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公开(公告)号：US20190264017A1
公开(公告)日：2019-08-29
申请号：US16305372
申请日：2017-06-07
Inventor： Kristian ANDERSSON , Geir FONNUM , Korbinian HEIL
IPC: C08L25/14 , C08F212/08 , B01J19/00
Abstract: This invention relates to polymer particles for solid phase oligonucleotide synthesis. The oligonucleotide may be linked to the particle via a linker having an amide-oligoethyleneglycol-amine structure. The particles may be considered to act as a solid support during the oligonucleotide synthesis. Also disclosed are processes for preparing such polymer particles, compositions and systems comprising such particles, and uses thereof.
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公开(公告)号：US20180237595A1
公开(公告)日：2018-08-23
申请号：US15871863
申请日：2018-01-15
Applicant: Life Technologies AS , Life Technologies Corporation
Inventor： Geir FONNUM , Steven M. MENCHEN , M. Talha GOKMEN , Pontus LUNDBERG , Prasanna Krishnan THWAR , Alfred LUI , Lily LU , Wolfgang HINZ , Lene Husaboe , Elisabeth BREIVOLD , Astrid Evenroed MOLTEBERG , Synne LARSEN
CPC classification number: C08J3/075 , C08F8/12 , C08F220/58 , C08F220/70 , C08F2230/085 , C08J2333/26 , C08F222/38
Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
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公开(公告)号：US20180215852A1
公开(公告)日：2018-08-02
申请号：US15745620
申请日：2016-07-19
Applicant: LIFE TECHNOLOGIES AS
Inventor： Geir FONNUM , Nils LUNDBERG , Muhammed GOKMEN , Synne LARSEN , Wilhelm Glomm , Heidi Johnsen , Ruth SCHMID , Lars Kilaas
IPC: C08F265/10 , C08F120/54 , C08F265/06
CPC classification number: C08F265/10 , C08F120/54 , C08F265/06 , C08F220/56
Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
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公开(公告)号：US20160097094A1
公开(公告)日：2016-04-07
申请号：US14970192
申请日：2015-12-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir FONNUM , Grete Irene MODAHL , Nini Hofslokken KJUS , Astrid Evenroed MOLTEBERG , Diem TRAN , Jo AASERUD , Talha M. GOKMEN , Steven M. MENCHEN , Carl FULLER , Luisa ANDRUZZI , Wolfgang HINZ
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US20140080966A1
公开(公告)日：2014-03-20
申请号：US14081263
申请日：2013-11-15
Applicant: LIFE TECHNOLOGIES AS , LIFE TECHNOLOGIES CORPORATION
Inventor： Nini H. KJUS , Geir FONNUM , Bruce BRANCHAUD , Lai-Qiang Ying , Steven M. MENCHEN , Dmitriy GREMYACHINSKIY , Hee Chol KANG
IPC: C07F7/10 , C08K3/20 , C08F236/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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Patent Agency Ranking
公开(公告)号：US20240101999A1
公开(公告)日：2024-03-28
申请号：US18235205
申请日：2023-08-17
Applicant: Thermo Fisher Scientific GENEART GmbH , LIFE TECHNOLOGIES AS , LIFE TECHNOLOGIES CORPORATION
Inventor： Thomas POEHMERER , Phillip KUHN , Frank NOTKA , Andreas ZEIDLER , Korbinian HEIL , Axel TREFZER , Geir FONNUM , Federico KATZEN , Kristian ANDERSSON , Xiquan LIANG
CPC classification number: C12N15/101 , B01L3/502761 , B03C5/026 , C25B3/29 , C25B9/70 , C25B11/04 , C25B15/02 , B01J2219/00468 , B01J2219/005 , B01J2219/00653 , B01J2219/00695 , B01J2219/00722 , B01L3/502715 , B01L2200/0642 , B01L2200/0647 , B01L2300/0819 , B01L2300/0893 , B01L2400/046 , B01L2400/0487 , B03C2201/26
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US20180163255A1
公开(公告)日：2018-06-14
申请号：US15891535
申请日：2018-02-08
Applicant: LIFE TECHNOLOGIES AS
Inventor： Darren ELLIS , Geir FONNUM , Nini KJUS
IPC: C12Q1/6806 , C12N15/10
CPC classification number: C12Q1/6806 , C12N15/1006 , C12N15/1013
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
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公开(公告)号：US20170204398A1
公开(公告)日：2017-07-20
申请号：US15431678
申请日：2017-02-13
Applicant: LIFE TECHNOLOGIES AS
Inventor： Darren ELLIS , Geir FONNUM , Nini KJUS
CPC classification number: C12Q1/6806 , C12N15/1006 , C12N15/1013
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
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公开(公告)号：US20160075800A1
公开(公告)日：2016-03-17
申请号：US14867394
申请日：2015-09-28
Applicant: Arvid BERGE , Viola Ugelstad , LIFE TECHNOLOGIES AS
Inventor： Arne JØRGEDAL , Elin Marie AKSNES , Geir FONNUM , Astrid MOLTEBERG , Rolf NORDAL , Henning PETTERSEN , Tollef TÅARNEBY , Solveig STAALE , Ellen WENG , Finn HANSEN , Silje NORDBØ , Oddvar AUNE , Arvid BERGE , John BJØRGUM , Turid ELLINGSEN , John UGELSTAD
CPC classification number: C08J9/16 , C08F2/22 , C08F257/02 , C08F265/04 , C08F265/10 , C08F291/00 , C08J9/22 , C08J9/224 , C08J2203/14 , C08J2325/06 , C08J2347/00
Abstract: A process for the preparation of monodisperse polymer particles which are formed by contacting monomers with aqueous dispersions comprising monodisperse swellable seed polymers/oligomers, and initiating polymerization in the presence of a steric stabilizer. The resulting swollen seed particles are characterized by the particle mode diameter.
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公开(公告)号：US20140231697A1
公开(公告)日：2014-08-21
申请号：US14228158
申请日：2014-03-27
Applicant: LIFE TECHNOLOGIES AS
Inventor： Ellen WENG , Geir FONNUM , Grete MODAHL , Astrid MOLTEBERG , Erling FINNE , Torkel STENE
CPC classification number: C09K11/06 , B82Y25/00 , B82Y40/00 , C08F220/18 , C09K11/025 , G01N33/5434 , H01F1/0018 , H01F1/01 , H01F1/26 , H01F41/00 , Y10T428/2991 , Y10T428/2998
Abstract: A coated magnetic particle comprising an optionally porous magnetic polymer particle of a matrix polymer, said polymer particle having on a surface and/or in the pores thereof superparamagnetic crystals, said coated particle having a coat formed of a coating polymer, wherein said coated magnetic particle is essentially non-autofluorescent.
Abstract translation: 一种涂覆的磁性颗粒，其包含基质聚合物的任选多孔磁性聚合物颗粒，所述聚合物颗粒在表面上和/或其孔中具有超顺磁性晶体，所述涂覆颗粒具有由涂覆聚合物形成的涂层，其中所述涂覆的磁性颗粒 本质上是非自发荧光。
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