细胞。 该组合包含真核细胞和细胞支架材料。 细胞支架材料包括蜘蛛丝蛋白的聚合物。

公开(公告)号：US09149343B2

公开(公告)日：2015-10-06

申请号：US13143654

申请日：2010-01-20

Applicant: Dan Ericson ,  Jan Johansson ,  Orjan Arkang ,  Stefan Leffler ,  Olof Larsson

Inventor： Dan Ericson ,  Jan Johansson ,  Orjan Arkang ,  Stefan Leffler ,  Olof Larsson

IPC: A61C7/00 ,  A61C5/12

CPC classification number: A61C5/127 ,  A61C5/85 ,  A61C5/88

Abstract: A dental instrument, suitable for use when creating a dental filling, is provided. The dental instrument includes a wedge and a matrix. The matrix is fixedly attached to the wedge, and the wedge is adapted to be inserted into the approximal space between two teeth of a patient. The wedge has a bow shape along a length axis of the wedge, the matrix has a first bow shape along a length axis of the matrix, and the matrix also has a second bow shape along an axis perpendicular to the length axis of the matrix. A method of using the dental instrument and a disposable system, which further comprises a protective member, is further provided.

Abstract translation: 提供了适用于创建牙科填充物时使用的牙科器械。 牙科仪器包括楔形物和矩阵。 矩阵固定地附接到楔形件，楔形件适于插入患者的两个牙齿之间的近似空间中。 楔形物沿着楔形物的长度轴线具有弓形形状，矩阵沿着矩阵的长度轴线具有第一弓形形状，矩阵还沿着垂直于矩阵的长度轴线的轴线具有第二弓形形状。 还提供了一种使用牙科器械的方法和还包括保护构件的一次性系统。

公开(公告)号：US08785391B2

公开(公告)日：2014-07-22

申请号：US13805574

申请日：2010-06-24

Applicant: Jan Johansson

Inventor： Jan Johansson

IPC: C07K14/47 ,  C07K16/18 ,  A61K38/48 ,  A61K49/00 ,  G01N33/53 ,  A61K9/00 ,  A61K38/00

CPC classification number: C07K14/47 ,  A61K9/0019 ,  A61K38/00 ,  C07K14/4711

Abstract: An isolated protein is provided for use in treatment of a condition selected from the group consisting of Alzheimer's disease, familial Danish dementia and familial British dementia in a mammal, including man. The isolated protein is selected from the group consisting of proteins comprising an amino acid sequence having at least 70% identity to residues 90-236 of Bri2 from human; and proteins comprising an amino acid sequence having at least 70% identity to any one of the Brichos domains of Bri2 from human, chimpanzee, bovine, pig, mouse and rat.

Abstract translation: 提供分离的蛋白质用于治疗哺乳动物（包括人）中从阿尔茨海默病，家族性丹麦痴呆和家族性英国痴呆中选择的病症。 分离的蛋白质选自包含与来自人的Bri2的残基90-236具有至少70％同一性的氨基酸序列的蛋白质; 和包含与来自人，黑猩猩，牛，猪，小鼠和大鼠的Bri2的任何一个Brichos结构域具有至少70％同一性的氨基酸序列的蛋白质。

公开(公告)号：US08642734B2

公开(公告)日：2014-02-04

申请号：US13264938

申请日：2010-04-21

Applicant: Jan Johansson ,  My Hedhammar ,  Anna Rising ,  Kerstin Nordling

Inventor： Jan Johansson ,  My Hedhammar ,  Anna Rising ,  Kerstin Nordling

IPC: A61K38/17

CPC classification number: C07K14/43518

Abstract: A method of producing polymers of an isolated spider silk protein involves providing a solution of said spider silk protein in a liquid medium at pH 6.4 or higher and/or an ion composition that prevents polymerization of the spider silk protein. The properties of the liquid medium are adjusted to a pH of 6.3 or lower and an ion composition that allows polymerization of the spider silk protein. The spider silk protein is allowed to form polymers in the liquid medium, and the resulting spider silk protein polymers are isolated from the liquid medium. The resulting polymers are useful as fibers, films, foams, nets or meshes.

Abstract translation: 制备分离的蜘蛛丝蛋白质的聚合物的方法包括提供所述蜘蛛丝蛋白质在pH6.4或更高的液体培养基中的溶液和/或防止蜘蛛丝蛋白聚合的离子组合物。 将液体介质的性质调节至6.3或更低的pH，以及允许蜘蛛丝蛋白质聚合的离子组合物。 允许蜘蛛丝蛋白在液体培养基中形成聚合物，并且从液体培养基中分离得到的蜘蛛丝蛋白聚合物。 所得聚合物可用作纤维，薄膜，泡沫，网或网。

公开(公告)号：US20130336721A1

公开(公告)日：2013-12-19

申请号：US13827465

申请日：2013-03-14

Applicant: Troy O. McBride ,  Jan Johansson ,  David Perkins ,  Dax Kepshire ,  Benjamin R. Bollinger ,  Adam Rauwerdink ,  Richard Brody ,  Arne LaVen ,  Jon Bessette

Inventor： Troy O. McBride ,  Jan Johansson ,  David Perkins ,  Dax Kepshire ,  Benjamin R. Bollinger ,  Adam Rauwerdink ,  Richard Brody ,  Arne LaVen ,  Jon Bessette

IPC: E21D11/00 ,  E21D13/00

CPC classification number: F17C1/007 ,  E21B36/00 ,  E21D11/00 ,  E21D11/38 ,  E21D13/00 ,  F17C1/14 ,  F17C2201/0109 ,  F17C2201/0138 ,  F17C2201/019 ,  F17C2201/035 ,  F17C2201/037 ,  F17C2201/052 ,  F17C2203/0304 ,  F17C2203/0604 ,  F17C2203/0617 ,  F17C2203/0619 ,  F17C2203/0639 ,  F17C2203/0678 ,  F17C2205/0142 ,  F17C2221/031 ,  F17C2221/033 ,  F17C2223/0123 ,  F17C2223/035 ,  F17C2223/036 ,  F17C2227/0192 ,  F17C2260/046 ,  F17C2270/0581

Abstract: In various embodiments, lined underground reservoirs and/or insulated pipeline vessels are utilized for storage of compressed fluid in conjunction with energy storage and recovery systems.

Abstract translation: 在各种实施例中，使用衬里的地下储存器和/或绝缘管道容器用于与能量储存和回收系统一起存储压缩流体。

公开(公告)号：US07811988B2

公开(公告)日：2010-10-12

申请号：US10558563

申请日：2004-05-26

Applicant: Jan Johansson ,  Tore Curstedt ,  Bengt Robertson

Inventor： Jan Johansson ,  Tore Curstedt ,  Bengt Robertson

IPC: A61K31/23

CPC classification number: A61K9/0073

Abstract: The present invention provides novel lipid mixtures for synthetic surfactants. In particular, the invention provides a specific lipid mixture containing a specific amount of polyunsaturated phospholipids to be used for the preparation of synthetic surfactants. Said surfactants and pharmaceutical compositions thereof are useful for the treatment of surfactant deficiencies like respiratory distress syndrome (RDS).

Abstract translation: 本发明提供了用于合成表面活性剂的新型脂质混合物。 特别地，本发明提供了一种含有特定量的用于制备合成表面活性剂的多不饱和磷脂的脂质混合物。 所述表面活性剂及其药物组合物可用于治疗表面活性剂缺乏症如呼吸窘迫综合征（RDS）。